Daniel V Runco, MD, MS

Daniel V Runco, MD, MS

Neuro-Oncology, Brain Tumor Program, Cancer and Blood Disorders Center

On staff since January 2024

Children's Title: Attending Physician, Cancer and Blood Disorders Center

Academic Title: Assistant Professor, Department of Pediatrics, University of Washington School of Medicine

Research Center: Ben Towne Center for Childhood Cancer Research

"Everything we do as pediatric oncologists should make children live longer or live better – and ideally both. As a pediatric neuro-oncologist, I am thankful to be part of a multidisciplinary team focused solely on improving things for children with cancer and walking through the most difficult days with them and their families. As a researcher, I am passionate about advancing treatments and understanding childhood cancer so our patients can live longer, better lives. "

  • Biography

    Daniel Runco, MD, MS is a Pediatric Oncologist in the Brain Tumor Program at Seattle Children’s Hospital and Assistant Professor at the University of Washington School of Medicine. Dr. Runco joined the faculty in 2024 as a Clinician Scholar with research interests in childhood cancer cachexia. His research is focused around better understanding nutrition and body composition changes that occur during cancer treatment and how that impacts long term survival and quality-of-life. He continues to be active in national and international clinical trials and collaborative societies around treating childhood brain tumors and cancer cachexia.

  • Patient Testimonials
  • Awards and Honors
    Award Name Award Description Awarded By Award Date
    Children’s Oncology Group Young Investigator Presentation Invitee COG Fall Meeting 2018
    Alpha Sigma Nu Jesuit National Honor Society, Creighton University, Omaha, NE 2007
  • Publications

    Other Publications

    • Zhao Z, Patel PA, Slatnick L, Sitthi-Amorn A, Bielamowicz KJ, Nunez FA, Walsh AM, Hess J, Rossoff J, Elgarten C, Myers R, Saab R, Basbous M, Mccormick M, Aftandilian C, Richards R, Nessle CN, Tribble AC, Sheth Bhutada JK, Coven SL, Runco D, Wilkes J, Gurunathan A, Guinipero T, Belsky JA, Lee K, Wong V, Malhotra M, Armstrong A, Jerkins LP, Cross SJ, Fisher L, Stein MT, Wu NL, Yi T, Orgel E, Haeusler GM, Wolf J, Demedis JM, Miller TP, Esbenshade AJ
      Prospective External Validation of the Esbenshade Vanderbilt Models Accurately Predicts Bloodstream Infection Risk in Febrile Non-Neutropenic Children With Cancer.
      38060973 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023 Dec 7 : JCO2301814
    • Moody KM, Andersen C, Bradley J, Draper L, Garrington T, Gill J, Harrison D, Hayashi M, Heaton A, Holladay C, Lion A, Rajan A, Rozo B, Runco D, Salvador L, Ferguson V, Arnold R
      In-person and virtual adaptation of an interprofessional palliative care communications skills training course for pediatric oncology clinicians.
      37609163 Research square, 2023 Aug 11 : PMCID:PMC10441465
    • Runco DV, DiMeglio LA, Vanderpool CP, Han Y, Daggy J, Kelley MM, Mikesell R, Zimmers TA
      Growth differentiation factor 15 (GDF15) elevation in children with newly diagnosed cancer.
      38146512 Frontiers in oncology, 2023 : 131295228 PMCID:PMC10749306
    • Franke J, Bishop C, Runco DV
      Malnutrition screening and treatment in pediatric oncology: a scoping review.
      36550508 BMC nutrition, 2022 Dec 22 : 8(1)150 PMCID:PMC9773580
    • Runco DV, Zimmers TA, Bonetto A
      The urgent need to improve childhood cancer cachexia.
      35931609 Trends in cancer, 2022 Dec. : 8(12)976-979 PMCID:PMC10029855
    • Runco DV, Stanek JR, Yeager ND, Belsky JA
      Malnutrition identification and management variability: An administrative database study of children with solid tumors.
      35040171 JPEN. Journal of parenteral and enteral nutrition, 2022 Sept. : 46(7)1559-1567 PMCID:PMC9544103
    • Belsky J, Stanek J, Yeager N, Runco D
      Constipation and GI diagnoses in children with solid tumours: prevalence and management.
      36041819 BMJ supportive & palliative care, 2022 Aug 30
    • Runco DV, Wasilewski-Masker K, Mazewski CM, Patterson BC, Mertens AC
      Features Associated With Weight Loss and Growth Stunting for Young Children During Cancer Therapy.
      34133373 Journal of pediatric hematology/oncology, 2021 Nov 1 : 43(8)301-307 PMCID:PMC9580507
    • Schultz KAP, Nelson A, Harris AK, Finch M, Field A, Jarzembowski JA, Wilhelm M, Mize W, Kreiger P, Conard K, Walter A, Olson T, Mitchell S, Runco DV, Bechtel A, Klawinski D, Bradfield S, Gettinger K, Stewart DR, Messinger Y, Dehner LP, Ashley Hill D
      Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.
      32415267 Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020 Oct. : 33(10)1922-1929 PMCID:PMC7529703
    • Runco DV, Wasilewski-Masker K, McCracken CE, Wetzel M, Mazewski CM, Patterson BC, Mertens AC
      Normalized measures and patient characteristics to identify undernutrition in infants and young children treated for cancer.
      32690155 Clinical nutrition ESPEN, 2020 Aug. : 38185-191 PMCID:PMC7975630
    • Runco DV, Yoon L, Grooss SA, Wong CK
      Nutrition & Exercise Interventions in Pediatric Patients with Brain Tumors: A Narrative Review.
      31532532 Journal of the National Cancer Institute. Monographs, 2019 Sep 1 : 2019(54)163-168
    • Runco DV, Josephson CD, Raikar SS, Goldsmith KC, Lew G, Pauly M, Fasano RM
      Hyperleukocytosis in infant acute leukemia: a role for manual exchange transfusion for leukoreduction.
      29399859 Transfusion, 2018 May : 58(5)1149-1156 PMCID:PMC5912979
    • Runco DV, Taylor JF, Helft PR
      Ethical Barriers in Adolescent Oncofertility Counseling.
      27879541 Journal of pediatric hematology/oncology, 2017 Jan. : 39(1)56-61
    • Badura Brack, A, Runco, DV, Cadwallader, LA, and Kelley, M.
      An exploratory study of undergraduate students’ referral preferences.
      J College Stud Psychother, 2012 - 2012 : (26(2))155-162
    • Cherney ID, Brabec CM, Runco DV
      Mapping out spatial ability: sex differences in way-finding navigation.
      19235405 Perceptual and motor skills, 2008 Dec. : 107(3)747-60
    • Wang EW, Agostini G, Olomu O, Runco D, Jung JY, Chole RA
      Gentian violet and ferric ammonium citrate disrupt Pseudomonas aeruginosa biofilms.
      18849857 The Laryngoscope, 2008 Nov. : 118(11)2050-6 PMCID:PMC7301310
  • Presentations
    Presentations Title Event Location Date
    Healthcare utilization of pediatric patients with cancer near end-of-life. Kelly, JP, Slaven, JE, Runco, DV, and Niehaus, JZ. Pediatric Academic Societies. Washington, D.C. Apr 28, 2023 - Apr 28, 2023
    Characterization of Endocrinopathies in Children treated for Medulloblastomas. Almutlaq, NN, Haddad, N, Runco, DV. Presented at the 54th Annual Meeting of the International Society of Paediatric Oncology (SIOP). Barcelona, Spain Sep 29, 2022 - Sep 29, 2022
    A pilot investigation of GDF15 in children with cancer. Runco, DV, DiMeglio, LA, Vanderpool, CP, Halsey, DM, Zimmers, TA. Presented at the 54th Annual Meeting of the International Society of Paediatric Oncology (SIOP). Barcelona, Spain Sep 29, 2022 - Sep 29, 2022
    Change in Body Mass Index in Childhood Brain Tumor Survivors. Chatila, D, DiMeglio, L, Runco, D, Haddad, N. Poster presentation at Pediatric Endocrine Society Annual (Virtual) Meeting Apr 28, 2022 - Apr 28, 2022
    Malnutrition Screening and Treatment in Pediatric Oncology: A systematic review Franke, J, Bishop, C, Runco, DV. Poster presented at the Indiana Physiological Society, 12th Annual Meeting, Marian University Indianapolis, IN Apr 9, 2022 - Apr 9, 2022
    Identifying Therapeutic Options for Pediatric Patients with Central Nervous System (CNS) Tumors Through Precision-Guided Deep Sequencing of DNA and RNA. Ferguson, MJ; Helvie, AE; Ivanovich, JL; Schmitt, MR; Coven, SL; Runco, DV; Lion, AH; Renbarger, JL; Marshall, MS. Oral presentation at the 53rd Congress of the International Society of Paediatric Oncology (SIOP 2021) Honolulu, Hawaii Oct 21, 2021 - Oct 21, 2021
    Variability in malnutrition diagnoses and management in children with solid tumors. Runco, DV, Stanek, JR, Yeager, ND, Belsky, JA. Poster presented at the Cancer Cachexia Society 2021. Gainesville, FL Sep 28, 2021 - Sep 28, 2021
    Systematic Review: Exercise and Nutrition Interventions on Quality of Life in Pediatric Brain Tumor Patients. Yoon, LH, Runco, DV, Grooss, SA, Wong, CK. Poster presented at the Combined Sections Meeting for the American Physical Therapy Association. Denver, Colorado Feb 15, 2020 - Feb 15, 2020
    Food for thought: Improving nutrition during pediatric cancer treatment. Runco, DV. Oral Presentation at Indiana University School of Medicine Department of Pediatrics Grand Rounds. Indianapolis, IN Jan 29, 2020 - Jan 29, 2020
    Patterns of weight loss in patients less than 3 years old treated for cancer. Runco, DV, Wasilewski-Masker, K, McCracken, CE, Mazewski, CM, Patterson, BC, and Mertens, AC. Oral Presentation at the Aflac Spring Research Symposium. Atlanta, GA May 23, 2019 - May 23, 2019
    Risk factors for weight loss in infants and young children undergoing cancer treatment. Runco, DV, Wasilewski-Masker, K, Mazewski, CM, Patterson, BC, and Mertens, AC. Poster presented at the American Society for Pediatric Hematology Oncology 2019 Conference. New Orleans, Louisiana May 3, 2019 - May 3, 2019
    Influence of treatment intensity and tumor type on weight and height through cancer therapy in children less than 3 years old Runco, DV, Wasilewski-Masker, K, Mazewski, CM, Patterson, BC, and Mertens, AC. Poster presented at the Children’s Oncology Group Annual Meeting, Young Investigator Session. Dallas, TX Oct 4, 2018 - Oct 4, 2018
    Impact of tumor type and treatment intensity on weight-for-age z-scores through cancer therapy in children under 3 years old Runco, DV, Wasilewski-Masker, K, McCracken, CE, Mazewski, CM, Patterson, BC, and Mertens, AC. Poster presented at the American Society for Pediatric Hematology Oncology 2018 Conference Pittsburgh, PA May 3, 2018 - May 3, 2018
    Impact of tumor type and treatment intensity on weight-for-age z-scores through cancer therapy in children under 3 years old Runco, DV, Wasilewski-Masker, K, McCracken, CE, Mazewski, CM, Patterson, BC, and Mertens, AC., Oral Presentation at the Aflac Spring Research Conference Atlanta, GA Apr 24, 2018 - Apr 24, 2018
    Nutritional outcomes in pediatric oncology patients less than 3 years of age Runco, DV, Mertens, AC, & Wasilewski-Masker, K., Poster presented at Translational Science 2018 Conference Washington, DC Apr 19, 2018 - Apr 19, 2018
  • Research Funding
    Grant Title Grantor Amount Award Date
    Anthropometric and Biochemical Markers of Nutrition in Children with Cancer: A Pilot Investigation of GDF15. IU Simon Comprehensive Cancer Center $22,855 Jan. 2021 - Dec. 2023
    Evaluation of the Communication Plan Early through End-of-Life (IMPACT). Aug. 2019 - Dec. 2023
    A Predictive Model for Weight Loss and Growth Stunting for Infants and Children Undergoing Cancer Treatment. Emory University School of Medicine $3,890 Jan. 2019 - June 2019
    Georgia Clinical and Translational Science Alliance Postdoctoral Research Training Award. Emory University Sept. 2017 - June 2022

Overview

Board Certification(s)

Pediatrics
Pediatric Hematology-Oncology

Medical/Professional School

Emory University, Atlanta, GA
Stritch School of Medicine, Maywood, IL

Residency

Indiana University Pediatrics Residency Program, Indianapolis, IN

Fellowship

Emory University School of Medicine, Atlanta, GA

Clinical Interests

Pediatric neuro-oncology, clinical trials, nutrition, supportive care

Research Description

Dr. Runco focuses on identifying, quantifying, and describing childhood cancer cachexia – the muscle loss, weight loss, and body composition changes that occur with a cancer diagnosis and treatment. In addition to better understanding mediators of cachexia, Dr. Runco hopes to identify potential therapeutic targets as in order to mitigate cachexia, improve on-time and optimal cancer therapy delivery, and improve long-term outcomes for survivors of childhood cancers.