Chuan Zhou, PhD

Chuan  Zhou,  PhD

General Pediatrics

Academic Title: Research Associate Professor

Research Center: Center for Clinical and Translational Research

"In this information age when huge amounts of data are being collected constantly at personal and group levels through social media, digital devices and electronic records, it is crucial to tell good data from bad data, to separate true signals from noises, to tell truth from lies, and understand the implications and consequences of the knowledge we gain from analyzing such big data. Clinical research is no exception. As a biostatistician, my passion is analyzing and making sense of data, and ensuring our clinical studies are valid, efficient and reproducible."

  • Biography

    Chuan Zhou received his PhD in biostatistics from University of Washington, School of Public Health, Department of Biostatistics. After completing his post-doctoral training, he joined the faculty of Biostatistics Department at Vanderbilt, Nashville. In 2008 he moved back to Seattle and joined Pediatrics at University of Washington and Center for Child Health, Behavior, and Development at Seattle Childrens Research Institute as a research associate professor. Since joining the Research Institute, he has conducted analyses and provided statistical guidance for a wide range of clinical and health services research projects, with focus on 1) childhood obesity, home food environment and physical activity; 2) child and adolescent mental health; 3) cerebral palsy and disability; 4) environmental chemical exposure during pregnancy; 5) impact of screen time and media exposure on infant and toddler cognitive and social development, to name a few. His own statistical research interests include Bayesian statistics, high performance statistical computing, multilevel modeling, longitudinal data analysis, causal inference, and missing data methods.

  • Patient Testimonials
  • Publications

    Other Publications

    • Wrenn K, Lorenzen B, Jones I, Zhou C, Aronsky D
      Factors affecting stress in emergency medicine residents while working in the ED.
      20825921 The American journal of emergency medicine, 2010 Oct. : 897-902
    • He WB, Zhou C, Niu Z, Liang LJ
      [Study on panchromatic band broadening of new high-resolution satellite sensor]
      20827994 Guang pu xue yu guang pu fen xi = Guang pu, 2010 July : 1894-7
    • Smith CB, Barrett TW, Berger CL, Zhou C, Thurman RJ, Wrenn KD
      Prediction of blunt traumatic injury in high-acuity patients: bedside examination vs computed tomography.
      20825767 The American journal of emergency medicine, 2010 Mar 24
    • Barrett TW, Dipersio DM, Jenkins CA, Jack M, McCoin NS, Storrow AB, Singleton LM, Lee P, Zhou C, Slovis CM
      A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults.
      20825792 The American journal of emergency medicine, 2010 Mar 24
    • Tandon PS, Wright J, Zhou C, Rogers CB, Christakis DA
      Nutrition menu labeling may lead to lower-calorie restaurant meal choices for children.
      20100765 Pediatrics, 2010 Feb. : 244-8
    • Iida H, Lewis C, Zhou C, Novak L, Grembowski D
      Dental care needs, use and expenditures among U.S. children with and without special health care needs.
      20045826 Journal of the American Dental Association (1939), 2010 Jan. : 79-88
    • Lawrence LM, Jenkins CA, Zhou C, Givens TG
      The effect of diagnosis-specific computerized discharge instructions on 72-hour return visits to the pediatric emergency department.
      19864969 Pediatric emergency care, 2009 Nov. : 733-8
    • Hoot NR, Epstein SK, Allen TL, Jones SS, Baumlin KM, Chawla N, Lee AT, Pines JM, Klair AK, Gordon BD, Flottemesch TJ, LeBlanc LJ, Jones I, Levin SR, Zhou C, Gadd CS, Aronsky D
      Forecasting emergency department crowding: an external, multicenter evaluation.
      19716629 Annals of emergency medicine, 2009 Oct. : 514-522.e19
    • Wei J, Chan HP, Sahiner B, Zhou C, Hadjiiski LM, Roubidoux MA, Helvie MA
      Computer-aided detection of breast masses on mammograms: dual system approach with two-view analysis.
      19928076 Medical physics, 2009 Oct. : 4451-60
    • Zhou C, Chan HP, Sahiner B, Hadjiiski LM, Chughtai A, Patel S, Wei J, Cascade PN, Kazerooni EA
      Computer-aided detection of pulmonary embolism in computed tomographic pulmonary angiography (CTPA): performance evaluation with independent data sets.
      19746771 Medical physics, 2009 Aug. : 3385-96
    • McNaughton C, Zhou C, Robert L, Storrow A, Kennedy R
      A randomized, crossover comparison of injected buffered lidocaine, lidocaine cream, and no analgesia for peripheral intravenous cannula insertion.
      19217695 Annals of emergency medicine, 2009 Aug. : 214-20
    • Hoot NR, Leblanc LJ, Jones I, Levin SR, Zhou C, Gadd CS, Aronsky D
      Forecasting emergency department crowding: a prospective, real-time evaluation.
      19261948 Journal of the American Medical Informatics Association : JAMIA, 2009 May : 338-45
    • Cui J, Sahiner B, Chan HP, Nees A, Paramagul C, Hadjiiski LM, Zhou C, Shi J
      A new automated method for the segmentation and characterization of breast masses on ultrasound images.
      19544771 Medical physics, 2009 May : 1553-65
    • Barrett TW, Schierling M, Zhou C, Colfax JD, Russ S, Conatser P, Lancaster P, Wrenn K
      Prevalence of incidental findings in trauma patients detected by computed tomography imaging.
      19555613 The American journal of emergency medicine, 2009 May : 428-35
    • Zhang Y, Chan HP, Sahiner B, Wei J, Zhou C, Hadjiiski LM
      Artifact reduction methods for truncated projections in iterative breast tomosynthesis reconstruction.
      19478639 Journal of computer assisted tomography, 2009 May : 426-35
    • Han JH, Morandi A, Ely W, Callison C, Zhou C, Storrow AB, Dittus RS, Habermann R, Schnelle J
      Delirium in the nursing home patients seen in the emergency department.
      19484845 Journal of the American Geriatrics Society, 2009 May : 889-94
    • Tayo GO, Tang SX, Tan ZL, Sun ZH, Wang M, Zhou CS, Han XF
      Determination of endogenous faecal phosphorus loss in goats.
      19489453 Archives of animal nutrition, 2009 April : 104-11
    • Yu C, Zhang S, Zhou C, Sile S
      A likelihood ratio test of population Hardy-Weinberg equilibrium for case-control studies.
      19025784 Genetic epidemiology, 2009 April : 275-80
    • Filev P, Hadjiiski L, Chan HP, Sahiner B, Ge J, Helvie MA, Roubidoux M, Zhou C
      Automated regional registration and characterization of corresponding microcalcification clusters on temporal pairs of mammograms for interval change analysis.
      19175093 Medical physics, 2008 Dec. : 5340-50
    • Douglas JA, Roy-Gagnon MH, Zhou C, Mitchell BD, Shuldiner AR, Chan HP, Helvie MA
      Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors.
      19029399 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Dec. : 3509-16
    • Storrow AB, Zhou C, Gaddis G, Han JH, Miller K, Klubert D, Laidig A, Aronsky D
      Decreasing lab turnaround time improves emergency department throughput and decreases emergency medical services diversion: a simulation model.
      18638034 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2008 Nov. : 1130-5
    • Zhou C, Rao Y, Rao Y
      A subset of octopaminergic neurons are important for Drosophila aggression.
      19160504 Nature neuroscience, 2008 Sept. : 1059-67
    • Hoot NR, LeBlanc LJ, Jones I, Levin SR, Zhou C, Gadd CS, Aronsky D
      Forecasting emergency department crowding: a discrete event simulation.
      18387699 Annals of emergency medicine, 2008 Aug. : 116-25
    • Chan HP, Hadjiiski L, Zhou C, Sahiner B
      Computer-aided diagnosis of lung cancer and pulmonary embolism in computed tomography-a review.
      18423310 Academic radiology, 2008 May : 535-55
    • Cao CG, Weinger MB, Slagle J, Zhou C, Ou J, Gillin S, Sheh B, Mazzei W
      Differences in day and night shift clinical performance in anesthesiology.
      18516838 Human factors, 2008 April : 276-90
    • Way TW, Chan HP, Goodsitt MM, Sahiner B, Hadjiiski LM, Zhou C, Chughtai A
      Effect of CT scanning parameters on volumetric measurements of pulmonary nodules by 3D active contour segmentation: a phantom study.
      18296763 Physics in medicine and biology, 2008 Mar 7 : 1295-312
    • Shi J, Sahiner B, Chan HP, Ge J, Hadjiiski L, Helvie MA, Nees A, Wu YT, Wei J, Zhou C, Zhang Y, Cui J
      Characterization of mammographic masses based on level set segmentation with new image features and patient information.
      18293583 Medical physics, 2008 Jan. : 280-90
    • Zhou C, Chan HP, Sahiner B, Hadjiiski LM, Chughtai A, Patel S, Wei J, Ge J, Cascade PN, Kazerooni EA
      Automatic multiscale enhancement and segmentation of pulmonary vessels in CT pulmonary angiography images for CAD applications.
      18196782 Medical physics, 2007 Dec. : 4567-77
    • Zhang Y, Chan HP, Sahiner B, Wu YT, Zhou C, Ge J, Wei J, Hadjiiski LM
      Application of boundary detection information in breast tomosynthesis reconstruction.
      17926964 Medical physics, 2007 Sept. : 3603-13
    • Wu YT, Wei J, Hadjiiski LM, Sahiner B, Zhou C, Ge J, Shi J, Zhang Y, Chan HP
      Bilateral analysis based false positive reduction for computer-aided mass detection.
      17879797 Medical physics, 2007 Aug. : 3334-44
    • Wei J, Hadjiiski LM, Sahiner B, Chan HP, Ge J, Roubidoux MA, Helvie MA, Zhou C, Wu YT, Paramagul C, Zhang Y
      Computer-aided detection systems for breast masses: comparison of performances on full-field digital mammograms and digitized screen-film mammograms.
      17502255 Academic radiology, 2007 June : 659-69
    • Hoot NR, Zhou C, Jones I, Aronsky D
      Measuring and forecasting emergency department crowding in real time.
      17391809 Annals of emergency medicine, 2007 June : 747-55
    • Shi J, Sahiner B, Chan HP, Hadjiiski L, Zhou C, Cascade PN, Bogot N, Kazerooni EA, Wu YT, Wei J
      Pulmonary nodule registration in serial CT scans based on rib anatomy and nodule template matching.
      17500464 Medical physics, 2007 April : 1336-47
    • Han JH, Zhou C, France DJ, Zhong S, Jones I, Storrow AB, Aronsky D
      The effect of emergency department expansion on emergency department overcrowding.
      17400996 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2007 April : 338-43
    • Ge J, Hadjiiski LM, Sahiner B, Wei J, Helvie MA, Zhou C, Chan HP
      Computer-aided detection system for clustered microcalcifications: comparison of performance on full-field digital mammograms and digitized screen-film mammograms.
      17264365 Physics in medicine and biology, 2007 Feb 21 : 981-1000
    • Moore IN, Snyder SL, Miller C, An AQ, Blackford JU, Zhou C, Hickson GB
      Confidentiality and privacy in health care from the patient's perspective: does HIPAA help?
      18326392 Health matrix (Cleveland, Ohio : 1991), 2007 : 215-72
    • Wei J, Chan HP, Sahiner B, Hadjiiski LM, Helvie MA, Roubidoux MA, Zhou C, Ge J
      Dual system approach to computer-aided detection of breast masses on mammograms.
      17153394 Medical physics, 2006 Nov. : 4157-68
    • Zhang Y, Chan HP, Sahiner B, Wei J, Goodsitt MM, Hadjiiski LM, Ge J, Zhou C
      A comparative study of limited-angle cone-beam reconstruction methods for breast tomosynthesis.
      17089843 Medical physics, 2006 Oct. : 3781-95
    • Martin KE, Helvie MA, Zhou C, Roubidoux MA, Bailey JE, Paramagul C, Blane CE, Klein KA, Sonnad SS, Chan HP
      Mammographic density measured with quantitative computer-aided method: comparison with radiologists' estimates and BI-RADS categories.
      16857974 Radiology, 2006 Sept. : 656-65
    • Ge J, Sahiner B, Hadjiiski LM, Chan HP, Wei J, Helvie MA, Zhou C
      Computer aided detection of clusters of microcalcifications on full field digital mammograms.
      16964876 Medical physics, 2006 Aug. : 2975-88
    • Zhou C
      Computer-aided diagnosis: radiologists' "second opinion" in breast cancer diagnosis on mammography.
      17015925 The Indian journal of medical research, 2006 Aug. : 123-4
    • Sahiner B, Chan HP, Hadjiiski LM, Helvie MA, Paramagul C, Ge J, Wei J, Zhou C
      Joint two-view information for computerized detection of microcalcifications on mammograms.
      16898462 Medical physics, 2006 July : 2574-85
    • Way TW, Hadjiiski LM, Sahiner B, Chan HP, Cascade PN, Kazerooni EA, Bogot N, Zhou C
      Computer-aided diagnosis of pulmonary nodules on CT scans: segmentation and classification using 3D active contours.
      16898434 Medical physics, 2006 July : 2323-37
    • Zhou C, Wakefield J
      A Bayesian mixture model for partitioning gene expression data.
      16918916 Biometrics, 2006 June : 515-25
    • Wei J, Sahiner B, Hadjiiski LM, Chan HP, Petrick N, Helvie MA, Roubidoux MA, Ge J, Zhou C
      Computer-aided detection of breast masses on full field digital mammograms.
      16266097 Medical physics, 2005 Sept. : 2827-38
    • Ge Z, Sahiner B, Chan HP, Hadjiiski LM, Cascade PN, Bogot N, Kazerooni EA, Wei J, Zhou C
      Computer-aided detection of lung nodules: false positive reduction using a 3D gradient field method and 3D ellipsoid fitting.
      16193773 Medical physics, 2005 Aug. : 2443-54
    • Zhou XH, Castelluccio P, Zhou C
      Nonparametric estimation of ROC curves in the absence of a gold standard.
      16011710 Biometrics, 2005 June : 600-9
    • Zhou C, Chan HP, Patel S, Cascade PN, Sahiner B, Hadjiiski LM, Kazerooni EA
      Preliminary investigation of computer-aided detection of pulmonary embolism in three-dimensional computed tomography pulmonary angiography images.
      15935977 Academic radiology, 2005 June : 782-92
    • Wang JD, Deng XC, Jin XJ, Zhou C, Zhang C, Xie M, Zhou JQ, Qian MF
      [Clinical research on 2228 cases of thyroid gland tumors]
      16008266 Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2005 April : 295-9
    • Zhou C, Chan HP, Paramagul C, Roubidoux MA, Sahiner B, Hadjiiski LM, Petrick N
      Computerized nipple identification for multiple image analysis in computer-aided diagnosis.
      15543797 Medical physics, 2004 Oct. : 2871-82
  • Research Funding
    Grant Title Grantor Amount Award Date
    Predicting Success in Implementing a Distance QI Intervention for Asthma unknown Dec 1, 2009
    National surveillance of emerging MDR in pediatric Enterobacteriaceae infections NIH NIAID Oct 1, 2009
    The effect of light rail transit on physical activity- a natural experiment (TRAC) NIH/NHLBI Sep 18, 2008
    Media Impact on Preschool Behavior NICHD Aug 20, 2008
    Dental Care in Children With and Without Special Health Care Needs NIDCR Sep 30, 2007
    Improving Heart Failure Risk Stratification in the ED (Stratify trial) National Heart, Lung, and Blood Institute NIH May 20, 2007
    Internet Based Patient-Centered Asthma Management System (AsthmaNet) NHLBI Sep 30, 2006
    Etiology of Childhood Obesity- A Longitudinal Study (ECHO) NIH/NHLBI Jun 1, 2006
    Child Weight Status, Physical Activity and Nutrition NIH/NIEHS Sep 6, 2005
    Etiology of Adolescent Obesity (IDEA) NCI unknown Sep 1, 2005


Research Description

Dr. Zhou's research focuses on myriad issues, notably 1) How to use accelerometers and smart watches to improve children?s physical activity in day care setting; 2) How the Pediatric Respiratory Illness Measurement System performs among pediatric patients with asthma, bronchiolitis, croup, community acquired pneumonia, and acute pulmonary exacerbation of cystic fibrosis; 3) Developing and evaluating the effectiveness of internet-based communication skills training for reducing antibiotic prescribing for bacterial acute respiratory infections, while maintaining or improving patient satisfaction; and 4) Developing and examining novel strategies to improve students? physical activity in under-served school districts in Houston area and Seattle area.