Christoph Grundner, PhD

Christoph Grundner, PhD

Infectious Disease Research

Children's Title: Principal Investigator, Supervisor, Center for Global Infectious Disease Research

Academic Title: Associate Professor

Research Center: Center for Global Infectious Disease Research

  • Biography

    Christoph Grundner received his PhD from the University of Heidelberg, Germany, for work on HIV vaccine design at the Dana-Farber Cancer Institute, Harvard Medical School, in Boston. He continued working on HIV at the Karolinska Institute in Stockholm, Sweden, before joining Tom Alber’s group at the University of California, Berkeley for a postdoc. 

    There, Grundner discovered his interest in Mycobacterium tuberculosis (Mtb), using structural biology and chemical tools to understand Mtb virulence mechanisms, work for which he received fellowships from the American Lung Association and the New York Community Trust, Heiser Fund. His interest in Mtb pathogenesis led him to the center, where he joined as an assistant professor in 2009. Grundner is also an affiliate assistant professor in the Department of Global Health and a member of the Molecular and Cell Biology Program at the University of Washington.

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    CFAR New Investigator Award University of Washington 2011 - 2013
    Research Training Fellowship American Lung Association of California 2006 - 2008
    Postdoctoral Fellowship New York Community Trust, Heiser Fund 2004 - 2006

  • Publications

    Manuscripts in Refereed Journals

    • Asquith CRM, Fleck N, Torrice CD, Crona DJ, Grundner C, Zuercher WJ.
      Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.
      Bioorg Med Chem Lett., 2019 Sep 15 : 29(18)2695-2699. PMCID:PMC6736633
      https://www.ncbi.nlm.nih.gov/pubmed/31378571
    • Grundner C.
      To fight tuberculosis, fund basic research.
      30252891 PLoS biology, 2018 Sept. : 16(9)e3000037 PMCID:PMC6155439
      https://www.ncbi.nlm.nih.gov/pubmed/30252891
    • Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.
      Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
      29119630 Protein science : a publication of the Protein Society, 2018 Feb. : 27(2)568-572 PMCID:PMC5775179
      https://www.ncbi.nlm.nih.gov/pubmed/29119630
    • Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck N, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith RD, Kappe SHI, Wright AT, Grundner C.
      A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes.
      29079720 Molecular & cellular proteomics : MCP, 2018 Jan. : 17(1)111-120 PMCID:PMC5750841
      https://www.ncbi.nlm.nih.gov/pubmed/29079720
    • Ortega C, Anderson LN, Frando A, Sadler NC, Brown RW, Smith RD, Wright AT, Grundner C.
      Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence.
      Cell Chem Biol., 2016 Feb 4 : 23(2)290-298 PMCID:PMC4803444
      https://www.ncbi.nlm.nih.gov/pubmed/26853625
    • Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J,Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.
      Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.
      J Struct Funct Genomics, 2015 June : 16(2)91-9 PMCID:PMC4631608
      https://www.ncbi.nlm.nih.gov/pubmed/25832174
    • Sherman DR, Grundner C.
      Agents of change-concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignaling. Review.
      Mol Microbiol., 2014 Oct. : 94(2)231-41
      https://www.ncbi.nlm.nih.gov/pubmed/25099260
    • Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, and Grundner C.
      Mycobacterium tuberculosis supports protein tyrosine phosphyorylation.
      Proc Natl Acad Scie USA., 2014 Jun 24 : 111(25)9265-70 PMCID:PMC4078798
      https://www.ncbi.nlm.nih.gov/pubmed/24927537
    • Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.
      Mycobacterium tuberculosis Rv2179c establishes a new exoribonuclease family with broad phylogenetic distribution.
      J Biol Chem., 2014 : 289(4)2139-47 PMCID:PMC3900960
      https://www.ncbi.nlm.nih.gov/pubmed/24311791
    • Ortega C, Liao R, Anderson LN, Rustad T, Ollodart A, Wright AT, Sherman DR, and Grundner C.
      Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.
      PLoS Biology, 2014 Jan. : 12(1)e1001746 PMCID:PMC3883633
      https://www.ncbi.nlm.nih.gov/pubmed/24409094
    • Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR.
      Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase.
      Proc Natl Acad Sci, USA., 2013 Dec 24 : 110(52)E5069-77 PMCID:PMC3876250
      https://www.ncbi.nlm.nih.gov/pubmed/24309377
    • Ansong C, Ortega C, Payne SH, Haft DH, Chauvignè-Hines LM, Lewis MP, Ollodart AR, Purvine SO, Shukla AK, Fortuin S, Smith RD, Adkins JN, Grundner C, Wright AT.
      Identification of Widespread Adenosine Nucleotide Binding in Mycobacterium tuberculosis.
      Chem Biol., 2013 Jan 24 : 20(1)123-33 PMCID:PMC3558932
      https://www.ncbi.nlm.nih.gov/pubmed/23352146
    • Edwards TE, Liao R, Phan I, Myler PJ, Grundner C.
      Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins
      Protein Sci., 2012 July : 21(7)1093-6 PMCID:PMC3403447
      https://www.ncbi.nlm.nih.gov/pubmed/22544630
    • Vega C, Chou S, Engel K, Harrell ME, Rajagopal L, Grundner C.
      Structure and Substrate Recognition of the Staphylococcus aureus Protein Tyrosine Phosphatase PtpA.
      J Mol Biol., 2011 Oct 14 : 413(1)24-31 PMCID:PMC3204379
      https://www.ncbi.nlm.nih.gov/pubmed/20644889
    • Rawls KA, Grundner C, Ellman JA.
      Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB
      Org Biomol Chem., 2010 Sep 21 : 8(18)4066-70 PMCID:PMC3009555
      https://www.ncbi.nlm.nih.gov/pubmed/20644889
    • Chou S, Jensen BC, Parsons M, Alber T, Grundner C.
      The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein, NOPP44/46.
      J Biol Chem., 2010 : 285(29)22075-81 PMCID:PMC2903352
      https://www.ncbi.nlm.nih.gov/pubmed/20444707
    • Rawls, KA, Lang PT, Takeuchi J, Imamura S, Baguley TD, Grundner C, Alber T, Ellman JA.
      Fragment-Based Discovery of Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpA.
      Bioorg Med Chem Lett., 2009 Dec 15 : 19(24)6851-4 PMCID:PMC2801607
      https://www.ncbi.nlm.nih.gov/pubmed/19889539
    • Grundner C, Cox JS, and Alber T.
      Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice.
      FEMS Microbiol Lett., 2008 Oct. : 287(2)181-4 PMCID:PMC3138331
      https://www.ncbi.nlm.nih.gov/pubmed/18752626
    • Forsell MNE, McInerney GM, Dosenovic P, Hidmark AS, Eriksson C, Liljestrom P, Grundner C and Karlsson Hedestam GB
      Increased human immunodeficiency virus type 1 Env expression and antibody induction using an enhanced alphavirus vector.
      J of Gen Virol., 2007 Oct. : 88(Pt 10)2774-9
      https://www.ncbi.nlm.nih.gov/pubmed/17872531
    • Soellner MB, Rawls KA, Grundner C, Alber T, Ellman JA.
      Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.
      J Am Chem Soc., 2007 Aug 8 : 129(31)9613-5
      https://www.ncbi.nlm.nih.gov/pubmed/17636914
    • Grundner C, Perrin D, Hooft van Huijsduijnen R, Swinnen D, Gonzalez J, Gee CL, Wells T, Alber T.
      Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.
      Structure., 2007 April : 15(4)499-509 PMCID:PMC2775457
      https://www.ncbi.nlm.nih.gov/pubmed/17437721
    • Greenstein AE, Grundner C, Echols N, Gay LM, Lombana TN, Miecskowski CA, Pullen KE, Sung PY, Alber T.
      Structure/function studies of Ser/Thr and Tyr protein phosphorylation in Mycobacterium tuberculosis.
      J Mol Microbiol Biotechnol., 2005 : 9(3-4)167-81
      https://www.ncbi.nlm.nih.gov/pubmed/16415590
    • Grundner C, Leung-Ng H, and Alber T.
      Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold with a buried active site.
      Structure., 2005 Nov. : 13(11)1625-34
      https://www.ncbi.nlm.nih.gov/pubmed/16271885
    • Grundner C, Gay LM, and Alber T.
      Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains.
      Protein Science., 2005 : (7)1918-21 PMCID:PMC2253351
      https://www.ncbi.nlm.nih.gov/pubmed/15987910
    • Grundner C, Li Y, Louder M, Mascola J, Yang X, Sodroski J, and Wyatt R.
      Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.
      Virology., 2005 Jan 5 : 331(1)33-46
      https://www.ncbi.nlm.nih.gov/pubmed/15582651
    • Grundner C, Pancera M, Kang J-M, Koch M, Sodroski J, and Wyatt R.
      Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.
      Virology., 2004 Dec 5 : 330(1)233-48
      https://www.ncbi.nlm.nih.gov/pubmed/15527849
    • Labrijn AF, Poignard P, Raja A, Zwick MB, Delgado K, Franti M, Binley J, Vivona V, Grundner C, Huang CC, Venturi M, Petropoulos CJ, Wrin T, Dimitrov DS, Robinson J, Kwong PD, Wyatt RT, Sodroski J, and Burton DR.
      Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
      J Virol., 2003 Oct. : 77(19)10557-65 PMCID:PMC228502
      https://www.ncbi.nlm.nih.gov/pubmed/12970440
    • Koch M, Pancera M, Kwong PD, Kolchinsky P, Grundner C, Wang L, Hendrickson WA, Sodroski J, and Wyatt R.
      Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.
      Virology., 2003 Sep 1 : 313(2)387-400
      https://www.ncbi.nlm.nih.gov/pubmed/12954207
    • Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski J, and Farzan M.
      Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.
      Cell., 2003 Jul 25 : 114(2)161-70
      https://www.ncbi.nlm.nih.gov/pubmed/12887918
    • Grundner C, Mirzabekov T, Sodroski J, and Wyatt R.
      Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins.
      J Virol., 2002 April : 76(7)3511-21 PMCID:PMC136030
      https://www.ncbi.nlm.nih.gov/pubmed/11884575
    • Baier K, Nicklisch S, Grundner C, Reinecke J, and Lockau W.
      Expression of two nblA-homologous genes is required for phycobilisome degradation in nitrogen-starved Synechocystis sp. PCC6803.
      FEMS Microbiol Lett., 2001 Feb 5 : 195(1)35-9
      https://www.ncbi.nlm.nih.gov/pubmed/11166992

  • Research Funding

    Grant Title Grantor Amount Award Date
    A combined host-pathogen approach to Mycobacterium tuberculosis drug resistance. American Lung Association $75,000 per year July 2019 - June 2020
    A chemical proteomics survey of Plasmodium gametocyte development. - R21AI133388-01A1 NIH/NIAID $189,107 Annual Direct Costs May 2018 - April 2020
    Serine hydrolase regulators of Mycobacterium tuberculosis non-replicating states. - R21AI137571 NIH/NIAID $150,000 Annual Direct Costs May 2018 - April 2020
    Phosphotyrosine Recognition in Bacteria. - 1R03AI137599-01 NIH/NIAID $50,000 Annual Direct Costs Feb. 2018 - Jan. 2020
    The role of Ser/Thr/Tyr phosphosignaling in the M. tuberculosis latency switch. - 1R01AI117023-01A1 NIH/NIAID $205,084 Annual Direct Costs Dec. 2015 - Nov. 2020

Overview

Research Description

The Grundner Lab seeks to map the signaling pathways that underlie Mycobacterium tuberculosis (Mtb) adaptability and pathogenesis. Read more about the Grundner Lab. 

Research Focus Area

Biotechnology, Drug Resistance, Genetic Engineering, Genetics, Global Health, Host-Pathogen Interaction, Immunology, Infectious Disease, Systems Biology, Tuberculosis