Christina L Greene, MD

Christina L Greene, MD

VAD Program, Cardiac Surgery, Heart Failure Program, Single Ventricle Program, Fetal Care and Treatment Center

On staff since September 2021

Children's Title: Cardiac Surgeon, Seattle Children’s; Surgical Site Director, Mary Bridge Children’s Hospital

Academic Title: Assistant Professor, Surgery UW

Research Center: Center for Integrative Brain Research

"In my first year of medical school, I observed a congenital heart operation and instantly knew this is what I wanted to do with my life. I was smitten with the technical challenge of the operations, the complex physiology and being able to follow the patients throughout their childhood. Now almost two decades later, it is still my life’s work and passion. I sincerely enjoy taking care of our congenital heart surgery patients and gain so much joy from seeing them reunited with their families and being able to go home and thrive."

  • Christina L. Greene, MD, is a cardiothoracic surgeon at Seattle Children's Hospital, assistant professor of surgery at the University of Washington School of Medicine and Surgical Site Director of Congenital Surgery at Mary Bridge Hospital. Her clinical and research interests focus on complex neonatal and biventricular repair.

    Dr. Greene's current research focuses on translational science and the genetics and proteomics of congenital heart disease. She is an investigator at the Seattle Children's Research Institute (SCRI) and member of the Center for Integrative Brain Research (CIBR). Her goal is to better understand what makes certain tissues grow or not grow in patients with common congenital heart diseases like Hypoplastic Left Heart Syndrome, Tetralogy of Fallot and Coarctation of the Aorta.


Board Certification(s)

Surgery (General Surgery)
Thoracic and Cardiac Surgery
Congenital Cardiac Surgery

Medical/Professional School

Keck School of Medicine at USC, Los Angeles, CA
Boston Children's Hospital: Harvard University, Boston, MA


Stanford University School of Medicine, Stanford, CA


Boston Children's Hospital, Boston, MA

Clinical Interests

Complex Neonatal Operations and Biventricular Repair

Research Description

As a congenital heart surgeon and scientist, who bridges the gap between the clinical and basic science worlds, I believe biventricular repair is the future of our specialty. Pressure and flow lead to ventricular and valvular growth. But what are the signals involved? And why do some ventricles/valves grow while others don't? Understanding the genetic and protein response to flow and pressure in the heart is a keystone to transitioning from a palliative strategy to a curative one and the focus of my research.