Brandon K Hadland, MD, PhD

Pediatric Blood and Marrow Transplant Program, Cancer and Blood Disorders Center

On staff since July 2012

Children's Title: Attending Physician, Blood and Marrow Transplant Program, Division of Pediatric Hematology, Oncology, Bone Marrow Transplant, and Cellular Therapy

Academic Title: Assistant Professor, Department of Pediatrics, University of Washington School of Medicine

Research Title: Principal Investigator

Research Center: Ben Towne Center for Childhood Cancer Research

"One of the things I love about pediatrics is the way kids persevere through adversity. They never stop being kids, even during difficult treatments; it’s really inspiring to support them as well as their families."

• Biography

  Dr. Hadland is an assistant professor in the Department of Pediatrics, Division of Pediatric Hematology/Oncology, at the University of Washington School of Medicine. He also is a member of the Fred Hutchinson Cancer Center, Clinical Research Division and Stem Cell and Gene Therapy Programs. 

   

   

  • Related Pages

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    Fred Hutchinson Cancer Center Profile

    Faculty profile for Dr. Brandon Hadland. Dr. Hadland's research focuses on the origin of hematopoietic stem cells, which give rise to blood and immune cells.

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    Hadland Lab Website

    The Hadland lab’s focus is in understanding the origin of blood and immune cells during development. We are particularly interested in determining the mechanisms by which hematopoietic stem cells (HSC) arise and how they acquire their unique properties, such as the capacity for life-long self-renewal and multilineage hematopoietic reconstitution following transplantation.

  • Full Listing of Publications

    Link to National Library of Medicine's PubMed

  • 

    Fred Hutchinson Cancer Center Profile

    Faculty profile for Dr. Brandon Hadland. Dr. Hadland's research focuses on the origin of hematopoietic stem cells, which give rise to blood and immune cells.

• Patient Testimonials
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• Awards and Honors

  Award Name	Award Description	Awarded By	Award Date
  American Society of Hematology Scholar Award			2018
  Hyundai Hope Scholar		Hyundai Hope on Wheels Foundation	2015
  Alex's Lemonade Stand Young Investigator Award		Alex's Lemonade Stand Foundation	2014
  Alpha Omega Alpha Honor Medical Society			2006
  Phi Lambda Upsilon Honorary Chemical Society			1998
  Safeway Early Career Award in Cancer Research		2020

• Publications

  Manuscripts in Refereed Journals

  • Le Q, Hadland B, Meshinchi S, Bernstein I
    Notch blockade overcomes endothelial cell-mediated resistance of FLT3/ITD-positive AML progenitors to AC220 treatment.
    32513964 Leukemia, 2021 Feb. : 35(2)601-605
  • Mandrycky C, Hadland B, Zheng Y
    3D curvature-instructed endothelial flow response and tissue vascularization.
    32938662 Science advances, 2020 Sept. : 6(38) PMCID:PMC7494348
  • Heck AM, Ishida T, Hadland B
    Location, Location, Location: How Vascular Specialization Influences Hematopoietic Fates During Development.
    33282876 Frontiers in cell and developmental biology, 2020 : 8602617 PMCID:PMC7691428
  • Dahlberg A, Leisenring W, Bleakley M, Meshinchi S, Baker KS, Summers C, Hadland B, Delaney C, Mallhi K, Burroughs L, Carpenter P, Woolfrey A
    Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children.
    30670822 Bone marrow transplantation, 2019 Aug. : 54(8)1337-1345 PMCID:PMC6646113
  • Kobayashi M, Tarnawsky SP, Wei H, Mishra A, Azevedo Portilho N, Wenzel P, Davis B, Wu J, Hadland B, Yoshimoto M
    Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo.
    31231025 Stem cell reports, 2019 Jul 9 : 13(1)21-30 PMCID:PMC6626887
  • Hadland BK, Varnum-Finney B, Nourigat-Mckay C, Flowers D, Bernstein ID
    Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture.
    29806841 Journal of visualized experiments : JoVE, 2018 May 8 : (135) PMCID:PMC6101165
  • Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II
    NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
    29739946 Nature communications, 2018 May 8 : 9(1)1828 PMCID:PMC5940870
  • Hadland B, Yoshimoto M
    Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells.
    29287940 Experimental hematology, 2018 April : 601-9 PMCID:PMC5857217
  • Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK, Gao P, Minoura K, Bernstein ID, Tan K, Speck NA
    Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
    29282253 The Journal of experimental medicine, 2018 Feb 5 : 215(2)645-659 PMCID:PMC5789403
  • Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE
    Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
    28813672 Cell reports, 2017 Aug 15 : 20(7)1597-1608 PMCID:PMC5576510
  • Li Y, Gao L, Hadland B, Tan K, Speck NA
    CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.
    28588017 Blood, 2017 Jul 20 : 130(3)372-376 PMCID:PMC5520475
  • Ganuza M, Hadland B, Chabot A, Li C, Kang G, Bernstein I, McKinney-Freeman S
    Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
    28450163 Experimental hematology, 2017 July : 5125-35.e6 PMCID:PMC5510025
  • Hadland BK, Varnum-Finney B, Mandal PK, Rossi DJ, Poulos MG, Butler JM, Rafii S, Yoder MC, Yoshimoto M, Bernstein ID
    A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells.
    28479303 Stem cell reports, 2017 Jun 6 : 8(6)1563-1572 PMCID:PMC5469918
  • Palpant NJ, Pabon L, Friedman CE, Roberts M, Hadland B, Zaunbrecher RJ, Bernstein I, Zheng Y, Murry CE
    Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells.
    27906170 Nature protocols, 2017 Jan. : 12(1)15-31 PMCID:PMC5576871
  • Lu YF, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ
    Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.
    28009288 Cell reports, 2016 Dec 20 : 17(12)3178-3192 PMCID:PMC5247798
  • Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE
    Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.
    26153229 Development (Cambridge, England), 2015 Sep 15 : 142(18)3198-209 PMCID:PMC4582173
  • Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID
    Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    25866967 The Journal of clinical investigation, 2015 May : 125(5)2032-45 PMCID:PMC4463208
  • Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ
    Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
    24094326 Cell stem cell, 2013 Oct. : 13(4)459-70
  • Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE
    Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
    23924634 Development (Cambridge, England), 2013 Sept. : 140(18)3799-808 PMCID:PMC3754478
  • Hadland BK, Bernstein ID
    Visualizing human ESC-derived hematopoiesis.
    23372149 Blood, 2013 Jan. : 121(5)717-8
  • Hadland BK, Longmore GD
    Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms.
    19636005 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Sept. : 27(25)4217-26
  • Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R
    Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.
    17215306 Development (Cambridge, England), 2007 Feb. : 134(3)535-44 PMCID:PMC2583343
  • Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD
    A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.
    15251982 Blood, 2004 Nov. : 104(10)3097-105
  • Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS
    Notch pathway is dispensable for adipocyte specification.
    15354292 Genesis (New York, N.Y. : 2000), 2004 Sept. : 40(1)40-4
  • Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R
    Gamma -secretase inhibitors repress thymocyte development.
    11416218 Proceedings of the National Academy of Sciences of the United States of America, 2001 June : 98(13)7487-91 PMCID:PMC34695

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• Research Funding

  Grant Title	Grantor	Amount	Award Date
  Safeway Early Career Award in Cancer Research			2020 - 2022
  American Society of Hematology Scholar Award			2018 - 2021
  NIH K08 Award			2018 - 2021