Brandon K. Hadland, MD, PhD

Brandon K. Hadland, MD, PhD

Pediatric Blood and Marrow Transplant Program, Cancer and Blood Disorders Center

On staff since July 2012

Children's Title: Attending Physician, Pediatric Hematology/Oncology and Bone Marrow Transplant

Academic Title: Acting Instructor

"I am amazed and humbled every day by the strength and resilience of our patients and their families. They are the inspiration for us to continue the pursuit of researching novel therapies and improving clinical care. "

  • Dr. Hadland is an Assistant Professor at the Fred Hutchinson Cancer Research Center and  University of Washington School of Medicine Division of Pediatric Hematology/Oncology. He is a member of the Fred Hutch Clinical Research Division and Stem Cell and Gene Therapy Programs. The goal of Dr. Hadland's research is to understand the developmental origin of blood and immune cells in order to find novel ways to cure pediatric leukemias and other blood disorders.

     

     

  • Award Name Award Description Awarded By Award Date
    American Society of Hematology Scholar Award 2018
    Hyundai Hope Scholar Hyundai Hope on Wheels Foundation 2015
    Alex's Lemonade Stand Young Investigator Award Alex's Lemonade Stand Foundation 2014
    Alpha Omega Alpha Honor Medical Society 2006
    Phi Lambda Upsilon Honorary Chemical Society 1998
    Safeway Early Career Award in Cancer Research 2020
  • Manuscripts in Refereed Journals

    • Le Q, Hadland B, Meshinchi S, Bernstein I
      Notch blockade overcomes endothelial cell-mediated resistance of FLT3/ITD-positive AML progenitors to AC220 treatment.
      32513964 Leukemia, 2021 Feb. : 35(2)601-605
    • Mandrycky C, Hadland B, Zheng Y
      3D curvature-instructed endothelial flow response and tissue vascularization.
      32938662 Science advances, 2020 Sept. : 6(38) PMCID:PMC7494348
    • Heck AM, Ishida T, Hadland B
      Location, Location, Location: How Vascular Specialization Influences Hematopoietic Fates During Development.
      33282876 Frontiers in cell and developmental biology, 2020 : 8602617 PMCID:PMC7691428
    • Dahlberg A, Leisenring W, Bleakley M, Meshinchi S, Baker KS, Summers C, Hadland B, Delaney C, Mallhi K, Burroughs L, Carpenter P, Woolfrey A
      Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children.
      30670822 Bone marrow transplantation, 2019 Aug. : 54(8)1337-1345 PMCID:PMC6646113
    • Kobayashi M, Tarnawsky SP, Wei H, Mishra A, Azevedo Portilho N, Wenzel P, Davis B, Wu J, Hadland B, Yoshimoto M
      Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo.
      31231025 Stem cell reports, 2019 July 9 : 13(1)21-30 PMCID:PMC6626887
    • Hadland BK, Varnum-Finney B, Nourigat-Mckay C, Flowers D, Bernstein ID
      Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture.
      29806841 Journal of visualized experiments : JoVE, 2018 May 8 : (135) PMCID:PMC6101165
    • Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II
      NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
      29739946 Nature communications, 2018 May 8 : 9(1)1828 PMCID:PMC5940870
    • Hadland B, Yoshimoto M
      Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells.
      29287940 Experimental hematology, 2018 April : 601-9 PMCID:PMC5857217
    • Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK, Gao P, Minoura K, Bernstein ID, Tan K, Speck NA
      Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
      29282253 The Journal of experimental medicine, 2018 Feb. 5 : 215(2)645-659 PMCID:PMC5789403
    • Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE
      Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
      28813672 Cell reports, 2017 Aug. 15 : 20(7)1597-1608 PMCID:PMC5576510
    • Li Y, Gao L, Hadland B, Tan K, Speck NA
      CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.
      28588017 Blood, 2017 July 20 : 130(3)372-376 PMCID:PMC5520475
    • Ganuza M, Hadland B, Chabot A, Li C, Kang G, Bernstein I, McKinney-Freeman S
      Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
      28450163 Experimental hematology, 2017 July : 5125-35.e6 PMCID:PMC5510025
    • Hadland BK, Varnum-Finney B, Mandal PK, Rossi DJ, Poulos MG, Butler JM, Rafii S, Yoder MC, Yoshimoto M, Bernstein ID
      A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells.
      28479303 Stem cell reports, 2017 June 6 : 8(6)1563-1572 PMCID:PMC5469918
    • Palpant NJ, Pabon L, Friedman CE, Roberts M, Hadland B, Zaunbrecher RJ, Bernstein I, Zheng Y, Murry CE
      Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells.
      27906170 Nature protocols, 2017 Jan. : 12(1)15-31 PMCID:PMC5576871
    • Lu YF, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ
      Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.
      28009288 Cell reports, 2016 Dec. 20 : 17(12)3178-3192 PMCID:PMC5247798
    • Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE
      Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.
      26153229 Development (Cambridge, England), 2015 Sept. 15 : 142(18)3198-209 PMCID:PMC4582173
    • Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID
      Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
      25866967 The Journal of clinical investigation, 2015 May : 125(5)2032-45 PMCID:PMC4463208
    • Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ
      Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
      24094326 Cell stem cell, 2013 Oct. : 13(4)459-70
    • Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE
      Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
      23924634 Development (Cambridge, England), 2013 Sept. : 140(18)3799-808 PMCID:PMC3754478
    • Hadland BK, Bernstein ID
      Visualizing human ESC-derived hematopoiesis.
      23372149 Blood, 2013 Jan. : 121(5)717-8
    • Hadland BK, Longmore GD
      Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms.
      19636005 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Sept. : 27(25)4217-26
    • Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R
      Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.
      17215306 Development (Cambridge, England), 2007 Feb. : 134(3)535-44 PMCID:PMC2583343
    • Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD
      A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.
      15251982 Blood, 2004 Nov. : 104(10)3097-105
    • Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS
      Notch pathway is dispensable for adipocyte specification.
      15354292 Genesis (New York, N.Y. : 2000), 2004 Sept. : 40(1)40-4
    • Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R
      Gamma -secretase inhibitors repress thymocyte development.
      11416218 Proceedings of the National Academy of Sciences of the United States of America, 2001 June : 98(13)7487-91 PMCID:PMC34695

  • Grant Title Grantor Amount Award Date
    Safeway Early Career Award in Cancer Research 2020 - 2022
    American Society of Hematology Scholar Award 2018 - 2021
    NIH K08 Award 2018 - 2021

Overview

Board Certification(s)

Pediatrics
Pediatric Hematology-Oncology

Medical/Professional School

Washington University School of Medicine, St Louis

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Hematology, University of Washington, Seattle

Clinical Interests

Hematopoietic cell transplantation, infant leukemias, pediatric myelodysplastic syndrome

Research Description

Research in Dr. Hadland's lab focuses on the origin of hematopoietic stem cells, which give rise to blood and immune cells, and how the pathways that regulate hematopoietic stem cell development contribute to mechanisms of resistance and relapse in childhood leukemias. The long-term goals of his lab's research include identifying new approaches to generate and expand hematopoietic stem cells for transplant and gene therapies and devising novel strategies to cure pediatric leukemias and prevent their recurrence.