Adrian M Piliponsky, PhD

Adrian M Piliponsky, PhD

Academic Title: Associate Professor, Pediatrics; Adjunct Professor, Pathology

Research Title: Principal Investigator, Seattle Children's Research Institute

Research Center: Center for Immunity and Immunotherapies

"I am passionate to come to the lab because I love what I do. Every day in the lab presents itself with new challenges and an infinite number of questions for which we usually have few or no answers. As a consequence of this, there is always work to be done and progress that ought to be celebrated and shared with the rest of the scientific community. I strongly believe that this is what research is about, and I am lucky to enjoy doing it every day."

  • Biography

    Adrian Piliponsky, PhD, is a principal investigator within the Center for Immunity and Immunotherapeutics at Seattle Childrens Research Institute, and an assistant professor in the Department of Pediatrics at the University of Washington School of Medicine.

    Dr. Piliponsky received his bachelors degree in Pharmacy from the University of Buenos Aires in Argentina. His passion for research eventually led him to The Hebrew University of Jerusalem in Israel where Dr. Piliponsky received his PhD. Under the mentorship of Francesca Levi-Schaffer, PhD, Dr. Piliponsky studied interactions of mast cells and eosinophils which are considered major players of allergies. With a desire to broaden his understanding of mast cells in vivo using mice with deficiencies in mast cells to study a variety of allergy and inflammatory disorders. Dr. Piliponsky took a post-doctoral position at Stanford University with Stephen J. Galli, MD, one of the lead researchers in the mast cell field.

    • Related Pages

    • Piliponsky Lab

      Piliponsky Lab

      The Piliponsky Lab studies inflammatory responses involving mast cells and myeloid cells. Our goal is to understand how the body controls the immune system’s response to bacterial infections – and how this process becomes dysregulated.

    • PiliponskyLab.org

      PiliponskyLab.org

      Working to understand mast cell biology to enhance innate immunity and treat allergic disease.

  • Patient Testimonials

    Be the first to recommend Dr. Adrian M. Piliponsky

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Early Career Faculty Travel Grant Honor received to attend the American Association of Immunologists (AAI) 99th AAI Annual Meeting-IMMUNOLOGY 2012TM American Association of Immunologists (AAI) 2012
    Travel Grant Honor received to attend The Fourth International Workshop on Signal Transduction in the Activation and Development of Mast Cells and NIH, Basophils at the Bethesda, MD The Aharon Katzir Center, Weizmann Institute of Science 2001
    Travel Grant Honor received to attend the American Academy of Allergy, Asthma and Immunology (AAAAI) 56th Annual Meeting in New Orleans, LA. American Academy of Allergy, Asthma and Immunology (AAAAI) 2001
    Superpharm Scholarship for PhD students at the School of Pharmacy The Hebrew University of Jerusalem, Israel 2000
    Travel Grant Honor received to attend the 8th Euroconference on Apoptosis, Davos, Switzerland European Cell Death Organization (ECDO) 2000
    Golda Meir Fellowship The Hebrew University of Jerusalem, Israel 1998 - 2001
    Zuckerman Fellowship Hebrew University of Jerusalem, Israel. National Institute of Drugs Fellowship, Ministry of Health, Buenos Aires, Argentina. 1995 - 1998
    National Institute of Drugs Fellowship Ministry of Health, Buenos Aires, Argentina 1995

  • Publications

    Manuscripts in Refereed Journals

    • Schäfer B, Piliponsky AM, Oka T, Song CH, Gerard NP, Gerard C, Tsai M, Kalesnikoff J, Galli SJ
      Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.
      22728083 The Journal of allergy and clinical immunology, 2013 Feb. : 131(2)541-8.e1-9 PMCID:PMC3597773
    • Piliponsky AM, Chen CC, Rios EJ, Treuting PM, Lahiri A, Abrink M, Pejler G, Tsai M, Galli SJ
      The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
      22901752 The American journal of pathology, 2012 Sept. : 181(3)875-86 PMCID:PMC3432424
    • Lilla JN, Chen CC, Mukai K, BenBarak MJ, Franco CB, Kalesnikoff J, Yu M, Tsai M, Piliponsky AM, Galli SJ
      Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
      22001390 Blood, 2011 Dec. : 118(26)6930-8 PMCID:PMC3245213
    • Akahoshi M, Song CH, Piliponsky AM, Metz M, Guzzetta A, Abrink M, Schlenner SM, Feyerabend TB, Rodewald HR, Pejler G, Tsai M, Galli SJ
      Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.
      21926462 The Journal of clinical investigation, 2011 Oct. : 121(10)4180-91 PMCID:PMC3195461
    • Piliponsky AM, Chen CC, Grimbaldeston MA, Burns-Guydish SM, Hardy J, Kalesnikoff J, Contag CH, Tsai M, Galli SJ
      Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.
      20035049 The American journal of pathology, 2010 Feb. : 176(2)926-38 PMCID:PMC2808097
    • Rios EJ, Piliponsky AM, Ra C, Kalesnikoff J, Galli SJ
      Rabaptin-5 regulates receptor expression and functional activation in mast cells.
      18698003 Blood, 2008 Nov. : 112(10)4148-57 PMCID:PMC2582003
    • Galli SJ, Tsai M, Piliponsky AM
      The development of allergic inflammation.
      18650915 Nature, 2008 July : 454(7203)445-54 PMCID:PMC3573758
    • Piliponsky AM, Chen CC, Nishimura T, Metz M, Rios EJ, Dobner PR, Wada E, Wada K, Zacharias S, Mohanasundaram UM, Faix JD, Abrink M, Pejler G, Pearl RG, Tsai M, Galli SJ
      Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.
      18376408 Nature medicine, 2008 April : 14(4)392-8 PMCID:PMC2873870
    • Metz M, Grimbaldeston MA, Nakae S, Piliponsky AM, Tsai M, Galli SJ
      Mast cells in the promotion and limitation of chronic inflammation.
      17498068 Immunological reviews, 2007 June : 217304-28
    • Nishimura T, Myles T, Piliponsky AM, Kao PN, Berry GJ, Leung LL
      Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.
      17105819 Blood, 2007 March : 109(5)1992-7 PMCID:PMC1801069
    • Metz M, Piliponsky AM, Chen CC, Lammel V, Abrink M, Pejler G, Tsai M, Galli SJ
      Mast cells can enhance resistance to snake and honeybee venoms.
      16873664 Science (New York, N.Y.), 2006 July : 313(5786)526-30
    • Berent-Maoz B, Piliponsky AM, Daigle I, Simon HU, Levi-Schaffer F
      Human mast cells undergo TRAIL-induced apoptosis.
      16455983 Journal of immunology (Baltimore, Md. : 1950), 2006 Feb. : 176(4)2272-8
    • Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N
      The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts.
      16387592 The Journal of allergy and clinical immunology, 2006 Jan. : 117(1)103-10
    • Matsuda K, Piliponsky AM, Iikura M, Nakae S, Wang EW, Dutta SM, Kawakami T, Tsai M, Galli SJ
      Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.
      16337471 The Journal of allergy and clinical immunology, 2005 Dec. : 116(6)1357-63
    • Grimbaldeston MA, Chen CC, Piliponsky AM, Tsai M, Tam SY, Galli SJ
      Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
      16127161 The American journal of pathology, 2005 Sept. : 167(3)835-48 PMCID:PMC1698741
    • Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F
      Human peripheral blood eosinophils induce angiogenesis.
      15618019 The international journal of biochemistry & cell biology, 2005 March : 37(3)628-36
    • Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M
      Mast cells as "tunable" effector and immunoregulatory cells: recent advances.
      15771585 Annual review of immunology, 2005 : 23749-86
    • Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ
      Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.
      15543132 Nature, 2004 Nov. : 432(7016)512-6
    • Levi-Schaffer F, Piliponsky AM
      Tryptase, a novel link between allergic inflammation and fibrosis.
      12697439 Trends in immunology, 2003 April : 24(4)158-61
    • Piliponsky AM, Gleich GJ, Nagler A, Bar I, Levi-Schaffer F
      Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor.
      12393403 Blood, 2003 March : 101(5)1898-904
    • Piliponsky AM, Gleich GJ, Bar I, Levi-Schaffer F
      Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
      12217410 Molecular immunology, 2002 Sept. : 38(16-18)1369
    • Levi-Schaffer F, Micera A, Zamir E, Mechoulam H, Puxeddu I, Piliponsky AM, Aloe L, Pe'er J
      Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus.
      12036989 Investigative ophthalmology & visual science, 2002 June : 43(6)1850-6

    Other Publications

    • Samanas NB, Murphy RC, Miralda I, Hallstrand TS, Piliponsky AM
      Neutrophilic asthma at an inhibitory checkpoint: A PD-1-targeted approach.
      36463980 The Journal of allergy and clinical immunology, 2023 Feb. : 151(2)420-422
    • Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K
      Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis.
      35552540 Nature immunology, 2022 June : 23(6)947-959
    • Saha SS, Samanas NB, Miralda I, Shubin NJ, Niino K, Bhise G, Acharya M, Seo AJ, Camp N, Deutsch GH, James RG, Piliponsky AM
      Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function.
      34324892 The Journal of allergy and clinical immunology, 2022 Feb. : 149(2)685-697 PMCID:PMC8792104
    • Al-Shaikhly T, Murphy RC, Parker A, Lai Y, Altman MC, Larmore M, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Peters MC, Hallstrand TS
      Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma.
      35027395 The European respiratory journal, 2022 Jan 13
    • Allenspach EJ, Shubin NJ, Cerosaletti K, Mikacenic C, Gorman JA, MacQuivey MA, Rosen ABI, Timms AE, Wray-Dutra MN, Niino K, Liggitt D, Wurfel MM, Buckner JH, Piliponsky AM, Rawlings DJ
      The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.
      34740959 Journal of immunology (Baltimore, Md. : 1950), 2021 Dec 1 : 207(11)2710-2719 PMCID:PMC8612972
    • Okamura DM, Brewer CM, Wakenight P, Bahrami N, Bernardi K, Tran A, Olson J, Shi X, Yeh SY, Piliponsky A, Collins SJ, Nguyen ED, Timms AE, MacDonald JW, Bammler TK, Nelson BR, Millen KJ, Beier DR, Majesky MW
      Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis.
      34849462 iScience, 2021 Nov 19 : 24(11)103269 PMCID:PMC8609232
    • Murphy RC, Lai Y, Barrow KA, Hamerman JA, Lacy-Hulbert A, Piliponsky AM, Ziegler SF, Altemeier WA, Debley JS, Gharib SA, Hallstrand TS
      Effects of Asthma and Human Rhinovirus A16 on the Expression of SARS-CoV-2 Entry Factors in Human Airway Epithelium.
      32946274 American journal of respiratory cell and molecular biology, 2020 Dec. : 63(6)859-863 PMCID:PMC7790138
    • Shubin NJ, Clauson M, Niino K, Kasprzak V, Tsuha A, Guga E, Bhise G, Acharya M, Snyder JM, Debley JS, Ziegler SF, Piliponsky AM
      Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition.
      32103153 Mucosal immunology, 2020 July : 13(4)584-594 PMCID:PMC7312418
    • Shubin NJ, Navalkar K, Sampson D, Yager TD, Cermelli S, Seldon T, Sullivan E, Zimmerman JJ, Permut LC, Piliponsky AM
      Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
      31714400 Critical care medicine, 2020 Jan. : 48(1)e48-e57
    • Piliponsky AM, Galli SJ
      Adoptive Transfer of Basophils Enriched from Mouse Spleen.
      33654915 Bio-protocol, 2019 Nov 5 : 9(21)e3416 PMCID:PMC7853924
    • Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, Altemeier WA, Larmore M, Frevert CW, Mulligan MS, Ziegler SF, Debley JS, Peters MC, Hallstrand TS
      Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling.
      31437129 The Journal of clinical investigation, 2019 Nov 1 : 129(11)4979-4991 PMCID:PMC6819127
    • Piliponsky AM, Acharya M, Shubin NJ
      Mast Cells in Viral, Bacterial, and Fungal Infection Immunity.
      31212724 International journal of molecular sciences, 2019 Jun 12 : 20(12) PMCID:PMC6627964
    • Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ
      Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.
      30664762 Nature immunology, 2019 Feb. : 20(2)129-140 PMCID:PMC6352314
    • Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS
      Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases.
      32047499 Frontiers in immunology, 2019 : 103159 PMCID:PMC6997473
    • Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM
      Mast cell chymase decreases the severity of group B Streptococcus infections.
      28916188 The Journal of allergy and clinical immunology, 2018 July : 142(1)120-129.e6 PMCID:PMC5847414
    • Piliponsky AM, Romani L
      The contribution of mast cells to bacterial and fungal infection immunity.
      29431211 Immunological reviews, 2018 March : 282(1)188-197 PMCID:PMC5812373
    • Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS
      Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen.
      29093264 JCI insight, 2017 Nov 2 : 2(21) PMCID:PMC5752296
    • Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM
      Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
      27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356
    • Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF
      Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis.
      26934097 American journal of respiratory cell and molecular biology, 2016 Aug. : 55(2)264-74 PMCID:PMC4979369
    • Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway DP, Adams Waldorf KM, Piliponsky AM, Rajagopal L
      Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection.
      26425734 Science advances, 2015 Jul 17 : 1(6)e1400225 PMCID:PMC4584422
    • Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR Jr, Gelb MH, Hallstrand TS
      Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33.
      24220317 The Journal of allergy and clinical immunology, 2014 May : 133(5)1448-55 PMCID:PMC4004718
    • Schäfer B, Piliponsky AM, Oka T, Song CH, Gerard NP, Gerard C, Tsai M, Kalesnikoff J, Galli SJ
      Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.
      22728083 The Journal of allergy and clinical immunology, 2013 Feb. : 131(2)541-8.e1-9 PMCID:PMC3597773
    • Piliponsky AM, Chen CC, Rios EJ, Treuting PM, Lahiri A, Abrink M, Pejler G, Tsai M, Galli SJ
      The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
      22901752 The American journal of pathology, 2012 Sept. : 181(3)875-86 PMCID:PMC3432424
    • Lilla JN, Chen CC, Mukai K, BenBarak MJ, Franco CB, Kalesnikoff J, Yu M, Tsai M, Piliponsky AM, Galli SJ
      Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
      22001390 Blood, 2011 Dec 22 : 118(26)6930-8 PMCID:PMC3245213
    • Akahoshi M, Song CH, Piliponsky AM, Metz M, Guzzetta A, Abrink M, Schlenner SM, Feyerabend TB, Rodewald HR, Pejler G, Tsai M, Galli SJ
      Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.
      21926462 The Journal of clinical investigation, 2011 Oct. : 121(10)4180-91 PMCID:PMC3195461
    • Piliponsky AM, Chen CC, Grimbaldeston MA, Burns-Guydish SM, Hardy J, Kalesnikoff J, Contag CH, Tsai M, Galli SJ
      Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.
      20035049 The American journal of pathology, 2010 Feb. : 176(2)926-38 PMCID:PMC2808097
    • Rios EJ, Piliponsky AM, Ra C, Kalesnikoff J, Galli SJ
      Rabaptin-5 regulates receptor expression and functional activation in mast cells.
      18698003 Blood, 2008 Nov 15 : 112(10)4148-57 PMCID:PMC2582003
    • Galli SJ, Tsai M, Piliponsky AM
      The development of allergic inflammation.
      18650915 Nature, 2008 Jul 24 : 454(7203)445-54 PMCID:PMC3573758
    • Piliponsky AM, Chen CC, Nishimura T, Metz M, Rios EJ, Dobner PR, Wada E, Wada K, Zacharias S, Mohanasundaram UM, Faix JD, Abrink M, Pejler G, Pearl RG, Tsai M, Galli SJ
      Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.
      18376408 Nature medicine, 2008 April : 14(4)392-8 PMCID:PMC2873870
    • Metz M, Grimbaldeston MA, Nakae S, Piliponsky AM, Tsai M, Galli SJ
      Mast cells in the promotion and limitation of chronic inflammation.
      17498068 Immunological reviews, 2007 June : 217304-28
    • Nishimura T, Myles T, Piliponsky AM, Kao PN, Berry GJ, Leung LL
      Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.
      17105819 Blood, 2007 Mar 1 : 109(5)1992-7 PMCID:PMC1801069
    • Metz M, Piliponsky AM, Chen CC, Lammel V, Abrink M, Pejler G, Tsai M, Galli SJ
      Mast cells can enhance resistance to snake and honeybee venoms.
      16873664 Science (New York, N.Y.), 2006 Jul 28 : 313(5786)526-30
    • Berent-Maoz B, Piliponsky AM, Daigle I, Simon HU, Levi-Schaffer F
      Human mast cells undergo TRAIL-induced apoptosis.
      16455983 Journal of immunology (Baltimore, Md. : 1950), 2006 Feb 15 : 176(4)2272-8
    • Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N
      The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts.
      16387592 The Journal of allergy and clinical immunology, 2006 Jan. : 117(1)103-10
    • Matsuda K, Piliponsky AM, Iikura M, Nakae S, Wang EW, Dutta SM, Kawakami T, Tsai M, Galli SJ
      Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.
      16337471 The Journal of allergy and clinical immunology, 2005 Dec. : 116(6)1357-63
    • Grimbaldeston MA, Chen CC, Piliponsky AM, Tsai M, Tam SY, Galli SJ
      Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
      16127161 The American journal of pathology, 2005 Sept. : 167(3)835-48 PMCID:PMC1698741
    • Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F
      Human peripheral blood eosinophils induce angiogenesis.
      15618019 The international journal of biochemistry & cell biology, 2005 March : 37(3)628-36
    • Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M
      Mast cells as "tunable" effector and immunoregulatory cells: recent advances.
      15771585 Annual review of immunology, 2005 : 23749-86
    • Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ
      Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.
      15543132 Nature, 2004 Nov 25 : 432(7016)512-6
    • Levi-Schaffer F, Piliponsky AM
      Tryptase, a novel link between allergic inflammation and fibrosis.
      12697439 Trends in immunology, 2003 April : 24(4)158-61
    • Piliponsky AM, Gleich GJ, Nagler A, Bar I, Levi-Schaffer F
      Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor.
      12393403 Blood, 2003 Mar 1 : 101(5)1898-904
    • Solomon A, Piliponsky AM, Peer J, Levi-Schaffer F.
      Mast cells as initiators and effectors of allergic inflammation. In: New Trends in Allergy V
      (Ring J, Behrendt H, Eds.), Springer-Verlag Berlin, Heidelberg 2003., 2003
    • Piliponsky AM, Gleich GJ, Bar I, Levi-Schaffer F
      Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
      12217410 Molecular immunology, 2002 Sept. : 38(16-18)1369
    • Levi-Schaffer F, Micera A, Zamir E, Mechoulam H, Puxeddu I, Piliponsky AM, Aloe L, Pe'er J
      Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus.
      12036989 Investigative ophthalmology & visual science, 2002 June : 43(6)1850-6

  • Presentations

    Presentation Title Event Location Date
    Role of mast cells and mast cell proteases in innate immunity SRI International Menlo Park, CA Nov 16, 2012
    Mast cells and sepsis Department of Pathology, Sanford University Stanford, CA Nov 15, 2012
    Mast cells: from anaphylaxis to mastocytosis and beyond Pediatric Grand Rounds Mar 15, 2012
    Role of mast cells in innate immunity Pulmonary Research Group, University of Washington University of Washington, Seattle, WA Jan 23, 2012
    TSLP promotes interleukin-3-independent basophil hematopoiesis and type 2 inflammation. Lung Division, University of Washington South Lake Union Sep 29, 2011
    Role of mast cells and mast cell proteases in innate immunity. Pediatric Inflammation Research Group, University of Washington South Lake Union Aug 24, 2011
    Mast cell chymase degrades TNF, limits inflammation, and promotes survival in a mouse model of sepsis 98th Annual Meeting of the American Association of Immunologists San Francisco, CA 2011
    What good things do mast cells do and why do we need them? The Mastocytosis Society, Inc. 17th Annual Conference, Boston 2011

Overview

Research Description

Dr. Adrian Piliponsky's research interests include investigating the importance and functions of mast cells in inflammatory disorders, such as sepsis, allergies, asthma and Group B Streptococcus, and testing whether these cells can be manipulated to prevent or control these processes.