Seattle Children’s Therapeutics
Children deserve to lead healthy lives and to achieve their full potential. All too frequently the diseases they are diagnosed with don't have medicines to heal and cure them. Seattle Children’s aims to change this.
Seattle Children’s Therapeutics is a novel non-profit therapeutics development enterprise, devoted to envisioning and testing next-generation cell and gene therapies for pediatric diseases so children have the medicines they deserve. While currently focused on cancer, Seattle Children’s Therapeutics plans to expand our focus to a host of other diseases that selectively afflict children and that are amenable to treatment using genetic and cellular therapies.
The team that currently makes up Seattle Children’s Therapeutics has designed, manufactured and launched a robust portfolio of immunotherapy clinical trials for childhood cancer since 2012 in the areas of leukemia and lymphoma, brain tumors and solid tumors. As a compassionate and dedicated team, Seattle Children’s Therapeutics is energized by the science behind our work and finding answers to difficult questions. We are dedicated to communities affected by complex and rare childhood diseases, and these patients and families are the inspiration for everything we do.
Our Manufacturing Facilities
Seattle Children’s Therapeutics Today
Today, Seattle Children’s Therapeutics encompasses Seattle Children’s cancer immunotherapy research program. It is comprised of an integrated set of resources similar to what you would find in a biotech company: research and development, technology development, a GMP facility for cell and vector manufacturing, clinical trials development and management, and business operations. By organizing our assets into a vertically integrated structure, we set the stage for accelerated and unprecedented impact in cancer and other debilitating pediatric diseases. Together, these capabilities and state-of-the-art facilities will allow us to expand our impact in cell and gene therapies for a variety of childhood diseases and conditions beyond cancer.
The CAR T-cell products used in our immunotherapy clinical trials are made on-site in our Therapeutics Cell Manufacturing facility. This means we can deliver investigational treatments quickly to patients enrolled in clinical trials at Seattle Children’s. Through our collaboration with CureWorks, patients at member hospitals can also access Seattle Children’s immunotherapy clinical trials in their own communities close to home.
Seattle Children’s Therapeutics in the Future
While Seattle Children’s Therapeutics is currently focused on cancer, in the next five years Seattle Children’s Therapeutics will move into designing and developing cell and gene therapies for other life-threatening and debilitating diseases that afflict children.
Other areas we will expand into include:
Intellectual property (IP) licensing, sponsored research and clinical research agreements: Seattle Children’s Therapeutics currently has partnerships in place with industry organizations who are licensing our IP and sponsoring pre-clinical research and clinical trials at our organization. We plan to collaborate with new external partners who share our vision of providing children with new cell and gene therapies.
CureWorks expansion: We expect to offer more of our phase 1 and 2 immunotherapy clinical trials to CureWorks member hospitals, thus bringing these experimental therapies as close to home for patients as possible.
In the News
- May 19, 2023 Novel leukemia treatment signals ‘new era in CAR T-cell therapy’ (Healio)
- April 26, 2023 Seattle Children's Studying CAR T-Cell Therapy Targeting Four Brain Cancer Antigens at Once (Precision Oncology)
- April 20, 2023 Seattle Children’s Therapeutics has reached a significant milestone, enrolling 500 patients in our chimeric antigen receptor (CAR) T-cell immunotherapy clinical trials. (On the Pulse)
- December 19, 2022 Could CAR-T-cell therapy offer hope to children with cancer? (Nature)
- October 21, 2022 Inside the Cure Factory (Voice of America)
- September 8, 2022 Young Girl Blossoming After Months at Seattle Children's (KOMO News)
Contact Seattle Children’s Therapeutics
If you are interested in partnering with Seattle Children’s Therapeutics, please email us.
If you are interested in learning more about how your donation can support Seattle Children’s Therapeutics’ critical work, please contact Brei Haywood, program manager at Seattle Children’s Foundation, by email or at 206-987-1087.