Torque Teno Virus And Clinical Outcomes In Pediatric Kidney Transplant Recipients
TTV-KIDS
What is the goal of the study?
Kidney transplantation maximizes the quantity and quality of life for children with kidney failure, but survival of the transplanted organ requires lifelong immunosuppression medications that can lead to infections and cancers. There is currently no method to individualize the level of immunosuppression medication needed in a patient. Torque teno virus (TTV) is a nonpathogenic virus present in over 95% of pediatric kidney transplant recipients. Studies of adult kidney transplant recipients have shown that TTV is a marker of overall immunosuppression, with higher TTV levels associated with an increased risk for infection and lower TTV levels associated with a risk for rejection. In this multicenter prospective cohort study of pediatric kidney transplant recipients, we aim to describe the natural course of TTV in the first 12 months after transplantation and describe the association between TTV levels and infection and rejection. We hope that the results of this study will identify a goal TTV range in pediatric kidney transplant recipients that balances the competing risks of rejection and infection, therefore allowing more targeted and personalized management of these vulnerable patients.
Who can participate in the study?
Please contact the study team listed below to learn more.