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Current Research Studies

Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly

STOP-BLOQ

What is the goal of the study?

Fetal complete (i.e., third degree) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies and results in death in a fifth of cases. To date no treatment of 3° AVB has been effective, which may be because current surveillance is limited to once- weekly fetal echocardiograms. This study comprises three steps: 1) to screen for high titer anti-Ro antibodies, which are necessary but not sufficient to develop fetal AVB; 2) to empower mothers to identify 2° AVB by using fetal heart rate and rhythm monitoring (FHRM) at home, and 3) to rapidly treat mothers who detect an abnormality by monitoring with an urgent echocardiogram that confirms 2° AVB with the hope of reversing 2° AVB before it becomes permanent (3° AVB). In addition, it will be determined if FHRM reduces the need for weekly echoes. Although mothers with low titer anti-Ro will not be continued in Step 2 and therefore not followed by FHRM, birth ECGs will be collected to confirm that high titer antibodies confer risk.

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team: