Current Research Studies

Evaluation of Fast-sequence Magnetic Resonance Imaging Brain Protocol for Surveillance for Subependymal Lesions and Associated Hydrocephalus in Pediatric Tuberous Sclerosis Complex

Fast MRI Brain Surveillance of Hydrocephalus & Subependymal Lesions in Pediatric Tuberous Sclerosis

What is the goal of the study?

We aim to prospectively assess adequacy, in pediatric tuberous sclerosis complex patients, of a non-sedated fast-sequence MRI [fsMRI] brain protocol (acquisition in < 1 minute) in detection of clinically relevant changes that may occur in the transformation of subependymal nodules into subependymal giant cell astrocytomas, and of any resultant dilation in ventricular caliber, in comparison to the currently employed standard MRI brain protocol (typically requiring 30 minutes, not infrequently requiring sedation). The goal would be to replace the standard surveillance MRI with the fsMRI. We will compare fsMRI to standard MRI brain protocols for identification and measurement of subependymal lesions 5 mm or larger, measurement of lateral ventricular diameter; and changes in measurements compared to the most recent prior standard surveillance MRI.

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team: