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Current Research Studies

ALTE2131: Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults with Cancer

ALTE2131

  • Condition(s): Brain and Nervous System, Hodgkin's Lymphoma, Leukemia, other, Non-Hodgkin's Lymphoma
  • Phase: III
  • Clinicaltrials.gov ID: NCT06513962

What is the goal of the study?

This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agent. Alkylating agents are part of standard chemotherapy but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team: