Informational Alert

Due to a measles case in the community, please call before coming to Seattle Children’s if you or your child has potential measles symptoms.

High Priority Alert

Masking and Visitation Changes: Due to high rates of respiratory illnesses in our community, we’ve made changes to our masking and visitation guidelines .

Current Research Studies

A Phase ½, Open-Label, Multicenter Trial with a Single Ascending Dose Cohort with Unilateral Intracochlear Injection Followed by Bilateral Injection Expansion Cohort to Evaluate the Safety, Tolerability, and Efficacy of DB-OTO in Children and Infants with Biallelic hOTOF Mutations

DB-OTO-001_Rubinstein_Phase 1/2

  • Phase: Early Phase I
  • Clinicaltrials.gov ID: NCT05788536

What is the goal of the study?

This is a multicenter international phase 1/2, open-label, 2-part trial with a single-ascending dose patient cohort (Part A) and a bilateral expansion patient cohort (Part B) to evaluate the safety, tolerability, and preliminary efficacy of DB-OTO in in young children and infants diagnosed with biallelic otoferlin gene (hOTOF) mutations.

Who can participate in the study?

Please contact the study team listed below to learn more.

Study Team: