Treatment for Pediatric Stroke
Understanding the genetic causes and treatment options of pediatric stroke patients and developing improved prognostic biomarkers
A frequent shortcoming in pediatric medicine is the off-label use of interventions originally developed for and tested on adult patients without further clinical validation in children. This is repeatedly seen in the treatment of pediatric stroke. Furthermore, the onset of pediatric stroke frequently involves different pathologies than those seen in adults, requiring special considerations for managing ongoing morbidities and treatments.
Dr. Amlie-Lefond is the Director of the Pediatric Vascular Neurology Program at Seattle Children’s Hospital, and specializes in treating patients with rare disorders that lead to childhood stroke. Dr. Amlie-Lefond treats children with arterial ischemic stroke, Moyamoya and other cerebral arteriopathies, neurovascular cutaneous disorders such as Sturge-Weber syndrome, intracranial vascular malformations, as well as other neurovascular diseases.
A common cause of pediatric stroke onset is the development of abnormal brain vasculature (“cerebral arteriopathy”) that can lead to repeated stroke occurrence. The development of optimal strategies to diagnose and manage cerebral arteriopathies is an area of intense study in pediatric stroke. Through her direct clinical experience with children with stroke and other neurovascular disorders, Dr. Amlie-Lefond is well positioned to collect and analyze patient data to better understand the underlying causes of pediatric stroke and to identify factors that are associated with increased stroke risk within specific rare diseases. Furthermore, clinical findings have demonstrated that children may recover unexpectedly well when compared to adults in some cases. Understanding these clinical successes in children could potentially offer insights into prognosis and potential response to specific therapeutics.
Dr. Amlie-Lefond is interested in collaborating with partners to develop pediatric-specific biomarkers to identify subsets of patients with the greatest risk for stroke, to predict disease course, and to direct treatment response. She is also interested in studies assessing the safety and efficacy of acute stroke treatment for adults in the pediatric population. Given her clinical and research expertise, Dr. Amlie-Lefond in an excellent position to collaborate at numerous stages of clinical development.
Stage of Development
- Clinical trial
- Biomarker investigation
- Collaborative research opportunity
- Development opportunity
- Sponsored research agreement
- Consultation agreement
- Ko P, Khalatbari H, Hatt D, Coufal N, Barry D, Wainwright M…Amlie-Lefond C. Anticoagulation use in childhood cardioembolic stroke does not increase the risk of hemorrhagic transformation. J Child Neurol, 2021, in press.
- Oesch G, Perez FA, Wainwright MS, Shaw DWW, Amlie-Lefond C. Focal cerebral arteriopathy of childhood: Clinical and imaging correlates in a modern cohort. Stroke. 2021; 52(7):2258-2265.
- Barry M, Barry D, Kansagra AP, Hallam D, Abraham M, Amlie-Lefond C, on behalf of Thrombolysis in Pediatric Stroke (TIPSTER) investigators. Higher quality data collection is critical to establish the safety and efficacy of pediatric mechanical thrombectomy. Stroke. 2021; 52(4):1213-1221.
- Lauzier DC, Galardi MM, Guilliams K, Goyal MS, Amlie-Lefond C, Hallam DK, et al. Pediatric thrombectomy: Design and workflow lessons from two experienced centers. Stroke. 2021; 52(4):1511-1519.
- Khalatbari H, Wright JN, Ishak GE, Perez FA, Amlie-Lefond C, Shaw DWW. Deep medullary vein engorgement and superficial medullary vein engorgement: two patterns of perinatal venous stroke. Pediatr Radiol. 2021;51(5):675-685.
- Boos MD, Bozarth XL, Sidbury R, Cooper AB, Perez F, Chon C…Amlie-Lefond C. Forehead location and large segmental pattern of facial port-wine stains predict risk of Sturge-Weber Syndrome. J Am Acad Dermatol. 2020;83(4):1110-1117.
- Perez FA, Oesch G. Amlie-Lefond C. MR vessel wall enhancement and other imaging biomarkers in pediatric focal cerebral arteriopathy-inflammatory subtype. Stroke. 2020; 51(3):853-859.
- Amlie-Lefond C, Shaw DWW, Cooper A, Wainwright M, Kirton A, et al. Risk of intracranial hemorrhage following intravenous tPA (tissue plasminogen activator) for acute stroke is low in children. Stroke. 2020; 51(2):542-548.