Catherine M Amlie-Lefond, MD

Catherine M Amlie-Lefond, MD

Neurosciences Center, Neurology, Moyamoya, Cerebral Palsy Program, Pediatric Vascular Neurology Program, Vascular Anomalies, Neonatal Neurocritical Care Unit (Neuro NICU)

On staff since August 2011

Children's Title: Director, Pediatric Vascular Neurology Program

Academic Title: Professor

Research Center: Center for Integrative Brain Research

    • Emily Logan UT 02.04.21

      I cannot speak highly enough of Dr. Amlie-Lefond. She set us on the path to testing and finally getting my son diagnosed with the disease that had caused a gaggle of mysterious symptoms for 9 years. She is very thorough and intelligent while also approachable and friendly. We've seen many, many doctors and specialists over the years and she is one of the very best. You'd be hard pressed to find a doctor as devoted to her patient's health as she is.

    • Kaitlyn Orting, WA 10.14.16

      Dr. Lefond is truly an amazing Neurologist. My daughter has a rare disorder and had some complicated issues. Dr. Lefond listened to my concerns, and has helped my daughter make AMAZING progress. Dr. Lefond is very knowledgeable, professional, intelligent and truly amazing. I would recommend any parent who is seeking a great Neurologist to see her. She listens to your concerns, she is knowledgeable, intelligent, and just over all kind hearted. I highly recommend her and I am just so grateful for her and all she has done for my daughter.

    • Shayne Gladstone, Michigan 06.11.14

      Dr Lefond took care of my son Andrew at Children's Hospital of Wisconsin, Milwaukee. Andrew had a brain pseudoaneurym rupture and suffered 3 strokes at 5 weeks of age. We traveled from Green Bay to see her and she was a great neurologist. (We have since moved to Michigan but continue care in Milwaukee.) We were sad to see her leave. Andrew is now 5 years old and has done remarkable for all he went thru- she would also be amazed. I agree with another parent, Seattle is very lucky to have her. Thank you Dr. Lefond for being so wonderful.

    • Christina Seattle, WA 08.20.13

      Dr. Le-Fond has been working with us over the past year regarding our son, who had a stroke at just over one years of age. I can't say enough positive things about her working demeanor and continued care of our son. I think it is not only her extensive knowledge of the subject matter, but also her approach to care that make her such a wonderful doctor. She carefully explains issues and is not afraid to consult with other specialists when necessary. I would not hesitate to recommend her to anyone facing these issues.

    • Jamie Sheboygan Falls, WI 04.22.13

      Dr Lefond was beyond amazing!!! My son, Leroy, had a stroke while still in utero and was having seizures that lasted 12-15 minutes long right after birth. He was shipped from our hosp in Sheboygan to Children's Hospital in Milwaukee and got the amazing fortune to have Dr Lefond as his doctor! She was so attentive to him and got him on the right medications. Leroy gained weight so fast that he outgrew his medication faster than expected, so he ended up having a couple extra trips to Milwaukee to see her, but each time she was such a pleasure to work with! She never got impatient with us, she always answered all of our questions, and she ALWAYS made sure Leroy was on the proper dosage of the right medications. For each check-up trip that we had to make to see Dr Lefond, even if she was over-booked by accident (which only happened once) she still made certain she herself came to see Leroy and see how he was doing...and she ALWAYS came into the room with a smile on her face! I don't think anyone could ask for a better neurologist for their child! My only disappointment is that she had to leave Wisconsin and we no longer have her for ourselves! ;) I recommend that anyone needing a child neurologist go to her, because there truly is no better than her! We miss her greatly here in Wisconsin, and I hope Seattle's Children's Hospital knows how blessed they are to have her!

    • Cole Belgrade, Montana 04.22.13

      Our daughter had just turned 3 when she suffered her stroke and so began our journey that led us to meeting with Dr. Lefond. We spent a week in the hospital at Seattle Children's, and although she had many patients, we truly felt like our little girl was Dr. Lefonds only patient. We could tell it was a personal mission for her to find a cause to our daughters stroke. She was very attentive to our questions and was very diligent in finding answers. We do not live close to Seattle and have had to travel there many times; she has really helped in coordinating our appointments and making our stressful visits quite pleasant. We have been seeing her for almost a year now and she has gone so far beyond our expectations as a healthcare professional. She truly cares about Colbies health and well-being. It will be a bittersweet day when we no longer need her expertise.

    • Cecilia Milwaukee, Wi 05.21.12

      Dr. Lefond was absolutely delightful to work with at Children's Hospital of Wisconsin. She is wonderful with children and she worked hard with our family to get answers regarding my son Levi having a stroke being only 10 years old. He was totally health and it turned our lives upside for a short while. Dr. Lefond has an incredible background in pediatric strokes. She did a very good job in making sure not only did we as Levi's parents understand his condition but that he also understood what was going on wig his body. We will dearly miss working with Dr. Lefond and her team. Wishing you all the best in life and your career <3 Sincerely, Cecilia and Family

  • Award Name Award Description Awarded By Award Date
    Seattle Top Doctor - 2022 Seattle Magazine 2022
    Sidney Carter Award in Child Neurology American Academy of Neurology 2022
    Seattle Top Doctor - 2021 Seattle Met Magazine 2021 - 2021
    Seattle Top Doctor - 2020 Seattle Magazine 2020 - 2020
    Seattle Top Doctor - 2020 Seattle Met Magazine 2020 - 2020
    Seattle Top Doctor - 2019 Seattle Magazine 2019
    Seattle Top Doctor - 2018 Seattle Magazine 2018
    Seattle Top Doctor - 2016 Seattle Met Magazine 2016
    Fellow, American Heart Association conferred by the Stroke Council 2013
    Fellow, American Neurological Association 2010
  • Manuscripts in Refereed Journals

    • Ellis MJ, Amlie-Lefond C, Orbach DB
      Endovascular therapy in children with acute ischemic stroke: review and recommendations.
      23008391 Neurology, 2012 Sept. : 79(13 Suppl 1)S158-64
    • Zaidat OO, Liebeskind DS, Edgell RC, Amlie-Lefond CM, Kalia JS, Alexandrov AV
      Clinical trial design for endovascular ischemic stroke intervention.
      23008403 Neurology, 2012 Sept. : 79(13 Suppl 1)S221-33
    • Thall PF, Szabo A, Nguyen HQ, Amlie-Lefond CM, Zaidat OO
      Optimizing the concentration and bolus of a drug delivered by continuous infusion.
      21401568 Biometrics, 2011 Dec. : 67(4)1638-46 PMCID:PMC3137757
    • Amlie-Lefond C, Zaidat OO, Lew SM
      Moyamoya disease in early infancy: case report and literature review.
      21397174 Pediatric neurology, 2011 April : 44(4)299-302
    • Ichord RN, Bastian R, Abraham L, Askalan R, Benedict S, Bernard TJ, Beslow L, Deveber G, Dowling M, Friedman N, Fullerton H, Jordan L, Kan L, Kirton A, Amlie-Lefond C, Licht D, Lo W, McClure C, Pavlakis S, Smith SE, Tan M, Kasner S, Jawad AF
      Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study.
      21317270 Stroke; a journal of cerebral circulation, 2011 March : 42(3)613-7 PMCID:PMC3065389
    • Amlie-Lefond C, Gill JC
      Pharmacology in childhood arterial ischemic stroke.
      21183130 Seminars in pediatric neurology, 2010 Dec. : 17(4)237-44
    • Lopez-Vicente M, Ortega-Gutierrez S, Amlie-Lefond C, Torbey MT
      Diagnosis and management of pediatric arterial ischemic stroke.
      20434043 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2010 May : 19(3)175-83
    • Amlie-Lefond C, Fullerton HJ
      Rashes, sniffles, and stroke: a role for infection in ischemic stroke of childhood.
      20166975 Infectious disorders drug targets, 2010 April : 10(2)67-75
    • Amlie-Lefond C, Jubelt B
      Neurologic manifestations of varicella zoster virus infections.
      19818229 Current neurology and neuroscience reports, 2009 Nov. : 9(6)430-4
    • Amlie-Lefond C, deVeber G, Chan AK, Benedict S, Bernard T, Carpenter J, Dowling MM, Fullerton H, Hovinga C, Kirton A, Lo W, Zamel K, Ichord R, International Pediatric Stroke Study
      Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study.
      19423401 Lancet neurology, 2009 June : 8(6)530-6
    • Amlie-Lefond C, Fullerton HJ
      Thrombolytics for hyperacute stroke in children.
      19382031 Pediatric hematology and oncology, 2009 April : 26(3)103-7
    • Amlie-Lefond C, Bernard TJ, Sébire G, Friedman NR, Heyer GL, Lerner NB, DeVeber G, Fullerton HJ, International Pediatric Stroke Study Group
      Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study.
      19255344 Circulation, 2009 March : 119(10)1417-23
    • Amlie-Lefond C, Chan AK, Kirton A, deVeber G, Hovinga CA, Ichord R, Stephens D, Zaidat OO, Thrombolysis in Pediatric Stroke (TIPS) Investigators
      Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial.
      19223687 Neuroepidemiology, 2009 : 32(4)279-86
    • Whelan HT, Cook JD, Amlie-Lefond CM, Hovinga CA, Chan AK, Ichord RN, Deveber GA, Thall PF
      Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children.
      18617665 Stroke; a journal of cerebral circulation, 2008 Sept. : 39(9)2627-36
    • Bernard TJ, Goldenberg NA, Armstrong-Wells J, Amlie-Lefond C, Fullerton HJ
      Treatment of childhood arterial ischemic stroke.
      18496844 Annals of neurology, 2008 June : 63(6)679-96
    • Amlie-Lefond C, Sébire G, Fullerton HJ
      Recent developments in childhood arterial ischaemic stroke.
      18420156 Lancet neurology, 2008 May : 7(5)425-35
    • Amlie-Lefond CM, Basir MA, Franciosi RA
      Fatal neonatal stroke from a prenatal cardiac thrombus.
      18206798 Pediatric neurology, 2008 Feb. : 38(2)140-2
    • Riou EM, Amlie-Lefond C, Echenne B, Farmer M, Sébire G
      Cerebrospinal fluid analysis in the diagnosis and treatment of arterial ischemic stroke.
      18054685 Pediatric neurology, 2008 Jan. : 38(1)1-9
    • Amlie-Lefond CM, Felgenhauer JL, Leong AD
      Localized purpura associated with lamotrigine.
      16939867 Pediatric neurology, 2006 Sept. : 35(3)227-8
    • Amlie-Lefond C, Paz DA, Connelly MP, Huffnagle GB, Whelan NT, Whelan HT
      Innate immunity for biodefense: a strategy whose time has come.
      16337468 The Journal of allergy and clinical immunology, 2005 Dec. : 116(6)1334-42

    Other Publications

    • Catherine M. Amlie-Lefond, MD
      Amlie-Lefond C. Stroke on Pediatric Wards. , 2013
      The Stroke Book, 2nd ed (Torbey and Selim, ed); Cambridge University Press, 2013
    • Amlie-Lefond C
      Childhood stroke: The devil is in the detail
      Lancet Neurology, 2011 : 10(7)606
    • Amlie-Lefond C
      Catheter angiogram in central nervous system vasculitis: still first among equals.
      20187886 Developmental medicine and child neurology, 2010 Sept. : 52(9)792
    • Kirton A, Chan AK, Amlie-Lefond C
      Arterial ischemic stroke: experience in Chinese children.
      18639765 Pediatric neurology, 2008 Aug. : 39(2)142-3; author reply 143-4

  • Presentations Title Event Location Date
    Pediatric Stroke and tPA Study Design Hemostasis and Thrombosis Research Society Apr 12, 2013
    Pediatric Stroke: International Perspective 2012 Canadian Stroke Congress Oct 1, 2012
    Thrombolysis in Pediatric Stroke American Academy of Neurology Apr 23, 2012
    Thrombolysis in Pediatric Stroke-ongoing clinical trials poster International Stroke Conference New Orleans, LA Feb 2, 2012
    Acute management of pediatric stroke: focus on tPA and other emergent treatments Child Neurology Society Meeting Louisville, KY Oct 17, 2009
    tPA in children with arterial ischemic stroke XX1st Congress of the International Society on Thrombosis and Haemostasis Geneva, Switzerland Jul 7, 2007


Board Certification(s)

Neurology with Special Qualification in Child Neurology

Medical/Professional School

University of California Los Angeles, Los Angeles, CA


Children's Hospital Colorado Otolaryngology, Derma, Aurora, CO
Colorado General Hospital, Aurora, CO


University of Colorado Neurology Residency, Aurora, CO

Clinical Interests

Pediatric stroke and cerebrovasculopathy, critical care neurology, general child neurology