Catherine M Amlie-Lefond, MD

Catherine M Amlie-Lefond, MD

Neurosciences Center, Neurology, Moyamoya, Cerebral Palsy Program, Pediatric Vascular Neurology Program, Vascular Anomalies, Neonatal Neurocritical Care Unit (Neuro NICU)

On staff since August 2011

Children's Title: Director, Pediatric Vascular Neurology Program

Academic Title: Professor

Research Center: Center for Integrative Brain Research

  • Patient Testimonials

    • Ashley Seattle, WA 01.13.24

      Dr. Amlie-Lefond helped to save my daughter's life. She was relentless in her pursuit to find the cause of my daughter's unknown strokes. She is dedicated, extremely knowledgeable, and goes above and beyond in every way. She took the time to make sure my daughter felt safe and secure with every procedure and also helped us to understand what was going on as things continued to happen. She is the perfect mix of an exceptional doctor and a kind person. We are forever grateful for her care!

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Seattle Top Doctor - 2022 Seattle Magazine 2022
    Sidney Carter Award in Child Neurology American Academy of Neurology 2022
    Seattle Top Doctor - 2021 Seattle Met Magazine 2021 - 2021
    Seattle Top Doctor - 2020 Seattle Magazine 2020 - 2020
    Seattle Top Doctor - 2020 Seattle Met Magazine 2020 - 2020
    Seattle Top Doctor - 2019 Seattle Magazine 2019
    Seattle Top Doctor - 2018 Seattle Magazine 2018
    Seattle Top Doctor - 2016 Seattle Met Magazine 2016
    Fellow, American Heart Association conferred by the Stroke Council 2013
    Fellow, American Neurological Association 2010
  • Publications

    Manuscripts in Refereed Journals

    • Ellis MJ, Amlie-Lefond C, Orbach DB
      Endovascular therapy in children with acute ischemic stroke: review and recommendations.
      23008391 Neurology, 2012 Sept. : 79(13 Suppl 1)S158-64
    • Zaidat OO, Liebeskind DS, Edgell RC, Amlie-Lefond CM, Kalia JS, Alexandrov AV
      Clinical trial design for endovascular ischemic stroke intervention.
      23008403 Neurology, 2012 Sept. : 79(13 Suppl 1)S221-33
    • Thall PF, Szabo A, Nguyen HQ, Amlie-Lefond CM, Zaidat OO
      Optimizing the concentration and bolus of a drug delivered by continuous infusion.
      21401568 Biometrics, 2011 Dec. : 67(4)1638-46 PMCID:PMC3137757
    • Amlie-Lefond C, Zaidat OO, Lew SM
      Moyamoya disease in early infancy: case report and literature review.
      21397174 Pediatric neurology, 2011 April : 44(4)299-302
    • Ichord RN, Bastian R, Abraham L, Askalan R, Benedict S, Bernard TJ, Beslow L, Deveber G, Dowling M, Friedman N, Fullerton H, Jordan L, Kan L, Kirton A, Amlie-Lefond C, Licht D, Lo W, McClure C, Pavlakis S, Smith SE, Tan M, Kasner S, Jawad AF
      Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study.
      21317270 Stroke; a journal of cerebral circulation, 2011 March : 42(3)613-7 PMCID:PMC3065389
    • Amlie-Lefond C, Gill JC
      Pharmacology in childhood arterial ischemic stroke.
      21183130 Seminars in pediatric neurology, 2010 Dec. : 17(4)237-44
    • Lopez-Vicente M, Ortega-Gutierrez S, Amlie-Lefond C, Torbey MT
      Diagnosis and management of pediatric arterial ischemic stroke.
      20434043 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2010 May : 19(3)175-83
    • Amlie-Lefond C, Fullerton HJ
      Rashes, sniffles, and stroke: a role for infection in ischemic stroke of childhood.
      20166975 Infectious disorders drug targets, 2010 April : 10(2)67-75
    • Amlie-Lefond C, Jubelt B
      Neurologic manifestations of varicella zoster virus infections.
      19818229 Current neurology and neuroscience reports, 2009 Nov. : 9(6)430-4
    • Amlie-Lefond C, deVeber G, Chan AK, Benedict S, Bernard T, Carpenter J, Dowling MM, Fullerton H, Hovinga C, Kirton A, Lo W, Zamel K, Ichord R, International Pediatric Stroke Study
      Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study.
      19423401 Lancet neurology, 2009 June : 8(6)530-6
    • Amlie-Lefond C, Fullerton HJ
      Thrombolytics for hyperacute stroke in children.
      19382031 Pediatric hematology and oncology, 2009 April : 26(3)103-7
    • Amlie-Lefond C, Bernard TJ, Sébire G, Friedman NR, Heyer GL, Lerner NB, DeVeber G, Fullerton HJ, International Pediatric Stroke Study Group
      Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study.
      19255344 Circulation, 2009 March : 119(10)1417-23
    • Amlie-Lefond C, Chan AK, Kirton A, deVeber G, Hovinga CA, Ichord R, Stephens D, Zaidat OO, Thrombolysis in Pediatric Stroke (TIPS) Investigators
      Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial.
      19223687 Neuroepidemiology, 2009 : 32(4)279-86
    • Whelan HT, Cook JD, Amlie-Lefond CM, Hovinga CA, Chan AK, Ichord RN, Deveber GA, Thall PF
      Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children.
      18617665 Stroke; a journal of cerebral circulation, 2008 Sept. : 39(9)2627-36
    • Bernard TJ, Goldenberg NA, Armstrong-Wells J, Amlie-Lefond C, Fullerton HJ
      Treatment of childhood arterial ischemic stroke.
      18496844 Annals of neurology, 2008 June : 63(6)679-96
    • Amlie-Lefond C, Sébire G, Fullerton HJ
      Recent developments in childhood arterial ischaemic stroke.
      18420156 Lancet neurology, 2008 May : 7(5)425-35
    • Amlie-Lefond CM, Basir MA, Franciosi RA
      Fatal neonatal stroke from a prenatal cardiac thrombus.
      18206798 Pediatric neurology, 2008 Feb. : 38(2)140-2
    • Riou EM, Amlie-Lefond C, Echenne B, Farmer M, Sébire G
      Cerebrospinal fluid analysis in the diagnosis and treatment of arterial ischemic stroke.
      18054685 Pediatric neurology, 2008 Jan. : 38(1)1-9
    • Amlie-Lefond CM, Felgenhauer JL, Leong AD
      Localized purpura associated with lamotrigine.
      16939867 Pediatric neurology, 2006 Sept. : 35(3)227-8
    • Amlie-Lefond C, Paz DA, Connelly MP, Huffnagle GB, Whelan NT, Whelan HT
      Innate immunity for biodefense: a strategy whose time has come.
      16337468 The Journal of allergy and clinical immunology, 2005 Dec. : 116(6)1334-42

    Other Publications

    • Catherine M. Amlie-Lefond, MD
      Amlie-Lefond C. Stroke on Pediatric Wards. , 2013
      The Stroke Book, 2nd ed (Torbey and Selim, ed); Cambridge University Press, 2013
    • Amlie-Lefond C
      Childhood stroke: The devil is in the detail
      Lancet Neurology, 2011 : 10(7)606
    • Amlie-Lefond C
      Catheter angiogram in central nervous system vasculitis: still first among equals.
      20187886 Developmental medicine and child neurology, 2010 Sept. : 52(9)792
    • Kirton A, Chan AK, Amlie-Lefond C
      Arterial ischemic stroke: experience in Chinese children.
      18639765 Pediatric neurology, 2008 Aug. : 39(2)142-3; author reply 143-4
  • Presentations

    Presentation Title Event Location Date
    Pediatric Stroke and tPA Study Design Hemostasis and Thrombosis Research Society Apr 12, 2013
    Pediatric Stroke: International Perspective 2012 Canadian Stroke Congress Oct 1, 2012
    Thrombolysis in Pediatric Stroke American Academy of Neurology Apr 23, 2012
    Thrombolysis in Pediatric Stroke-ongoing clinical trials poster International Stroke Conference New Orleans, LA Feb 2, 2012
    Acute management of pediatric stroke: focus on tPA and other emergent treatments Child Neurology Society Meeting Louisville, KY Oct 17, 2009
    tPA in children with arterial ischemic stroke XX1st Congress of the International Society on Thrombosis and Haemostasis Geneva, Switzerland Jul 7, 2007


Board Certification(s)

Neurology with Special Qualification in Child Neurology

Medical/Professional School

University of California Los Angeles, Los Angeles, CA


Children's Hospital Colorado Otolaryngology, Derma, Aurora, CO
Colorado General Hospital, Aurora, CO


University of Colorado Neurology Residency, Aurora, CO

Clinical Interests

Pediatric stroke and cerebrovasculopathy, critical care neurology, general child neurology