In cystic fibrosis (CF), respiratory infections increase inflammation leading to lung damage and lower lung function. Certain pathogens (such as Pseudomonas aeruginosa) lead to a steeper decline in lung function, more severe lung function and higher mortality. We are investigating how these pulmonary pathogens are contributing to more severe lung disease in Latino people with CF. We are also investigating how the pulmonary environment or microbiome may be different and contributing to health disparities.
Prior Findings
We have found that Latino people with CF are more likely to acquire severe pathogens (Pseudomonas aeruginosa and Staphylococcus aureus). Latino people with CF are more likely to convert to severe forms of these pathogens, such as mucoid. Latino people with CF also acquire these pathogens at a younger age than non-Latino white people.
Key Publications
- Ethnic differences in staphylococcus aureus acquisition in cystic fibrosis.
- Early acquisition and conversion of Pseudomonas aeruginosa in Hispanic youth with cystic fibrosis in the United States
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