Miller Lab
The mission of the Miller Lab is to reduce the burden of undiagnosed genetic diseases on patients and their families by improving the efficiency and effectiveness of genetic testing, and to better understand human genetic disease through the identification and characterization of novel disease-causing variation.
To do this, the Miller Lab uses new technologies, such as long-read DNA and RNA sequencing, to improve clinical genetic testing options, identify novel mechanisms of disease, reduce the time required to make a genetic diagnosis and lower barriers to obtaining comprehensive clinical genetic testing.
Clinically, Dr. Miller cares for patients in both general genetics and skeletal dysplasia clinics.
More information can be found on his University of Washington website.
Principal Investigator
Danny Erwin Miller, MD, PhD
Dr. Miller is a physician-scientist who specalizes in understanding the genetic basis of disease. His research applies new technology such as long-read sequencing (LRS) to improve genetic testing and reduce diagnostic times, with an emphasis on using these tools to understand how complex genomic variation contributes to disease.
Dr. Miller’s work encompasses evaluating genes linked to Mendelian conditions, identifying missing disease-causing variation, and implementing LRS into current clinical practice. He has assembled and analyzed genomes from multiple organisms and developed tools for LRS data analysis both at the population level and for rare genetic conditions. His lab is dedicated to simplifying diagnostic testing and improving patient outcomes through innovative LRS-based clinical tests, with a strong commitment to data sharing and collaboration.