Beier Lab

Publications

Dr. David Beier has authored dozens of research papers, including the selected publications listed below. To see more of his publications, view a complete list on PubMed.

  1. Herron BJ, Lu W, Rao C, Liu S, Peters H, Bronson RT, Justice MJ, McDonald JD, Beier DR. (2002). Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nature Genetics, 30:185-9.
  2. Liu S, Lu W, Obara T, Kuida K, Lehoczky J, Dewar K, Drummond IA, Beier DR. (2002). A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development, 129:5839-5846.
  3. Ackerman, K, Herron BJ, Vargas S, Huang H, Kochilas L, Rao C, Pober P, Babiuk R, Epstein J, Greer J, Beier DR.(2005). Fog2 is required for Normal Diaphragm and Lung Development in Mice and Man. PloS Genetics, 1:58-65. PMCID: PMC1183529.
  4. Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR. (2006). Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Research, 16:436-40. PMCID: PMC1415208.
  5. Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR. (2008). THM1 negatively modulates mouse Sonic Hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nature Genetics, 40: 403-10.
  6. Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafe L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR. (2010).Lethal skeletal dysplasia in mice and humans lacking the Golgin GMAP-210. N Engl J Med, 362:206-16. PMCID: PMC3108191.
  7. Kamp A, Peterson MA, Svenson KL, Bjork BC, Hentges KE, Rajapaksha TW, Moran J, Justice MJ, Seidman JG, Seidman CE, Moskowitz IP, Beier DR. (2010). Genome-wide identification of mouse congenital heart disease loci. Hum Mol Genet., 19:3105-13. PMCID: PMC2908466.
  8. Dwyer ND, Manning DK, Moran JL, Mudbhary R, Fleming MS, Favero CB, Vock VM, O'Leary DD, Walsh CA, Beier DR.(2011). A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct Emx2 mutant phenotype. Neural Development, 6:3. PMCID: PMC3024922.
  9. Stottmann RW, Moran JL, Turbe-Doan A, Driver E, Kelley M, Beier DR. (2011). Focusing forward genetics: A tri-partite ENU screen for neurodevelopmental mutations in the mouse. Genetics,188:615-24. 
  10. Stottmann RW, Turbe-Doan AT, Tran P, Kratz LE, Moran JL,, Kelley RI, Beier DR. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS Genetics, 2011, 7:e1002224. 
  11. Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR. Mutation mapping and identification by whole-genome sequencing. Genome Res. 2012 Aug;22(8):1541-8.
  12. Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR.Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol. 2013 Jan;24(1):100-12
  13. Tran PV, Talbott GC, Turbe-Doan A, Jacobs DT, Schonfeld MP, Silva LM, Chatterjee A, Prysak M, Allard BA, Beier DR.Downregulating Hedgehog signaling reduces renal cystogenic potential of mouse models. JASN, 2014, epub April 3.
  14. Ha S, Stottmann RW, Furley AJ, Beier DR. A Forward Genetic Screen in Mice Identifies Mutants with Abnormal Cortical Patterning. Cereb Cortex. 2015 Jan;25(1):167-79. PMID: 23968836
  15. Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV. ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Nat Commun. 2015 Jan 20;6:6023. PMID: 25599650
  16. Gallego-Llamas J, Timms AE, Geister KA, Lindsay A and Beier DR. Variant mapping and mutation discovery in inbred mice using next-generation sequencing. BMC Genomics. 2015 Nov 9;16(1):913. PMID: 26552429