Publications

Trafficking through the blood-brain barrier is directed by core and outer surface components of layer-by-layer nanoparticles.

Lamson NG, Pickering AJ, Wyckoff J, Ganesh P, Calle EA, Straehla JP, Hammond PT

39036092 Bioengineering & translational medicine , 2024 July: 9 (4 ) e10636 PMCID: PMC11256136

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.

Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WCW, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D

38767983 ACS nano , 2024 Jun 4: 18 (22 ) 13983-13999 PMCID: PMC11214758

Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain.

Pickering AJ, Lamson NG, Marand MH, Hwang W, Straehla JP, Hammond PT

37992211 ACS nano , 2023 Dec 12: 17 (23 ) 24154-24169 PMCID: PMC10964212

The Blood-Brain Barrier: Implications for Experimental Cancer Therapeutics.

Straehla JP, Reardon DA, Wen PY, Agar NYR

38323268 Annual review of cancer biology , 2023 April: 7 265-289 PMCID: PMC10846865

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery.

Boehnke N, Straehla JP, Safford HC, Kocak M, Rees MG, Ronan M, Rosenberg D, Adelmann CH, Chivukula RR, Nabar N, Berger AG, Lamson NG, Cheah JH, Li H, Roth JA, Koehler AN, Hammond PT

35862544 Science (New York, N.Y.) , 2022 Jul 22: 377 (6604 ) eabm5551 PMCID: PMC10249039

A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier-penetrant nanoparticles.

Straehla JP, Hajal C, Safford HC, Offeddu GS, Boehnke N, Dacoba TG, Wyckoff J, Kamm RD, Hammond PT

35648828 Proceedings of the National Academy of Sciences of the United States of America , 2022 Jun 7: 119 (23 ) e2118697119 PMCID: PMC9191661

Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia.

Johanssen T, McVeigh L, Erridge S, Higgins G, Straehla J, Frame M, Aittokallio T, Carragher NO, Ebner D

36733367 Frontiers in oncology , 2022: 12 1075559 PMCID: PMC9886867

Pharmacokinetic Principles and Their Application to Central Nervous System Tumors.

Straehla JP, Warren KE

33036139 Pharmaceutics , 2020 Oct 6: 12 (10 ) PMCID: PMC7601100

Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

Boehnke N, Correa S, Hao L, Wang W, Straehla JP, Bhatia SN, Hammond PT

31747099 Angewandte Chemie (International ed. in English) , 2020 Feb 10: 59 (7 ) 2776-2783 PMCID: PMC7002217

Embryonic stem cell secreted factors decrease invasiveness of triple-negative breast cancer cells through regulome modulation.

Tarasewicz E, Oakes RS, Aviles MO, Straehla J, Chilton KM, Decker JT, Wu J, Shea LD, Jeruss JS

29053396 Cancer biology & therapy , 2018 Apr 3: 19 (4 ) 271-281 PMCID: PMC5902235