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Trafficking through the blood-brain barrier is directed by core and outer surface components of layer-by-layer nanoparticles.
Lamson NG, Pickering AJ, Wyckoff J, Ganesh P, Calle EA, Straehla JP, Hammond PT
39036092 Bioengineering & translational medicine , 2024 July: 9 (4 ) e10636 PMCID: PMC11256136
Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.
Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WCW, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D
38767983 ACS nano , 2024 Jun 4: 18 (22 ) 13983-13999 PMCID: PMC11214758
Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain.
Pickering AJ, Lamson NG, Marand MH, Hwang W, Straehla JP, Hammond PT
37992211 ACS nano , 2023 Dec 12: 17 (23 ) 24154-24169 PMCID: PMC10964212
The Blood-Brain Barrier: Implications for Experimental Cancer Therapeutics.
Straehla JP, Reardon DA, Wen PY, Agar NYR
38323268 Annual review of cancer biology , 2023 April: 7 265-289 PMCID: PMC10846865
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery.
Boehnke N, Straehla JP, Safford HC, Kocak M, Rees MG, Ronan M, Rosenberg D, Adelmann CH, Chivukula RR, Nabar N, Berger AG, Lamson NG, Cheah JH, Li H, Roth JA, Koehler AN, Hammond PT
35862544 Science (New York, N.Y.) , 2022 Jul 22: 377 (6604 ) eabm5551 PMCID: PMC10249039
A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier-penetrant nanoparticles.
Straehla JP, Hajal C, Safford HC, Offeddu GS, Boehnke N, Dacoba TG, Wyckoff J, Kamm RD, Hammond PT
35648828 Proceedings of the National Academy of Sciences of the United States of America , 2022 Jun 7: 119 (23 ) e2118697119 PMCID: PMC9191661
Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia.
Johanssen T, McVeigh L, Erridge S, Higgins G, Straehla J, Frame M, Aittokallio T, Carragher NO, Ebner D
36733367 Frontiers in oncology , 2022: 12 1075559 PMCID: PMC9886867
Pharmacokinetic Principles and Their Application to Central Nervous System Tumors.
Straehla JP, Warren KE
33036139 Pharmaceutics , 2020 Oct 6: 12 (10 ) PMCID: PMC7601100
Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.
Boehnke N, Correa S, Hao L, Wang W, Straehla JP, Bhatia SN, Hammond PT
31747099 Angewandte Chemie (International ed. in English) , 2020 Feb 10: 59 (7 ) 2776-2783 PMCID: PMC7002217
Embryonic stem cell secreted factors decrease invasiveness of triple-negative breast cancer cells through regulome modulation.
Tarasewicz E, Oakes RS, Aviles MO, Straehla J, Chilton KM, Decker JT, Wu J, Shea LD, Jeruss JS
29053396 Cancer biology & therapy , 2018 Apr 3: 19 (4 ) 271-281 PMCID: PMC5902235