Engineering Combination Nanomedicines

This project aims to design innovative nanoparticle systems where the drug carrier itself works synergistically with the drug cargo to provide a powerful combination therapy, specifically targeting the unique vulnerabilities of pediatric cancers. This cutting-edge approach requires a deep understanding of how nanoparticles interact with cells and dynamic insights into cargo delivery at the subcellular level.

We begin by employing chemical and genetic screening techniques to understand the impact of specific lipids on cancer drug delivery. Leveraging the unique properties of nanoparticles, we strive to enhance therapeutic efficacy while reducing the side effects of treatments. By unraveling the fundamental mechanisms governing nanoparticle-cell interactions, we aim to unlock combination strategies that could be relevant to a wide range of cancers and potentially impact other devastating childhood diseases, as well.