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Gynecological Uses for Lupron Therapy

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Here is what you need to know about taking Lupron.

What is Lupron Therapy?

Lupron is a medicine that temporarily blocks the signals from the brain to the ovaries, which lowers estrogen levels, prevents the ovaries from releasing eggs and stops the menstrual cycle (monthly periods). Lupron is used to treat several health conditions, including early puberty and endometriosis. It may also be given to suppress periods during chemotherapy. Using Lupron during some chemotherapy may help protect the ovaries and make it more likely that periods will return after cancer treatment is complete.

How is Lupron given?

Lupron is given as an injection into the muscle. You may get an injection once every month or once every 3 months, depending on what your provider feels is best.

What are the side effects from this medicine?

In the first few weeks after the first injection, you may have vaginal bleeding and headaches. These are caused by a temporary increase in estrogen. After a few weeks, your estrogen level will drop, and your period will stop. You may have some spotting. Some teenagers have hot flashes or moodiness while taking Lupron.

Long term use may weaken your bones (lower your bone density).

We recommend that you take 1,000 IU (international units) of Vitamin D and 1,500 mg of Calcium while taking this medicine. You can find these vitamins over the counter at your pharmacy. Your provider will monitor your bone density if you are going to use this medicine long term.

How often will I need to see my healthcare provider?

Your provider will tell you when to return for a follow up visit. Usually we recommend that you return in 1 to 3 months to make sure the medicine is working.

Is Lupron effective for birth control?

No. Lupron is not a birth control medicine. It does not prevent pregnancy even though it can stop your period. If you need birth control, please talk to your provider about your options. If you think you may be pregnant while taking this medicine, please call your doctor right away.

Does Lupron protect against sexually transmitted infections?

No. Lupron does not protect against sexually transmitted infections (STIs). Condoms or a barrier device should be used to lower the risk of getting STIs. If you think that you have been exposed to a STI, please talk to your provider today or call the clinic. If you are sexually active, please talk to your provider about your safe sex options.

When should I call my healthcare provider?

You should call your clinic if you:

  • Have heavy vaginal bleeding
  • Have regular periods (menstruation) after 2 months of treatment
  • Think you may be pregnant

To Learn More

  • Adolescent Medicine  
    206-987-2028  
  • Ask your child’s healthcare provider
  • seattlechildrens.org/patient-education

Free Interpreter Services

  • In the hospital, ask your nurse.
  • From outside the hospital, call the toll-free Family Interpreting Line, 1-866-583-1527. Tell the interpreter the name or extension you need.
Seattle Children's Hospital

Seattle Children’s offers free interpreter services for patients, family members and legal representatives who are deaf or hard of hearing or speak a language other than English. Seattle Children’s will make this information available in alternate formats upon request. Call the Family Resource Center at 206-987-2201. This handout has been reviewed by clinical staff at Seattle Children’s. However, your needs are unique. Before you act or rely upon this information, please talk with your healthcare provider.

© 2026 Seattle Children’s, Seattle, Washington. All rights reserved.

01/01/2024
PE1695
Patient and Family Education | Adolescent Medicine

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