Lisa Maves, PhD

Lisa Maves, PhD
"At Seattle Children's, my work focuses on basic research on heart and muscle development. Each day offers a new opportunity to make a discovery that will impact new therapies for children with muscular dystrophy and congenital heart disorders."

  • Biography

    Dr. Lisa Maves is a principal investigator at Seattle Children’s Research Institute and an associate professor of Pediatrics at the University of Washington School of Medicine. She received her PhD from the University of Washington and completed postdoctoral research at the University of Oregon and at Fred Hutchinson Cancer Center. She was a staff scientist at Fred Hutchinson before joining Seattle Children's Research Institute in 2012.

     

    Research Description

    The Maves lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new understanding of, and treatments for, muscular dystrophy and heart disorders. We primarily use the zebrafish as an animal model because of its advantages for genetic manipulations, in vivo imaging, and drug screening. By using the power of genetics and embryo development, we can gain insights into the origins of heart and muscle disease. We currently have three main projects. 

    1) We are using a zebrafish model of Duchenne muscular dystrophy (the dmd mutant strain) to investigate the developmental biology and epigenetics of DMD as well as to identify new drug therapies for DMD. We also work closely with Dr. David Mack’s lab (https://iscrm.uw.edu/faculty/david-l-mack/) to take advantage of human iPSC and rat models of DMD. 

    2) We are investigating the mechanisms of skeletal muscle fiber-type differentiation. This work will eventually help us understand why certain types of muscle fibers are more susceptible to muscular dystrophy.

    3) We are using CRISPR genome screening and precision editing in zebrafish to engineer mutations in genes that have been implicated in human congenital heart defects. Recently our screening has identified several new genes required for heart development. Our goal is to gain insight into the complex genetics of congenital heart defects.

    Research Focus Area

    Congenital Heart Defects, Developmental Biology, Muscular Dystrophy

  • Related Resources

    • Welcome to the Maves Lab

      Welcome to the Maves Lab

      The Maves Lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new treatments for muscular dystrophy and heart disorders using zebrafish as an animal model because of advantages for genetic manipulations, in vivo imaging, and drug screening.

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  • Publications

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