Yongdong Zhao, MD, PhD, RhMSUS

Yongdong Zhao, MD, PhD, RhMSUS


"My research goal is to build a well-rounded clinical research program investigating chronic nonbacterial osteomyelitis (CNO) or CRMO, an inflammatory bone disease with unknown cause, which results in bone pain and bone destruction in children. There is a lack of sensitive and reliable laboratory tests to diagnose and monitor disease activity. My long-term goal is to develop comprehensive, reliable diagnostic and monitoring tools for CNO. Validated outcome measurements will enable us to evaluate the effectiveness of therapeutics on CNO in clinical trials. Inexpensive and reliable imaging is needed to improve the clinical care of CNO. I am currently evaluating the feasibility of using infrared thermal imaging to detect active lesions in CNO. Longitudinal studies are needed to determine the effectiveness of different therapies for CNO. Due to the relative rarity of this condition, no single center has enough patients to answer this research question alone. Our team has been the coordination center for two international collaborative projects, CNO classification criteria development and CHOIR registry. We appreciate your generous donation to fund our research in CRMO/CNO. Give via https://giveto.seattlechildrens.org/CRMOfund"
  • Biography

    Dr. Zhao received his medical degree from Beijing Medical University (now Peking University Health Science Center). He completed his first stage of residency in surgery at Beijing Medical University and his doctorate in nutrition sciences from Purdue University. Dr. Zhao studied the pathogenesis of Juvenile dermatomyositis as a postdoctoral fellow at Northwestern University. He completed his residency in pediatrics at Cincinnati Childrens Hospital Medical Center and fellowship in pediatric rheumatology at Childrens Hospital of Philadelphia.

    During his rheumatology fellowship training, Dr. Zhao recognized the need for reliable and valid assessment tools, and systematic evaluation methods, for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), a potentially debilitating condition. He developed a comprehensive MRI scoring tool to assess disease activity and damage. He used this tool in a retrospective study of children with CNO treated with TNF alpha inhibition, demonstrating significant improvements of disease activity and no damage progression.
    Dr. Zhao joined Seattle Children's Hospital and the University of Washington in 2013.

    Board Certification(s)

    Pediatric Rheumatology


    Peking University, Beijing
    Purdue University, West Lafayette, IN


    Children's Hospital of Philadelphia, Philadelphia, PA

    Clinical Interests

    Diagnosing and treating children with rheumatic diseases including juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), vasculitis, linear scleroderma, systemic sclerosis, chronic recurrent multifocal osteomyelitis (CRMO), periodic fever and other rare rheumatic disorders.

  • Patient Testimonials

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  • Awards and Honors

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  • Publications

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    No clinical trials found for Yongdong Zhao, MD, PhD, RhMSUS.