Tanya Parish, PhD

Tanya Parish, PhD
"As a trained microbiologist, I am motivated to use my scientific knowledge to make a difference in global health. My previous work on the basic biology of Mycobacterium tuberculosis formed an excellent foundation upon which to build a drug discovery team. Using knowledge of vulnerabilities in the bacterial pathogen, we can find tractable and novel drug targets. In addition, a grounding in bacterial physiology allows us to develop relevant screening platforms and to run a battery of experimental assays to select the best chemical series to work on in a drug discovery program. We work collaboratively with a large number of external partners, both industrial and academic, to advance new TB drugs. "

  • Biography

    Complete List of Published Work in MyBibliography: https://www.ncbi.nlm.nih.gov/myncbi/tanya.parish.1/bibliography/public/

    My current research is focused in two main areas: (i) understanding the biology of the global pathogen Mycobacterium tuberculosis and (ii) discovering and developing novel drugs for tuberculosis (TB) that are effective at curing drug sensitive and drug resistant tuberculosis.

    Previously, I was the Senior Vice President of Drug Discovery at the Infectious Disease Research Institute, where I established a research group focused on tuberculosis drug discovery. Prior to that, I was Professor of Mycobacteriology at Barts and the London School of Medicine and Dentistry (UK), with a research group focused on mycobacterial biology.

    Postdoctoral studies, London School of Hygiene & Tropical Medicine, UK

    PhD, National Institute for Medical Research, London, UK

    BSc in Microbiology and Genetics, University College London, UK

    Research Description

    My research team is comprised of both biologists and chemists focused on the global infectious disease tuberculosis. We work in two main areas.

    First, we are working on discovering new drugs for tuberculosis. TB is the leading cause of death from an infectious disease, with about 1.5 million deaths every year. The current treatment takes more than 6 months and involves multiple drugs. Our work aims to find new drug candidates that can be combined into a novel drug treatment regimen, with the aim of reducing the overall time of treatment. New drugs should also be able to treat drug resistant TB, which is becoming a major problem.

    Our research on the more basic science side is focused on understanding how antibiotics function. We focus on what leads to bacterial death when exposed to antibiotics. We also work on the mechanisms of antibiotic resistance. I am especially interested in cell wall biosynthesis and aerobic respiration, as well as other essential cellular processes and gene regulation.

  • Related Resources

    • About My Work

      Our current research is focused in two main areas: (i) understanding the biology of the global pathogen Mycobacterium tuberculosis; and (ii) discovering and developing novel drugs for tuberculosis (TB) that are effective at curing drug sensitive and drug resistant tuberculosis.

    • Tanya Parish, PhD Researcher Profile

      View the Seattle Children's Research Institute profile of Tanya Parish, PhD including their publications and grants.

  • Awards and Honors

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