Tanya Parish, PhD
Academic Title: Professor, Department of Pediatrics, University of Washington School of Medicine
Research Center: Center for Global Infectious Disease Research
"As a trained microbiologist, I am motivated to use my scientific knowledge to make a difference in global health. My previous work on the basic biology of Mycobacterium tuberculosis formed an excellent foundation upon which to build a drug discovery team. Using knowledge of vulnerabilities in the bacterial pathogen, we can find tractable and novel drug targets. In addition, a grounding in bacterial physiology allows us to develop relevant screening platforms and to run a battery of experimental assays to select the best chemical series to work on in a drug discovery program. We work collaboratively with a large number of external partners, both industrial and academic, to advance new TB drugs. "
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Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/tanya.parish.1/bibliography/public/
My current research is focused in two main areas: (i) understanding the biology of the global pathogen Mycobacterium tuberculosis and (ii) discovering and developing novel drugs for tuberculosis (TB) that are effective at curing drug sensitive and drug resistant tuberculosis.
Previously, I was the Senior Vice President of Drug Discovery at the Infectious Disease Research Institute, where I established a research group focused on tuberculosis drug discovery. Prior to that, I was Professor of Mycobacteriology at Barts and the London School of Medicine and Dentistry (UK), with a research group focused on mycobacterial biology.
Postdoctoral studies, London School of Hygiene & Tropical Medicine, UK
PhD, National Institute for Medical Research, London, UK
BSc in Microbiology and Genetics, University College London, UK
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Related Pages
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Our current research is focused in two main areas: (i) understanding the biology of the global pathogen Mycobacterium tuberculosis; and (ii) discovering and developing novel drugs for tuberculosis (TB) that are effective at curing drug sensitive and drug resistant tuberculosis.
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Manuscripts in Refereed Journals
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Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish TSpirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.
33521468 ACS omega, 2021 Jan. 26 : 6(3)2284-2311 PMCID:PMC7841955 -
Thayer MB, Parish TPhenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
33481781 PloS one, 2021 : 16(1)e0239353 PMCID:PMC7822546 -
McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish TMultiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.
33055263 mSphere, 2020 Oct. 14 : 5(5) PMCID:PMC7565900 -
de Oliveira JAM, Williams DE, Bonnett S, Johnson J, Parish T, Andersen RJDiterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.
32404991 The Journal of antibiotics, 2020 Aug. : 73(8)568-573 -
Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova SStructure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.
32421305 ACS chemical biology, 2020 June 19 : 15(6)1581-1594 PMCID:PMC7385556 -
Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard ADiscovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
32034201 Scientific reports, 2020 Feb. 7 : 10(1)2112 PMCID:PMC7005898 -
Flint L, Korkegian A, Parish TInhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.
33201882 PloS one, 2020 : 15(11)e0239354 PMCID:PMC7671525 -
Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli FIntegrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA.
31454170 ChemMedChem, 2019 Oct. 4 : 14(19)1735-1741 PMCID:PMC6800809 -
Odingo JO, Early JV, Smith J, Johnson J, Bailey MA, Files M, Guzman J, Ollinger J, Korkegian A, Kumar A, Ovechkina Y, Parish T8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.
30893501 Drug development research, 2019 Aug. : 80(5)566-572 PMCID:PMC6767403 -
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SMDual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
31047750 Bioorganic & medicinal chemistry letters, 2019 July 1 : 29(13)1665-1672 PMCID:PMC6531345 -
Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish TNovel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.
30962346 Antimicrobial agents and chemotherapy, 2019 June : 63(6) PMCID:PMC6535543 -
Smith J, Wescott H, Early J, Mullen S, Guzman J, Odingo J, Lamar J, Parish TAnthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential.
31303991 MedChemComm, 2019 June 1 : 10(6)934-945 PMCID:PMC6596218 -
Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JCStructure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
31002508 Journal of medicinal chemistry, 2019 May 9 : 62(9)4483-4499 PMCID:PMC6511943 -
Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJEfficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.
30745397 Antimicrobial agents and chemotherapy, 2019 April : 63(4) PMCID:PMC6496157 -
Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish TIdentification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.
30501173 ACS infectious diseases, 2019 Feb. 8 : 5(2)272-280 PMCID:PMC6371205 -
McNeil MB, Chettiar S, Awasthi D, Parish TCell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.
32974492 Access microbiology, 2019 : 1(1)e000006 PMCID:PMC7470358 -
Early JV, Mullen S, Parish TA rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.
31589621 PloS one, 2019 : 14(10)e0222970 PMCID:PMC6779252 -
Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DCCharacterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.
30978223 PloS one, 2019 : 14(4)e0214958 PMCID:PMC6461227 -
Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish TA high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis.
30650074 PloS one, 2019 : 14(1)e0205479 PMCID:PMC6334966 -
Melief E, Bonnett SA, Zuniga ES, Parish TActivation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase.
30323042 Antimicrobial agents and chemotherapy, 2019 Jan. : 63(1) PMCID:PMC6325208 -
McGuffin S, Mullen S, Early J, Parish T.Development of a series of high-throughput screens to identify leads for nontuberculous mycobacteria drug design.
Open Forum Infectious Diseases, 2019 - 2019 : Supplement(6); S485. -
Carroll P, Muwanguzi-Karugaba J, Parish TCodon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis.
30285840 BMC research notes, 2018 Oct. 1 : 11(1)685 PMCID:PMC6167837 -
Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PGIdentification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
29944372 Journal of medicinal chemistry, 2018 Aug. 9 : 61(15)6592-6608 PMCID:PMC6089501 -
Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish TIdentification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.
29954459 BMC research notes, 2018 June 28 : 11(1)416 PMCID:PMC6022709 -
Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley MDiscovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
30456352 Life science alliance, 2018 June : 1(3)e201800025 PMCID:PMC6238539 -
Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish TSynthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
29680666 Bioorganic & medicinal chemistry letters, 2018 June 1 : 28(10)1758-1764 PMCID:PMC5946847 -
O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish TImidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.
29632008 Antimicrobial agents and chemotherapy, 2018 June : 62(6) PMCID:PMC5971599 -
Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish TConstruction of an overexpression library for Mycobacterium tuberculosis.
30197930 Biology methods & protocols, 2018 : 3(1)bpy009 PMCID:PMC6118195 -
Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish TThe 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.
29523334 Tuberculosis (Edinburgh, Scotland), 2018 Jan. : 10896-98 PMCID:PMC5854369 -
Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish TIdentification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.
30416491 Frontiers in microbiology, 2018 : 92542 PMCID:PMC6213970 -
Berube BJ, Castro L, Russell D, Ovechkina Y, Parish TNovel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus.
30364170 Frontiers in microbiology, 2018 : 92417 PMCID:PMC6191478 -
Bonnett SA, Dennison D, Files M, Bajpai A, Parish TA class of hydrazones are active against non-replicating Mycobacterium tuberculosis.
30332412 PloS one, 2018 : 13(10)e0198059 PMCID:PMC6192558 -
Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish THigh content, high-throughput screening for small molecule inducers of NF-κB translocation.
29953522 PloS one, 2018 : 13(6)e0199966 PMCID:PMC6023200 -
Berube BJ, Parish TCombinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.
29061760 Antimicrobial agents and chemotherapy, 2018 Jan. : 62(1) PMCID:PMC5740367 -
Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish TImproved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.
29035551 ACS infectious diseases, 2017 Dec. 8 : 3(12)898-916 PMCID:PMC5727484 -
McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish TMechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.
29050761 Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 107133-136 PMCID:PMC5679704 -
McNeil MB, Dennison DD, Shelton CD, Parish TIn Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.
28760892 Antimicrobial agents and chemotherapy, 2017 Oct. : 61(10) PMCID:PMC5610523 -
Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish TA Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
28674058 Antimicrobial agents and chemotherapy, 2017 Sept. : 61(9) PMCID:PMC5571309 -
Manning AJ, Ovechkina Y, McGillivray A, Flint L, Roberts DM, Parish TA high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis.
28366666 Methods (San Diego, Calif.), 2017 Aug. 15 : 1273-11 -
Zuniga ES, Korkegian A, Mullen S, Hembre EJ, Ornstein PL, Cortez G, Biswas K, Kumar N, Cramer J, Masquelin T, Hipskind PA, Odingo J, Parish TThe synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.
28576632 Bioorganic & medicinal chemistry, 2017 Aug. 1 : 25(15)3922-3946 PMCID:PMC5513444 -
McNeil MB, Dennison D, Parish TMutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis.
28703701 Microbiology (Reading, England), 2017 July : 163(7)1065-1070 -
Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish TImidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.
28180188 ACS omega, 2017 Jan. 31 : 2(1)41-51 PMCID:PMC5286457 -
Kokoczka R, Schuessler DL, Early JV, Parish TMycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.
28061949 Tuberculosis (Edinburgh, Scotland), 2017 Jan. : 1023-7 PMCID:PMC5225668 -
Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish TNitazoxanide is active against Mycobacterium leprae.
28850614 PloS one, 2017 : 12(8)e0184107 PMCID:PMC5574600 -
Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish TA Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.
27642770 ACS infectious diseases, 2016 Dec. 9 : 2(12)893-902 PMCID:PMC5215716 -
Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MRDiscovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
27503647 Antimicrobial agents and chemotherapy, 2016 Oct. : 60(10)6271-80 PMCID:PMC5038265 -
Degiacomi G, Personne Y, Mondésert G, Ge X, Mandava CS, Hartkoorn RC, Boldrin F, Goel P, Peisker K, Benjak A, Barrio MB, Ventura M, Brown AC, Leblanc V, Bauer A, Sanyal S, Cole ST, Lagrange S, Parish T, Manganelli RMicrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.
27553416 Tuberculosis (Edinburgh, Scotland), 2016 Sept. : 10095-101 -
MartÃnez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro ASynergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.
27139471 Antimicrobial agents and chemotherapy, 2016 July : 60(7)4375-9 PMCID:PMC4914650 -
Early JV, Casey A, Martinez-Grau MA, Gonzalez Valcarcel IC, Vieth M, Ollinger J, Bailey MA, Alling T, Files M, Ovechkina Y, Parish TOxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.
27044545 Antimicrobial agents and chemotherapy, 2016 June : 60(6)3608-16 PMCID:PMC4879361 -
Kesicki EA, Bailey MA, Ovechkina Y, Early JV, Alling T, Bowman J, Zuniga ES, Dalai S, Kumar N, Masquelin T, Hipskind PA, Odingo JO, Parish TSynthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents.
27171280 PloS one, 2016 : 11(5)e0155209 PMCID:PMC4865136 -
Chandrasekera NS, Alling T, Bailey MA, Files M, Early JV, Ollinger J, Ovechkina Y, Masquelin T, Desai PV, Cramer JW, Hipskind PA, Odingo JO, Parish TIdentification of Phenoxyalkylbenzimidazoles with Antitubercular Activity.
26295286 Journal of medicinal chemistry, 2015 Sept. 24 : 58(18)7273-85 -
Russo F, Gising J, Åkerbladh L, Roos AK, Naworyta A, Mowbray SL, Sokolowski A, Henderson I, Alling T, Bailey MA, Files M, Parish T, Karlén A, Larhed MOptimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.
26246997 ChemistryOpen, 2015 June : 4(3)342-62 PMCID:PMC4522185 -
Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson S, Barranis NJ, hAinmhire E, Chen WL, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, Rathod PK, Parish T, Cho S, Franzblau SG, Murphy BTDiaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.
26594660 ACS infectious diseases, 2015 April 10 : 1(4)168-174 PMCID:PMC4648258 -
Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJA novel antimycobacterial compound acts as an intracellular iron chelator.
25645825 Antimicrobial agents and chemotherapy, 2015 April : 59(4)2256-64 PMCID:PMC4356758 -
Schreuder LJ, Carroll P, Muwanguzi-Karugaba J, Kokoczka R, Brown AC, Parish TMycobacterium tuberculosis H37Rv has a single nucleotide polymorphism in PhoR which affects cell wall hydrophobicity and gene expression.
25635271 Microbiology (Reading, England), 2015 April : 161(Pt 4)765-773 -
Chandrasekera NS, Alling T, Bailey M, Korkegian A, Ahn J, Ovechkina Y, Odingo J, Parish TThe 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity.
25881065 Journal of negative results in biomedicine, 2015 Feb. 13 : 144 PMCID:PMC4336482 -
Moraski GC, Miller PA, Bailey MA, Ollinger J, Parish T, Boshoff HI, Cho S, Anderson JR, Mulugeta S, Franzblau SG, Miller MJPutting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and "Anagrams" Generated Potent Antituberculosis Agents.
25984566 ACS infectious diseases, 2015 Feb. 13 : 1(2)85-90 PMCID:PMC4426345 -
Carroll P, Parish TDeletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.
26197389 PloS one, 2015 : 10(7)e0133129 PMCID:PMC4510303 -
Goude R, Roberts DM, Parish TElectroporation of mycobacteria.
25779313 Methods in molecular biology (Clifton, N.J.), 2015 : 1285117-30 -
Brown AC, Kokoczka R, Parish TLytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically Redundant.
26309039 PloS one, 2015 : 10(8)e0135638 PMCID:PMC4550268 -
Korkegian A, Roberts DM, Blair R, Parish TMutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.
25352598 The Journal of biological chemistry, 2014 Dec. 19 : 289(51)35172-81 PMCID:PMC4271206 -
Odingo J, O'Malley T, Kesicki EA, Alling T, Bailey MA, Early J, Ollinger J, Dalai S, Kumar N, Singh RV, Hipskind PA, Cramer JW, Ioerger T, Sacchettini J, Vickers R, Parish TSynthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.
25456390 Bioorganic & medicinal chemistry, 2014 Dec. 15 : 22(24)6965-79 -
Carroll P, Muwanguzi-Karugaba J, Melief E, Files M, Parish TIdentification of the translational start site of codon-optimized mCherry in Mycobacterium tuberculosis.
24934902 BMC research notes, 2014 June 17 : 7366 PMCID:PMC4091752 -
Ekins S, Casey AC, Roberts D, Parish T, Bunin BABayesian models for screening and TB Mobile for target inference with Mycobacterium tuberculosis.
24440548 Tuberculosis (Edinburgh, Scotland), 2014 March : 94(2)162-9 PMCID:PMC4394018 -
Chandrasekera NS, Bailey MA, Files M, Alling T, Florio SK, Ollinger J, Odingo JO, Parish TSynthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides.
25320680 PeerJ, 2014 : 2e612 PMCID:PMC4193402 -
Personne Y, Parish TMycobacterium tuberculosis possesses an unusual tmRNA rescue system.
24145139 Tuberculosis (Edinburgh, Scotland), 2014 Jan. : 94(1)34-42 -
Schreuder LJ, Parish TMycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia.
25211224 PloS one, 2014 : 9(9)e107283 PMCID:PMC4161423 -
Karkare S, Brown AC, Parish T, Maxwell AIdentification of the likely translational start of Mycobacterium tuberculosis GyrB.
23856181 BMC research notes, 2013 July 15 : 6274 PMCID:PMC3724585 -
Moraski GC, Markley LD, Cramer J, Hipskind PA, Boshoff H, Bailey M, Alling T, Ollinger J, Parish T, Miller MJAdvancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis.
23930153 ACS medicinal chemistry letters, 2013 July 11 : 4(7)675-679 PMCID:PMC3733398 -
Kumar D, Raj KK, Bailey M, Alling T, Parish T, Rawat DSAntimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives.
23357633 Bioorganic & medicinal chemistry letters, 2013 March 1 : 23(5)1365-9 -
Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JCIdentification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.
24086479 PloS one, 2013 : 8(9)e75245 PMCID:PMC3781026 -
Kumar A, Casey A, Odingo J, Kesicki EA, Abrahams G, Vieth M, Masquelin T, Mizrahi V, Hipskind PA, Sherman DR, Parish TA high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.
24244263 PloS one, 2013 : 8(11)e72786 PMCID:PMC3820577 -
Personne Y, Brown AC, Schuessler DL, Parish TMycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.
23560081 PloS one, 2013 : 8(4)e60228 PMCID:PMC3613350 -
Tan S, Sukumar N, Abramovitch RB, Parish T, Russell DGMycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell.
23592993 PLoS pathogens, 2013 : 9(4)e1003282 PMCID:PMC3616970 -
Ollinger J, Bailey MA, Moraski GC, Casey A, Florio S, Alling T, Miller MJ, Parish TA dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis.
23593234 PloS one, 2013 : 8(4)e60531 PMCID:PMC3617142 -
James JN, Hasan ZU, Ioerger TR, Brown AC, Personne Y, Carroll P, Ikeh M, Tilston-Lunel NL, Palavecino C, Sacchettini JC, Parish TDeletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.
22956756 Microbiology (Reading, England), 2012 Nov. : 158(Pt 11)2724-2731 -
Zelmer A, Carroll P, Andreu N, Hagens K, Mahlo J, Redinger N, Robertson BD, Wiles S, Ward TH, Parish T, Ripoll J, Bancroft GJ, Schaible UEA new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.
22635525 The Journal of antimicrobial chemotherapy, 2012 Aug. : 67(8)1948-60 PMCID:PMC3394442 -
Ollinger J, O'Malley T, Ahn J, Odingo J, Parish TInhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.
22427625 Journal of bacteriology, 2012 May : 194(10)2614-9 PMCID:PMC3347204 -
Schuessler DL, Parish TThe promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis.
22485172 PloS one, 2012 : 7(4)e34471 PMCID:PMC3317779 -
Pecsi I, Hirmondo R, Brown AC, Lopata A, Parish T, Vertessy BG, Tóth JThe dUTPase enzyme is essential in Mycobacterium smegmatis.
22655049 PloS one, 2012 : 7(5)e37461 PMCID:PMC3360063 -
Carroll P, Waddell SJ, Butcher PD, Parish TMethionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1.
21875360 Microbial drug resistance (Larchmont, N.Y.), 2011 Sept. : 17(3)351-5 PMCID:PMC3161625 -
Carroll P, Faray-Kele MC, Parish TIdentifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach.
21642404 Applied and environmental microbiology, 2011 July : 77(14)5040-3 PMCID:PMC3147394 -
Davey MS, Lin CY, Roberts GW, Heuston S, Brown AC, Chess JA, Toleman MA, Gahan CG, Hill C, Parish T, Williams JD, Davies SJ, Johnson DW, Topley N, Moser B, Eberl MHuman neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection.
21589907 PLoS pathogens, 2011 May : 7(5)e1002040 PMCID:PMC3093373 -
Muttucumaru DG, Smith DA, McMinn EJ, Reese V, Coler RN, Parish TMycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity.
21216669 Tuberculosis (Edinburgh, Scotland), 2011 March : 91(2)111-6 -
Driscoll MD, McLean KJ, Cheesman MR, Jowitt TA, Howard M, Carroll P, Parish T, Munro AWExpression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.
20621636 Biochimica et biophysica acta, 2011 Jan. : 1814(1)76-87 -
Roberts G, Vadrevu IS, Madiraju MV, Parish TControl of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.
21698211 PloS one, 2011 : 6(6)e21090 PMCID:PMC3116866 -
Sacco E, Slama N, Bäckbro K, Parish T, Laval F, Daffé M, Eynard N, Quémard ARevisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.
20511508 Journal of bacteriology, 2010 Aug. : 192(15)4037-44 PMCID:PMC2916384 -
Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR Jr, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JCVariation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.
20472797 Journal of bacteriology, 2010 July : 192(14)3645-53 PMCID:PMC2897344 -
Andreu N, Zelmer A, Fletcher T, Elkington PT, Ward TH, Ripoll J, Parish T, Bancroft GJ, Schaible U, Robertson BD, Wiles SOptimisation of bioluminescent reporters for use with mycobacteria.
20520722 PloS one, 2010 May 24 : 5(5)e10777 PMCID:PMC2875389 -
Brown AC, Eberl M, Crick DC, Jomaa H, Parish TThe nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs.
20172995 Journal of bacteriology, 2010 May : 192(9)2424-33 PMCID:PMC2863480 -
Carroll P, Schreuder LJ, Muwanguzi-Karugaba J, Wiles S, Robertson BD, Ripoll J, Ward TH, Bancroft GJ, Schaible UE, Parish TSensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters.
20352111 PloS one, 2010 March 23 : 5(3)e9823 PMCID:PMC2843721 -
Movahedzadeh F, Wheeler PR, Dinadayala P, Av-Gay Y, Parish T, Daffé M, Stoker NGInositol monophosphate phosphatase genes of Mycobacterium tuberculosis.
20167072 BMC microbiology, 2010 Feb. 18 : 1050 PMCID:PMC2834668 -
Eoh H, Narayanasamy P, Brown AC, Parish T, Brennan PJ, Crick DCExpression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.
20064433 Chemistry & biology, 2009 Dec. 24 : 16(12)1230-9 PMCID:PMC4020808 -
Goude R, Amin AG, Chatterjee D, Parish TThe arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis.
19596878 Antimicrobial agents and chemotherapy, 2009 Oct. : 53(10)4138-46 PMCID:PMC2764220 -
McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AWCharacterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
18818197 The Journal of biological chemistry, 2008 Nov. 28 : 283(48)33406-16 PMCID:PMC2662266 -
Covarrubias AS, Högbom M, Bergfors T, Carroll P, Mannerstedt K, Oscarson S, Parish T, Jones TA, Mowbray SLStructural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.
18621388 Journal of molecular biology, 2008 Sept. 5 : 381(3)622-33 -
Movahedzadeh F, Williams A, Clark S, Hatch G, Smith D, ten Bokum A, Parish T, Bacon J, Stoker NConstruction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers.
18457997 Tuberculosis (Edinburgh, Scotland), 2008 Sept. : 88(5)375-81 -
Carroll P, Pashley CA, Parish TFunctional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis.
18469098 Journal of bacteriology, 2008 July : 190(14)4894-902 PMCID:PMC2446997 -
Goude R, Parish TThe genetics of cell wall biosynthesis in Mycobacterium tuberculosis.
18505396 Future microbiology, 2008 June : 3(3)299-313 -
Goude R, Amin AG, Chatterjee D, Parish TThe critical role of embC in Mycobacterium tuberculosis.
18424526 Journal of bacteriology, 2008 June : 190(12)4335-41 PMCID:PMC2446762 -
Brown AC, Parish TDxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.
18489786 BMC microbiology, 2008 May 20 : 878 PMCID:PMC2409342 -
Schneider CZ, Parish T, Basso LA, Santos DSThe two chorismate mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids.
17965159 Journal of bacteriology, 2008 Jan. : 190(1)122-34 PMCID:PMC2223748 -
Amin AG, Goude R, Shi L, Zhang J, Chatterjee D, Parish TEmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis.
18174142 Microbiology (Reading, England), 2008 Jan. : 154(Pt 1)240-248 PMCID:PMC2885622 -
Eoh H, Brown AC, Buetow L, Hunter WN, Parish T, Kaur D, Brennan PJ, Crick DCCharacterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.
17921290 Journal of bacteriology, 2007 Dec. : 189(24)8922-7 PMCID:PMC2168624 -
Buetow L, Brown AC, Parish T, Hunter WNThe structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.
17956607 BMC structural biology, 2007 Oct. 23 : 768 PMCID:PMC2151065 -
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffé M, Bäckbro K, Quémard AThe missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
17804795 Proceedings of the National Academy of Sciences of the United States of America, 2007 Sept. 11 : 104(37)14628-33 PMCID:PMC1976197 -
Carroll P, Brown AC, Hartridge AR, Parish TExpression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin.
17623030 FEMS microbiology letters, 2007 Sept. : 274(1)73-82 -
Robertson D, Carroll P, Parish TRapid recombination screening to test gene essentiality demonstrates that pyrH is essential in Mycobacterium tuberculosis.
17719852 Tuberculosis (Edinburgh, Scotland), 2007 Sept. : 87(5)450-8 -
Read R, Pashley CA, Smith D, Parish TThe role of GlnD in ammonia assimilation in Mycobacterium tuberculosis.
17303474 Tuberculosis (Edinburgh, Scotland), 2007 July : 87(4)384-90 PMCID:PMC1913930 -
Parish T, Roberts G, Laval F, Schaeffer M, Daffé M, Duncan KFunctional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG.
17337570 Journal of bacteriology, 2007 May : 189(10)3721-8 PMCID:PMC1913321 -
Pashley CA, Brown AC, Robertson D, Parish TIdentification of the Mycobacterium tuberculosis GlnE promoter and its response to nitrogen availability.
16946267 Microbiology (Reading, England), 2006 Sept. : 152(Pt 9)2727-2734 -
Brown AC, Parish TInstability of the acetamide-inducible expression vector pJAM2 in Mycobacterium tuberculosis.
16125237 Plasmid, 2006 Jan. : 55(1)81-6 -
Carroll P, Muttucumaru DG, Parish TUse of a tetracycline-inducible system for conditional expression in Mycobacterium tuberculosis and Mycobacterium smegmatis.
15933004 Applied and environmental microbiology, 2005 June : 71(6)3077-84 PMCID:PMC1151860 -
Parish T, Schaeffer M, Roberts G, Duncan KHemZ is essential for heme biosynthesis in Mycobacterium tuberculosis.
15850757 Tuberculosis (Edinburgh, Scotland), 2005 May : 85(3)197-204 -
Wheeler PR, Coldham NG, Keating L, Gordon SV, Wooff EE, Parish T, Hewinson RGFunctional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria.
15576367 The Journal of biological chemistry, 2005 March 4 : 280(9)8069-78 -
Williams A, Hatch GJ, Clark SO, Gooch KE, Hatch KA, Hall GA, Huygen K, Ottenhoff TH, Franken KL, Andersen P, Doherty TM, Kaufmann SH, Grode L, Seiler P, Martin C, Gicquel B, Cole ST, Brodin P, Pym AS, Dalemans W, Cohen J, Lobet Y, Goonetilleke N, McShane H, Hill A, Parish T, Smith D, Stoker NG, Lowrie DB, Källenius G, Svenson S, Pawlowski A, Blake K, Marsh PDEvaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis.
15687025 Tuberculosis (Edinburgh, Scotland), 2005 Jan. : 85(1-2)29-38 -
Bhakta S, Besra GS, Upton AM, Parish T, Sholto-Douglas-Vernon C, Gibson KJ, Knutton S, Gordon S, DaSilva RP, Anderton MC, Sim EArylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.
15117974 The Journal of experimental medicine, 2004 May 3 : 199(9)1191-9 PMCID:PMC2211905 -
Muttucumaru DG, Roberts G, Hinds J, Stabler RA, Parish TGene expression profile of Mycobacterium tuberculosis in a non-replicating state.
15207493 Tuberculosis (Edinburgh, Scotland), 2004 : 84(3-4)239-46 -
Kendall SL, Movahedzadeh F, Rison SC, Wernisch L, Parish T, Duncan K, Betts JC, Stoker NGThe Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses.
15207494 Tuberculosis (Edinburgh, Scotland), 2004 : 84(3-4)247-55 -
Pashley CA, Parish TEfficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis.
14680701 FEMS microbiology letters, 2003 Dec. 12 : 229(2)211-5 -
Parish TStarvation survival response of Mycobacterium tuberculosis.
14594845 Journal of bacteriology, 2003 Nov. : 185(22)6702-6 PMCID:PMC262115 -
Parish T, Smith DA, Roberts G, Betts J, Stoker NGThe senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence.
12777483 Microbiology (Reading, England), 2003 June : 149(Pt 6)1423-1435 -
Roberts G, Muttucumaru DG, Parish TControl of the acetamidase gene of Mycobacterium smegmatis by multiple regulators.
12694921 FEMS microbiology letters, 2003 April 11 : 221(1)131-6 -
Parish T, Smith DA, Kendall S, Casali N, Bancroft GJ, Stoker NGDeletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.
12595424 Infection and immunity, 2003 March : 71(3)1134-40 PMCID:PMC148821 -
Wernisch L, Kendall SL, Soneji S, Wietzorrek A, Parish T, Hinds J, Butcher PD, Stoker NGAnalysis of whole-genome microarray replicates using mixed models.
12499293 Bioinformatics (Oxford, England), 2003 Jan. : 19(1)53-61 -
Pashley CA, Parish T, McAdam RA, Duncan K, Stoker NGGene replacement in mycobacteria by using incompatible plasmids.
12514036 Applied and environmental microbiology, 2003 Jan. : 69(1)517-23 PMCID:PMC152386 -
Greendyke R, Rajagopalan M, Parish T, Madiraju MVVSConditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene.
12480893 Microbiology (Reading, England), 2002 Dec. : 148(Pt 12)3887-3900 -
Parish T, Stoker NGThe common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis.
12368440 Microbiology (Reading, England), 2002 Oct. : 148(Pt 10)3069-3077 -
Dziadek J, Rajagopalan M, Parish T, Kurepina N, Greendyke R, Kreiswirth BN, Madiraju MVMutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome.
12081955 Journal of bacteriology, 2002 July : 184(14)3848-55 PMCID:PMC135179 -
Smith DA, Parish T, Stoker NG, Bancroft GJCharacterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates.
11160012 Infection and immunity, 2001 Feb. : 69(2)1142-50 PMCID:PMC97996 -
Parish T, Lewis J, Stoker NGUse of the mycobacteriophage L5 excisionase in Mycobacterium tuberculosis to demonstrate gene essentiality.
11800587 Tuberculosis (Edinburgh, Scotland), 2001 : 81(5-6)359-64 -
Gordhan BG, Parish TGene Replacement using Pretreated DNA.
21341070 Methods in molecular medicine, 2001 : 5477-92 -
Parish T, Turner J, Stoker NGamiA is a negative regulator of acetamidase expression in Mycobacterium smegmatis.
11570974 BMC microbiology, 2001 : 119 PMCID:PMC56589 -
Parish T, Stoker NGglnE is an essential gene in Mycobacterium tuberculosis.
11004169 Journal of bacteriology, 2000 Oct. : 182(20)5715-20 PMCID:PMC94692 -
Parish T, Stoker NGUse of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement.
10931901 Microbiology (Reading, England), 2000 Aug. : 146 ( Pt 81969-1975 -
Parish T, Gordhan BG, McAdam RA, Duncan K, Mizrahi V, Stoker NGProduction of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination.
10627047 Microbiology (Reading, England), 1999 Dec. : 145 ( Pt 13497-3503 -
Hinds J, Mahenthiralingam E, Kempsell KE, Duncan K, Stokes RW, Parish T, Stoker NGEnhanced gene replacement in mycobacteria.
10217485 Microbiology (Reading, England), 1999 March : 145 ( Pt 3519-527 -
Triccas JA, Parish T, Britton WJ, Gicquel BAn inducible expression system permitting the efficient purification of a recombinant antigen from Mycobacterium smegmatis.
9809415 FEMS microbiology letters, 1998 Oct. 15 : 167(2)151-6 -
McNerney R, Wilson SM, Sidhu AM, Harley VS, al Suwaidi Z, Nye PM, Parish T, Stoker NGInactivation of mycobacteriophage D29 using ferrous ammonium sulphate as a tool for the detection of viable Mycobacterium smegmatis and M. tuberculosis.
9766200 Research in microbiology, 1998 July : 149(7)487-95 -
Wren BW, Stabler RA, Das SS, Butcher PD, Mangan JA, Clarke JD, Casali N, Parish T, Stoker NGCharacterization of a haemolysin from Mycobacterium tuberculosis with homology to a virulence factor of Serpulina hyodysenteriae.
9611795 Microbiology (Reading, England), 1998 May : 144 ( Pt 51205-11
Other Publications
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Ikeh MA, Parish TRv0233 is not essential for the survival of Mycobacterium tuberculosis in stress conditions.
36149732 Microbiology (Reading, England), 2022 Sept. : 168(9) -
Kumar A, Chettiar S, Brown BS, Early J, Ollinger J, Files M, Bailey MA, Korkegian A, Dennison D, McNeil M, Metz J, Osuma A, Curtin M, Kunzer A, Freiberg G, Bruncko M, Kempf D, Parish TNovel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening.
36050506 Scientific reports, 2022 Sept. 1 : 12(1)14879 PMCID:PMC9435431 -
Galina L, Hopf FSM, Abbadi BL, Sperotto NDM, Czeczot AM, Duque-Villegas MA, Perello MA, Matter LB, de Souza EV, Parish T, Machado P, Basso LA, Bizarro CVEvaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.
35862980 Microbiology spectrum, 2022 Aug. 31 : 10(4)e0072822 PMCID:PMC9430761 -
Parish TThe driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation.
35939679 Proceedings of the National Academy of Sciences of the United States of America, 2022 Aug. 16 : 119(33)e2211130119 PMCID:PMC9388100 -
Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish TCorrection for Shelton et al., "Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis".
35876578 Antimicrobial agents and chemotherapy, 2022 Aug. 16 : 66(8)e0096222 PMCID:PMC9380578 -
Njikan S, Ahmed S, Manning A, Awasthi D, Ovechkina Y, Chowdhury S, Butts A, Parish TChemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis.
35612308 Microbiology spectrum, 2022 June 29 : 10(3)e0116122 PMCID:PMC9241686 -
Basarab GS, Ghorpade S, Gibhard L, Mueller R, Njoroge M, Peton N, Govender P, Massoudi LM, Robertson GT, Lenaerts AJ, Boshoff HI, Joerss D, Parish T, Durand-Reville TF, Perros M, Singh V, Chibale KSpiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
35266826 Antimicrobial agents and chemotherapy, 2022 April 19 : 66(4)e0219221 PMCID:PMC9017349 -
Shelton C, McNeil M, Allen R, Flint L, Russell D, Berube B, Korkegian A, Ovechkina Y, Parish TTriazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis.
35262374 Antimicrobial agents and chemotherapy, 2022 April 19 : 66(4)e0204121 PMCID:PMC9017309 -
Gold B, Zhang J, Quezada LL, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L, Bacqué E, Lagrange S, Filoche-Rommé B, Vieth M, Hipskind PA, Jungheim LN, Aubé J, Scarry SM, McDonald SL, Li K, Perkowski A, Nguyen Q, Dartois V, Zimmerman M, Olsen DB, Young K, Bonnett S, Joerss D, Parish T, Boshoff HI, Arora K, Barry CE 3rd, Guijarro L, Anca S, Rullas J, Rodríguez-Salguero B, Martínez-Martínez MS, Porras-De Francisco E, Cacho M, Barros-Aguirre D, Smith P, Berthel SJ, Nathan C, Bates RHIdentification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.
35192346 ACS infectious diseases, 2022 March 11 : 8(3)557-573 PMCID:PMC8922279 -
Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RSKupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis.
35193957 Proceedings of the National Academy of Sciences of the United States of America, 2022 Feb. 22 : 119(8) PMCID:PMC8872721 -
Satish S, Chitral R, Kori A, Sharma B, Puttur J, Khan AA, Desle D, Raikuvar K, Korkegian A, Martis EAF, Iyer KR, Coutinho EC, Parish T, Nandan SDesign, synthesis and SAR of antitubercular benzylpiperazine ureas.
33385288 Molecular diversity, 2022 Feb. : 26(1)73-96 -
Bhagwat A, Deshpande A, Parish THow Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery.
36159638 Frontiers in cellular and infection microbiology, 2022 : 12974101 PMCID:PMC9500310 -
Zloh M, Gupta M, Parish T, Brucoli FNovel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoBS522L strain and display a different binding mode at the RNAP β-subunit site compared to rifampicin.
34418786 European journal of medicinal chemistry, 2021 Dec. 5 : 225113734 -
Punetha A, Green KD, Garzan A, Thamban Chandrika N, Willby MJ, Pang AH, Hou C, Holbrook SYL, Krieger K, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova SStructure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance.
34825186 RSC medicinal chemistry, 2021 Nov. 17 : 12(11)1894-1909 PMCID:PMC8597425 -
Mandal S, Parish TA Novel Benzoxaborole Is Active against Escherichia coli and Binds to FabI.
34152809 Antimicrobial agents and chemotherapy, 2021 Aug. 17 : 65(9)e0262220 PMCID:PMC8370241 -
Aldridge BB, Barros-Aguirre D, Barry CE 3rd, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, Lelièvre J, Lenaerts AJ, McNamara CW, Mizrahi V, Nathan C, Olsen DB, Parish T, Petrassi HM, Pym A, Rhee KY, Robertson GT, Rock JM, Rubin EJ, Russell B, Russell DG, Sacchettini JC, Schnappinger D, Schrimpf M, Upton AM, Warner P, Wyatt PG, Yuan YThe Tuberculosis Drug Accelerator at year 10: what have we learned?
34226736 Nature medicine, 2021 Aug. : 27(8)1333-1337 -
Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish TDeletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis.
33619059 Antimicrobial agents and chemotherapy, 2021 Feb. 22 : PMCID:PMC8092897 -
Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish TSpirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.
33521468 ACS omega, 2021 Jan. 26 : 6(3)2284-2311 PMCID:PMC7841955 -
Soares de Melo C, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A, Parish T, Su Q, Myers TG, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden PD, Buchanan KI, Bayliss T, Green SR, Ray PC, Wyatt PG, Basarab GS, Eyermann CJ, Chibale K, Ghorpade SRAntitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
33395287 Journal of medicinal chemistry, 2021 Jan. 14 : 64(1)719-740 PMCID:PMC7816196 -
Ahmed S, Manning A, Flint L, Awasthi D, Ovechkina Y, Parish TIdentification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages.
35046812 Frontiers in pharmacology, 2021 : 12790583 PMCID:PMC8762250 -
Parish TElectroporation of Mycobacteria.
34235658 Methods in molecular biology (Clifton, N.J.), 2021 : 2314273-284 -
Hembre E, Early JV, Odingo J, Shelton C, Anoshchenko O, Guzman J, Flint L, Dennison D, McNeil MB, Korkegian A, Ovechkina Y, Ornstein P, Masquelin T, Hipskind PA, Parish TNovel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis.
33996738 Frontiers in chemistry, 2021 : 9613349 PMCID:PMC8117417 -
Thayer MB, Parish TPhenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
33481781 PloS one, 2021 : 16(1)e0239353 PMCID:PMC7822546 -
McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish TMultiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.
33055263 mSphere, 2020 Oct. 14 : 5(5) PMCID:PMC7565900 -
de Oliveira JAM, Williams DE, Bonnett S, Johnson J, Parish T, Andersen RJDiterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.
32404991 The Journal of antibiotics, 2020 Aug. : 73(8)568-573 -
Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova SStructure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.
32421305 ACS chemical biology, 2020 June 19 : 15(6)1581-1594 PMCID:PMC7385556 -
Parish TIn vitro drug discovery models for Mycobacterium tuberculosis relevant for host infection.
31899974 Expert opinion on drug discovery, 2020 March : 15(3)349-358 -
Parish T, Grech DAn interview with Dr Tanya Parish and her perspectives on women in drug discovery.
31992092 Expert opinion on drug discovery, 2020 March : 15(3)277-278 -
Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard ADiscovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
32034201 Scientific reports, 2020 Feb. 7 : 10(1)2112 PMCID:PMC7005898 -
Flint L, Korkegian A, Parish TInhA inhibitors have activity against non-replicating Mycobacterium tuberculosis.
33201882 PloS one, 2020 : 15(11)e0239354 PMCID:PMC7671525 -
Parish TMicrobiology revamps its scope.
31674900 Microbiology (Reading, England), 2019 Dec. : 165(12)1251 -
Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli FIntegrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA.
31454170 ChemMedChem, 2019 Oct. 4 : 14(19)1735-1741 PMCID:PMC6800809 -
Odingo JO, Early JV, Smith J, Johnson J, Bailey MA, Files M, Guzman J, Ollinger J, Korkegian A, Kumar A, Ovechkina Y, Parish T8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.
30893501 Drug development research, 2019 Aug. : 80(5)566-572 PMCID:PMC6767403 -
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SMDual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
31047750 Bioorganic & medicinal chemistry letters, 2019 July 1 : 29(13)1665-1672 PMCID:PMC6531345 -
Smith J, Wescott H, Early J, Mullen S, Guzman J, Odingo J, Lamar J, Parish TAnthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential.
31303991 MedChemComm, 2019 June 1 : 10(6)934-945 PMCID:PMC6596218 -
Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish TNovel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.
30962346 Antimicrobial agents and chemotherapy, 2019 June : 63(6) PMCID:PMC6535543 -
Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JCStructure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
31002508 Journal of medicinal chemistry, 2019 May 9 : 62(9)4483-4499 PMCID:PMC6511943 -
Mandal S, Njikan S, Kumar A, Early JV, Parish TThe relevance of persisters in tuberculosis drug discovery.
30775961 Microbiology (Reading, England), 2019 May : 165(5)492-499 -
Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJEfficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.
30745397 Antimicrobial agents and chemotherapy, 2019 April : 63(4) PMCID:PMC6496157 -
Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish TIdentification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.
30501173 ACS infectious diseases, 2019 Feb. 8 : 5(2)272-280 PMCID:PMC6371205 -
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson NDORA Editorial.
30516466 Journal of medical microbiology, 2019 Feb. : 68(2)117-118 -
Parish TSteps to address anti-microbial drug resistance in today's drug discovery.
30466326 Expert opinion on drug discovery, 2019 Feb. : 14(2)91-94 -
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson NDORA Editorial.
30516468 Microbiology (Reading, England), 2019 Feb. : 165(2)125-126 -
Morbidoni HR, de la Iglesia AI, Figueroa V, Di Capua C, Ioerger TR, Parish TMutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.
32974504 Access microbiology, 2019 : 1(10)e000070 PMCID:PMC7491931 -
Melief E, Bonnett SA, Zuniga ES, Parish TActivation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase.
30323042 Antimicrobial agents and chemotherapy, 2019 Jan. : 63(1) PMCID:PMC6325208 -
McNeil MB, Chettiar S, Awasthi D, Parish TCell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.
32974492 Access microbiology, 2019 : 1(1)e000006 PMCID:PMC7470358 -
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson NDORA Editorial.
30516467 The Journal of general virology, 2019 Jan. : 100(1)1-2 -
Early JV, Mullen S, Parish TA rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.
31589621 PloS one, 2019 : 14(10)e0222970 PMCID:PMC6779252 -
Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish TA high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis.
30650074 PloS one, 2019 : 14(1)e0205479 PMCID:PMC6334966 -
Morbidoni HR, de la Iglesia AI, Figueroa V, Di Capua C, Ioerger TR, Parish TMutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.
32974504 Access microbiology, 2019 : 1(10)e000070 PMCID:PMC7491931 -
Dhiman RK, Pujari V, Kincaid JM, Ikeh MA, Parish T, Crick DCCharacterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.
30978223 PloS one, 2019 : 14(4)e0214958 PMCID:PMC6461227 -
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson NDORA Editorial.
30516461 International journal of systematic and evolutionary microbiology, 2019 Jan. : 69(1)1-2 -
Parish T, Harris M, Fry N, Mathee K, Trujillo ME, Bentley S, Thomson NDORA Editorial.
30516464 Microbial genomics, 2018 Dec. : 4(12) PMCID:PMC6412037 -
Carroll P, Muwanguzi-Karugaba J, Parish TCodon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis.
30285840 BMC research notes, 2018 Oct. 1 : 11(1)685 PMCID:PMC6167837 -
Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PGIdentification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
29944372 Journal of medicinal chemistry, 2018 Aug. 9 : 61(15)6592-6608 PMCID:PMC6089501 -
Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish TIdentification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.
29954459 BMC research notes, 2018 June 28 : 11(1)416 PMCID:PMC6022709 -
O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish TImidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.
29632008 Antimicrobial agents and chemotherapy, 2018 June : 62(6) PMCID:PMC5971599 -
Martinez-Grau MA, Valcarcel ICG, Early JV, Gessner RK, de Melo CS, de la Nava EMM, Korkegian A, Ovechkina Y, Flint L, Gravelle A, Cramer JW, Desai PV, Street LJ, Odingo J, Masquelin T, Chibale K, Parish TSynthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
29680666 Bioorganic & medicinal chemistry letters, 2018 June 1 : 28(10)1758-1764 PMCID:PMC5946847 -
Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley MDiscovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
30456352 Life science alliance, 2018 June : 1(3)e201800025 PMCID:PMC6238539 -
McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish TCorrigendum to "Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA" [Tuberculosis 107 (December 2017) 133-136].
29429955 Tuberculosis (Edinburgh, Scotland), 2018 May : 110123 -
Gordon SV, Parish TMicrobe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe.
29465344 Microbiology (Reading, England), 2018 April : 164(4)437-439 -
Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish TThe 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.
29523334 Tuberculosis (Edinburgh, Scotland), 2018 Jan. : 10896-98 PMCID:PMC5854369 -
Bonnett SA, Dennison D, Files M, Bajpai A, Parish TA class of hydrazones are active against non-replicating Mycobacterium tuberculosis.
30332412 PloS one, 2018 : 13(10)e0198059 PMCID:PMC6192558 -
Njikan S, Manning AJ, Ovechkina Y, Awasthi D, Parish THigh content, high-throughput screening for small molecule inducers of NF-κB translocation.
29953522 PloS one, 2018 : 13(6)e0199966 PMCID:PMC6023200 -
Berube BJ, Castro L, Russell D, Ovechkina Y, Parish TNovel Screen to Assess Bactericidal Activity of Compounds Against Non-replicating Mycobacterium abscessus.
30364170 Frontiers in microbiology, 2018 : 92417 PMCID:PMC6191478 -
Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish TIdentification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.
30416491 Frontiers in microbiology, 2018 : 92542 PMCID:PMC6213970 -
Berube BJ, Parish TCombinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.
29061760 Antimicrobial agents and chemotherapy, 2018 Jan. : 62(1) PMCID:PMC5740367 -
Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish TConstruction of an overexpression library for Mycobacterium tuberculosis.
30197930 Biology methods & protocols, 2018 : 3(1)bpy009 PMCID:PMC6118195 -
Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish TImproved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.
29035551 ACS infectious diseases, 2017 Dec. 8 : 3(12)898-916 PMCID:PMC5727484 -
McNeil MB, Dennison D, Shelton C, Flint L, Korkegian A, Parish TMechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.
29050761 Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 107133-136 PMCID:PMC5679704 -
McNeil MB, Dennison DD, Shelton CD, Parish TIn Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.
28760892 Antimicrobial agents and chemotherapy, 2017 Oct. : 61(10) PMCID:PMC5610523 -
Odingo J, Bailey MA, Files M, Early JV, Alling T, Dennison D, Bowman J, Dalai S, Kumar N, Cramer J, Masquelin T, Hipskind PA, Parish TIn Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis.
30023755 ACS omega, 2017 Sept. 30 : 2(9)5873-5890 PMCID:PMC6044914 -
Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish TA Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
28674058 Antimicrobial agents and chemotherapy, 2017 Sept. : 61(9) PMCID:PMC5571309 -
Manning AJ, Ovechkina Y, McGillivray A, Flint L, Roberts DM, Parish TA high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis.
28366666 Methods (San Diego, Calif.), 2017 Aug. 15 : 1273-11 -
Zuniga ES, Korkegian A, Mullen S, Hembre EJ, Ornstein PL, Cortez G, Biswas K, Kumar N, Cramer J, Masquelin T, Hipskind PA, Odingo J, Parish TThe synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.
28576632 Bioorganic & medicinal chemistry, 2017 Aug. 1 : 25(15)3922-3946 PMCID:PMC5513444 -
McNeil MB, Dennison D, Parish TMutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis.
28703701 Microbiology (Reading, England), 2017 July : 163(7)1065-1070 -
Rodrigues L, Parish T, Balganesh M, Ainsa JAAntituberculosis drugs: reducing efflux=increasing activity.
28089787 Drug discovery today, 2017 March : 22(3)592-599 -
Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish TImidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.
28180188 ACS omega, 2017 Jan. 31 : 2(1)41-51 PMCID:PMC5286457 -
Kokoczka R, Schuessler DL, Early JV, Parish TMycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.
28061949 Tuberculosis (Edinburgh, Scotland), 2017 Jan. : 1023-7 PMCID:PMC5225668 -
Kumar A, Chettiar S, Parish TCurrent challenges in drug discovery for tuberculosis.
27797593 Expert opinion on drug discovery, 2017 Jan. : 12(1)1-4 -
Bailey MA, Na H, Duthie MS, Gillis TP, Lahiri R, Parish TNitazoxanide is active against Mycobacterium leprae.
28850614 PloS one, 2017 : 12(8)e0184107 PMCID:PMC5574600
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Overview
- Research Description
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My research team is comprised of both biologists and chemists focused on the global infectious disease tuberculosis. We work in two main areas.
First, we are working on discovering new drugs for tuberculosis. TB is the leading cause of death from an infectious disease, with about 1.5 million deaths every year. The current treatment takes more than 6 months and involves multiple drugs. Our work aims to find new drug candidates that can be combined into a novel drug treatment regimen, with the aim of reducing the overall time of treatment. New drugs should also be able to treat drug resistant TB, which is becoming a major problem.
Our research on the more basic science side is focused on understanding how antibiotics function. We focus on what leads to bacterial death when exposed to antibiotics. We also work on the mechanisms of antibiotic resistance. I am especially interested in cell wall biosynthesis and aerobic respiration, as well as other essential cellular processes and gene regulation.