Stephen Ray Reeves, MD, PhD
On staff since September 2014
Academic Title: Assistant Professor
Research Title: Principal Investigator
Research Center: Center for Respiratory Biology and Therapeutics
"I strive to understand the underlying causes for respiratory diseases so that we can develop innovative approaches to treat them. I hope to someday put myself out of work."
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Stephen R. Reeves, MD, PhD is an attending physician in the Division of Pulmonary and Sleep Medicine at Seattle Children's Hospital. He is a native of Kentucky and completed his MD and PhD degrees at the University of Louisville as part of the combined MD/PhD physician scientist training program. Following completion of his degrees, Steve moved to Southern California to complete his residency in General Pediatric Medicine at the University of California San Diego Department of Pediatrics. He then completed his Pediatric Pulmonary Medicine fellowship at Seattle Children’s Hospital and the University of Washington School of Medicine. Steve’s clinical interests include asthma management, chronic respiratory failure, and technology dependent children, as well as general pulmonary medicine.
In addition to his clinical duties, Steve is a principal investigator in the Center for Immunity and Immunotherapies at the Seattle Children’s Research Institute. His research interests include investigating the contribution of extracellular matrix changes during lung disease and evaluating the effects of the extracellular matrix remodeling on airway inflammation. Steve’s specific areas of research interest include lung epithelial cell – stromal cell crosstalk that promotes a pro-inflammatory microenvironment during chronic lung inflammation (ex. asthma) and acute lung inflammation (ex. viral infections).
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I recommend that Dr Reeves be the pulmonology provider that any family have there children see. Dr Reeves has seen my son for the past 2 years. He has always been very receptive to any ideas that I have had and he has always listened to all of my son's problems and tried always to find the root of his problems. He always has been kind and caring. Thank you Doctor for showing us there still are good medical doctors in this world who care about their patients. Sincerely the Teall-Watson family
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Other Publications
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Barrow KA, Rich LM, Vanderwall ER, Reeves SR, Rathe JA, White MP, Debley JSInactivation of Material from SARS-CoV-2-Infected Primary Airway Epithelial Cell Cultures.
33430421 Methods and protocols, 2021 Jan 7 : 4(1) PMCID:PMC7839057 -
Kellar GG, Reeves SR, Barrow KA, Debley JS, Wight TN, Ziegler SFJuvenile, but Not Adult, Mice Display Increased Myeloid Recruitment and Extracellular Matrix Remodeling during Respiratory Syncytial Virus Infection.
33097575 Journal of immunology (Baltimore, Md. : 1950), 2020 Dec 1 : 205(11)3050-3057 PMCID:PMC7747670 -
Kellar GG, Barrow KA, Rich LM, Debley JS, Wight TN, Ziegler SF, Reeves SRLoss of versican and production of hyaluronan in lung epithelial cells are associated with airway inflammation during RSV infection.
33429211 The Journal of biological chemistry, 2020 Nov 21 : 296100076 -
Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JSRespiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases.
32047499 Frontiers in immunology, 2019 : 103159 PMCID:PMC6997473 -
Reeves SR, Barrow KA, Kolstad TK, White MP, Rich LM, Wight TN, Debley JSFibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history.
30361541 Scientific reports, 2018 Oct 25 : 8(1)15768 PMCID:PMC6202408 -
Reeves SR, Kang I, Chan CK, Barrow KA, Kolstad TK, White MP, Ziegler SF, Wight TN, Debley JSAsthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts.
30071849 Respiratory research, 2018 Aug 2 : 19(1)146 PMCID:PMC6090698 -
James RG, Reeves SR, Barrow KA, White MP, Glukhova VA, Haghighi C, Seyoum D, Debley JSDeficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-Myofibroblast Transition.
29394092 American journal of respiratory cell and molecular biology, 2018 July : 59(1)104-113 PMCID:PMC6039878 -
Reeves SR, Barrow KA, White MP, Rich LM, Naushab M, Debley JSStability of gene expression by primary bronchial epithelial cells over increasing passage number.
29843677 BMC pulmonary medicine, 2018 May 29 : 18(1)91 PMCID:PMC5975426 -
Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JSInterferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.
29106997 The Journal of allergy and clinical immunology, 2017 Oct 26 -
Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SFInterplay of extracellular matrix and leukocytes in lung inflammation.
28077237 Cellular immunology, 2017 Feb. : 3121-14 PMCID:PMC5290208 -
Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AMProteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
27302551 The Journal of allergy and clinical immunology, 2017 Jan. : 139(1)323-334 PMCID:PMC5107356 -
Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TNSubepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.
27126823 The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2016 June : 64(6)364-80 PMCID:PMC4888411 -
Reeves SR, Kolstad T, Lien TY, Herrington-Shaner S, Debley JSFibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
25849331 Respiratory research, 2015 Feb 13 : 1621 PMCID:PMC4333174 -
Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JSAsthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.
24875618 The Journal of allergy and clinical immunology, 2014 Sept. : 134(3)663-670.e1 PMCID:PMC4149938 -
Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski NNetwork analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.
18826996 Physiological genomics, 2008 Dec 12 : 36(1)24-34 PMCID:PMC2604785 -
Reeves SR, Simakajornboon N, Gozal DThe role of nitric oxide in the neural control of breathing.
18786658 Respiratory physiology and neurobiology, 2008 Dec 10 : 164(1-2)143-50 -
Reeves SR, Gozal DProtein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats.
17675414 Experimental physiology, 2007 Nov. : 92(6)1057-66 -
Reeves SR, Gozal DRespiratory and metabolic responses to early postnatal chronic intermittent hypoxia and sustained hypoxia in the developing rat.
17065578 Pediatric research, 2006 Dec. : 60(6)680-6 -
Reeves SR, Guo SZ, Brittian KR, Row BW, Gozal DAnatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia.
16697524 Neuroscience letters, 2006 Jul 24 : 402(3)233-7 -
Reeves SR, Mitchell GS, Gozal DEarly postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
16455761 American journal of physiology. Regulatory, integrative and comparative physiology, 2006 June : 290(6)R1664-71 -
Reeves SR, Gozal DChanges in ventilatory adaptations associated with long-term intermittent hypoxia across the age spectrum in the rat.
15908284 Respiratory physiology and neurobiology, 2006 Feb 28 : 150(2-3)135-43 -
Reeves SR, Gozal DDevelopmental plasticity of respiratory control following intermittent hypoxia.
16203218 Respiratory physiology and neurobiology, 2005 Nov 15 : 149(1-3)301-11 -
Reeves SR, Gozal DDevelopmental plasticity of respiratory control following intermittent hypoxia.
16203218 Respiratory physiology & neurobiology, 2005 Nov 15 : 149(1-3)301-11 -
Reeves SR, Carter ES, Guo SZ, Gozal DCalcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats.
15890791 American journal of physiology. Regulatory, integrative and comparative physiology, 2005 Sept. : 289(3)R871-6 -
Reeves SR, Gozal DPlatelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice.
15087283 American journal of physiology. Regulatory, integrative and comparative physiology, 2004 Aug. : 287(2)R369-74 -
Reeves SR, Gozal DPlatelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia.
15234672 Respiratory physiology and neurobiology, 2004 Jul 12 : 141(1)13-20 -
Reeves SR, Gozal E, Guo SZ, Sachleben LR Jr, Brittian KR, Lipton AJ, Gozal DEffect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat.
14555663 Journal of applied physiology (Bethesda, Md. : 1985), 2003 Nov. : 95(5)1767-74 -
Gozal D, Reeves SR, Row BW, Neville JJ, Guo SZ, Lipton AJRespiratory effects of gestational intermittent hypoxia in the developing rat.
12626349 American journal of respiratory and critical care medicine, 2003 Jun 1 : 167(11)1540-7 -
Gozal D, Gozal E, Reeves SR, Lipton AJGasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxia.
11842051 Journal of applied physiology (Bethesda, Md. : 1985), 2002 March : 92(3)1141-4
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Presentations Title Event Location Date Pediatric Asthma Cases 47th Annual University of Washington Family Medicine and Primary Care Conference Seattle, WA 2019 Pediatric Asthma: An Overview 46th Annual University of Washington Family Medicine and Primary Care Conference Seattle, WA 2018 Novel multi-color assay for extracellular matrix/leukocyte interactions in the airway Asthma and Allergic Diseases Cooperative Research Centers Steering Committee Meeting, NIAID Rockville, MD 2018 Regulation of leukocyte trafficking and activation by the extracellular matrix component hyaluronan during respiratory viral infections Pacific Northwest Epithelial Biology Group Meeting Seattle, WA 2018 Extra-cellular matrix accumulation of hyaluronan is increased by RSV infection in airway epithelium - lung fibroblast co-cultures Pacific Northwest Epithelial Biology Group Meeting Seattle, WA 2017 Pediatric Asthma Cases Workshop 45th Annual University of Washington Family Medicine and Primary Care Conference Seattle, WA 2017 Pediatric Asthma Cases Workshop 44th Annual University of Washington Family Medicine and Primary Care Conference Seattle, WA 2016 Airway epithelial regulation of extracellular matrix constituents in asthmatic airway Pacific Northwest Epithelial Biology Group Meeting Seattle, WA 2016 Asthmatic Airway Epithelium in Airway Remodeling and Pacific Northwest Epithelial Biology Group Portland, OR 2014 The NTS and Hypoxic Ventilatory Control; From Signaling to (Patho) Physiology Experimental Biology Conference New Orleans, LA 2009
Overview
- Board Certification(s)
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Pediatrics
Pediatric Pulmonology
- Medical/Professional School
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University of Louisville, Louisville, KY
- Residency
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University of California San Diego-Pediatrics, San Diego, CA
- Fellowship
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University of Washington School of Medicine GME, Seattle, WA
- Clinical Interests
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Asthma, transient wheezing of infancy, chronic cough, recurrent lung infections, respiratory viruses, chronic respiratory failure
- Research Description
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Asthma, airway biology, respiratory viruses and wheezing