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Shan Lin, PhD

Shan Lin, PhD
"It is amazing to see many clinical transformations are initiated from laboratory research. I am fascinated in the molecular mechanisms governing the leukemia development and leukemia vulnerabilities. I am enthusiastic about translating our discoveries into therapeutic strategies to help patients and their families in combating cancer. "

  • Biography

    Dr. Shan Lin received his PhD degree in molecular and developmental biology at the University of Cincinnati, where he focused on using human hematopoietic stem and progenitor cells to model the pathogenesis of acute leukemia driven by fusion proteins and characterizing critical pathways contributing to leukemia development. During his postdoctoral training at the Dana-Farber Cancer Institute, he applied functional genomic approaches, including an in vivo CRISPR screen pipeline, to identify the novel targets of acute myeloid leukemia (AML), and to discover the synergistic targets that enhance the efficacy of apoptosis-stimulating agents against AML. He joined the Ben Towne Center for Childhood Cancer and Blood Disorders Research at Seattle Children’s Research Institute in 2023. The research interests of his lab include investigating the molecular mechanisms of programmed cell death regulation in leukemia and harnessing this knowledge to advance the treatment of difficult-to-treat hematologic malignancies.

  • Related Resources

    • Shan Lin, PhD Researcher Profile

      View the Seattle Children's Research Institute profile of Shan Lin, PhD including their publications and grants.

    • Shan Lin, PhD Researcher Profile

      View the Seattle Children's Research Institute profile of Shan Lin, PhD including their publications and grants.

    • Lin Lab

      Lin Lab

      Our research goals are to expand the knowledge domain of programmed cell death and leverage it in treating acute myeloid leukemia (AML) and other hematological malignancies.

  • Awards and Honors

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  • Publications

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