Ron L Gibson, MD, PhD
Pulmonary, Cystic Fibrosis Research, Cystic Fibrosis Program
On staff since November 1987
Children's Title: Director, Cystic Fibrosis Center; Co-Director, Cystic Fibrosis Therapeutic Development Center; Associate Program Director, Pediatric Pulmonary Fellowship
Academic Title: Professor
Research Center: Center for Clinical and Translational Research
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Ronald L. Gibson, MD, PhD, is Director of the Cystic Fibrosis (CF) Center, Director of the Pediatric Pulmonary Fellowship program, and attending physician at Seattle Children’s Hospital; he is a Professor in the Department of Pediatrics at the University of Washington School of Medicine. He earned his MD and PhD at Washington University in St. Louis. He completed pediatrics residency training and a fellowship in pediatric pulmonology at the University of Washington.
He is committed to high-quality, multidisciplinary patient care, small group teaching, research and the acquisition of new knowledge. His primary research focus is on early events in the pathogenesis of lung disease in CF, with a focus on the risk factors for and the treatment of Pseudomonas aeruginosa airway infections in young children with cystic fibrosis (CF). As a co–principal investigator of the university’s CF Translational Therapeutic Development Center, he has been lead and co-investigator for several phase I to phase III clinical trials involving novel antimicrobial agents, anti-inflammatory compounds and modulators of ion transport. Dr. Gibson is also director of the clinical core of the university’s CF research development program with the goal of catalyzing collaborations between local basic and clinical investigators.
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Dr. Gibson has been our favorite doctor since the day we met him. There are many great doctors on the CF team but we always request Dr. Gibson and we are extremely bummed if he is not available during our necessary times. He has been my daughter Emma's preferred doctor since she was three. She is now sixteen. He always listens to our concerns and is good at explaining difficult issues. We love his positive spirit and outlook on life. He makes long visits more bearable. Thanks Dr. Gibson!!!
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Dr. Gibson was very kind, honest and thorough with his daily visits to my 3 year old daughter who had been admitted to Children's with a pneumothorax. We really appreciated the time he spent in explaining what was happening and what we could or could not expect.
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Award Name Award Description Awarded By Award Date SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022 SEATTLE TOP DOCTOR - 2019 Seattle Magazine 2019 SEATTLE'S TOP DOCTOR - 2018 Seattle Magazine 2018 SEATTLE'S TOP DOCTOR - 2017 Seattle Magazine 2017 SEATTLE'S TOP DOCTOR - 2016 Seattle Magazine 2016 Seattles Top Doctor 2016 Seattle Met Magazine 2016 SEATTLE'S TOP DOCTOR - 2015 Seattle Met Magazine 2015 SEATTLE MAGAZINE TOP DOCTOR - 2015 Seattle Magazine 2015 SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014 SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014 Seattle's Top Doc Seattle Met Magazine 2013 Seattle Magazine Top Doctor - 2013 Seattle Magazine 2013 U.S. News Top Doctor U.S. News and World Report 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012 Seattles Top Doctors Seattle Magazine 2011 Seattles Top Doctors Seattle Magazine 2010 Nominee, Family Choice Award from Family Advisory Council Seattle Children's Hospital 2009 Mentoring Award from the University of Washington School of Medicine Department of Pediatrics , University of Washington 2008 Selected to Best Doctors in America Best Doctors in America 2007 - 2009 -
Manuscripts in Refereed Journals
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Mayer-Hamblett N, Rosenfeld M, Gibson RL, Ramsey BW, Kulasekara HD, Retsch-Bogart GZ, Morgan W, Wolter DJ, Pope CE, Houston LS, Kulasekara BR, Khan U, Burns JL, Miller SI, Hoffman LRPseudomonas aeruginosa in vitro Phenotypes Distinguish Cystic Fibrosis Infection Stages and Outcomes.
24937177 American journal of respiratory and critical care medicine, 2014 June
Published Abstracts
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Ron Gibson, MD, PhDAbstracts - Available upon request
Other Publications
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Zemanick ET, Emerson J, Thompson V, McNamara S, Morgan W, Gibson RL, Rosenfeld M, EPIC Study GroupClinical outcomes after initial pseudomonas acquisition in cystic fibrosis.
24644274 Pediatric pulmonology, 2015 Jan. : 50(1)42-8 -
Brown PS, Pope CE, Marsh RL, Qin X, McNamara S, Gibson R, Burns JL, Deutsch G, Hoffman LRDirectly sampling the lung of a young child with cystic fibrosis reveals diverse microbiota.
25072206 Annals of the American Thoracic Society, 2014 Sept. : 11(7)1049-55 PMCID:PMC4214062 -
Emerson J, Cochrane E, McNamara S, Kuypers J, Gibson RL, Campbell APHome Self-Collection of Nasal Swabs for Diagnosis of Acute Respiratory Virus Infections in Children With Cystic Fibrosis.
24363931 Journal of the Pediatric Infectious Diseases Society, 2013 Dec. : 2(4)345-351 PMCID:PMC3869469 -
Mayer-Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch-Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW, EPIC, ESCF InvestigatorsStandard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis.
23818295 Pediatric pulmonology, 2013 Oct. : 48(10)943-53 -
Mayer-Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch-Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW, EPIC, ESCF InvestigatorsStandard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis.
23818295 Pediatric pulmonology, 2013 Oct. : 48(10)943-53 -
Guo DC, Regalado E, Casteel DE, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA, GenTAC Registry Consortium, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Kim C, Milewicz DMRecurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections.
23910461 American journal of human genetics, 2013 Aug. 8 : 93(2)398-404 PMCID:PMC3738837 -
Wolter DJ, Emerson JC, McNamara S, Buccat AM, Qin X, Cochrane E, Houston LS, Rogers GB, Marsh P, Prehar K, Pope CE, Blackledge M, Déziel E, Bruce KD, Ramsey BW, Gibson RL, Burns JL, Hoffman LRStaphylococcus aureus small-colony variants are independently associated with worse lung disease in children with cystic fibrosis.
23625938 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013 Aug. : 57(3)384-91 -
Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, NHLBI Exome Sequencing Project, Akey JMAnalysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.
23201682 Nature, 2013 Jan. 10 : 493(7431)216-20 PMCID:PMC3676746 -
O'Connor TD, Kiezun A, Bamshad M, Rich SS, Smith JD, Turner E, NHLBIGO Exome Sequencing Project, ESP Population Genetics, Statistical Analysis Working Group, Leal SM, Akey JMFine-scale patterns of population stratification confound rare variant association tests.
23861739 PloS one, 2013 : 8(7)e65834 PMCID:PMC3701690 -
Rosenfeld M, Bernardo-Ocampo C, Emerson J, Genatossio A, Burns J, Gibson RPrevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis care.
22551927 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2012 Sept. : 11(5)456-7 -
Rosenfeld M, Emerson J, McNamara S, Thompson V, Ramsey BW, Morgan W, Gibson RL, EPIC Study GroupRisk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohort.
22554417 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2012 Sept. : 11(5)446-53 -
Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project, Lung GO, Gibson RL, Bamshad MJExome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis.
22772370 Nature genetics, 2012 July 8 : 44(8)886-9 PMCID:PMC3702264 -
Quon BS, Patrick DL, Edwards TC, Aitken ML, Gibson RL, Genatossio A, McNamara S, Goss CHFeasibility of using pedometers to measure daily step counts in cystic fibrosis and an assessment of its responsiveness to changes in health state.
22226414 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2012 May : 11(3)216-22 -
Mayer-Hamblett N, Kronmal RA, Gibson RL, Rosenfeld M, Retsch-Bogart G, Treggiari MM, Burns JL, Khan U, Ramsey BW, EPIC InvestigatorsInitial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.
21830317 Pediatric pulmonology, 2012 Feb. : 47(2)125-34 PMCID:PMC3214247 -
Mayer-Hamblett N, Kronmal RA, Gibson RL, Rosenfeld M, Retsch-Bogart G, Treggiari MM, Burns JL, Khan U, Ramsey BW, EPIC InvestigatorsInitial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.
21830317 Pediatric pulmonology, 2012 Feb. : 47(2)125-34 PMCID:PMC3214247 -
Oermann CM, McCoy KS, Retsch-Bogart GZ, Gibson RL, McKevitt M, Montgomery ABPseudomonas aeruginosa antibiotic susceptibility during long-term use of aztreonam for inhalation solution (AZLI).
21784781 The Journal of antimicrobial chemotherapy, 2011 Oct. : 66(10)2398-404 -
Treggiari MM, Retsch-Bogart G, Mayer-Hamblett N, Khan U, Kulich M, Kronmal R, Williams J, Hiatt P, Gibson RL, Spencer T, Orenstein D, Chatfield BA, Froh DK, Burns JL, Rosenfeld M, Ramsey BW, Early Pseudomonas Infection Control (EPIC) InvestigatorsComparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis.
21893650 Archives of pediatrics & adolescent medicine, 2011 Sept. : 165(9)847-56 -
Wainwright CE, Quittner AL, Geller DE, Nakamura C, Wooldridge JL, Gibson RL, Lewis S, Montgomery ABAztreonam for inhalation solution (AZLI) in patients with cystic fibrosis, mild lung impairment, and P. aeruginosa.
21441078 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2011 July : 10(4)234-42 -
Moskowitz SM, Emerson JC, McNamara S, Shell RD, Orenstein DM, Rosenbluth D, Katz MF, Ahrens R, Hornick D, Joseph PM, Gibson RL, Aitken ML, Benton WW, Burns JLRandomized trial of biofilm testing to select antibiotics for cystic fibrosis airway infection.
20963843 Pediatric pulmonology, 2011 Feb. : 46(2)184-92 PMCID:PMC3479399 -
Oermann CM, Retsch-Bogart GZ, Quittner AL, Gibson RL, McCoy KS, Montgomery AB, Cooper PJAn 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis.
20672296 Pediatric pulmonology, 2010 Nov. : 45(11)1121-34 PMCID:PMC3867945 -
Rosenfeld M, Emerson J, McNamara S, Joubran K, Retsch-Bogart G, Graff GR, Gutierrez HH, Kanga JF, Lahiri T, Noyes B, Ramsey B, Ren CL, Schechter M, Morgan W, Gibson RL, EPIC Study Group Participating Clinical SitesBaseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort.
20597081 Pediatric pulmonology, 2010 Sept. : 45(9)934-44 -
Sanders DB, Hoffman LR, Emerson J, Gibson RL, Rosenfeld M, Redding GJ, Goss CHReturn of FEV1 after pulmonary exacerbation in children with cystic fibrosis.
20054859 Pediatric pulmonology, 2010 Feb. : 45(2)127-34 -
Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M Jr, Rowland M, Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemková D, Hannah WB, Phillips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM, Durie PR, Knowles MR, Gene Modifier Study GroupGenetic modifiers of liver disease in cystic fibrosis.
19738092 JAMA : the journal of the American Medical Association, 2009 Sept. 9 : 302(10)1076-83 PMCID:PMC3711243 -
Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA, Ramsey BW, EPIC Study GroupEarly anti-pseudomonal acquisition in young patients with cystic fibrosis: rationale and design of the EPIC clinical trial and observational study'.
19470318 Contemporary clinical trials, 2009 May : 30(3)256-68 PMCID:PMC2783320 -
Retsch-Bogart GZ, Quittner AL, Gibson RL, Oermann CM, McCoy KS, Montgomery AB, Cooper PJEfficacy and safety of inhaled aztreonam lysine for airway pseudomonas in cystic fibrosis.
19420195 Chest, 2009 May : 135(5)1223-32 PMCID:PMC2818415 -
Sagel SD, Gibson RL, Emerson J, McNamara S, Burns JL, Wagener JS, Ramsey BW, Inhaled Tobramycin in Young Children Study Group, Cystic Fibrosis Foundation Therapeutics Development NetworkImpact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis.
18822427 The Journal of pediatrics, 2009 Feb. : 154(2)183-8 PMCID:PMC2654617 -
Moskowitz SM, Chmiel JF, Sternen DL, Cheng E, Gibson RL, Marshall SG, Cutting GRClinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders.
19092437 Genetics in medicine : official journal of the American College of Medical Genetics, 2008 Dec. : 10(12)851-68 PMCID:PMC2810953 -
McCoy KS, Quittner AL, Oermann CM, Gibson RL, Retsch-Bogart GZ, Montgomery ABInhaled aztreonam lysine for chronic airway Pseudomonas aeruginosa in cystic fibrosis.
18658109 American journal of respiratory and critical care medicine, 2008 Nov. 1 : 178(9)921-8 PMCID:PMC2577727 -
Retsch-Bogart GZ, Burns JL, Otto KL, Liou TG, McCoy K, Oermann C, Gibson RL, AZLI Phase II Study GroupA phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection.
18041081 Pediatric pulmonology, 2008 Jan. : 43(1)47-58 -
Treggiari MM, Rosenfeld M, Retsch-Bogart G, Gibson R, Ramsey BApproach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis.
17647287 Pediatric pulmonology, 2007 Sept. : 42(9)751-6 -
Treggiari MM, Rosenfeld M, Retsch-Bogart G, Gibson R, Ramsey BApproach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis.
17647287 Pediatric pulmonology, 2007 Sept. : 751-6 -
Clancy JP, Rowe SM, Bebok Z, Aitken ML, Gibson R, Zeitlin P, Berclaz P, Moss R, Knowles MR, Oster RA, Mayer-Hamblett N, Ramsey BNo detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations.
17347447 American journal of respiratory cell and molecular biology, 2007 July : 37(1)57-66 PMCID:PMC1899350 -
Clancy JP, Rowe SM, Bebok Z, Aitken ML, Gibson R, Zeitlin P, Berclaz P, Moss R, Knowles MR, Oster RA, Mayer-Hamblett N, Ramsey BNo detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations.
17347447 American journal of respiratory cell and molecular biology, 2007 July : 57-66 -
Kulich M, Rosenfeld M, Campbell J, Kronmal R, Gibson RL, Goss CH, Ramsey BDisease-specific reference equations for lung function in patients with cystic fibrosis.
15976373 American journal of respiratory and critical care medicine, 2005 Oct. 1 : 172(7)885-91 -
Kulich M, Rosenfeld M, Campbell J, Kronmal R, Gibson RL, Goss CH, Ramsey BDisease-specific reference equations for lung function in patients with cystic fibrosis.
15976373 American journal of respiratory and critical care medicine, 2005 Oct. 1 : 885-91 -
Deterding R, Retsch-Bogart G, Milgram L, Gibson R, Daines C, Zeitlin PL, Milla C, Marshall B, Lavange L, Engels J, Mathews D, Gorden J, Schaberg A, Williams J, Ramsey BSafety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis.
15704203 Pediatric pulmonology, 2005 April : 339-48
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Presentations Title Event Location Date Comparison of exome variants from phenotype extremes to a large population-based sample identifies CAV2 and TMC6 as interacting modifiers of chronic Pseudomonas infection in cystic fibrosis North American Cystic Fibrosis Conference Salt Lake City, Utah 2013
Overview
- Board Certification(s)
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Pediatrics
Pediatric Pulmonology
- Medical/Professional School
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Washington University School of Medicine, Saint Louis, MO
- Residency
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University of Washington School of Medicine, Seattle, WA
- Fellowship
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University of Washington School of Medicine, Seattle, WA
- Research Focus Area
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Cystic Fibrosis