Nathan Baertsch, PhD

Nathan  Baertsch,  PhD


Academic Title: Assistant Professor, Department of Pediatrics, University of Washington School of Medicine

Research Title: Principal Investigator, Center for Integrative Brain Research

Research Center: Center for Integrative Brain Research

    • Related Pages

    • Baertsch Lab

      The Baertsch Lab investigates how breathing is generated and regulated by the brain. By uncovering fundamental cellular and network mechanisms of respiratory control, we hope to inspire new therapeutic interventions to treat breathing disorders associated with neurological pathology, prematurity, and opioid use.

  • Other Publications

    • Burgraff NJ, Phillips RS, Severs LJ, Bush NE, Baertsch NA, Ramirez JM
      Inspiratory rhythm generation is stabilized by Ih.
      35675444 Journal of neurophysiology, 2022 Jun 8
    • Stokes JC, Bornstein RL, James K, Park KY, Spencer KA, Vo K, Snell JC, Johnson BM, Morgan PG, Sedensky MM, Baertsch NA, Johnson SC
      Leukocytes mediate disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome.
      35050903 JCI insight, 2022 Mar 8 : 7(5) PMCID:PMC8983133
    • Burgraff NJ, Bush NE, Ramirez JM, Baertsch NA
      Dynamic Rhythmogenic Network States Drive Differential Opioid Responses in the In Vitro Respiratory Network.
      34697095 The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021 Dec 1 : 41(48)9919-9931 PMCID:PMC8638687
    • Baertsch NA, Bush NE, Burgraff NJ, Ramirez JM
      Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network.
      34402425 eLife, 2021 Aug 17 : 10 PMCID:PMC8390004
    • Oliveira LM, Baertsch NA, Moreira TS, Ramirez JM, Takakura AC
      Unraveling the Mechanisms Underlying Irregularities in Inspiratory Rhythm Generation in a Mouse Model of Parkinson's Disease.
      33863785 The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021 May 26 : 41(21)4732-4747 PMCID:PMC8260248
    • Heavner WE, Lautz JD, Speed HE, Gniffke EP, Immendorf KB, Welsh JP, Baertsch NA, Smith SEP
      Remodeling of the Homer-Shank interactome mediates homeostatic plasticity.
      33947797 Science signaling, 2021 May 4 : 14(681) PMCID:PMC8300860
    • Ramirez JM, Burgraff NJ, Wei AD, Baertsch NA, Varga AG, Baghdoyan HA, Lydic R, Morris KF, Bolser DC, Levitt ES
      Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.
      33826874 Journal of neurophysiology, 2021 May 1 : 125(5)1899-1919 PMCID:PMC8424565
    • Burgraff NJ, Baertsch NA, Ramirez JM
      Peptides, Breathing, and Sudden Infant Death Syndrome.
      33549332 Trends in neurosciences, 2021 March : 44(3)167-169 PMCID:PMC8645383
    • Bowen AJ, Chen JY, Huang YW, Baertsch NA, Park S, Palmiter RD
      Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons.
      32856589 eLife, 2020 Aug 28 : 9 PMCID:PMC7556873
    • Baertsch NA, Ramirez JM
      Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P.
      31804180 eLife, 2019 Dec 5 : 8 PMCID:PMC6957314
    • Baertsch NA, Severs LJ, Anderson TM, Ramirez JM
      A spatially dynamic network underlies the generation of inspiratory behaviors.
      30918122 Proceedings of the National Academy of Sciences of the United States of America, 2019 Apr 9 : 116(15)7493-7502 PMCID:PMC6462111
    • Ramirez JM, Baertsch NA
      Modeling breathing rhythms.
      30907725 eLife, 2019 Mar 25 : 8 PMCID:PMC6433460
    • Ramirez SC, Koschnitzky JE, Youngquist TM, Baertsch NA, Smith CV, Ramirez JM
      Perinatal Breathing Patterns and Survival in Mice Born Prematurely and at Term.
      31543825 Frontiers in physiology, 2019 : 101113 PMCID:PMC6728753
    • Ramirez JM, Baertsch NA
      The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.
      29709210 Annual review of neuroscience, 2018 Jul 8 : 41475-499 PMCID:PMC6548330
    • Baertsch NA, Baertsch HC, Ramirez JM
      The interdependence of excitation and inhibition for the control of dynamic breathing rhythms.
      29483589 Nature communications, 2018 Feb 26 : 9(1)843 PMCID:PMC5827754
    • Baertsch NA, Baker TL
      Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway.
      28814632 Journal of neurophysiology, 2017 Nov 1 : 118(5)2702-2710 PMCID:PMC5672539
    • Baertsch NA, Baker TL
      Reduced respiratory neural activity elicits a long-lasting decrease in the CO2 threshold for apnea in anesthetized rats.
      27474512 Experimental neurology, 2017 Jan. : 287(Pt 2)235-242 PMCID:PMC5683180
    • Anderson TM, Garcia AJ 3rd, Baertsch NA, Pollak J, Bloom JC, Wei AD, Rai KG, Ramirez JM
      A novel excitatory network for the control of breathing.
      27462817 Nature, 2016 Aug 4 : 536(7614)76-80 PMCID:PMC5479418
    • Baertsch NA, Baker-Herman TL
      Intermittent reductions in respiratory neural activity elicit spinal TNF-α-independent, atypical PKC-dependent inactivity-induced phrenic motor facilitation.
      25673781 American journal of physiology. Regulatory, integrative and comparative physiology, 2015 Apr 15 : 308(8)R700-7 PMCID:PMC4398856
    • Broytman O, Baertsch NA, Baker-Herman TL
      Spinal TNF is necessary for inactivity-induced phrenic motor facilitation.
      23878370 The Journal of physiology, 2013 Nov 15 : 591(22)5585-98 PMCID:PMC3853497
    • Strey KA, Baertsch NA, Baker-Herman TL
      Inactivity-induced respiratory plasticity: protecting the drive to breathe in disorders that reduce respiratory neural activity.
      23816599 Respiratory physiology & neurobiology, 2013 Nov 1 : 189(2)384-94 PMCID:PMC3898815
    • Baertsch NA, Baker-Herman TL
      Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea.
      23493368 Journal of applied physiology (Bethesda, Md. : 1985), 2013 May 15 : 114(10)1388-95 PMCID:PMC3656425
    • Strey KA, Nichols NL, Baertsch NA, Broytman O, Baker-Herman TL
      Spinal atypical protein kinase C activity is necessary to stabilize inactivity-induced phrenic motor facilitation.
      23152633 The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012 Nov 14 : 32(46)16510-20 PMCID:PMC3530258