Margaret Rosenfeld, MD, MPH
Pulmonary, Cystic Fibrosis Research, Cystic Fibrosis Program, Primary Ciliary Dyskinesia and Bronchiectasis Clinic
On staff since May 1995
Children's Title: Professor and Associate Vice-Chair for Clinical Research, Department of Pediatrics
Research Center: Center for Clinical and Translational Research
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Margaret Rosenfeld, MD, MPH, is attending physician at Seattle Children's Hospital, Professor in the Department of Pediatrics at the University of Washington School of Medicine and Adjunct Professor in the Department of Epidemiology at the University of Washington School of Public Health. She is Associate Vice Chair for Clinical Research in the Department of Pediatrics and Co-Director of the Center for Clinical and Translational Research at the Seattle Children's Research Institute.
Her clinical interests focus on the diagnosis and management of respiratory illnesses in children of all ages, working closely with families. She serves as CF consultant to the Washington State Newborn Screening Program. Her research program focuses on NIH and foundation-sponsored multicenter observational and interventional studies in pediatric chronic lung diseases, including cystic fibrosis and primary ciliary dyskinesia. She also conducts research on mobile health tools for respiratory diseases including home spirometry.
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Related Pages
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Margaret Rosenfeld
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We met with Dr. Rosenfeld to follow up after our toddler's recent admission for Reactive Airway Disease. She was warm, knowledgeable, and spent plenty of time with us answering our questions. She validated our concerns/fears and gave us good insight into his condition. We felt confidence in the plan of action after the appointment. We feel really grateful to have her as part of our son's medical team.
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We first saw Dr. Rosenfeld when our child was very young, around 4 months old. We were seeing her to determine if our child had PCD. She was very caring, thourough, and was willing to sit and answer all our questions as long as we needed. She has continued caring for our child, who is now 2. We are so greatful to have such a knowledgable Doctor taking care of our child and helping us prevent future health problems and research this rare pulmonary disorder. We highly recommend her. Ellisa Alderson
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Award Name Award Description Awarded By Award Date SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022 Finalist, UW School of Medicine Mentoring Award 2016 Finalist, UW School of Medicine Mentoring Award 2013 Finalist, UW School of Medicine Mentoring Award 2010 Physician Scientist Fellowship Award Glaxo Corporation 1993 Leroy Matthews Physician Scientist Award Cystic Fibrosis Foundation 1992 - 1998 -
Manuscripts in Refereed Journals
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Pope CE, Vo AT, Hayden HS, Weiss EJ, Durfey S, McNamara S, Ratjen A, Grogan B, Carter S, Nay L, Parsek MR, Singh PK, McKone EF, Aitken ML, Rosenfeld MR, Hoffman LRChanges in fecal microbiota with CFTR modulator therapy: A pilot study.
J Cyst Fibros, 2020 : 20(5)742-746
https://pubmed.ncbi.nlm.nih.gov/33390317/ -
Beydon N, Gochicoa L, Jones MJ, Lands LC, Lombardi E, Rosenfeld M, Sly P, Weiner DJ, Yilmaz OPediatric lung function testing during a pandemic: An international perspective
Paediatr Respir Rev, 2020 Oct. 11 : 36106-108 PMCID:PMC7548117
https://pubmed.ncbi.nlm.nih.gov/33160838/ -
Fink AK, Graff G, Byington CL, Loeffler DR, Rosenfeld M, Saiman L. Palivizumab and Long-term Outcomes in Cystic Fibrosis.Palivizumab and Long-term Outcomes in Cystic Fibrosis
Pediatrics, 2019 -
Ratjen F, Davis SD, Stanojevic S, Kronmal RA, Hinckley Stukovsky KD, Jorgensen N, Rosenfeld M; SHIP Study GroupInhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.
Lancet Respir Med, 2019 -
Sanders DB, Ostrenga JS, Rosenfeld M, Fink AK, Schechter MS, Sawicki GS, Flume PA, Morgan WJPredictors of pulmonary exacerbation treatment in cystic fibrosis.
J Cyst Fibros, 2019 -
Rosenfeld M, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Chilvers M, Higgins M, Tian S, Cooke J, Davies JC; KLIMB study groupAn open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB).
J Cyst Fibros, 2019 -
Davis SD, Rosenfeld M, Lee HS, Ferkol TW, Sagel SD, Dell SD, Milla C, Pittman JE, Shapiro AJ, Sullivan KM, Nykamp KR, Krischer JP, Zariwala MA, Knowles MR, Leigh MW; and Genetic Disorders of Mucociliary Clearance ConsortiumPrimary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype.
Am J Respir Crit Care Med, 2018 -
Chi DL, Rosenfeld M, Manci L, Chung WO, Presland RB, Sarvas E, Rothen M, Alkhateeb A, McNamara S, Genatossio A, Virella-Lowell I, Milla C, Scott JAge-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study
J Cyst Fibros, 2018 -
Mayer-Hamblett N, Retsch-Bogart G, Kloster M, Accurso F, Rosenfeld M, Albers G, Black P, Brown P, Cairns A, Davis S, Graff G, Kerby G, Orenstein D, Buckingham R, Ramsey B, for the OPTIMIZE Study GroupAzithromycin for Early Pseudomonas Infection in Cystic Fibrosis: The Optimize Randomized Trial
Annals of the American Thoracic Society, 2018 -
Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, Pittman JE, Daniels MLA, Jones MH, Janahi IA, Ware SM, Daniel SJ, Cooper ML, Nogee LM, Anton B, Eastvold T, Ehrne L, Guadagno E, Knowles MR, Leigh MW, Lavergne VDiagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.
Am J Respir Crit Care Med, 2018 : e24-e39 -
Rosenfeld M, Wainwright CE, Higgins M, Wang LT, McKee C, Campbell D, Schneider J, Cunningham S, Davies JC, ARRIVAL study groupIvacaftor treatment in children 12 to <24 months old with cystic fibrosis and a CFTR gating mutation: results from the a phase 3 single-arm study
Lancet Respir Med, 2018 : 30202-9 -
Rosenfeld M, VanDevanter DR, Ren CL, Elkin EP, Pasta DJ, Konstan MW, Morgan WJDecline in Lung Function Does not Predict Future Decline in Lung Function in Cystic Fibrosis Patients
Pediatr Pulmonol, 2018 -
Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld MChanges in Lung Clearance Index in Preschool Cystic Fibrosis Patients Treated with Ivacaftor
Am J Respir Crit Care Med, 2018 -
Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen FATS Assembly on Pediatrics. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement
Am J Respir Crit Care Med, 2018 -
Cogen JD, Onchiri F, Emerson J, Gibson RL, Hoffman LR, Nichols DP, Rosenfeld MChronic Azithromycin Use in Cystic Fibrosis and Risk of Treatment-Emergent Respiratory Pathogens
Ann Am Thorac Soc, 2018 -
Edwards TC, Emerson J, Genatossio A, McNamara S, Onchiri F, Goss C, Patrick DL, Rosenfeld MInitial Development and Pilot Testing of Observer-Reported Outcomes (ObsROs) for Children with Cystic Fibrosis Ages 0-11 Years
J Cyst Fibros, 2018 -
Sawicki GS, Ostrenga J, Petren K, Fink AK, D'Agostino E, Strassle C, Schechter MS, Rosenfeld MRisk Factors for Gaps in Care during Transfer from Pediatric to Adult Cystic Fibrosis Programs in the United States.
Ann Am Thorac Soc, 2017 -
Culver B, Graham B, Coates A, Wanger J, Berry C, Clarke P, Hallstrand T, Hankinson J, Kaminsky D, MacIntyre N, McCormack M, Rosenfeld M, Stanojevic S, Weiner DRecommendations for a Standardized Pulmonary Function Report - An ATS Technical Statement
Am J Resp Crit Care Med , 2017 : 1463-1472 -
Heltshe SL, Khan U, Beckett V, Baines A, Emerson J, Sanders DB, Gibson RL, Morgan W, Rosenfeld MLongitudinal development of initial, chronic and mucoid Pseudomonas aeruginosa infection in young children with cystic fibrosis.
J Cyst Fibros, 2017 -
Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, Milla CE, Robinson PD, Waltz D, Davies JC; VX14-809-109 investigator group; Rosenfeld MEfficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial
Lancet Respir Med, 2017 : 557-567 -
Psoter KJ, DeRoos AJ, Wakefield J, Mayer J, Rosenfeld MAir pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis
BMC Pulm Med, 2017 : 106 -
Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld MSeasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis
BMC Infect Dis, 2017 : 411 -
Otjen JP, Swanson JO, Oron A, DiBlasi RM, Swortzel T, Van Well J, Gommers E, Rosenfeld MSpirometry-assisted HRCT in children: Is it worth the effort? Current Problems in Diagnostic Radiology
Curr Probl Diagn Radiol, 2017 : 30164-5 -
Cogen J, Oron A, Gibson RL, Hoffman L, Kronman M, Ong T, Rosenfeld MCharacterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations
Pediatrics, 2017 : 139(2) -
Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M, Sermet-Gaudelus I, Southern KW, Marshall BC, Sosnay PRDiagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation
J Pediatr, 2017 -
Ong T, Schechter M, Yang J, Peng L, Emerson J, Gibson RL, Morgan W, Rosenfeld M for the EPIC Study GroupSocioeconomic Status and Environmental Tobacco Smoke Impact on Lung Outcomes in Cystic Fibrosis
Pediatrics, 2017 : 139(2) -
Farrell PM, White TB, Howenstine MS, Munck A, Parad RB, Rosenfeld M, Sommerburg O, Accurso FJ, Davies JC, Rock MJ, Sanders DB, Wilschanski M, Sermet-Gaudelus I, Blau H, Gartner S, McColley SADiagnosis of Cystic Fibrosis in Screened Populations
J Pediatr , 2017 -
Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MRClinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents.
Ann Am Thorac Soc, 2016 : 1305-13 -
Lahiri T, Hempstead SE, Brady C, Cannon C, Clark K, Condren ME, Guill MF, Guillerman RP, Leone CG, Maguiness K, Rosenfeld M, Schwarzenberg SJ, Tompkins CL, Zemanick ET, Davis SDClinical Practice Guidelines for Preschoolers with Cystic Fibrosis
Journal of Pediatrics, 2016 : 137(4) -
Leigh MW, Ferkol TW, Davis SD, Lai HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MZ, Pittman J, Shapiro AJ, Corson JS, Krischer J, Hazucha M, Knowles MClinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents
Ann Am Thoracic Society, 2016 -
Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD. Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MWDiagnosis, Evaluation, and Treatment of Primary Ciliary Dyskinesia:PCD Foundation Consensus Recommendations Based on State of the Art Review
Pediatric Pediatr Pulmonol, 2016 : 115-32 -
Davies, JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GW, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld MAn Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Patients Aged 2 to 5 Years with Cystic Fibrosis from a CFTR Gating Mutation: The KIWI Study
Lancet Respir Med, 2016 : 107-15 -
Peterson-Carmichael S, Seddon P, Cheifetz I, Frerichs I, Hall GL, Hammer J, Hantos Z, van Kaam AH, McEvoy CT, Newth CJL. Pillow JJ, Rafferty GF, Rosenfeld M, Stocks J, Ranganathan SAn Official ATS/ERS Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care Units
Ann Am Thorac Soc, 2016 : S1-S11 -
Davis SD, Ratjen F, Brumback LC, Johnson RC, Filbrun AG, Kerby GS, Panitch HB, Donaldson SH, Rosenfeld MInfant lung function tests as endpoints in the ISIS multicenter clinical trial in cystic fibrosis
J Cyst Fibros, 2015 -
Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Bryan M, Rosenfeld MAssociation of meteorologic and geographic factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis
Association of meteorologic and geographic factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis, 2015 : 1-9 -
Sanders DB, Fink A, Mayer-Hamblett N, Schechter MS, Sawicki GS, Rosenfeld M, Flume PA, Morgan WJEarly Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years
J Pediatr, 2015 -
Sanders DB, Emerson J, Ren C, Schechter MS, Gibson RL, Morgan W, Rosenfeld M for the EPIC Study GroupEarly childhood risk factors for decreased FEV1 at age 6-7 years in young children with cystic fibrosis
Ann Am Thorac Soc, 2015 : 1170-6 -
Ren C, Fink A, Petren K, Borowitz D, McColley S, Rosenfeld M, Sanders D, Marshall BOutcomes of Infants with Indeterminate Diagnosis Detected by Cystic Fibrosis Newborn Screening
Pediatrics, 2015 : 2014-3698 -
Subbarao P, Milla C, Aurora P, Davies J, Davis S, Hall G, Heltshe S, Latzin P, Linblad A, Pittman J, Robinson P, Rosenfeld M, Singer F, Starner T, Ratjen F, Morgan WMultiple Breath Washout as a Lung Function Test in Cystic Fibrosis: Ready for Prime Time?
Ann Am Thorac Soc, 2015 : 932-9 -
Cogen J, Sanders DB, Ren C, Schechter M, Emerson J, Gibson R, Morgan W, Rosenfeld M for the EPIC Study GroupRisk factors for lung function decline in a large cohort of young cystic fibrosis patients
Pediatr Pulmonol, 2015 : 763-70 -
Schechter MS, Regelmann W, Sawicki GS, Rasouliyan L, VanDeVanter DR, Rosenfeld M, Pasta D, Morgan W, Konstan MWAntibiotic treatment of pulmonary exacerbations: a comparison by care site
Pediatr Pulmonol, 2015 : 431-40 -
Psoter KJ, De Roos AJ, Mayer JD, Kaufman JD, Wakefield J, Rosenfeld MFine particular matter exposure and initial Pseudomonas aeruginosa acquisition in cystic fibrosis
Ann Am Thorac Soc, 2015 : 385-91 -
Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MWClinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype
Am J Respir Crit Care Med, 2015 : 316- 24 -
Zemanick ET, Emerson J, Thompson V, McNamara Sh, Morgan W, Gibson RL, Rosenfeld M for the EPIC Study GroupClinical outcomes after initial Pseudomonas acquisition in cystic fibrosis
Pediatric Pulmonology, 2015 : 42-8 -
Mogayzel PJ Jr, Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, Rosenfeld M, Simon RH, Hazle L, Sabadosa K, Marshall BCCystic Fibrosis Foundation Pulmonary Clinical Practice Guidelines Committee. Cystic Fibrosis Foundation pulmonary guideline. pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection.
Ann Am Thorac Soc, 2014 : 1640-50 -
Alpern AN, Brumback LC, Ratjen F, Rosenfeld M, Davis SD, Quittner ALInitial validation of the Parent Cystic Fibrosis Questionnaire-Revised (CFQ-R) in infants and young children. Journal of Cystic Fibrosis
Journal of Cystic Fibrosis , 2014 -
Mayer-Hamblett N, Ramsey BW, Kulasekara HD, Wolter DJ, Houston LS, Pope CE, Kulasekara BR, Armbruster CR, Burns JL, Retsch-Bogart G, Rosenfeld M, Gibson RL, Miller SI, Khan U, Hoffman LRPseudomonas aeruginosa phenotypes associated with eradication failure in children with cystic fibrosis
Clin Infect Dis , 2014 : 624-31 -
Daines C, VanDeVanter D, Khan U, Emerson J, Heltshe S, McNamara S, Anstead M, Langkamp M, Doring G, Ratjen F, Ramsey B, Gibson RL, Morgan W, Rosenfeld M; EPIC InvestigatorsSerology as a diagnostic tool for predicting initial Pseudomonas aeruginosa acquisition in children with cystic fibrosis
J Cyst Fibros , 2014 : 542-9 -
Mayer-Hamblett N, Rosenfeld M, Gibson RL, Ramsey BW, Kulasekara HD, Retsch-Bogart GZ, Morgan W, Wolter DJ, Pope CE, Houston LS, Kulasekara BR, Khan U, Burns JL,Milller SI, Hoffman LRPseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes
Am J Respir Crit Care Med, 2014 : 289-97 -
Psoter KJ, Rosenfeld M, De Roos AJ, Mayer JD, Wakefield JDifferential Geographical Risk of Initial Pseudomonas aeruginosa Acquisition in Young U.S. Children with Cystic Fibrosis
American Journal of Epidemiology , 2014 June : 1503-13 -
Stanojevic, S., Stocks, J., Bountziouka, V,. Aurora, P., Kirkby, J., Bourke, S., Carr, S.B., Gunn, E., Prasad, A., Rosenfeld, M., Bilton, DThe Impact of switching to the new Global Lung Function Initiative Equations on Spirometry Results in the UK CF Registry
Journal of Cystic Fibrosis, 2014 May : 319-27 -
Brumback LC, Baines A, Ratjen F, Davis SD, Daniel SL, Quittner AL, Rosenfeld M; for the ISIS Study GroupPulmonary exacerbations and parent-reported outcomes in children <6 years with cystic fibrosis.
Pediatr Pulmonol, 2014 -
Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR; the Genetic Disorders of Mucociliary Clearance ConsortiumStandardizing Nasal Nitric Oxide Measurement as a Test for Primary Ciliary Dyskinesia
12406843 Ann Am Thorac Soc, 2013 Dec. : 574-81
Other Publications
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Davis CS, Faino AV, Onchiri F, Gibson RL, Merjaneh L, Ramsey BW, Rosenfeld M, Cogen JDSystemic Corticosteroids in the Management of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
36044723 Annals of the American Thoracic Society, 2023 Jan. : 20(1)75-82 -
Sagel SD, Kupfer O, Wagner BD, Davis SD, Dell SD, Ferkol TW, Hoppe JE, Rosenfeld M, Sullivan KM, Tiddens HAWM, Knowles MR, Leigh MWAirway Inflammation in Children with Primary Ciliary Dyskinesia.
35984413 Annals of the American Thoracic Society, 2023 Jan. : 20(1)67-74 PMCID:PMC9819265 -
Spurr R, Ng E, Onchiri FM, Rapha B, Nakatumba-Nabende J, Rosenfeld M, Najjingo I, Stout JW, Nantanda R, Ellington LEPerformance and usability of a new mobile application for measuring respiratory rate in young children with acute lower respiratory infections.
35996862 Pediatric pulmonology, 2022 Dec. : 57(12)3009-3016 -
Kinghorn B, Rosenfeld M, Sullivan E, Onchiri F, Ferkol TW, Sagel SD, Dell SD, Milla C, Shapiro AJ, Sullivan KM, Zariwala MA, Pittman JE, Mollica F, Tiddens HAWM, Kemner-van de Corput M, Knowles MR, Davis SD, Leigh MW, Genetic Disorders of Mucociliary Clearance ConsortiumAirway Disease in Children with Primary Ciliary Dyskinesia: Impact of Ciliary Ultrastructure Defect and Genotype.
36442147 Annals of the American Thoracic Society, 2022 Nov. 28 -
Rayment JH, Asfour F, Rosenfeld M, Higgins M, Liu L, Mascia M, Paz-Diaz H, Tian S, Zahigian R, McColley SAA Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR.
35771568 American journal of respiratory and critical care medicine, 2022 Nov. 15 : 206(10)1239-1247 PMCID:PMC9746849 -
Rayment JH, Asfour F, Rosenfeld M, Higgins M, Liu L, Mascia M, Paz-Diaz H, Tian S, Zahigian R, McColley SAA Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR.
35771568 American journal of respiratory and critical care medicine, 2022 Nov. 15 : 206(10)1239-1247 PMCID:PMC9746849 -
Barber AT, Shapiro AJ, Davis SD, Ferkol TW, Atkinson JJ, Sagel SD, Dell SD, Olivier KN, Milla CE, Rosenfeld M, Li L, Lin FC, Sullivan KM, Capps NA, Zariwala MA, Knowles MR, Leigh MW, Genetic Disorders of Mucociliary Clearance Consortium (GDMCC)Laterality Defects in Primary Ciliary Dyskinesia: Relationship to Ultrastructural Defect or Genotype.
36342963 Annals of the American Thoracic Society, 2022 Nov. 7 -
Wee WB, Leigh MW, Davis SD, Rosenfeld M, Sullivan KM, Sawras MG, Ferkol TW, Knowles MR, Milla C, Sagel SD, Zariwala MA, Pullenayegum E, Dell SDAssociation of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia.
35657736 Annals of the American Thoracic Society, 2022 Nov. : 19(11)1865-1870 PMCID:PMC9667809 -
Schwarzenberg SJ, Vu PT, Skalland M, Hoffman LR, Pope C, Gelfond D, Narkewicz MR, Nichols DP, Heltshe SL, Donaldson SH, Frederick CA, Kelly A, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Solomon GM, Stalvey MS, Clancy JP, Rowe SM, Freedman SD, Promise Study GroupElexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI.
36280527 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022 Oct. 21 -
Aksit MA, Ling H, Pace RG, Raraigh KS, Onchiri F, Faino AV, Pagel K, Pugh E, Stilp AM, Sun Q, Blue EE, Wright FA, Zhou YH, Bamshad MJ, Gibson RL, Knowles MR, Cutting GR, Blackman SM, CF Genome ProjectPleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis.
36206743 American journal of human genetics, 2022 Oct. 6 : 109(10)1894-1908 PMCID:PMC9606479 -
Rosenfeld M, Ostrenga J, Cromwell EA, Magaret A, Szczesniak R, Fink A, Schechter MS, Faro A, Ren CL, Morgan W, Sanders DBReal-world Associations of US Cystic Fibrosis Newborn Screening Programs With Nutritional and Pulmonary Outcomes.
35913705 JAMA pediatrics, 2022 Oct. 1 : 176(10)990-999 PMCID:PMC9344390 -
Zhai J, Emond MJ, Spangenberg A, Stern DA, Vasquez MM, Blue EE, Buckingham KJ, Sherrill DL, Halonen M, Gibson RL, Rosenfeld M, Sagel SD, Bamshad MJ, Morgan WJ, Guerra SClub cell secretory protein and lung function in children with cystic fibrosis.
35367162 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022 Sept. : 21(5)811-820 PMCID:PMC9509401 -
Rice JD, Johnson RL, Juarez-Colunga E, Zemanick ET, Rosenfeld M, Wagner BDApplication of gap time analysis with flexible hazards to pulmonary exacerbations in the EPIC observational study.
35434808 Biometrical journal. Biometrische Zeitschrift, 2022 Aug. : 64(6)1075-1089 -
Cogen JD, Faino AV, Onchiri F, Gibson RL, Hoffman LR, Nichols DP, Rosenfeld M, Kronman MPClinical Outcomes of Antipseudomonal versus Other Antibiotics among Children with Cystic Fibrosis without Pseudomonas aeruginosa.
35289740 Annals of the American Thoracic Society, 2022 Aug. : 19(8)1320-1327 -
Rosenfeld M, Ratjen FCOMBATing airway inflammation in infants with cystic fibrosis.
35662407 The Lancet. Respiratory medicine, 2022 Aug. : 10(8)727-729 -
Kingston H, Stilp AM, Gordon W, Broome J, Gogarten SM, Ling H, Barnard J, Dugan-Perez S, Ellinor PT, Gabriel S, Germer S, Gibbs RA, Gupta N, Rice K, Smith AV, Zody MC, Cystic Fibrosis Genome Project, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Blackman SM, Cutting G, Knowles MR, Zhou YH, Rosenfeld M, Gibson RL, Bamshad M, Fohner A, Blue EEAccounting for population structure in genetic studies of cystic fibrosis.
35647563 HGG advances, 2022 July 14 : 3(3)100117 PMCID:PMC9136666 -
Stanojevic S, Kaminsky DA, Miller MR, Thompson B, Aliverti A, Barjaktarevic I, Cooper BG, Culver B, Derom E, Hall GL, Hallstrand TS, Leuppi JD, MacIntyre N, McCormack M, Rosenfeld M, Swenson ERERS/ATS technical standard on interpretive strategies for routine lung function tests.
34949706 The European respiratory journal, 2022 July : 60(1) -
Tiddens HAWM, Chen Y, Andrinopoulou ER, Davis SD, Rosenfeld M, Ratjen F, Kronmal RA, Hinckley Stukovsky KD, Dasiewicz A, Stick SM, SHIP-CT Study GroupThe effect of inhaled hypertonic saline on lung structure in children aged 3-6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial.
35286860 The Lancet. Respiratory medicine, 2022 July : 10(7)669-678 -
Nichols DP, Paynter AC, Heltshe SL, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Clancy JP, Kirby S, Van Dalfsen JM, Kloster MH, Rowe SM, PROMISE Study groupClinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial.
34784492 American journal of respiratory and critical care medicine, 2022 March 1 : 205(5)529-539 PMCID:PMC8906485 -
Cogen JD, Onchiri FM, Hamblett NM, Gibson RL, Morgan WJ, Rosenfeld MAssociation of Intensity of Antipseudomonal Antibiotic Therapy With Risk of Treatment-Emergent Organisms in Children With Cystic Fibrosis and Newly Acquired Pseudomonas Aeruginosa.
33693586 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 Sept. 15 : 73(6)987-993 -
Rosenfeld M, Faino AV, Onchiri F, Aksit MA, Blackman SM, Blue EE, Collaco JM, Gordon WW, Pace RG, Raraigh KS, Zhou YH, Cutting GR, Knowles MR, Bamshad MJ, Gibson RLComparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis.
34393091 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021 Aug. 12 -
Graustein AD, Berrington WR, Buckingham KJ, Nguyen FK, Joudeh LL, Rosenfeld M, Bamshad MJ, Gibson RL, Hawn TR, Emond MJInflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.
33848452 American journal of respiratory cell and molecular biology, 2021 Aug. : 65(2)157-166 PMCID:PMC8399576 -
Ellington LE, Najjingo I, Rosenfeld M, Stout JW, Farquhar SA, Vashistha A, Nekesa B, Namiya Z, Kruse AJ, Anderson R, Nantanda RHealth workers' perspectives of a mobile health tool to improve diagnosis and management of paediatric acute respiratory illnesses in Uganda: a qualitative study.
34281930 BMJ open, 2021 July 19 : 11(7)e049708 PMCID:PMC8291301 -
Cogen JD, Faino AV, Onchiri F, Hoffman LR, Kronman MP, Nichols DP, Rosenfeld M, Gibson RLAssociation Between Number of Intravenous Antipseudomonal Antibiotics and Clinical Outcomes of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
34100912 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 June 8 -
Merjaneh L, Toprak D, McNamara S, Nay L, Sullivan E, Rosenfeld MAcute hyperglycaemia in cystic fibrosis pulmonary exacerbations.
33855211 Endocrinology, diabetes & metabolism, 2021 April : 4(2)e00208 PMCID:PMC8029509 -
Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SMPROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy.
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Zemanick ET, Hoffman L, Rosenfeld MNarrowing in on early cystic fibrosis lung disease.
25398104 American journal of respiratory and critical care medicine, 2014 Nov. 15 : 190(10)1082-4 -
Shapiro AJ, Davis SD, Ferkol T, Dell SD, Rosenfeld M, Olivier KN, Sagel SD, Milla C, Zariwala MA, Wolf W, Carson JL, Hazucha MJ, Burns K, Robinson B, Knowles MR, Leigh MW, Genetic Disorders of Mucociliary Clearance Consortium.Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy.
24577564 Chest, 2014 Nov. : 146(5)1176-1186 PMCID:PMC4219335 -
Shapiro AJ, Weck KE, Chao KC, Rosenfeld M, Nygren AO, Knowles MR, Leigh MW, Zariwala MACri du chat syndrome and primary ciliary dyskinesia: a common genetic cause on chromosome 5p.
25066065 The Journal of pediatrics, 2014 Oct. : 165(4)858-61 PMCID:PMC4177261 -
Daines C, VanDeVanter D, Khan U, Emerson J, Heltshe S, McNamara S, Anstead M, Langkamp M, Doring G, Ratjen F, Ramsey B, Gibson RL, Morgan W, Rosenfeld M, EPIC Investigators.Serology as a diagnostic tool for predicting initialPseudomonas aeruginosa acquisition in children with cystic fibrosis.
25027419 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014 Sept. : 13(5)542-9 -
Mayer-Hamblett N, Ramsey BW, Kulasekara HD, Wolter DJ, Houston LS, Pope CE, Kulasekara BR, Armbruster CR, Burns JL, Retsch-Bogart G, Rosenfeld M, Gibson RL, Miller SI, Khan U, Hoffman LRPseudomonas aeruginosa phenotypes associated with eradication failure in children with cystic fibrosis.
24863401 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014 Sept. 1 : 59(5)624-31 PMCID:PMC4148602 -
Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA, NHLBI Exome Sequencing Project., Bamshad MJPathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results.
25087612 American journal of human genetics, 2014 Aug. 7 : 95(2)183-93 PMCID:PMC4129409 -
Mayer-Hamblett N, Rosenfeld M, Gibson RL, Ramsey BW, Kulasekara HD, Retsch-Bogart GZ, Morgan W, Wolter DJ, Pope CE, Houston LS, Kulasekara BR, Khan U, Burns JL, Miller SI, Hoffman LRPseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes.
24937177 American journal of respiratory and critical care medicine, 2014 Aug. 1 : 190(3)289-97 PMCID:PMC4226041 -
Ren CL, Konstan MW, Rosenfeld M, Pasta DJ, Millar SJ, Morgan WJ, Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis.Early childhood wheezing is associated with lower lung function in cystic fibrosis.
24123917 Pediatric pulmonology, 2014 Aug. : 49(8)745-50 PMCID:PMC4107871 -
Psoter KJ, Rosenfeld M, De Roos AJ, Mayer JD, Wakefield JDifferential geographical risk of initial Pseudomonas aeruginosa acquisition in young US children with cystic fibrosis.
24875373 American journal of epidemiology, 2014 June 15 : 179(12)1503-13 -
Stanojevic S, Stocks J, Bountziouka V, Aurora P, Kirkby J, Bourke S, Carr SB, Gunn E, Prasad A, Rosenfeld M, Bilton DThe impact of switching to the new global lung function initiative equations on spirometry results in the UK CF registry.
24332996 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014 May : 13(3)319-27 -
Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ, Bamshad MJ, Nickerson DA, NHLBI GO Exome Sequencing Project.Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset.
24282029 Human molecular genetics, 2014 April 15 : 23(8)1957-63 PMCID:PMC3959810 -
Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Zariwala MAMutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype.
24568568 American journal of respiratory and critical care medicine, 2014 March 15 : 189(6)707-17 PMCID:PMC3983840 -
Simon TD, Mayer-Hamblett N, Whitlock KB, Langley M, Kestle JR, Riva-Cambrin J, Rosenfeld M, Thorell EAFew Patient, Treatment, and Diagnostic or Microbiological Factors, Except Complications and Intermittent Negative Cerebrospinal Fluid (CSF) Cultures During First CSF Shunt Infection, Are Associated With Reinfection.
24567841 Journal of the Pediatric Infectious Diseases Society, 2014 March : 3(1)15-22 PMCID:PMC3933045 -
Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, Flannick J, Zhang J, Fuchsberger C, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL, Gottesman O, Lu Y, Ruderfer D, Stahl EA, Duan Q, Li Y, Durda P, Jiao S, Isaacs A, Hofman A, Bis JC, Correa A, Griswold ME, Jakobsdottir J, Smith AV, Schreiner PJ, Feitosa MF, Zhang Q, Huffman JE, Crosby J, Wassel CL, Do R, Franceschini N, Martin LW, Robinson JG, Assimes TL, Crosslin DR, Rosenthal EA, Tsai M, Rieder MJ, Farlow DN, Folsom AR, Lumley T, Fox ER, Carlson CS, Peters U, Jackson RD, van Duijn CM, Uitterlinden AG, Levy D, Rotter JI, Taylor HA, Gudnason V Jr, Siscovick DS, Fornage M, Borecki IB, Hayward C, Rudan I, Chen YE, Bottinger EP, Loos RJ, Sætrom P, Hveem K, Boehnke M, Groop L, McCarthy M, Meitinger T, Ballantyne CM, Gabriel SB, O'Donnell CJ, Post WS, North KE, Reiner AP, Boerwinkle E, Psaty BM, Altshuler D, Kathiresan S, Lin DY, Jarvik GP, Cupples LA, Kooperberg C, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, Tracy RP, Willer CJ, NHLBI Grand Opportunity Exome Sequencing Project.Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
24507775 American journal of human genetics, 2014 Feb. 6 : 94(2)233-45 PMCID:PMC3928660 -
Simon TD, Pope CE, Browd SR, Ojemann JG, Riva-Cambrin J, Mayer-Hamblett N, Rosenfeld M, Zerr DM, Hoffman LEvaluation of microbial bacterial and fungal diversity in cerebrospinal fluid shunt infection.
24421877 PloS one, 2014 : 9(1)e83229 PMCID:PMC3885436 -
Rosenthal EA, Ranchalis J, Crosslin DR, Burt A, Brunzell JD, Motulsky AG, Nickerson DA, NHLBI GO Exome Sequencing Project., Wijsman EM, Jarvik GPJoint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.
24268658 American journal of human genetics, 2013 Dec. 5 : 93(6)1035-45 PMCID:PMC3852929 -
Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt FZebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.
24094744 American journal of human genetics, 2013 Oct. 3 : 93(4)672-86 PMCID:PMC3791264
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Presentations Title Event Location Date Early Pseudomonas Infection: Risk Factors and Outcomes North American Cystic Fibrosis Conference Indianapolis, IN 2017 The Promise and Challenge of Precision Medicine in Cystic Fibrosis and Beyond American Thoracic Society International Conference Washington DC 2017 Pediatric Lung Function Testing Across the Ages American Thoracic Society International Conference San Diego, CA 2017 The U.S. Approach to Preschool Airway Health Early CF Years Meeting Liverpool, UK 2016 Safety, Tolerability, and Pharmacodynamics of Combination Lumacaftor/Ivacaftor Therapy in Patients Aged 6-11 Yrs with CF Homozygous for the F508del-CFTR Mutation North American Cystic Fibrosis Conference Orlando, FL 2016 Lung Function Testing Across the Ages American Thoracic Society International Conference San Francisco, CA 2016 Clinical Trials in Infants and Young Children with CF: Where are we Heading? California CF Center Consortium Annual Conference Carmel, CA 2016 Detecting Early CF Lung Disease North American Cystic Fibrosis Conference Phoenix, AZ 2015 The CF Therapeutics Pipeline: Ushering in an Era of Great Hope Cystic Fibrosis Research Institute Redwood City, CA 2015 Results of the KIWI Trial of Ivacaftor in 2 to 5 Year Olds with CF and Gating Mutations European Cystic Fibrosis Conference Brussels, Belgium 2015 Early Lung Disease in CF - What Works? American Thoracic Society International Conference Denver, CO May 15, 2015 Research, a Straight Path Forward...or Not! American Thoracic Society International Society International Conference Denver, CO 2015 Cystic Fibrosis in Children American Thoracic Society International Conference Denver, CO 2015 Digital health monitoring: Beyond heart rates and pedometers Association for Women in Science 30th anniversary meeting Seattle, WA Feb. 18, 2015 Home spirometry: whats on the horizon North American Cystic Fibrosis Conference Atlanta, GA Oct. 2014 Clinical trials in preschool children with CF European Cystic Fibrosis Conference Gothenburg, Sweden June 14, 2014 Survey of clinical infant lung function testing practices. International Symposium on Respiratory Disease Shanghai, China Nov. 9, 2013 Early CF Lung Disease: Diagnosis, Treatment and Prevention Duke University School of Medicine Nov. 28, 2012 Pulmonary Exacerbation as a Clinical Trial Endpoint: The Pros and Cons North American CF Conference Orlando, FL Oct. 2012 Designing Investigator Initiated Trials Presentation In symposium "Multidisciplinary Approach to Investigator-initiated Trials," North American CF Conference Orlando, FL Oct. 2012 Pulmonary and Nutritional Consequences of CF in the First 6 Years of Life presentation in symposium "After the Newborn Screen: What to Do Next?" North American CF Conference Orlando, FL Oct. 2012 What lung function test is best for managing young children with CF talk in session "Is it time to bring pre-school lung function testing to the clinic? Update from the ATS/ERS Task Force" European Respiratory Society Congress Vienna, Austria Sept. 2012 Writing Your First Grant ITHS career development series, University of Washington Seattle, WA Oct. 30, 2009 Successful Transition to an Academic Career half-day SCH Fellows’ College workshop unknown Oct. 28, 2009 Risk factors for early age at acquisition of Pseudomonas aeruginosa North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009 Newborn screening North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009 Pulmonary Exacerbations: How do we define them Symposium presentation, North American Cystic Fibrosis Conference Minneapolis, MN Oct. 16, 2009 Comparison of published pulmonary exacerbation definitions Cystic Fibrosis Foundation Workshop on Pulmonary Exacerbations Bethesda, MD Sept. 9, 2009 Guidelines for Care of theGuidelines for Care of the Infant with CF Infant with CF Cystic Fibrosis annual Northwest regional conference, Center for Urban Horticulture unknown July 24, 2009 Risk factors for early Pseudomonas acquisition Cystic Fibrosis Epidemiology/Biostatistics Working Group annual meeting, Center for Urban Horticulture unknown July 23, 2009 Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia and recurrernt wheezing in children under 6 years of age American Thoracic Society annual convention San Diego, CA May 12, 2009 unknown ITHS Career Development Seminar- Career Development (K Award) Seminar unknown Jan. 29, 2009
Overview
- Board Certification(s)
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Pediatric Pulmonology
- Medical/Professional School
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University of Washington, Seattle, WA
Harvard Medical School, Boston, MA - Clinical Interests
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Diagnosis and management of all pediatric lung conditions
- Research Description
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Multicenter observational studies and investigator-initiated clinical trials in cystic fibrosis emphasizing early CF lung disease. Multicenter observational studies in primary ciliary dyskinesia. Mobile health applications and remote monitoring, including home spirometry. Development of outcome measures for clinical trials, including home spirometry, home cough monitoring, infant and preschool lung function tests. Global health, including mobile health tools for diagnosis of respiratory distress and pneumonia in low resource settings.
- Research Focus Area
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Translational research, observational studies, investigator-initiated interventional studies, Therapeutic Trials