Margaret Rosenfeld, MD, MPH

Margaret Rosenfeld, MD, MPH

Pulmonary, Cystic Fibrosis Research, Cystic Fibrosis Program, Primary Ciliary Dyskinesia and Bronchiectasis Clinic

On staff since May 1995

Children's Title: Professor and Associate Vice-Chair for Clinical Research, Department of Pediatrics

Research Title: Interim Co-Director, Center for Clinical and Translational Research

Research Center: Center for Clinical and Translational Research

  • Margaret Rosenfeld, MD, MPH, is attending physician at Seattle Children's Hospital and Professor in the Department of Pediatrics at the University of Washington School of Medicine. Her clinical interests focus on the diagnosis and management of respiratory illnesses in children of all ages, working closely with families. Her research program focuses on NIH and foundation-sponsored multicenter observational and interventional studies in pediatric chronic lung diseases, including cystic fibrosis and primary ciliary dyskinesia. She also conducts research on mobile health tools for respiratory diseases including home spirometry.

    She is director of the Clinical Research Scholars Program, codirector of the Seattle Children's Fellows College. She serves as CF consultant to the Washington State Newborn Screening Program.

    • Chelsea Bothell, WA 09.13.17

      We met with Dr. Rosenfeld to follow up after our toddler's recent admission for Reactive Airway Disease. She was warm, knowledgeable, and spent plenty of time with us answering our questions. She validated our concerns/fears and gave us good insight into his condition. We felt confidence in the plan of action after the appointment. We feel really grateful to have her as part of our son's medical team.

    • Ellisa Chehalis, WA 03.21.11

      We first saw Dr. Rosenfeld when our child was very young, around 4 months old. We were seeing her to determine if our child had PCD. She was very caring, thourough, and was willing to sit and answer all our questions as long as we needed. She has continued caring for our child, who is now 2. We are so greatful to have such a knowledgable Doctor taking care of our child and helping us prevent future health problems and research this rare pulmonary disorder. We highly recommend her. Ellisa Alderson

    Recommend Margaret Rosenfeld, MD, MPH
  • Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    Finalist, UW School of Medicine Mentoring Award 2013
    Finalist, UW School of Medicine Mentoring Award 2010
    Physician Scientist Fellowship Award Glaxo Corporation 1993
    Leroy Matthews Physician Scientist Award Cystic Fibrosis Foundation 1992 - 1998

  • Manuscripts in Refereed Journals

    • Fink AK, Graff G, Byington CL, Loeffler DR, Rosenfeld M, Saiman L. Palivizumab and Long-term Outcomes in Cystic Fibrosis.
      Palivizumab and Long-term Outcomes in Cystic Fibrosis
      Pediatrics, 2019
    • Ratjen F, Davis SD, Stanojevic S, Kronmal RA, Hinckley Stukovsky KD, Jorgensen N, Rosenfeld M; SHIP Study Group
      Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.
      Lancet Respir Med, 2019
    • Sanders DB, Ostrenga JS, Rosenfeld M, Fink AK, Schechter MS, Sawicki GS, Flume PA, Morgan WJ
      Predictors of pulmonary exacerbation treatment in cystic fibrosis.
      J Cyst Fibros, 2019
    • Rosenfeld M, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Chilvers M, Higgins M, Tian S, Cooke J, Davies JC; KLIMB study group
      An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB).
      J Cyst Fibros, 2019
    • M. Rosenfeld, S. Cunningham, W.T. Harris, et al
      An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2–5 years (KLIMB)
      Journal of Cystic Fibrosis, 2019
    • Davis SD, Rosenfeld M, Lee HS, Ferkol TW, Sagel SD, Dell SD, Milla C, Pittman JE, Shapiro AJ, Sullivan KM, Nykamp KR, Krischer JP, Zariwala MA, Knowles MR, Leigh MW; and Genetic Disorders of Mucociliary Clearance Consortium
      Primary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype.
      Am J Respir Crit Care Med, 2018
    • Chi DL, Rosenfeld M, Manci L, Chung WO, Presland RB, Sarvas E, Rothen M, Alkhateeb A, McNamara S, Genatossio A, Virella-Lowell I, Milla C, Scott J
      Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study
      J Cyst Fibros, 2018
    • Mayer-Hamblett N, Retsch-Bogart G, Kloster M, Accurso F, Rosenfeld M, Albers G, Black P, Brown P, Cairns A, Davis S, Graff G, Kerby G, Orenstein D, Buckingham R, Ramsey B, for the OPTIMIZE Study Group
      Azithromycin for Early Pseudomonas Infection in Cystic Fibrosis: The Optimize Randomized Trial
      Annals of the American Thoracic Society, 2018
    • Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, Pittman JE, Daniels MLA, Jones MH, Janahi IA, Ware SM, Daniel SJ, Cooper ML, Nogee LM, Anton B, Eastvold T, Ehrne L, Guadagno E, Knowles MR, Leigh MW, Lavergne V
      Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.
      Am J Respir Crit Care Med, 2018 : e24-e39
    • Rosenfeld M, Wainwright CE, Higgins M, Wang LT, McKee C, Campbell D, Schneider J, Cunningham S, Davies JC, ARRIVAL study group
      Ivacaftor treatment in children 12 to <24 months old with cystic fibrosis and a CFTR gating mutation: results from the a phase 3 single-arm study
      Lancet Respir Med, 2018 : 30202-9
    • Rosenfeld M, VanDevanter DR, Ren CL, Elkin EP, Pasta DJ, Konstan MW, Morgan WJ
      Decline in Lung Function Doest not Predict Future Decline in Lung Function in Cystic Fibrosis Patients
      Pediatr Pulmonol, 2018
    • Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld M
      Changes in Lung Clearance Index in Preschool Cystic Fibrosis Patients Treated with Ivacaftor
      Am J Respir Crit Care Med, 2018
    • Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen F
      ATS Assembly on Pediatrics. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement
      Am J Respir Crit Care Med, 2018
    • Cogen JD, Onchiri F, Emerson J, Gibson RL, Hoffman LR, Nichols DP, Rosenfeld M
      Chronic Azithromycin Use in Cystic Fibrosis and Risk of Treatment-Emergent Respiratory Pathogens
      Ann Am Thorac Soc, 2018
    • Edwards TC, Emerson J, Genatossio A, McNamara S, Onchiri F, Goss C, Patrick DL, Rosenfeld M
      Development and Pilot Testing of Observer-Reported Outcomes (ObsROs) for Children with Cystic Fibrosis Ages 0-11 Years
      J Cyst Fibros, 2018
    • Sawicki GS, Ostrenga J, Petren K, Fink AK, D'Agostino E, Strassle C, Schechter MS, Rosenfeld M
      Risk Factors for Gaps in Care during Transfer from Pediatric to Adult Cystic Fibrosis Programs in the United States.
      Ann Am Thorac Soc, 2017
    • Culver B, Graham B, Coates A, Wanger J, Berry C, Clarke P, Hallstrand T, Hankinson J, Kaminsky D, MacIntyre N, McCormack M, Rosenfeld M, Stanojevic S, Weiner D
      Recommendations for a Standardized Pulmonary Function Report - An ATS Technical Statement
      Am J Resp Crit Care Med , 2017 : 1463-1472
    • Heltshe SL, Khan U, Beckett V, Baines A, Emerson J, Sanders DB, Gibson RL, Morgan W, Rosenfeld M
      Longitudinal development of initial, chronic and mucoid Pseudomonas aeruginosa infection in young children with cystic fibrosis.
      J Cyst Fibros, 2017
    • Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, Milla CE, Robinson PD, Waltz D, Davies JC; VX14-809-109 investigator group; Rosenfeld M
      Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial
      Lancet Respir Med, 2017 : 557-567
    • Psoter KJ, DeRoos AJ, Wakefield J, Mayer J, Rosenfeld M
      Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis
      BMC Pulm Med, 2017 : 106
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld M
      Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis
      BMC Infect Dis, 2017 : 411
    • Otjen JP, Swanson JO, Oron A, DiBlasi RM, Swortzel T, Van Well J, Gommers E, Rosenfeld M
      Spirometry-assisted HRCT in children: Is it worth the effort? Current Problems in Diagnostic Radiology
      Curr Probl Diagn Radiol, 2017 : 30164-5
    • Cogen J, Oron A, Gibson RL, Hoffman L, Kronman M, Ong T, Rosenfeld M
      Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations
      Pediatrics, 2017 : 139(2)
    • Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M, Sermet-Gaudelus I, Southern KW, Marshall BC, Sosnay PR
      Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation
      J Pediatr, 2017
    • Ong T, Schechter M, Yang J, Peng L, Emerson J, Gibson RL, Morgan W, Rosenfeld M for the EPIC Study Group
      Socioeconomic Status and Environmental Tobacco Smoke Impact on Lung Outcomes in Cystic Fibrosis
      Pediatrics, 2017 : 139(2)
    • Farrell PM, White TB, Howenstine MS, Munck A, Parad RB, Rosenfeld M, Sommerburg O, Accurso FJ, Davies JC, Rock MJ, Sanders DB, Wilschanski M, Sermet-Gaudelus I, Blau H, Gartner S, McColley SA
      Diagnosis of Cystic Fibrosis in Screened Populations
      J Pediatr , 2017
    • Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MR
      Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents.
      Ann Am Thorac Soc, 2016 : 1305-13
    • Lahiri T, Hempstead SE, Brady C, Cannon C, Clark K, Condren ME, Guill MF, Guillerman RP, Leone CG, Maguiness K, Rosenfeld M, Schwarzenberg SJ, Tompkins CL, Zemanick ET, Davis SD
      Clinical Practice Guidelines for Preschoolers with Cystic Fibrosis
      Journal of Pediatrics, 2016 : 137(4)
    • Leigh MW, Ferkol TW, Davis SD, Lai HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MZ, Pittman J, Shapiro AJ, Corson JS, Krischer J, Hazucha M, Knowles M
      Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents
      Ann Am Thoracic Society, 2016
    • Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD. Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW
      Diagnosis, Evaluation, and Treatment of Primary Ciliary Dyskinesia:PCD Foundation Consensus Recommendations Based on State of the Art Review
      Pediatric Pediatr Pulmonol, 2016 : 115-32
    • Davies, JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GW, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld M
      An Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Patients Aged 2 to 5 Years with Cystic Fibrosis from a CFTR Gating Mutation: The KIWI Study
      Lancet Respir Med, 2016 : 107-15
    • Peterson-Carmichael S, Seddon P, Cheifetz I, Frerichs I, Hall GL, Hammer J, Hantos Z, van Kaam AH, McEvoy CT, Newth CJL. Pillow JJ, Rafferty GF, Rosenfeld M, Stocks J, Ranganathan S
      An Official ATS/ERS Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care Units
      Ann Am Thorac Soc, 2016 : S1-S11
    • Davis SD, Ratjen F, Brumback LC, Johnson RC, Filbrun AG, Kerby GS, Panitch HB, Donaldson SH, Rosenfeld M
      Infant lung function tests as endpoints in the ISIS multicenter clinical trial in cystic fibrosis
      J Cyst Fibros, 2015
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Bryan M, Rosenfeld M
      Association of meteorologic and geographic factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis
      Association of meteorologic and geographic factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis, 2015 : 1-9
    • Sanders DB, Fink A, Mayer-Hamblett N, Schechter MS, Sawicki GS, Rosenfeld M, Flume PA, Morgan WJ
      Early Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years
      J Pediatr, 2015
    • Sanders DB, Emerson J, Ren C, Schechter MS, Gibson RL, Morgan W, Rosenfeld M for the EPIC Study Group
      Early childhood risk factors for decreased FEV1 at age 6-7 years in young children with cystic fibrosis
      Ann Am Thorac Soc, 2015 : 1170-6
    • Ren C, Fink A, Petren K, Borowitz D, McColley S, Rosenfeld M, Sanders D, Marshall B
      Outcomes of Infants with Indeterminate Diagnosis Detected by Cystic Fibrosis Newborn Screening
      Pediatrics, 2015 : 2014-3698
    • Subbarao P, Milla C, Aurora P, Davies J, Davis S, Hall G, Heltshe S, Latzin P, Linblad A, Pittman J, Robinson P, Rosenfeld M, Singer F, Starner T, Ratjen F, Morgan W
      Multiple Breath Washout as a Lung Function Test in Cystic Fibrosis: Ready for Prime Time?
      Ann Am Thorac Soc, 2015 : 932-9
    • Cogen J, Sanders DB, Ren C, Schechter M, Emerson J, Gibson R, Morgan W, Rosenfeld M for the EPIC Study Group
      Risk factors for lung function decline in a large cohort of young cystic fibrosis patients
      Pediatr Pulmonol, 2015 : 763-70
    • Schechter MS, Regelmann W, Sawicki GS, Rasouliyan L, VanDeVanter DR, Rosenfeld M, Pasta D, Morgan W, Konstan MW
      Antibiotic treatment of pulmonary exacerbations: a comparison by care site
      Pediatr Pulmonol, 2015 : 431-40
    • Psoter KJ, De Roos AJ, Mayer JD, Kaufman JD, Wakefield J, Rosenfeld M
      Fine particular matter exposure and initial Pseudomonas aeruginosa acquisition in cystic fibrosis
      Ann Am Thorac Soc, 2015 : 385-91
    • Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MW
      Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype
      Am J Respir Crit Care Med, 2015 : 316- 24
    • Zemanick ET, Emerson J, Thompson V, McNamara Sh, Morgan W, Gibson RL, Rosenfeld M for the EPIC Study Group
      Clinical outcomes after initial Pseudomonas acquisition in cystic fibrosis
      Pediatric Pulmonology, 2015 : 42-8
    • Mogayzel PJ Jr, Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, Rosenfeld M, Simon RH, Hazle L, Sabadosa K, Marshall BC
      Cystic Fibrosis Foundation Pulmonary Clinical Practice Guidelines Committee. Cystic Fibrosis Foundation pulmonary guideline. pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection.
      Ann Am Thorac Soc, 2014 : 1640-50
    • Alpern AN, Brumback LC, Ratjen F, Rosenfeld M, Davis SD, Quittner AL
      Initial validation of the Parent Cystic Fibrosis Questionnaire-Revised (CFQ-R) in infants and young children. Journal of Cystic Fibrosis
      Journal of Cystic Fibrosis , 2014
    • Mayer-Hamblett N, Ramsey BW, Kulasekara HD, Wolter DJ, Houston LS, Pope CE, Kulasekara BR, Armbruster CR, Burns JL, Retsch-Bogart G, Rosenfeld M, Gibson RL, Miller SI, Khan U, Hoffman LR
      Pseudomonas aeruginosa phenotypes associated with eradication failure in children with cystic fibrosis
      Clin Infect Dis , 2014 : 624-31
    • Daines C, VanDeVanter D, Khan U, Emerson J, Heltshe S, McNamara S, Anstead M, Langkamp M, Doring G, Ratjen F, Ramsey B, Gibson RL, Morgan W, Rosenfeld M; EPIC Investigators
      Serology as a diagnostic tool for predicting initial Pseudomonas aeruginosa acquisition in children with cystic fibrosis
      J Cyst Fibros , 2014 : 542-9
    • Mayer-Hamblett N, Rosenfeld M, Gibson RL, Ramsey BW, Kulasekara HD, Retsch-Bogart GZ, Morgan W, Wolter DJ, Pope CE, Houston LS, Kulasekara BR, Khan U, Burns JL,Milller SI, Hoffman LR
      Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes
      Am J Respir Crit Care Med, 2014 : 289-97
    • Psoter KJ, Rosenfeld M, De Roos AJ, Mayer JD, Wakefield J
      Differential Geographical Risk of Initial Pseudomonas aeruginosa Acquisition in Young U.S. Children with Cystic Fibrosis
      American Journal of Epidemiology , 2014 June : 1503-13
    • Stanojevic, S., Stocks, J., Bountziouka, V,. Aurora, P., Kirkby, J., Bourke, S., Carr, S.B., Gunn, E., Prasad, A., Rosenfeld, M., Bilton, D
      The Impact of switching to the new Global Lung Function Initiative Equations on Spirometry Results in the UK CF Registry
      Journal of Cystic Fibrosis, 2014 May : 319-27
    • Brumback LC, Baines A, Ratjen F, Davis SD, Daniel SL, Quittner AL, Rosenfeld M; for the ISIS Study Group
      Pulmonary exacerbations and parent-reported outcomes in children <6 years with cystic fibrosis.
      Pediatr Pulmonol, 2014
    • Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR; the Genetic Disorders of Mucociliary Clearance Consortium
      Standardizing Nasal Nitric Oxide Measurement as a Test for Primary Ciliary Dyskinesia
      12406843 Ann Am Thorac Soc, 2013 Dec. : 574-81

    Other Publications

    • Cogen JD, Onchiri FM, Hamblett NM, Gibson RL, Morgan WJ, Rosenfeld M
      Association of Intensity of Antipseudomonal Antibiotic Therapy With Risk of Treatment-Emergent Organisms in Children With Cystic Fibrosis and Newly Acquired Pseudomonas Aeruginosa.
      33693586 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 Sept. 15 : 73(6)987-993
    • Rosenfeld M, Faino AV, Onchiri F, Aksit MA, Blackman SM, Blue EE, Collaco JM, Gordon WW, Pace RG, Raraigh KS, Zhou YH, Cutting GR, Knowles MR, Bamshad MJ, Gibson RL
      Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis.
      34393091 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021 Aug. 12
    • Graustein AD, Berrington WR, Buckingham KJ, Nguyen FK, Joudeh LL, Rosenfeld M, Bamshad MJ, Gibson RL, Hawn TR, Emond MJ
      Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.
      33848452 American journal of respiratory cell and molecular biology, 2021 Aug. : 65(2)157-166 PMCID:PMC8399576
    • Ellington LE, Najjingo I, Rosenfeld M, Stout JW, Farquhar SA, Vashistha A, Nekesa B, Namiya Z, Kruse AJ, Anderson R, Nantanda R
      Health workers' perspectives of a mobile health tool to improve diagnosis and management of paediatric acute respiratory illnesses in Uganda: a qualitative study.
      34281930 BMJ open, 2021 July 19 : 11(7)e049708 PMCID:PMC8291301
    • Cogen JD, Faino AV, Onchiri F, Hoffman LR, Kronman MP, Nichols DP, Rosenfeld M, Gibson RL
      Association Between Number of Intravenous Antipseudomonal Antibiotics and Clinical Outcomes of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
      34100912 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 June 8
    • Merjaneh L, Toprak D, McNamara S, Nay L, Sullivan E, Rosenfeld M
      Acute hyperglycaemia in cystic fibrosis pulmonary exacerbations.
      33855211 Endocrinology, diabetes & metabolism, 2021 April : 4(2)e00208 PMCID:PMC8029509
    • Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM
      PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy.
      33619012 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021 March : 20(2)205-212
    • Banks JT, Rosenfeld M, Mancl L, Chi DL
      Survey and electronic health record-based medication use agreement in children with cystic fibrosis: A retrospective cross-sectional study.
      32936971 International journal of paediatric dentistry, 2021 March : 31(2)247-253
    • Davies JC, Wainwright CE, Sawicki GS, Higgins MN, Campbell D, Harris C, Panorchan P, Haseltine E, Tian S, Rosenfeld M
      Ivacaftor in Infants Aged 4 to <12 Months with Cystic Fibrosis and a Gating Mutation. Results of a Two-Part Phase 3 Clinical Trial.
      33023304 American journal of respiratory and critical care medicine, 2021 March 1 : 203(5)585-593 PMCID:PMC7924576
    • Taylor JB, Oermann CM, Deterding RR, Redding G, Davis SD, Piccione J, Moore PE, Kupfer O, Santiago MT, Rosenfeld M, Ingram DG, Ross K, DeBoer EM
      Innovating and adapting in pediatric pulmonology and sleep medicine during the COVID-19 pandemic: ATS pediatric assembly web committee consensus statement for initial COVID-19 virtual response.
      33300286 Pediatric pulmonology, 2021 Feb. : 56(2)539-550
    • Cogen JD, Faino AV, Onchiri F, Gibson RL, Hoffman LR, Kronman MP, Rosenfeld M, Nichols DP
      Effect of Concomitant Azithromycin and Tobramycin Use on Cystic Fibrosis Pulmonary Exacerbation Treatment.
      32810412 Annals of the American Thoracic Society, 2021 Feb. : 18(2)266-272 PMCID:PMC7869777
    • Cogen JD, Faino AV, Onchiri F, Hoffman LR, Kronman MP, Nelson M, Nichols DP, Rosenfeld M, VanDevanter DR, Gibson RL
      Association of Inhaled Antibiotics in Addition to Standard Intravenous Therapy and Outcomes of Pediatric Inpatient Pulmonary Exacerbations.
      32726564 Annals of the American Thoracic Society, 2020 Dec. : 17(12)1590-1598 PMCID:PMC7924435
    • Hoppe JE, Hinds DM, Colborg A, Wagner BD, Morgan WJ, Rosenfeld M, Zemanick ET, Sanders DB
      Oral antibiotic prescribing patterns for treatment of pulmonary exacerbations in two large pediatric CF centers.
      32970375 Pediatric pulmonology, 2020 Dec. : 55(12)3400-3406
    • Wilson KC, Kaminsky DA, Michaud G, Sharma S, Nici L, Folz RJ, Barjaktarevic I, Bhakta NR, Cheng G, Chupp GL, Cole A, Dixon AE, Finigan JH, Graham B, Hallstrand TS, Haynes J, Hankinson J, MacIntyre N, Mandel J, McCarthy K, McCormack M, Patil SP, Rosenfeld M, Senitko M, Sethi S, Swenson ER, Stanojevic S, Teodorescu M, Weiner DJ, Wiener RS, Powell CA
      Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens. From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force.
      32663071 Annals of the American Thoracic Society, 2020 Nov. : 17(11)1343-1351 PMCID:PMC7640724
    • Rosenfeld M, Rayner O, Smyth AR
      Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.
      32997797 The Cochrane database of systematic reviews, 2020 Sept. 30 : 9CD001912 PMCID:PMC8430459
    • Kinghorn B, McNamara S, Genatossio A, Sullivan E, Siegel M, Bauer I, Clem C, Johnson RC, Davis M, Griffiths A, Wheeler W, Johnson K, Davis SD, Leigh MW, Rosenfeld M, Pittman J
      Comparison of Multiple Breath Washout and Spirometry in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis and Healthy Controls.
      32603187 Annals of the American Thoracic Society, 2020 Sept. : 17(9)1085-1093 PMCID:PMC7462330
    • Sanders DB, Ostrenga JS, Rosenfeld M, Fink AK, Schechter MS, Sawicki GS, Flume PA, Morgan WJ
      Predictors of pulmonary exacerbation treatment in cystic fibrosis.
      31257102 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020 May : 19(3)407-414 PMCID:PMC6940539
    • Toprak D, Nay L, McNamara S, Rosenberg AR, Rosenfeld M, Yi-Frazier JP
      Resilience in adolescents and young adults with cystic fibrosis: A pilot feasibility study of the promoting resilience in stress management intervention.
      31794160 Pediatric pulmonology, 2020 March : 55(3)638-645
    • Juarez-Colunga E, Rosenfeld M, Zemanick ET, Wagner B
      Application of multiple event analysis as an alternative approach to studying pulmonary exacerbations as an outcome measure.
      30642785 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020 Jan. : 19(1)114-118 PMCID:PMC8127951
    • Suthoff E, Mainz JG, Cox DW, Thorat T, Grossoehme DH, Fridman M, Sawicki GS, Rosenfeld M
      Caregiver Burden Due to Pulmonary Exacerbations in Patients with Cystic Fibrosis.
      31761140 The Journal of pediatrics, 2019 Dec. : 215164-171.e2
    • Toprak D, Davis C, Rosenfeld M
      Treating the Airway Consequences of Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction.
      31659732 Seminars in respiratory and critical care medicine, 2019 Dec. : 40(6)751-761
    • Rosenfeld M, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Chilvers M, Higgins M, Tian S, Cooke J, Davies JC, KLIMB study group.
      An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB).
      31053538 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019 Nov. : 18(6)838-843 PMCID:PMC6821553
    • Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC, Oropez CE, Rosenfeld M, Stanojevic S, Swanney MP, Thompson BR
      Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement.
      31613151 American journal of respiratory and critical care medicine, 2019 Oct. 15 : 200(8)e70-e88 PMCID:PMC6794117
    • Ratjen F, Davis SD, Stanojevic S, Kronmal RA, Hinckley Stukovsky KD, Jorgensen N, Rosenfeld M, SHIP Study Group.
      Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.
      31178421 The Lancet. Respiratory medicine, 2019 Sept. : 7(9)802-809
    • Hannah WB, DeBrosse S, Kinghorn B, Strausbaugh S, Aitken ML, Rosenfeld M, Wolf WE, Knowles MR, Zariwala MA
      The expanding phenotype of OFD1-related disorders: Hemizygous loss-of-function variants in three patients with primary ciliary dyskinesia.
      31373179 Molecular genetics & genomic medicine, 2019 Sept. : 7(9)e911 PMCID:PMC6732318
    • Kinghorn B, Fretts AM, O'Leary RA, Karr CJ, Rosenfeld M, Best LG
      Socioeconomic and Environmental Risk Factors for Pediatric Asthma in an American Indian Community.
      31103883 Academic pediatrics, 2019 Aug. : 19(6)631-637
    • Fink AK, Graff G, Byington CL, Loeffler DR, Rosenfeld M, Saiman L
      Palivizumab and Long-term Outcomes in Cystic Fibrosis.
      31239289 Pediatrics, 2019 July : 144(1)
    • Hopkinson NS, Hart N, Jenkins G, Rosenfeld M, Smyth AR, Wilkinson AJK, Kaminski N
      Climate change and lung health: presidential failure, professional responsibility.
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      Few Patient, Treatment, and Diagnostic or Microbiological Factors, Except Complications and Intermittent Negative Cerebrospinal Fluid (CSF) Cultures During First CSF Shunt Infection, Are Associated With Reinfection.
      24567841 Journal of the Pediatric Infectious Diseases Society, 2014 March : 3(1)15-22 PMCID:PMC3933045
    • Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, Flannick J, Zhang J, Fuchsberger C, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL, Gottesman O, Lu Y, Ruderfer D, Stahl EA, Duan Q, Li Y, Durda P, Jiao S, Isaacs A, Hofman A, Bis JC, Correa A, Griswold ME, Jakobsdottir J, Smith AV, Schreiner PJ, Feitosa MF, Zhang Q, Huffman JE, Crosby J, Wassel CL, Do R, Franceschini N, Martin LW, Robinson JG, Assimes TL, Crosslin DR, Rosenthal EA, Tsai M, Rieder MJ, Farlow DN, Folsom AR, Lumley T, Fox ER, Carlson CS, Peters U, Jackson RD, van Duijn CM, Uitterlinden AG, Levy D, Rotter JI, Taylor HA, Gudnason V Jr, Siscovick DS, Fornage M, Borecki IB, Hayward C, Rudan I, Chen YE, Bottinger EP, Loos RJ, Sætrom P, Hveem K, Boehnke M, Groop L, McCarthy M, Meitinger T, Ballantyne CM, Gabriel SB, O'Donnell CJ, Post WS, North KE, Reiner AP, Boerwinkle E, Psaty BM, Altshuler D, Kathiresan S, Lin DY, Jarvik GP, Cupples LA, Kooperberg C, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, Tracy RP, Willer CJ, NHLBI Grand Opportunity Exome Sequencing Project.
      Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
      24507775 American journal of human genetics, 2014 Feb. 6 : 94(2)233-45 PMCID:PMC3928660
    • Simon TD, Pope CE, Browd SR, Ojemann JG, Riva-Cambrin J, Mayer-Hamblett N, Rosenfeld M, Zerr DM, Hoffman L
      Evaluation of microbial bacterial and fungal diversity in cerebrospinal fluid shunt infection.
      24421877 PloS one, 2014 : 9(1)e83229 PMCID:PMC3885436
    • Rosenthal EA, Ranchalis J, Crosslin DR, Burt A, Brunzell JD, Motulsky AG, Nickerson DA, NHLBI GO Exome Sequencing Project., Wijsman EM, Jarvik GP
      Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.
      24268658 American journal of human genetics, 2013 Dec. 5 : 93(6)1035-45 PMCID:PMC3852929
    • Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F
      Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.
      24094744 American journal of human genetics, 2013 Oct. 3 : 93(4)672-86 PMCID:PMC3791264

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  • Presentations Title Event Location Date
    Digital health monitoring: Beyond heart rates and pedometers Association for Women in Science 30th anniversary meeting Seattle, WA Feb. 18, 2015
    Home spirometry: whats on the horizon North American Cystic Fibrosis Conference Atlanta, GA Oct. 2014
    Clinical trials in preschool children with CF European Cystic Fibrosis Conference Gothenburg, Sweden June 14, 2014
    Survey of clinical infant lung function testing practices. International Symposium on Respiratory Disease Shanghai, China Nov. 9, 2013
    Early CF Lung Disease: Diagnosis, Treatment and Prevention Duke University School of Medicine Nov. 28, 2012
    Pulmonary Exacerbation as a Clinical Trial Endpoint: The Pros and Cons North American CF Conference Orlando, FL Oct. 2012
    Designing Investigator Initiated Trials Presentation In symposium "Multidisciplinary Approach to Investigator-initiated Trials," North American CF Conference Orlando, FL Oct. 2012
    Pulmonary and Nutritional Consequences of CF in the First 6 Years of Life presentation in symposium "After the Newborn Screen: What to Do Next?" North American CF Conference Orlando, FL Oct. 2012
    What lung function test is best for managing young children with CF talk in session "Is it time to bring pre-school lung function testing to the clinic? Update from the ATS/ERS Task Force" European Respiratory Society Congress Vienna, Austria Sept. 2012
    Writing Your First Grant ITHS career development series, University of Washington Seattle, WA Oct. 30, 2009
    Successful Transition to an Academic Career half-day SCH Fellows’ College workshop unknown Oct. 28, 2009
    Risk factors for early age at acquisition of Pseudomonas aeruginosa North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009
    Newborn screening North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009
    Pulmonary Exacerbations: How do we define them Symposium presentation, North American Cystic Fibrosis Conference Minneapolis, MN Oct. 16, 2009
    Comparison of published pulmonary exacerbation definitions Cystic Fibrosis Foundation Workshop on Pulmonary Exacerbations Bethesda, MD Sept. 9, 2009
    Guidelines for Care of theGuidelines for Care of the Infant with CF Infant with CF Cystic Fibrosis annual Northwest regional conference, Center for Urban Horticulture unknown July 24, 2009
    Risk factors for early Pseudomonas acquisition Cystic Fibrosis Epidemiology/Biostatistics Working Group annual meeting, Center for Urban Horticulture unknown July 23, 2009
    Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia and recurrernt wheezing in children under 6 years of age American Thoracic Society annual convention San Diego, CA May 12, 2009
    unknown ITHS Career Development Seminar- Career Development (K Award) Seminar unknown Jan. 29, 2009

Overview

Board Certification(s)

Pediatric Pulmonology

Medical/Professional School

University of Washington, Seattle, WA
Harvard Medical School, Boston, MA

Clinical Interests

Diagnosis and management of all pediatric lung conditions

Research Description

Multicenter observational studies and investigator-initiated clinical trials in cystic fibrosis emphasizing early CF lung disease. Multicenter observational studies in primary ciliary dyskinesia. Mobile health applications and remote monitoring, including home spirometry. Development of outcome measures for clinical trials, including home spirometry, home cough monitoring, infant and preschool lung function tests. Global health, including mobile health tools for diagnosis of respiratory distress and pneumonia in low resource settings

Research Focus Area

Translational research, observational studies, investigator-initiated interventional studies, Therapeutic Trials