Margaret Rosenfeld, MD, MPH

Margaret Rosenfeld, MD, MPH

Pulmonary, Cystic Fibrosis Research, Cystic Fibrosis Program, Primary Ciliary Dyskinesia and Bronchiectasis Clinic

On staff since May 1995

Children's Title: Professor and Associate Vice-Chair for Clinical Research, Department of Pediatrics

Research Center: Center for Clinical and Translational Research

  • Margaret Rosenfeld, MD, MPH, is attending physician at Seattle Children's Hospital, Professor in the Department of Pediatrics at the University of Washington School of Medicine and Adjunct Professor in the Department of Epidemiology at the University of Washington School of Public Health. She is Associate Vice Chair for Clinical Research in the Department of Pediatrics and Co-Director of the Center for Clinical and Translational Research at the Seattle Children's Research Institute. 

    Her clinical interests focus on the diagnosis and management of respiratory illnesses in children of all ages, working closely with families. She serves as CF consultant to the Washington State Newborn Screening Program. Her research program focuses on NIH and foundation-sponsored multicenter observational and interventional studies in pediatric chronic lung diseases, including cystic fibrosis and primary ciliary dyskinesia. She also conducts research on mobile health tools for respiratory diseases including home spirometry.

    • Chelsea Bothell, WA 09.13.17

      We met with Dr. Rosenfeld to follow up after our toddler's recent admission for Reactive Airway Disease. She was warm, knowledgeable, and spent plenty of time with us answering our questions. She validated our concerns/fears and gave us good insight into his condition. We felt confidence in the plan of action after the appointment. We feel really grateful to have her as part of our son's medical team.

    • Ellisa Chehalis, WA 03.21.11

      We first saw Dr. Rosenfeld when our child was very young, around 4 months old. We were seeing her to determine if our child had PCD. She was very caring, thourough, and was willing to sit and answer all our questions as long as we needed. She has continued caring for our child, who is now 2. We are so greatful to have such a knowledgable Doctor taking care of our child and helping us prevent future health problems and research this rare pulmonary disorder. We highly recommend her. Ellisa Alderson

    Recommend Margaret Rosenfeld, MD, MPH
  • Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    Finalist, UW School of Medicine Mentoring Award 2016
    Finalist, UW School of Medicine Mentoring Award 2013
    Finalist, UW School of Medicine Mentoring Award 2010
    Physician Scientist Fellowship Award Glaxo Corporation 1993
    Leroy Matthews Physician Scientist Award Cystic Fibrosis Foundation 1992 - 1998

  • Manuscripts in Refereed Journals

    • Pope CE, Vo AT, Hayden HS, Weiss EJ, Durfey S, McNamara S, Ratjen A, Grogan B, Carter S, Nay L, Parsek MR, Singh PK, McKone EF, Aitken ML, Rosenfeld MR, Hoffman LR
      Changes in fecal microbiota with CFTR modulator therapy: A pilot study.
      J Cyst Fibros, 2020 : 20(5)742-746
      https://pubmed.ncbi.nlm.nih.gov/33390317/
    • Beydon N, Gochicoa L, Jones MJ, Lands LC, Lombardi E, Rosenfeld M, Sly P, Weiner DJ, Yilmaz O
      Pediatric lung function testing during a pandemic: An international perspective
      Paediatr Respir Rev, 2020 Oct. 11 : 36106-108 PMCID:PMC7548117
      https://pubmed.ncbi.nlm.nih.gov/33160838/
    • Fink AK, Graff G, Byington CL, Loeffler DR, Rosenfeld M, Saiman L. Palivizumab and Long-term Outcomes in Cystic Fibrosis.
      Palivizumab and Long-term Outcomes in Cystic Fibrosis
      Pediatrics, 2019
    • Ratjen F, Davis SD, Stanojevic S, Kronmal RA, Hinckley Stukovsky KD, Jorgensen N, Rosenfeld M; SHIP Study Group
      Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.
      Lancet Respir Med, 2019
    • Sanders DB, Ostrenga JS, Rosenfeld M, Fink AK, Schechter MS, Sawicki GS, Flume PA, Morgan WJ
      Predictors of pulmonary exacerbation treatment in cystic fibrosis.
      J Cyst Fibros, 2019
    • Rosenfeld M, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Chilvers M, Higgins M, Tian S, Cooke J, Davies JC; KLIMB study group
      An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB).
      J Cyst Fibros, 2019
    • Davis SD, Rosenfeld M, Lee HS, Ferkol TW, Sagel SD, Dell SD, Milla C, Pittman JE, Shapiro AJ, Sullivan KM, Nykamp KR, Krischer JP, Zariwala MA, Knowles MR, Leigh MW; and Genetic Disorders of Mucociliary Clearance Consortium
      Primary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype.
      Am J Respir Crit Care Med, 2018
    • Chi DL, Rosenfeld M, Manci L, Chung WO, Presland RB, Sarvas E, Rothen M, Alkhateeb A, McNamara S, Genatossio A, Virella-Lowell I, Milla C, Scott J
      Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study
      J Cyst Fibros, 2018
    • Mayer-Hamblett N, Retsch-Bogart G, Kloster M, Accurso F, Rosenfeld M, Albers G, Black P, Brown P, Cairns A, Davis S, Graff G, Kerby G, Orenstein D, Buckingham R, Ramsey B, for the OPTIMIZE Study Group
      Azithromycin for Early Pseudomonas Infection in Cystic Fibrosis: The Optimize Randomized Trial
      Annals of the American Thoracic Society, 2018
    • Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, Pittman JE, Daniels MLA, Jones MH, Janahi IA, Ware SM, Daniel SJ, Cooper ML, Nogee LM, Anton B, Eastvold T, Ehrne L, Guadagno E, Knowles MR, Leigh MW, Lavergne V
      Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.
      Am J Respir Crit Care Med, 2018 : e24-e39
    • Rosenfeld M, Wainwright CE, Higgins M, Wang LT, McKee C, Campbell D, Schneider J, Cunningham S, Davies JC, ARRIVAL study group
      Ivacaftor treatment in children 12 to <24 months old with cystic fibrosis and a CFTR gating mutation: results from the a phase 3 single-arm study
      Lancet Respir Med, 2018 : 30202-9
    • Rosenfeld M, VanDevanter DR, Ren CL, Elkin EP, Pasta DJ, Konstan MW, Morgan WJ
      Decline in Lung Function Does not Predict Future Decline in Lung Function in Cystic Fibrosis Patients
      Pediatr Pulmonol, 2018
    • Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld M
      Changes in Lung Clearance Index in Preschool Cystic Fibrosis Patients Treated with Ivacaftor
      Am J Respir Crit Care Med, 2018
    • Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen F
      ATS Assembly on Pediatrics. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement
      Am J Respir Crit Care Med, 2018
    • Cogen JD, Onchiri F, Emerson J, Gibson RL, Hoffman LR, Nichols DP, Rosenfeld M
      Chronic Azithromycin Use in Cystic Fibrosis and Risk of Treatment-Emergent Respiratory Pathogens
      Ann Am Thorac Soc, 2018
    • Edwards TC, Emerson J, Genatossio A, McNamara S, Onchiri F, Goss C, Patrick DL, Rosenfeld M
      Initial Development and Pilot Testing of Observer-Reported Outcomes (ObsROs) for Children with Cystic Fibrosis Ages 0-11 Years
      J Cyst Fibros, 2018
    • Sawicki GS, Ostrenga J, Petren K, Fink AK, D'Agostino E, Strassle C, Schechter MS, Rosenfeld M
      Risk Factors for Gaps in Care during Transfer from Pediatric to Adult Cystic Fibrosis Programs in the United States.
      Ann Am Thorac Soc, 2017
    • Culver B, Graham B, Coates A, Wanger J, Berry C, Clarke P, Hallstrand T, Hankinson J, Kaminsky D, MacIntyre N, McCormack M, Rosenfeld M, Stanojevic S, Weiner D
      Recommendations for a Standardized Pulmonary Function Report - An ATS Technical Statement
      Am J Resp Crit Care Med , 2017 : 1463-1472
    • Heltshe SL, Khan U, Beckett V, Baines A, Emerson J, Sanders DB, Gibson RL, Morgan W, Rosenfeld M
      Longitudinal development of initial, chronic and mucoid Pseudomonas aeruginosa infection in young children with cystic fibrosis.
      J Cyst Fibros, 2017
    • Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, Milla CE, Robinson PD, Waltz D, Davies JC; VX14-809-109 investigator group; Rosenfeld M
      Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial
      Lancet Respir Med, 2017 : 557-567
    • Psoter KJ, DeRoos AJ, Wakefield J, Mayer J, Rosenfeld M
      Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis
      BMC Pulm Med, 2017 : 106
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld M
      Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis
      BMC Infect Dis, 2017 : 411
    • Otjen JP, Swanson JO, Oron A, DiBlasi RM, Swortzel T, Van Well J, Gommers E, Rosenfeld M
      Spirometry-assisted HRCT in children: Is it worth the effort? Current Problems in Diagnostic Radiology
      Curr Probl Diagn Radiol, 2017 : 30164-5
    • Cogen J, Oron A, Gibson RL, Hoffman L, Kronman M, Ong T, Rosenfeld M
      Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations
      Pediatrics, 2017 : 139(2)
    • Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M, Sermet-Gaudelus I, Southern KW, Marshall BC, Sosnay PR
      Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation
      J Pediatr, 2017
    • Ong T, Schechter M, Yang J, Peng L, Emerson J, Gibson RL, Morgan W, Rosenfeld M for the EPIC Study Group
      Socioeconomic Status and Environmental Tobacco Smoke Impact on Lung Outcomes in Cystic Fibrosis
      Pediatrics, 2017 : 139(2)
    • Farrell PM, White TB, Howenstine MS, Munck A, Parad RB, Rosenfeld M, Sommerburg O, Accurso FJ, Davies JC, Rock MJ, Sanders DB, Wilschanski M, Sermet-Gaudelus I, Blau H, Gartner S, McColley SA
      Diagnosis of Cystic Fibrosis in Screened Populations
      J Pediatr , 2017
    • Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MR
      Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents.
      Ann Am Thorac Soc, 2016 : 1305-13
    • Lahiri T, Hempstead SE, Brady C, Cannon C, Clark K, Condren ME, Guill MF, Guillerman RP, Leone CG, Maguiness K, Rosenfeld M, Schwarzenberg SJ, Tompkins CL, Zemanick ET, Davis SD
      Clinical Practice Guidelines for Preschoolers with Cystic Fibrosis
      Journal of Pediatrics, 2016 : 137(4)
    • Leigh MW, Ferkol TW, Davis SD, Lai HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MZ, Pittman J, Shapiro AJ, Corson JS, Krischer J, Hazucha M, Knowles M
      Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents
      Ann Am Thoracic Society, 2016
    • Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD. Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW
      Diagnosis, Evaluation, and Treatment of Primary Ciliary Dyskinesia:PCD Foundation Consensus Recommendations Based on State of the Art Review
      Pediatric Pediatr Pulmonol, 2016 : 115-32
    • Davies, JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GW, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld M
      An Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Patients Aged 2 to 5 Years with Cystic Fibrosis from a CFTR Gating Mutation: The KIWI Study
      Lancet Respir Med, 2016 : 107-15
    • Peterson-Carmichael S, Seddon P, Cheifetz I, Frerichs I, Hall GL, Hammer J, Hantos Z, van Kaam AH, McEvoy CT, Newth CJL. Pillow JJ, Rafferty GF, Rosenfeld M, Stocks J, Ranganathan S
      An Official ATS/ERS Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care Units
      Ann Am Thorac Soc, 2016 : S1-S11
    • Davis SD, Ratjen F, Brumback LC, Johnson RC, Filbrun AG, Kerby GS, Panitch HB, Donaldson SH, Rosenfeld M
      Infant lung function tests as endpoints in the ISIS multicenter clinical trial in cystic fibrosis
      J Cyst Fibros, 2015
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Bryan M, Rosenfeld M
      Association of meteorologic and geographic factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis
      Association of meteorologic and geographic factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis, 2015 : 1-9
    • Sanders DB, Fink A, Mayer-Hamblett N, Schechter MS, Sawicki GS, Rosenfeld M, Flume PA, Morgan WJ
      Early Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years
      J Pediatr, 2015
    • Sanders DB, Emerson J, Ren C, Schechter MS, Gibson RL, Morgan W, Rosenfeld M for the EPIC Study Group
      Early childhood risk factors for decreased FEV1 at age 6-7 years in young children with cystic fibrosis
      Ann Am Thorac Soc, 2015 : 1170-6
    • Ren C, Fink A, Petren K, Borowitz D, McColley S, Rosenfeld M, Sanders D, Marshall B
      Outcomes of Infants with Indeterminate Diagnosis Detected by Cystic Fibrosis Newborn Screening
      Pediatrics, 2015 : 2014-3698
    • Subbarao P, Milla C, Aurora P, Davies J, Davis S, Hall G, Heltshe S, Latzin P, Linblad A, Pittman J, Robinson P, Rosenfeld M, Singer F, Starner T, Ratjen F, Morgan W
      Multiple Breath Washout as a Lung Function Test in Cystic Fibrosis: Ready for Prime Time?
      Ann Am Thorac Soc, 2015 : 932-9
    • Cogen J, Sanders DB, Ren C, Schechter M, Emerson J, Gibson R, Morgan W, Rosenfeld M for the EPIC Study Group
      Risk factors for lung function decline in a large cohort of young cystic fibrosis patients
      Pediatr Pulmonol, 2015 : 763-70
    • Schechter MS, Regelmann W, Sawicki GS, Rasouliyan L, VanDeVanter DR, Rosenfeld M, Pasta D, Morgan W, Konstan MW
      Antibiotic treatment of pulmonary exacerbations: a comparison by care site
      Pediatr Pulmonol, 2015 : 431-40
    • Psoter KJ, De Roos AJ, Mayer JD, Kaufman JD, Wakefield J, Rosenfeld M
      Fine particular matter exposure and initial Pseudomonas aeruginosa acquisition in cystic fibrosis
      Ann Am Thorac Soc, 2015 : 385-91
    • Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MW
      Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype
      Am J Respir Crit Care Med, 2015 : 316- 24
    • Zemanick ET, Emerson J, Thompson V, McNamara Sh, Morgan W, Gibson RL, Rosenfeld M for the EPIC Study Group
      Clinical outcomes after initial Pseudomonas acquisition in cystic fibrosis
      Pediatric Pulmonology, 2015 : 42-8
    • Mogayzel PJ Jr, Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, Rosenfeld M, Simon RH, Hazle L, Sabadosa K, Marshall BC
      Cystic Fibrosis Foundation Pulmonary Clinical Practice Guidelines Committee. Cystic Fibrosis Foundation pulmonary guideline. pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection.
      Ann Am Thorac Soc, 2014 : 1640-50
    • Alpern AN, Brumback LC, Ratjen F, Rosenfeld M, Davis SD, Quittner AL
      Initial validation of the Parent Cystic Fibrosis Questionnaire-Revised (CFQ-R) in infants and young children. Journal of Cystic Fibrosis
      Journal of Cystic Fibrosis , 2014
    • Mayer-Hamblett N, Ramsey BW, Kulasekara HD, Wolter DJ, Houston LS, Pope CE, Kulasekara BR, Armbruster CR, Burns JL, Retsch-Bogart G, Rosenfeld M, Gibson RL, Miller SI, Khan U, Hoffman LR
      Pseudomonas aeruginosa phenotypes associated with eradication failure in children with cystic fibrosis
      Clin Infect Dis , 2014 : 624-31
    • Daines C, VanDeVanter D, Khan U, Emerson J, Heltshe S, McNamara S, Anstead M, Langkamp M, Doring G, Ratjen F, Ramsey B, Gibson RL, Morgan W, Rosenfeld M; EPIC Investigators
      Serology as a diagnostic tool for predicting initial Pseudomonas aeruginosa acquisition in children with cystic fibrosis
      J Cyst Fibros , 2014 : 542-9
    • Mayer-Hamblett N, Rosenfeld M, Gibson RL, Ramsey BW, Kulasekara HD, Retsch-Bogart GZ, Morgan W, Wolter DJ, Pope CE, Houston LS, Kulasekara BR, Khan U, Burns JL,Milller SI, Hoffman LR
      Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes
      Am J Respir Crit Care Med, 2014 : 289-97
    • Psoter KJ, Rosenfeld M, De Roos AJ, Mayer JD, Wakefield J
      Differential Geographical Risk of Initial Pseudomonas aeruginosa Acquisition in Young U.S. Children with Cystic Fibrosis
      American Journal of Epidemiology , 2014 June : 1503-13
    • Stanojevic, S., Stocks, J., Bountziouka, V,. Aurora, P., Kirkby, J., Bourke, S., Carr, S.B., Gunn, E., Prasad, A., Rosenfeld, M., Bilton, D
      The Impact of switching to the new Global Lung Function Initiative Equations on Spirometry Results in the UK CF Registry
      Journal of Cystic Fibrosis, 2014 May : 319-27
    • Brumback LC, Baines A, Ratjen F, Davis SD, Daniel SL, Quittner AL, Rosenfeld M; for the ISIS Study Group
      Pulmonary exacerbations and parent-reported outcomes in children <6 years with cystic fibrosis.
      Pediatr Pulmonol, 2014
    • Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR; the Genetic Disorders of Mucociliary Clearance Consortium
      Standardizing Nasal Nitric Oxide Measurement as a Test for Primary Ciliary Dyskinesia
      12406843 Ann Am Thorac Soc, 2013 Dec. : 574-81

    Other Publications

    • Davis CS, Faino AV, Onchiri F, Gibson RL, Merjaneh L, Ramsey BW, Rosenfeld M, Cogen JD
      Systemic Corticosteroids in the Management of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
      36044723 Annals of the American Thoracic Society, 2023 Jan. : 20(1)75-82
    • Sagel SD, Kupfer O, Wagner BD, Davis SD, Dell SD, Ferkol TW, Hoppe JE, Rosenfeld M, Sullivan KM, Tiddens HAWM, Knowles MR, Leigh MW
      Airway Inflammation in Children with Primary Ciliary Dyskinesia.
      35984413 Annals of the American Thoracic Society, 2023 Jan. : 20(1)67-74 PMCID:PMC9819265
    • Spurr R, Ng E, Onchiri FM, Rapha B, Nakatumba-Nabende J, Rosenfeld M, Najjingo I, Stout JW, Nantanda R, Ellington LE
      Performance and usability of a new mobile application for measuring respiratory rate in young children with acute lower respiratory infections.
      35996862 Pediatric pulmonology, 2022 Dec. : 57(12)3009-3016
    • Kinghorn B, Rosenfeld M, Sullivan E, Onchiri F, Ferkol TW, Sagel SD, Dell SD, Milla C, Shapiro AJ, Sullivan KM, Zariwala MA, Pittman JE, Mollica F, Tiddens HAWM, Kemner-van de Corput M, Knowles MR, Davis SD, Leigh MW, Genetic Disorders of Mucociliary Clearance Consortium
      Airway Disease in Children with Primary Ciliary Dyskinesia: Impact of Ciliary Ultrastructure Defect and Genotype.
      36442147 Annals of the American Thoracic Society, 2022 Nov. 28
    • Rayment JH, Asfour F, Rosenfeld M, Higgins M, Liu L, Mascia M, Paz-Diaz H, Tian S, Zahigian R, McColley SA
      A Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR.
      35771568 American journal of respiratory and critical care medicine, 2022 Nov. 15 : 206(10)1239-1247 PMCID:PMC9746849
    • Rayment JH, Asfour F, Rosenfeld M, Higgins M, Liu L, Mascia M, Paz-Diaz H, Tian S, Zahigian R, McColley SA
      A Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR.
      35771568 American journal of respiratory and critical care medicine, 2022 Nov. 15 : 206(10)1239-1247 PMCID:PMC9746849
    • Barber AT, Shapiro AJ, Davis SD, Ferkol TW, Atkinson JJ, Sagel SD, Dell SD, Olivier KN, Milla CE, Rosenfeld M, Li L, Lin FC, Sullivan KM, Capps NA, Zariwala MA, Knowles MR, Leigh MW, Genetic Disorders of Mucociliary Clearance Consortium (GDMCC)
      Laterality Defects in Primary Ciliary Dyskinesia: Relationship to Ultrastructural Defect or Genotype.
      36342963 Annals of the American Thoracic Society, 2022 Nov. 7
    • Wee WB, Leigh MW, Davis SD, Rosenfeld M, Sullivan KM, Sawras MG, Ferkol TW, Knowles MR, Milla C, Sagel SD, Zariwala MA, Pullenayegum E, Dell SD
      Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia.
      35657736 Annals of the American Thoracic Society, 2022 Nov. : 19(11)1865-1870 PMCID:PMC9667809
    • Schwarzenberg SJ, Vu PT, Skalland M, Hoffman LR, Pope C, Gelfond D, Narkewicz MR, Nichols DP, Heltshe SL, Donaldson SH, Frederick CA, Kelly A, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Solomon GM, Stalvey MS, Clancy JP, Rowe SM, Freedman SD, Promise Study Group
      Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI.
      36280527 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022 Oct. 21
    • Aksit MA, Ling H, Pace RG, Raraigh KS, Onchiri F, Faino AV, Pagel K, Pugh E, Stilp AM, Sun Q, Blue EE, Wright FA, Zhou YH, Bamshad MJ, Gibson RL, Knowles MR, Cutting GR, Blackman SM, CF Genome Project
      Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis.
      36206743 American journal of human genetics, 2022 Oct. 6 : 109(10)1894-1908 PMCID:PMC9606479
    • Rosenfeld M, Ostrenga J, Cromwell EA, Magaret A, Szczesniak R, Fink A, Schechter MS, Faro A, Ren CL, Morgan W, Sanders DB
      Real-world Associations of US Cystic Fibrosis Newborn Screening Programs With Nutritional and Pulmonary Outcomes.
      35913705 JAMA pediatrics, 2022 Oct. 1 : 176(10)990-999 PMCID:PMC9344390
    • Zhai J, Emond MJ, Spangenberg A, Stern DA, Vasquez MM, Blue EE, Buckingham KJ, Sherrill DL, Halonen M, Gibson RL, Rosenfeld M, Sagel SD, Bamshad MJ, Morgan WJ, Guerra S
      Club cell secretory protein and lung function in children with cystic fibrosis.
      35367162 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022 Sept. : 21(5)811-820 PMCID:PMC9509401
    • Rice JD, Johnson RL, Juarez-Colunga E, Zemanick ET, Rosenfeld M, Wagner BD
      Application of gap time analysis with flexible hazards to pulmonary exacerbations in the EPIC observational study.
      35434808 Biometrical journal. Biometrische Zeitschrift, 2022 Aug. : 64(6)1075-1089
    • Cogen JD, Faino AV, Onchiri F, Gibson RL, Hoffman LR, Nichols DP, Rosenfeld M, Kronman MP
      Clinical Outcomes of Antipseudomonal versus Other Antibiotics among Children with Cystic Fibrosis without Pseudomonas aeruginosa.
      35289740 Annals of the American Thoracic Society, 2022 Aug. : 19(8)1320-1327
    • Rosenfeld M, Ratjen F
      COMBATing airway inflammation in infants with cystic fibrosis.
      35662407 The Lancet. Respiratory medicine, 2022 Aug. : 10(8)727-729
    • Kingston H, Stilp AM, Gordon W, Broome J, Gogarten SM, Ling H, Barnard J, Dugan-Perez S, Ellinor PT, Gabriel S, Germer S, Gibbs RA, Gupta N, Rice K, Smith AV, Zody MC, Cystic Fibrosis Genome Project, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Blackman SM, Cutting G, Knowles MR, Zhou YH, Rosenfeld M, Gibson RL, Bamshad M, Fohner A, Blue EE
      Accounting for population structure in genetic studies of cystic fibrosis.
      35647563 HGG advances, 2022 July 14 : 3(3)100117 PMCID:PMC9136666
    • Stanojevic S, Kaminsky DA, Miller MR, Thompson B, Aliverti A, Barjaktarevic I, Cooper BG, Culver B, Derom E, Hall GL, Hallstrand TS, Leuppi JD, MacIntyre N, McCormack M, Rosenfeld M, Swenson ER
      ERS/ATS technical standard on interpretive strategies for routine lung function tests.
      34949706 The European respiratory journal, 2022 July : 60(1)
    • Tiddens HAWM, Chen Y, Andrinopoulou ER, Davis SD, Rosenfeld M, Ratjen F, Kronmal RA, Hinckley Stukovsky KD, Dasiewicz A, Stick SM, SHIP-CT Study Group
      The effect of inhaled hypertonic saline on lung structure in children aged 3-6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial.
      35286860 The Lancet. Respiratory medicine, 2022 July : 10(7)669-678
    • Nichols DP, Paynter AC, Heltshe SL, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Clancy JP, Kirby S, Van Dalfsen JM, Kloster MH, Rowe SM, PROMISE Study group
      Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial.
      34784492 American journal of respiratory and critical care medicine, 2022 March 1 : 205(5)529-539 PMCID:PMC8906485
    • Cogen JD, Onchiri FM, Hamblett NM, Gibson RL, Morgan WJ, Rosenfeld M
      Association of Intensity of Antipseudomonal Antibiotic Therapy With Risk of Treatment-Emergent Organisms in Children With Cystic Fibrosis and Newly Acquired Pseudomonas Aeruginosa.
      33693586 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 Sept. 15 : 73(6)987-993
    • Rosenfeld M, Faino AV, Onchiri F, Aksit MA, Blackman SM, Blue EE, Collaco JM, Gordon WW, Pace RG, Raraigh KS, Zhou YH, Cutting GR, Knowles MR, Bamshad MJ, Gibson RL
      Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis.
      34393091 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021 Aug. 12
    • Graustein AD, Berrington WR, Buckingham KJ, Nguyen FK, Joudeh LL, Rosenfeld M, Bamshad MJ, Gibson RL, Hawn TR, Emond MJ
      Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.
      33848452 American journal of respiratory cell and molecular biology, 2021 Aug. : 65(2)157-166 PMCID:PMC8399576
    • Ellington LE, Najjingo I, Rosenfeld M, Stout JW, Farquhar SA, Vashistha A, Nekesa B, Namiya Z, Kruse AJ, Anderson R, Nantanda R
      Health workers' perspectives of a mobile health tool to improve diagnosis and management of paediatric acute respiratory illnesses in Uganda: a qualitative study.
      34281930 BMJ open, 2021 July 19 : 11(7)e049708 PMCID:PMC8291301
    • Cogen JD, Faino AV, Onchiri F, Hoffman LR, Kronman MP, Nichols DP, Rosenfeld M, Gibson RL
      Association Between Number of Intravenous Antipseudomonal Antibiotics and Clinical Outcomes of Pediatric Cystic Fibrosis Pulmonary Exacerbations.
      34100912 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021 June 8
    • Merjaneh L, Toprak D, McNamara S, Nay L, Sullivan E, Rosenfeld M
      Acute hyperglycaemia in cystic fibrosis pulmonary exacerbations.
      33855211 Endocrinology, diabetes & metabolism, 2021 April : 4(2)e00208 PMCID:PMC8029509
    • Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM
      PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy.
      33619012 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021 March : 20(2)205-212
    • Banks JT, Rosenfeld M, Mancl L, Chi DL
      Survey and electronic health record-based medication use agreement in children with cystic fibrosis: A retrospective cross-sectional study.
      32936971 International journal of paediatric dentistry, 2021 March : 31(2)247-253
    • Davies JC, Wainwright CE, Sawicki GS, Higgins MN, Campbell D, Harris C, Panorchan P, Haseltine E, Tian S, Rosenfeld M
      Ivacaftor in Infants Aged 4 to <12 Months with Cystic Fibrosis and a Gating Mutation. Results of a Two-Part Phase 3 Clinical Trial.
      33023304 American journal of respiratory and critical care medicine, 2021 March 1 : 203(5)585-593 PMCID:PMC7924576
    • Taylor JB, Oermann CM, Deterding RR, Redding G, Davis SD, Piccione J, Moore PE, Kupfer O, Santiago MT, Rosenfeld M, Ingram DG, Ross K, DeBoer EM
      Innovating and adapting in pediatric pulmonology and sleep medicine during the COVID-19 pandemic: ATS pediatric assembly web committee consensus statement for initial COVID-19 virtual response.
      33300286 Pediatric pulmonology, 2021 Feb. : 56(2)539-550
    • Cogen JD, Faino AV, Onchiri F, Gibson RL, Hoffman LR, Kronman MP, Rosenfeld M, Nichols DP
      Effect of Concomitant Azithromycin and Tobramycin Use on Cystic Fibrosis Pulmonary Exacerbation Treatment.
      32810412 Annals of the American Thoracic Society, 2021 Feb. : 18(2)266-272 PMCID:PMC7869777
    • Cogen JD, Faino AV, Onchiri F, Hoffman LR, Kronman MP, Nelson M, Nichols DP, Rosenfeld M, VanDevanter DR, Gibson RL
      Association of Inhaled Antibiotics in Addition to Standard Intravenous Therapy and Outcomes of Pediatric Inpatient Pulmonary Exacerbations.
      32726564 Annals of the American Thoracic Society, 2020 Dec. : 17(12)1590-1598 PMCID:PMC7924435
    • Hoppe JE, Hinds DM, Colborg A, Wagner BD, Morgan WJ, Rosenfeld M, Zemanick ET, Sanders DB
      Oral antibiotic prescribing patterns for treatment of pulmonary exacerbations in two large pediatric CF centers.
      32970375 Pediatric pulmonology, 2020 Dec. : 55(12)3400-3406
    • Wilson KC, Kaminsky DA, Michaud G, Sharma S, Nici L, Folz RJ, Barjaktarevic I, Bhakta NR, Cheng G, Chupp GL, Cole A, Dixon AE, Finigan JH, Graham B, Hallstrand TS, Haynes J, Hankinson J, MacIntyre N, Mandel J, McCarthy K, McCormack M, Patil SP, Rosenfeld M, Senitko M, Sethi S, Swenson ER, Stanojevic S, Teodorescu M, Weiner DJ, Wiener RS, Powell CA
      Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens. From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force.
      32663071 Annals of the American Thoracic Society, 2020 Nov. : 17(11)1343-1351 PMCID:PMC7640724
    • Rosenfeld M, Rayner O, Smyth AR
      Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.
      32997797 The Cochrane database of systematic reviews, 2020 Sept. 30 : 9CD001912 PMCID:PMC8430459
    • Kinghorn B, McNamara S, Genatossio A, Sullivan E, Siegel M, Bauer I, Clem C, Johnson RC, Davis M, Griffiths A, Wheeler W, Johnson K, Davis SD, Leigh MW, Rosenfeld M, Pittman J
      Comparison of Multiple Breath Washout and Spirometry in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis and Healthy Controls.
      32603187 Annals of the American Thoracic Society, 2020 Sept. : 17(9)1085-1093 PMCID:PMC7462330
    • Sanders DB, Ostrenga JS, Rosenfeld M, Fink AK, Schechter MS, Sawicki GS, Flume PA, Morgan WJ
      Predictors of pulmonary exacerbation treatment in cystic fibrosis.
      31257102 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020 May : 19(3)407-414 PMCID:PMC6940539
    • Toprak D, Nay L, McNamara S, Rosenberg AR, Rosenfeld M, Yi-Frazier JP
      Resilience in adolescents and young adults with cystic fibrosis: A pilot feasibility study of the promoting resilience in stress management intervention.
      31794160 Pediatric pulmonology, 2020 March : 55(3)638-645
    • Juarez-Colunga E, Rosenfeld M, Zemanick ET, Wagner B
      Application of multiple event analysis as an alternative approach to studying pulmonary exacerbations as an outcome measure.
      30642785 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020 Jan. : 19(1)114-118 PMCID:PMC8127951
    • Suthoff E, Mainz JG, Cox DW, Thorat T, Grossoehme DH, Fridman M, Sawicki GS, Rosenfeld M
      Caregiver Burden Due to Pulmonary Exacerbations in Patients with Cystic Fibrosis.
      31761140 The Journal of pediatrics, 2019 Dec. : 215164-171.e2
    • Toprak D, Davis C, Rosenfeld M
      Treating the Airway Consequences of Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction.
      31659732 Seminars in respiratory and critical care medicine, 2019 Dec. : 40(6)751-761
    • Rosenfeld M, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Chilvers M, Higgins M, Tian S, Cooke J, Davies JC, KLIMB study group.
      An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB).
      31053538 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019 Nov. : 18(6)838-843 PMCID:PMC6821553
    • Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC, Oropez CE, Rosenfeld M, Stanojevic S, Swanney MP, Thompson BR
      Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement.
      31613151 American journal of respiratory and critical care medicine, 2019 Oct. 15 : 200(8)e70-e88 PMCID:PMC6794117
    • Ratjen F, Davis SD, Stanojevic S, Kronmal RA, Hinckley Stukovsky KD, Jorgensen N, Rosenfeld M, SHIP Study Group.
      Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.
      31178421 The Lancet. Respiratory medicine, 2019 Sept. : 7(9)802-809
    • Hannah WB, DeBrosse S, Kinghorn B, Strausbaugh S, Aitken ML, Rosenfeld M, Wolf WE, Knowles MR, Zariwala MA
      The expanding phenotype of OFD1-related disorders: Hemizygous loss-of-function variants in three patients with primary ciliary dyskinesia.
      31373179 Molecular genetics & genomic medicine, 2019 Sept. : 7(9)e911 PMCID:PMC6732318
    • Kinghorn B, Fretts AM, O'Leary RA, Karr CJ, Rosenfeld M, Best LG
      Socioeconomic and Environmental Risk Factors for Pediatric Asthma in an American Indian Community.
      31103883 Academic pediatrics, 2019 Aug. : 19(6)631-637
    • Fink AK, Graff G, Byington CL, Loeffler DR, Rosenfeld M, Saiman L
      Palivizumab and Long-term Outcomes in Cystic Fibrosis.
      31239289 Pediatrics, 2019 July : 144(1)
    • Hopkinson NS, Hart N, Jenkins G, Rosenfeld M, Smyth AR, Wilkinson AJK, Kaminski N
      Climate change and lung health: presidential failure, professional responsibility.
      31010935 Thorax, 2019 July : 74(7)627-628
    • Szczesniak RD, Cogen JD, Rosenfeld M
      Associating antimicrobial susceptibility testing with clinical outcomes in cystic fibrosis: More rigor and less frequency?
      30824378 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019 March : 18(2)159-160 PMCID:PMC7020339
    • Davis SD, Rosenfeld M, Lee HS, Ferkol TW, Sagel SD, Dell SD, Milla C, Pittman JE, Shapiro AJ, Sullivan KM, Nykamp KR, Krischer JP, Zariwala MA, Knowles MR, Leigh MW
      Primary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype.
      30067075 American journal of respiratory and critical care medicine, 2019 Jan. 15 : 199(2)190-198 PMCID:PMC6353004
    • Chi DL, Rosenfeld M, Mancl L, Chung WO, Presland RB, Sarvas E, Rothen M, Alkhateeb A, McNamara S, Genatossio A, Virella-Lowell I, Milla C, Scott J
      Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study.
      30005828 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2018 Nov. : 17(6)747-759 PMCID:PMC6589399
    • Mayer-Hamblett N, Retsch-Bogart G, Kloster M, Accurso F, Rosenfeld M, Albers G, Black P, Brown P, Cairns A, Davis SD, Graff GR, Kerby GS, Orenstein D, Buckingham R, Ramsey BW, OPTIMIZE Study Group.
      Azithromycin for Early Pseudomonas Infection in Cystic Fibrosis. The OPTIMIZE Randomized Trial.
      29890086 American journal of respiratory and critical care medicine, 2018 Nov. 1 : 198(9)1177-1187 PMCID:PMC6221579
    • Rosenthal EA, Shirts BH, Amendola LM, Horike-Pyne M, Robertson PD, Hisama FM, Bennett RL, Dorschner MO, Nickerson DA, Stanaway IB, Nassir R, Vickers KT, Li C, Grady WM, Peters U, Jarvik GP, NHLBI GO Exome Sequencing Project.
      Rare loss of function variants in candidate genes and risk of colorectal cancer.
      30267214 Human genetics, 2018 Oct. : 137(10)795-806 PMCID:PMC6283057
    • Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld M
      Changes in Lung Clearance Index in Preschool-aged Patients with Cystic Fibrosis Treated with Ivacaftor (GOAL): A Clinical Trial.
      29614238 American journal of respiratory and critical care medicine, 2018 Aug. 15 : 198(4)526-528 PMCID:PMC6835087
    • Culver BH, Graham BL, MacIntyre NR, McCormack M, Kaminsky DA, Coates AL, Weiner DJ, Rosenfeld M, Wanger J, ATS Committee on Proficiency Standards for Pulmonary Function Laboratories.
      Reply to Johnson: Improve Pulmonary Function Test Reporting.
      29533673 American journal of respiratory and critical care medicine, 2018 July 1 : 198(1)138-139
    • Rosenfeld M, Wainwright CE, Higgins M, Wang LT, McKee C, Campbell D, Tian S, Schneider J, Cunningham S, Davies JC, ARRIVAL study group.
      Ivacaftor treatment of cystic fibrosis in children aged 12 to <24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study.
      29886024 The Lancet. Respiratory medicine, 2018 July : 6(7)545-553 PMCID:PMC6626762
    • Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, Pittman JE, Daniels MLA, Jones MH, Janahi IA, Ware SM, Daniel SJ, Cooper ML, Nogee LM, Anton B, Eastvold T, Ehrne L, Guadagno E, Knowles MR, Leigh MW, Lavergne V, American Thoracic Society Assembly on Pediatrics.
      Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.
      29905515 American journal of respiratory and critical care medicine, 2018 June 15 : 197(12)e24-e39 PMCID:PMC6006411
    • Cogen JD, Onchiri F, Emerson J, Gibson RL, Hoffman LR, Nichols DP, Rosenfeld M
      Chronic Azithromycin Use in Cystic Fibrosis and Risk of Treatment-Emergent Respiratory Pathogens.
      29474110 Annals of the American Thoracic Society, 2018 June : 15(6)702-709 PMCID:PMC6850787
    • Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen F, ATS Assembly on Pediatrics.
      Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement.
      29493315 American journal of respiratory and critical care medicine, 2018 March 1 : 197(5)e1-e19
    • Rosenfeld M, Ostrowski LE, Zariwala MA
      Primary ciliary dyskinesia: keep it on your radar.
      29133352 Thorax, 2018 Feb. : 73(2)101-102 PMCID:PMC6040643
    • Cogen JD, Rosenfeld M
      Treating Cystic Fibrosis Pulmonary Exacerbations: In the Hospital with a Physician or at Home under Your Own Supervision?
      29388818 Annals of the American Thoracic Society, 2018 Feb. : 15(2)169-170
    • Sawicki GS, Ostrenga J, Petren K, Fink AK, D'Agostino E, Strassle C, Schechter MS, Rosenfeld M
      Risk Factors for Gaps in Care during Transfer from Pediatric to Adult Cystic Fibrosis Programs in the United States.
      29220199 Annals of the American Thoracic Society, 2018 Feb. : 15(2)234-240
    • Hurley MN, Fogarty A, McKeever TM, Goss CH, Rosenfeld M, Smyth AR
      Early Respiratory Bacterial Detection and Antistaphylococcal Antibiotic Prophylaxis in Young Children with Cystic Fibrosis.
      29035090 Annals of the American Thoracic Society, 2018 Jan. : 15(1)42-48 PMCID:PMC5822417
    • Otjen JP, Swanson JO, Oron A, DiBlasi RM, Swortzel T, van Well JAM, Gommers EAE, Rosenfeld M
      Spirometry-Assisted High Resolution Chest Computed Tomography in Children: Is it Worth the Effort?
      28552547 Current problems in diagnostic radiology, 2018 Jan. : 47(1)14-18 PMCID:PMC6628913
    • Culver BH, Graham BL, Coates AL, Wanger J, Berry CE, Clarke PK, Hallstrand TS, Hankinson JL, Kaminsky DA, MacIntyre NR, McCormack MC, Rosenfeld M, Stanojevic S, Weiner DJ, ATS Committee on Proficiency Standards for Pulmonary Function Laboratories.
      Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement.
      29192835 American journal of respiratory and critical care medicine, 2017 Dec. 1 : 196(11)1463-1472
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld M
      Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis.
      28750627 BMC pulmonary medicine, 2017 July 27 : 17(1)106 PMCID:PMC5530959
    • Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, Milla CE, Robinson PD, Waltz D, Davies JC, VX14-809-109 investigator group.
      Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial.
      28606620 The Lancet. Respiratory medicine, 2017 July : 5(7)557-567
    • Shapiro AJ, Josephson M, Rosenfeld M, Yilmaz O, Davis SD, Polineni D, Guadagno E, Leigh MW, Lavergne V
      Accuracy of Nasal Nitric Oxide Measurement as a Diagnostic Test for Primary Ciliary Dyskinesia. A Systematic Review and Meta-analysis.
      28481653 Annals of the American Thoracic Society, 2017 July : 14(7)1184-1196 PMCID:PMC6137897
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld M
      Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis.
      28599639 BMC infectious diseases, 2017 June 9 : 17(1)411 PMCID:PMC5466772
    • Cogen J, Rosenfeld M
      Pseudomonas aeruginosa eradication: Finally moving the needle?
      28416146 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017 May : 16(3)309-310
    • Pittman J, Rosenfeld M
      Elementary, My Dear Watson! The Accumulating Evidence for the Lung Clearance Index in Monitoring Early Cystic Fibrosis Lung Disease.
      28459345 American journal of respiratory and critical care medicine, 2017 May 1 : 195(9)1131-1132
    • Smyth AR, Rosenfeld M
      Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.
      28417451 The Cochrane database of systematic reviews, 2017 April 18 : 4CD001912 PMCID:PMC6478147
    • Milla CE, Ratjen F, Marigowda G, Liu F, Waltz D, Rosenfeld M, VX13-809-011 Part B Investigator Group *.
      Lumacaftor/Ivacaftor in Patients Aged 6-11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR.
      27805836 American journal of respiratory and critical care medicine, 2017 April 1 : 195(7)912-920 PMCID:PMC5440888
    • Hopkinson NS, Hart N, Jenkins G, Kaminski N, Rosenfeld M, Smyth A, Wilkinson A
      Climate change and lung health: the challenge for a new president.
      28104829 Thorax, 2017 April : 72(4)295-296
    • Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M, Sermet-Gaudelus I, Southern KW, Marshall BC, Sosnay PR
      Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation.
      28129811 The Journal of pediatrics, 2017 Feb. : 181SS4-S15.e1
    • Farrell PM, White TB, Howenstine MS, Munck A, Parad RB, Rosenfeld M, Sommerburg O, Accurso FJ, Davies JC, Rock MJ, Sanders DB, Wilschanski M, Sermet-Gaudelus I, Blau H, Gartner S, McColley SA
      Diagnosis of Cystic Fibrosis in Screened Populations.
      28129810 The Journal of pediatrics, 2017 Feb. : 181SS33-S44.e2
    • Cogen JD, Oron AP, Gibson RL, Hoffman LR, Kronman MP, Ong T, Rosenfeld M
      Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations.
      28126911 Pediatrics, 2017 Feb. : 139(2) PMCID:PMC5472380
    • Ong T, Schechter M, Yang J, Peng L, Emerson J, Gibson RL, Morgan W, Rosenfeld M, EPIC Study Group.
      Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis.
      28093464 Pediatrics, 2017 Feb. : 139(2) PMCID:PMC5260155
    • Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MR
      Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents.
      27070726 Annals of the American Thoracic Society, 2016 Aug. : 13(8)1305-13 PMCID:PMC5021075
    • Rosenfeld M, Sontag MK, Ren CL
      Cystic Fibrosis Diagnosis and Newborn Screening.
      27469178 Pediatric clinics of North America, 2016 Aug. : 63(4)599-615
    • Davis SD, Ratjen F, Brumback LC, Johnson RC, Filbrun AG, Kerby GS, Panitch HB, Donaldson SH, Rosenfeld M, ISIS Study Group.
      Infant lung function tests as endpoints in the ISIS multicenter clinical trial in cystic fibrosis.
      26547590 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2016 May : 15(3)386-91 PMCID:PMC4854797
    • Lahiri T, Hempstead SE, Brady C, Cannon CL, Clark K, Condren ME, Guill MF, Guillerman RP, Leone CG, Maguiness K, Monchil L, Powers SW, Rosenfeld M, Schwarzenberg SJ, Tompkins CL, Zemanick ET, Davis SD
      Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis.
      27009033 Pediatrics, 2016 April : 137(4)
    • Davies JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld M, KIWI Study Group.
      Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study.
      26803277 The Lancet. Respiratory medicine, 2016 Feb. : 4(2)107-15 PMCID:PMC6734927
    • Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD, Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW, Genetic Disorders of Mucociliary Clearance Consortium.
      Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review.
      26418604 Pediatric pulmonology, 2016 Feb. : 51(2)115-32 PMCID:PMC4912005
    • Peterson-Carmichael S, Seddon PC, Cheifetz IM, Frerichs I, Hall GL, Hammer J, Hantos Z, van Kaam AH, McEvoy CT, Newth CJ, Pillow JJ, Rafferty GF, Rosenfeld M, Stocks J, Ranganathan SC, ATS/ERS Working Group on Infant and Young Children Pulmonary Function Testing.
      An Official American Thoracic Society/European Respiratory Society Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care Units.
      26848609 Annals of the American Thoracic Society, 2016 Feb. : 13(2)S1-11 PMCID:PMC5461957
    • Morgan WJ, VanDevanter DR, Pasta DJ, Foreman AJ, Wagener JS, Konstan MW, Scientific Advisory Group., Investigators and Coordinators of Epidemiologic Study of Cystic Fibrosis.
      Forced Expiratory Volume in 1 Second Variability Helps Identify Patients with Cystic Fibrosis at Risk of Greater Loss of Lung Function.
      26388208 The Journal of pediatrics, 2016 Feb. : 169116-21.e2
    • Ruddy J, Emerson J, McNamara S, Genatossio A, Breuner C, Weber T, Rosenfeld M
      Yoga as a Therapy for Adolescents and Young Adults With Cystic Fibrosis: A Pilot Study.
      26665020 Global advances in health and medicine, 2015 Nov. : 4(6)32-6 PMCID:PMC4653591
    • Sanders DB, Fink A, Mayer-Hamblett N, Schechter MS, Sawicki GS, Rosenfeld M, Flume PA, Morgan WJ
      Early Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years.
      26340874 The Journal of pediatrics, 2015 Nov. : 167(5)1081-8.e1 PMCID:PMC5017309
    • Mayer-Hamblett N, Kloster M, Rosenfeld M, Gibson RL, Retsch-Bogart GZ, Emerson J, Thompson V, Ramsey BW
      Impact of Sustained Eradication of New Pseudomonas aeruginosa Infection on Long-term Outcomes in Cystic Fibrosis.
      25972024 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015 Sept. 1 : 61(5)707-15 PMCID:PMC4626753
    • Rosenfeld M, VanDevanter DR, Ren CL, Elkin EP, Pasta DJ, Konstan MW, Morgan WJ, Investigators of Coordinators of the Epidemiologic Study of Cystic Fibrosis.
      Decline in lung function does not predict future decline in lung function in cystic fibrosis patients.
      26086901 Pediatric pulmonology, 2015 Sept. : 50(9)856-62
    • Sanders DB, Emerson J, Ren CL, Schechter MS, Gibson RL, Morgan W, Rosenfeld M, EPIC Study Group.
      Early Childhood Risk Factors for Decreased FEV1 at Age Six to Seven Years in Young Children with Cystic Fibrosis.
      26288390 Annals of the American Thoracic Society, 2015 Aug. : 12(8)1170-6 PMCID:PMC4566413
    • Cogen J, Emerson J, Sanders DB, Ren C, Schechter MS, Gibson RL, Morgan W, Rosenfeld M, EPIC Study Group.
      Risk factors for lung function decline in a large cohort of young cystic fibrosis patients.
      26061914 Pediatric pulmonology, 2015 Aug. : 50(8)763-70 PMCID:PMC5462119
    • Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT Jr, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, Hsu L, Jackson RD, Jarvik GP, Kim DS, Lakshminarayan K, Lange LA, Manichaikul A, Quinlan AR, Singleton AB, Thornton TA, Nickerson DA, Peters U, Rich SS, National Heart, Lung, and Blood Institute Exome Sequencing Project.
      Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
      25961151 JAMA neurology, 2015 July : 72(7)781-8 PMCID:PMC4673986
    • Subbarao P, Milla C, Aurora P, Davies JC, Davis SD, Hall GL, Heltshe S, Latzin P, Lindblad A, Pittman JE, Robinson PD, Rosenfeld M, Singer F, Starner TD, Ratjen F, Morgan W
      Multiple-Breath Washout as a Lung Function Test in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report.
      26075554 Annals of the American Thoracic Society, 2015 June : 12(6)932-9 PMCID:PMC5466249
    • Ren CL, Fink AK, Petren K, Borowitz DS, McColley SA, Sanders DB, Rosenfeld M, Marshall BC
      Outcomes of infants with indeterminate diagnosis detected by cystic fibrosis newborn screening.
      25963008 Pediatrics, 2015 June : 135(6)e1386-92
    • Alpern AN, Brumback LC, Ratjen F, Rosenfeld M, Davis SD, Quittner AL
      Initial evaluation of the Parent Cystic Fibrosis Questionnaire--Revised (CFQ-R) in infants and young children.
      25443473 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2015 May : 14(3)403-11
    • Schechter MS, Regelmann WE, Sawicki GS, Rasouliyan L, VanDevanter DR, Rosenfeld M, Pasta D, Morgan W, Konstan MW
      Antibiotic treatment of signs and symptoms of pulmonary exacerbations: a comparison by care site.
      25530325 Pediatric pulmonology, 2015 May : 50(5)431-40
    • Psoter KJ, De Roos AJ, Mayer JD, Kaufman JD, Wakefield J, Rosenfeld M
      Fine particulate matter exposure and initial Pseudomonas aeruginosa acquisition in cystic fibrosis.
      25594356 Annals of the American Thoracic Society, 2015 March : 12(3)385-91
    • Brumback LC, Baines A, Ratjen F, Davis SD, Daniel SL, Quittner AL, Rosenfeld M, ISIS Study Group.
      Pulmonary exacerbations and parent-reported outcomes in children <6 years with cystic fibrosis.
      24777957 Pediatric pulmonology, 2015 March : 50(3)236-243 PMCID:PMC4213320
    • Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, NHLBI Exome Sequencing Project., Girelli D, Martinelli N, Farlow DN, DePristo MA, Roberts R, Stewart AF, Saleheen D, Danesh J, Epstein SE, Sivapalaratnam S, Hovingh GK, Kastelein JJ, Samani NJ, Schunkert H, Erdmann J, Shah SH, Kraus WE, Davies R, Nikpay M, Johansen CT, Wang J, Hegele RA, Hechter E, Marz W, Kleber ME, Huang J, Johnson AD, Li M, Burke GL, Gross M, Liu Y, Assimes TL, Heiss G, Lange EM, Folsom AR, Taylor HA, Olivieri O, Hamsten A, Clarke R, Reilly DF, Yin W, Rivas MA, Donnelly P, Rossouw JE, Psaty BM, Herrington DM, Wilson JG, Rich SS, Bamshad MJ, Tracy RP, Cupples LA, Rader DJ, Reilly MP, Spertus JA, Cresci S, Hartiala J, Tang WH, Hazen SL, Allayee H, Reiner AP, Carlson CS, Kooperberg C, Jackson RD, Boerwinkle E, Lander ES, Schwartz SM, Siscovick DS, McPherson R, Tybjaerg-Hansen A, Abecasis GR, Watkins H, Nickerson DA, Ardissino D, Sunyaev SR, O'Donnell CJ, Altshuler D, Gabriel S, Kathiresan S
      Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.
      25487149 Nature, 2015 Feb. 5 : 518(7537)102-6 PMCID:PMC4319990
    • Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MW
      Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.
      25493340 American journal of respiratory and critical care medicine, 2015 Feb. 1 : 191(3)316-24 PMCID:PMC4351577
    • Zemanick ET, Emerson J, Thompson V, McNamara S, Morgan W, Gibson RL, Rosenfeld M, EPIC Study Group.
      Clinical outcomes after initial pseudomonas acquisition in cystic fibrosis.
      24644274 Pediatric pulmonology, 2015 Jan. : 50(1)42-8
    • Mogayzel PJ Jr, Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, Rosenfeld M, Simon RH, Hazle L, Sabadosa K, Marshall BC, Cystic Fibrosis Foundation Pulmonary Clinical Practice Guidelines Committee.
      Cystic Fibrosis Foundation pulmonary guideline. pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection.
      25549030 Annals of the American Thoracic Society, 2014 Dec. : 11(10)1640-50
    • Zemanick ET, Hoffman L, Rosenfeld M
      Narrowing in on early cystic fibrosis lung disease.
      25398104 American journal of respiratory and critical care medicine, 2014 Nov. 15 : 190(10)1082-4
    • Shapiro AJ, Davis SD, Ferkol T, Dell SD, Rosenfeld M, Olivier KN, Sagel SD, Milla C, Zariwala MA, Wolf W, Carson JL, Hazucha MJ, Burns K, Robinson B, Knowles MR, Leigh MW, Genetic Disorders of Mucociliary Clearance Consortium.
      Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy.
      24577564 Chest, 2014 Nov. : 146(5)1176-1186 PMCID:PMC4219335
    • Shapiro AJ, Weck KE, Chao KC, Rosenfeld M, Nygren AO, Knowles MR, Leigh MW, Zariwala MA
      Cri du chat syndrome and primary ciliary dyskinesia: a common genetic cause on chromosome 5p.
      25066065 The Journal of pediatrics, 2014 Oct. : 165(4)858-61 PMCID:PMC4177261
    • Daines C, VanDeVanter D, Khan U, Emerson J, Heltshe S, McNamara S, Anstead M, Langkamp M, Doring G, Ratjen F, Ramsey B, Gibson RL, Morgan W, Rosenfeld M, EPIC Investigators.
      Serology as a diagnostic tool for predicting initialPseudomonas aeruginosa acquisition in children with cystic fibrosis.
      25027419 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014 Sept. : 13(5)542-9
    • Mayer-Hamblett N, Ramsey BW, Kulasekara HD, Wolter DJ, Houston LS, Pope CE, Kulasekara BR, Armbruster CR, Burns JL, Retsch-Bogart G, Rosenfeld M, Gibson RL, Miller SI, Khan U, Hoffman LR
      Pseudomonas aeruginosa phenotypes associated with eradication failure in children with cystic fibrosis.
      24863401 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014 Sept. 1 : 59(5)624-31 PMCID:PMC4148602
    • Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA, NHLBI Exome Sequencing Project., Bamshad MJ
      Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results.
      25087612 American journal of human genetics, 2014 Aug. 7 : 95(2)183-93 PMCID:PMC4129409
    • Mayer-Hamblett N, Rosenfeld M, Gibson RL, Ramsey BW, Kulasekara HD, Retsch-Bogart GZ, Morgan W, Wolter DJ, Pope CE, Houston LS, Kulasekara BR, Khan U, Burns JL, Miller SI, Hoffman LR
      Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes.
      24937177 American journal of respiratory and critical care medicine, 2014 Aug. 1 : 190(3)289-97 PMCID:PMC4226041
    • Ren CL, Konstan MW, Rosenfeld M, Pasta DJ, Millar SJ, Morgan WJ, Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis.
      Early childhood wheezing is associated with lower lung function in cystic fibrosis.
      24123917 Pediatric pulmonology, 2014 Aug. : 49(8)745-50 PMCID:PMC4107871
    • Psoter KJ, Rosenfeld M, De Roos AJ, Mayer JD, Wakefield J
      Differential geographical risk of initial Pseudomonas aeruginosa acquisition in young US children with cystic fibrosis.
      24875373 American journal of epidemiology, 2014 June 15 : 179(12)1503-13
    • Stanojevic S, Stocks J, Bountziouka V, Aurora P, Kirkby J, Bourke S, Carr SB, Gunn E, Prasad A, Rosenfeld M, Bilton D
      The impact of switching to the new global lung function initiative equations on spirometry results in the UK CF registry.
      24332996 Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014 May : 13(3)319-27
    • Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ, Bamshad MJ, Nickerson DA, NHLBI GO Exome Sequencing Project.
      Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset.
      24282029 Human molecular genetics, 2014 April 15 : 23(8)1957-63 PMCID:PMC3959810
    • Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Zariwala MA
      Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype.
      24568568 American journal of respiratory and critical care medicine, 2014 March 15 : 189(6)707-17 PMCID:PMC3983840
    • Simon TD, Mayer-Hamblett N, Whitlock KB, Langley M, Kestle JR, Riva-Cambrin J, Rosenfeld M, Thorell EA
      Few Patient, Treatment, and Diagnostic or Microbiological Factors, Except Complications and Intermittent Negative Cerebrospinal Fluid (CSF) Cultures During First CSF Shunt Infection, Are Associated With Reinfection.
      24567841 Journal of the Pediatric Infectious Diseases Society, 2014 March : 3(1)15-22 PMCID:PMC3933045
    • Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, Flannick J, Zhang J, Fuchsberger C, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL, Gottesman O, Lu Y, Ruderfer D, Stahl EA, Duan Q, Li Y, Durda P, Jiao S, Isaacs A, Hofman A, Bis JC, Correa A, Griswold ME, Jakobsdottir J, Smith AV, Schreiner PJ, Feitosa MF, Zhang Q, Huffman JE, Crosby J, Wassel CL, Do R, Franceschini N, Martin LW, Robinson JG, Assimes TL, Crosslin DR, Rosenthal EA, Tsai M, Rieder MJ, Farlow DN, Folsom AR, Lumley T, Fox ER, Carlson CS, Peters U, Jackson RD, van Duijn CM, Uitterlinden AG, Levy D, Rotter JI, Taylor HA, Gudnason V Jr, Siscovick DS, Fornage M, Borecki IB, Hayward C, Rudan I, Chen YE, Bottinger EP, Loos RJ, Sætrom P, Hveem K, Boehnke M, Groop L, McCarthy M, Meitinger T, Ballantyne CM, Gabriel SB, O'Donnell CJ, Post WS, North KE, Reiner AP, Boerwinkle E, Psaty BM, Altshuler D, Kathiresan S, Lin DY, Jarvik GP, Cupples LA, Kooperberg C, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, Tracy RP, Willer CJ, NHLBI Grand Opportunity Exome Sequencing Project.
      Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
      24507775 American journal of human genetics, 2014 Feb. 6 : 94(2)233-45 PMCID:PMC3928660
    • Simon TD, Pope CE, Browd SR, Ojemann JG, Riva-Cambrin J, Mayer-Hamblett N, Rosenfeld M, Zerr DM, Hoffman L
      Evaluation of microbial bacterial and fungal diversity in cerebrospinal fluid shunt infection.
      24421877 PloS one, 2014 : 9(1)e83229 PMCID:PMC3885436
    • Rosenthal EA, Ranchalis J, Crosslin DR, Burt A, Brunzell JD, Motulsky AG, Nickerson DA, NHLBI GO Exome Sequencing Project., Wijsman EM, Jarvik GP
      Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.
      24268658 American journal of human genetics, 2013 Dec. 5 : 93(6)1035-45 PMCID:PMC3852929
    • Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F
      Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.
      24094744 American journal of human genetics, 2013 Oct. 3 : 93(4)672-86 PMCID:PMC3791264

    Show More Hide

  • Presentations Title Event Location Date
    Early Pseudomonas Infection: Risk Factors and Outcomes North American Cystic Fibrosis Conference Indianapolis, IN 2017
    The Promise and Challenge of Precision Medicine in Cystic Fibrosis and Beyond American Thoracic Society International Conference Washington DC 2017
    Pediatric Lung Function Testing Across the Ages American Thoracic Society International Conference San Diego, CA 2017
    The U.S. Approach to Preschool Airway Health Early CF Years Meeting Liverpool, UK 2016
    Safety, Tolerability, and Pharmacodynamics of Combination Lumacaftor/Ivacaftor Therapy in Patients Aged 6-11 Yrs with CF Homozygous for the F508del-CFTR Mutation North American Cystic Fibrosis Conference Orlando, FL 2016
    Lung Function Testing Across the Ages American Thoracic Society International Conference San Francisco, CA 2016
    Clinical Trials in Infants and Young Children with CF: Where are we Heading? California CF Center Consortium Annual Conference Carmel, CA 2016
    Detecting Early CF Lung Disease North American Cystic Fibrosis Conference Phoenix, AZ 2015
    The CF Therapeutics Pipeline: Ushering in an Era of Great Hope Cystic Fibrosis Research Institute Redwood City, CA 2015
    Results of the KIWI Trial of Ivacaftor in 2 to 5 Year Olds with CF and Gating Mutations European Cystic Fibrosis Conference Brussels, Belgium 2015
    Early Lung Disease in CF - What Works? American Thoracic Society International Conference Denver, CO May 15, 2015
    Research, a Straight Path Forward...or Not! American Thoracic Society International Society International Conference Denver, CO 2015
    Cystic Fibrosis in Children American Thoracic Society International Conference Denver, CO 2015
    Digital health monitoring: Beyond heart rates and pedometers Association for Women in Science 30th anniversary meeting Seattle, WA Feb. 18, 2015
    Home spirometry: whats on the horizon North American Cystic Fibrosis Conference Atlanta, GA Oct. 2014
    Clinical trials in preschool children with CF European Cystic Fibrosis Conference Gothenburg, Sweden June 14, 2014
    Survey of clinical infant lung function testing practices. International Symposium on Respiratory Disease Shanghai, China Nov. 9, 2013
    Early CF Lung Disease: Diagnosis, Treatment and Prevention Duke University School of Medicine Nov. 28, 2012
    Pulmonary Exacerbation as a Clinical Trial Endpoint: The Pros and Cons North American CF Conference Orlando, FL Oct. 2012
    Designing Investigator Initiated Trials Presentation In symposium "Multidisciplinary Approach to Investigator-initiated Trials," North American CF Conference Orlando, FL Oct. 2012
    Pulmonary and Nutritional Consequences of CF in the First 6 Years of Life presentation in symposium "After the Newborn Screen: What to Do Next?" North American CF Conference Orlando, FL Oct. 2012
    What lung function test is best for managing young children with CF talk in session "Is it time to bring pre-school lung function testing to the clinic? Update from the ATS/ERS Task Force" European Respiratory Society Congress Vienna, Austria Sept. 2012
    Writing Your First Grant ITHS career development series, University of Washington Seattle, WA Oct. 30, 2009
    Successful Transition to an Academic Career half-day SCH Fellows’ College workshop unknown Oct. 28, 2009
    Risk factors for early age at acquisition of Pseudomonas aeruginosa North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009
    Newborn screening North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009
    Pulmonary Exacerbations: How do we define them Symposium presentation, North American Cystic Fibrosis Conference Minneapolis, MN Oct. 16, 2009
    Comparison of published pulmonary exacerbation definitions Cystic Fibrosis Foundation Workshop on Pulmonary Exacerbations Bethesda, MD Sept. 9, 2009
    Guidelines for Care of theGuidelines for Care of the Infant with CF Infant with CF Cystic Fibrosis annual Northwest regional conference, Center for Urban Horticulture unknown July 24, 2009
    Risk factors for early Pseudomonas acquisition Cystic Fibrosis Epidemiology/Biostatistics Working Group annual meeting, Center for Urban Horticulture unknown July 23, 2009
    Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia and recurrernt wheezing in children under 6 years of age American Thoracic Society annual convention San Diego, CA May 12, 2009
    unknown ITHS Career Development Seminar- Career Development (K Award) Seminar unknown Jan. 29, 2009

Overview

Board Certification(s)

Pediatric Pulmonology

Medical/Professional School

University of Washington, Seattle, WA
Harvard Medical School, Boston, MA

Clinical Interests

Diagnosis and management of all pediatric lung conditions

 

Research Description

Multicenter observational studies and investigator-initiated clinical trials in cystic fibrosis emphasizing early CF lung disease. Multicenter observational studies in primary ciliary dyskinesia. Mobile health applications and remote monitoring, including home spirometry. Development of outcome measures for clinical trials, including home spirometry, home cough monitoring, infant and preschool lung function tests. Global health, including mobile health tools for diagnosis of respiratory distress and pneumonia in low resource settings.

 

Research Focus Area

Translational research, observational studies, investigator-initiated interventional studies, Therapeutic Trials