Madhavi M. Lakkaraja, MD, MPH
On staff since September 2022
Children's Title: Attending Physician, Pediatric Bone Marrow Transplantation Service, Cancer and Blood Disorders Center
Academic Title: Assistant Professor, Department of Pediatrics, University of Washington School of Medicine
"I am fortunate to be able to care for children with blood and immune disorders. It is a humbling experience to be with children and their families through this process and then see them come out of a stem cell transplant and move forward in their lives. Research is a key component of this specialty, so I can provide patient care and push the field forward at the same time. Seeing a child smile and to be able to make a difference for my patients and their families is what really keeps me going."
Dr. Madhavi Lakkaraja is a physician-researcher who specializes in the treatment of children with non-malignant disorders through use of stem cell transplantation and cellular therapies. These include bone marrow failure disorders and inherited immune disorders. Her research work focuses on developing personalized approaches to stem cell transplant and cellular therapies and immune reconstitution post stem cell transplant.
Manuscripts in Refereed Journals
Lakkaraja M, Scordo M, Mauguen A, Cho C, Devlin S, Ruiz JD, Klein E, Avecilla ST, Boulad F, Cancio MI, Curran KJ, Jakubowski AA, Kernan NA, Kung AL, O'Reilly RJ, Papadopoulos EB, Prockop S, van Roessel I, Scaradavou A, Shaffer BC, Shah G, Spitzer B, Tamari R, Giralt SA, Perales MA, Boelens JJ.Antithymocyte globulin exposure in CD34+ T-cell-depleted allogeneic hematopoietic cell transplantation.
Blood, 2022 Feb. : 6(3)1054-1063 PMCID:PMC8945304
Miltiadous O, Waters NR, Andrlova H, Dai A, Nguyen CL, Burgos da Silva M, Lindner S, Slingerland J, Giardina P, Clurman A, Armijo GK, Gomes AL, Lakkaraja M., Maslak PG, Scordo M, Shouval R, Staffas A, O'Reilly RJ, Taur Y, Prockop S, Boelens JJ, Giralt S, Perales MA, Devlin SM, Peled JU, Markey KA, van den Brink MRMEarly intestinal microbial features are associated with CD4 T cell recovery after allogeneic hematopoietic transplant.
Blood, 2022 Jan. : 139(18)2758-2769 PMCID:PMC9074404
Groth DJ, Lakkaraja M.M., Ferreira JO, Feuille EJ, Bassetti JA, Kaicker SMManagement of Chronic Immune Thrombocytopenia and Presumed Autoimmune Hepatitis in a Child with IKAROS Haploinsufficiency
J Clin Immunol., 2020 April : 40(4)653-657
Jin JC, Lakkaraja M.M., Ferd P, Manotas K, Gabor J, Wissert M, Berkowitz RL, McFarland JG, Bussel JB.Maternal sensitization occurs before delivery in severe cases of fetal alloimmune thrombocytopenia.
American journal of hematology, 2019 May : 94(8)E213-E215
Lakkaraja M., Berkowitz RL, Vinograd CA, et alOmission of fetal sampling in treatment of subsequent pregnancies in fetal-neonatal alloimmune thrombocytopenia.
American journal of obstetrics and gynecology, 2016 Oct. : 215(4)471.e1-9
Lakkaraja M., Jin J, Manotas K, Vinograd C, Gabor J, Selegean J, Ferd P, Wissert M, Berkowitz RL, McFarland JG, Bussel JB.Blood Type A Mothers are More Likely to Develop Anemia During Antenatal Intravenous Immunoglobulin Treatment of Fetal and Neonatal Alloimmune Thrombocytopenia
Transfusion, 2016 : 56(10)2449-2454
Liu ZJ, Bussel JB, Lakkaraja M, Ferrer-Marin F, Ghevaert C, Feldman HA, McFarland JG, Chavda C, Sola-Visner MSuppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies.
26209661 Blood, 2015 Sep 3 : 126(10)1234-6 PMCID:PMC4559934
Viswanathan K, Swaminathan N, Viswanathan R, Lakkaraja MCaregiver's Health Locus of Control and Medication Adherence in Sickle Cell Disease.
27282723 Journal of the National Medical Association, 2015 March : 107(3)51-5
Bussel JB, Lakkaraja MThrombopoietic agents: there is still much to learn.
24680422 Presse medicale (Paris, France : 1983), 2014 April : 43(4 Pt 2)e69-78
- Board Certification(s)
- Medical/Professional School
Dartmouth College, Hanover, NH
KJ Somaiya Medical College, Mumbai
Brookdale University Hospital and Medical Center, Brooklyn, NY
Memorial Sloan-Kettering Cancer Center, New York, NY
Texas Children's Hospital, Houston, TX
- Clinical Interests
Bone Marrow Transplantation and Cellular Therapies for non-malignant disorders, high risk leukemias.