Lincoln S Smith, MD

Lincoln S Smith, MD

Critical Care, Pediatric Intensive Care Unit (PICU)

On staff since July 2006

Academic Title: Associate Professor

Research Center: Center for Respiratory Biology and Therapeutics

"Working in the ICU at Seattle Children's Hospital is such an incredible privilege. From the "routine" postoperative admissions to the children with life-threatening infections, our attention to details and careful application of state-of-the-art care for children allow us the opportunity to give those children the best possible second chance in life."

  • Biography

    Lincoln Smith, MD, is attending physician at Seattle Childrens Hospital and Harborview Medical Center and assistant professor of pediatrics at the University of Washington School of Medicine. He is the Program Director of the Pediatric Critical Care Medicine Fellowship. He earned his MD at the University of Wisconsin, in Madison, and completed his pediatrics residency at Childrens Hospital of Buffalo where he served as chief resident. Smith completed his pediatric critical care fellowship training at Seattle Childrens, and he is board certified in general pediatrics and pediatric critical care medicine.

    Smiths laboratory research is at the Pulmonary Research Laboratories at Veterans Administration Puget Sound Medical Center in Seattle. Smith is investigating the role of lung development in ventilator-induced lung injury. He is focusing on molecular mechanisms by which juvenile mice are protected from synergistic inflammatory and injurious interactions between activation of innate immunity and mechanical ventilation in adult mice.

  • Patient Testimonials

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Faculty Teaching and Mentoring Award Seattle Children's Hospital, Division of Pediatric Critical Care Medicine 2011
     Pediatric Research Loan Repayment Program - NIH NIH - NHLBI Oct 1, 2006 - Sep 30, 2010
  • Publications

    Other Publications

    • Smith LS, Gharib SA, Frevert CW, Martin TR
      Effects of Age on the Synergistic Interactions between Lipopolysaccharide and Mechanical Ventilation in Mice.
      19901347 American journal of respiratory cell and molecular biology, 2009 Nov 9
    • Smith LS, Kajikawa O, Elson G, Wick M, Mongovin S, Kosco-Vilbois M, Martin TR, Frevert CW
      Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin.
      18465402 Experimental lung research, 2008 June : 225-43
  • Research Funding

    Grant Title Grantor Amount Award Date
    Developmental Mechanisms in Acute Lung Injury NIH/NHLBI $588,500.00 Aug 11, 2009


Board Certification(s)

Pediatric Critical Care Medicine

Medical/Professional School

University of Wisconsin School of Medicine & Public Health, Madison, WI


Women & Childrens Hospital of Buffalo-GME, Buffalo, NY


Seattle Children's Hospital, Seattle, WA

Clinical Interests

Respiratory failure

Cardiorespiratory interactions

Research Description

My research involves investigation of the role of lung development in the pulmonary responses to innate immune activation and mechanical stretch.

Research Focus Area

Translational Research