Kasey Joanne Leger, MD, MSc

Kasey Joanne Leger, MD, MSc


"Its an honor to partner with my patients and their families in their life changing battle against cancer. I am inspired to help my patients and those who will face this disease in the future to not only overcome cancer, but to experience healthy and fulfilling lives after cancer."
  • Biography

    Kasey Leger, MD, is an attending physician at Seattle Childrens Hospital and associate professor of pediatrics at the University of Washington School of Medicine. Her clinical interests focus on management of leukemia, lymphoma, and cardiovascular health during cancer therapy.

    My research focus on cardiotoxicity centers largely on early biomarkers of anthracycline-induced cardiac injury and cardiomyopathy risk prediction. Additionally, I am committed to optimizing strategies of cardioprotection, primary and ultimately secondary wherein validated risk prediction models are critical. I lead the Children’s Oncology Group (COG) Myeloid Cardiotoxicity Working Group and am the cardiac chair of the ongoing COG Phase III randomized trial for patients with de novo AML comparing standard therapy to CPX-351 (AAML1831). This large, multi-institutional trial will assess strategies to mitigate cardiotoxicity and leverage a large, high-risk cohort to capture detailed cardiac phenotyping by echocardiographic measures of cardiac function and mechanics and circulating biomarkers of cardiac injury and stress. Additionally, I am the principal investigator of a cardiotoxicity biomarker cohort study at Seattle Children’s in which we are studying circulating microRNAs, high sensitivity troponin, myocardial deformation imaging (strain), and other novel blood and imaging based markers of cardiotoxicity.

    Board Certification(s)

    Pediatric Hematology-Oncology


    University of Texas Health Science Center, Houston, TX
    University of Texas Southwestern Medical School, Dallas, TX


    Children's Hospital Colorado Otolaryngology, Derma, Aurora, CO


    University of Texas Southwestern Medical Center, Dallas, TX

    Clinical Interests

    Leukemia, lymphoma and cardiovascular health during cancer therapy

    Research Description

    Early identification and prevention of cancer therapy-induced cardiovascular disease

    Research Focus Area

    Novel Therapeutics

  • Patient Testimonials

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  • Awards and Honors

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  • Publications

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  • Clinical Trials and Research Studies

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