Kasey Joanne Leger, MD, MSc

Cancer and Blood Disorders Center, Leukemia and Lymphoma Program, Apheresis

On staff since August 2014

Academic Title: Assistant Professor

Research Center: Ben Towne Center for Childhood Cancer Research

"Its an honor to partner with my patients and their families in their life changing battle against cancer. I am inspired to help my patients and those who will face this disease in the future to not only overcome cancer, but to experience healthy and fulfilling lives after cancer."

• Biography

  Kasey Leger, MD, is an attending physician at Seattle Childrens Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her clinical interests focus on leukemia, lymphoma, and cancer survivorship.

  Dr. Leger's research interests focus on the cardiovascular health of survivors of childhood cancer. She is currently working to identify early predictors of chemotherapy-induced heart injury. Early diagnosis and targeted treatment of cancer therapy-related cardiovascular disease could help preserve the cardiac health of childhood cancer survivors.

• Patient Testimonials

  • Theresa Portland, Oregon 07.09.20

    We are grateful beyond measure for Dr. Leger.

  Recommend Kasey Joanne Leger, MD, MSc

• Awards and Honors

  Award Name	Award Description	Awarded By	Award Date
  Clinical Research Scholar		Seattle Children's Center for Clinical and Translational Research	May 2015
  American Society of Clinical Oncology (ASCO) Young Investigator Award		American Society of Clinical Oncology	2012 - 2013
  Selected participant in AACR/ASCO Workshop: Methods in Clinical Cancer Research			2012
  Alpha Omega Alpha Honor Society			2005

• Publications

  Manuscripts in Refereed Journals

  • Leger KJ, Cushing-Haugen K, Hansen JA, Fan W, Leisenring WM, Martin PJ, Zhao LP, Chow EJ
    Clinical and Genetic Determinants of Cardiomyopathy Risk among Hematopoietic Cell Transplantation Survivors.
    26968791 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2016 Mar 8
  • Leger K, Slone T, Lemler M, Leonard D, Cochran C, Bowman WP, Bashore L, Winick N
    Subclinical cardiotoxicity in childhood cancer survivors exposed to very low dose anthracycline therapy.
    25176022 Pediatric blood and cancer, 2015 Jan. : 62(1)123-7
  • Lipshultz SE, Diamond MB, Franco VI, Aggarwal S, Leger K, Santos MV, Sallan SE, Chow EJ
    Managing chemotherapy-related cardiotoxicity in survivors of childhood cancers.
    25134924 Paediatric drugs, 2014 Oct. : 16(5)373-89 PMCID:PMC4417358

  Manuscripts Submitted

  • Leger K, Singh S, Canseco D, Collins S, Karim-Ud-Din S, Mishkin JD, Patel PC, Markham DW, Drazner MH, Mammen PP
    Whole blood microRNA profiling reveals novel miRs in ischemic cardiomyopathy
    2016
  • Leger K, Leonard D, Nielson D, Cochran C, De Lemos JA, Mammen PP, Winick NJ
    microRNAs as novel markers of acute anthracycline-induced cardiotoxicity in children
    Journal of Clinical Oncology, 2016
  • Leger K, Singh S, Canseco D, Collins S, Karim-Ud-Din S, Mishkin JD, Patel PC, Markham DW, Drazner MH, Mammen PP
    Whole blood microRNA profiling reveals novel miRs in ischemic cardiomyopathy
    Circulation Heart Failure, 2016
  • Schuh AM, Leger KJ, Summers C, Uspal N.
    Lactic acidosis in a critically ill patient: Not always sepsis
    Pediatric Emergency Care, 2016

  Published Abstracts

  • Leger K, Leonard D, Nielson D, de Lemos JA, Winick NJ, Mammen PP
    Evaluation of microRNAs as Novel Markers of Cardiotoxicity in Patients Treated With Anthracycline Therapy for Childhood Cancer
    American Heart Association 2013 Scientific Sessions, Vol 128(Issue 22 s)
  • Leger K, Singh S1, Canseco D, Collins S, Karim-Ud-Din S, Drazner MH, Mammen PP
    Identification of novel circulating microRNAs in ischemic cardiomyopathy utilizing whole blood microRNA profiling
    American Heart Association 2013 Scientific Sessions, 2013 : Vol 128(Issue 22 S)
  • Leonard D, Nielson D, de Lemos JA, Nielson D, Mammen PP, Winick NJ
    Plasma microRNAs: Novel markers of cardiotoxicity in children undergoing anthracycline chemotherapy
    J Clin Oncol, Vol 32(No 15_supp)

  Other Publications

  • Leger K
    The Potential Role of Plasma MicroRNAs as Novel Markers of Hypertrophy and Fibrosis in Patients with HCM
    http:/Biomarkers.Cardiosource.org, 2014
    http://biomarkers.cardiosource.org/Article-of-the-Month/2014/06/The-Potential-Role-of-Plasma-MicroRNAs.aspx.

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• Presentations

  Presentations Title	Event	Location	Date
  Treatment Approaches in Atypical Neuroblastoma	Childrens Medical Center Tumor Board		2010
  Detection of Bone Marrow Involvement in Hodgkins Lymphoma	Childrens Medical Center Tumor Board		2010
  Prospective Evaluation of Early Markers of Cardiotoxicity in Children Undergoing Anthracycline Chemotherapy	UT Southwestern Clinical Science Forum		2013
  The use of Rituximab in Treatment of Burkitts Lymphoma	Childrens Medical Center Tumor Board		2011
  Acute Alterations in Plasma microRNA Expression Following Anthracycline Therapy	UT Southwestern Translational Science Forum Works in Progress		2013
  Cardiovascular Disease in Childhood Cancer Survivors: Case Presentations. Cardiovascular Disease in Survivors of Childhood Cancer: Novel Insights into Pathophysiology, Screening, and Prevention Workshop	American Society of Pediatric Hematology/ Oncology Annual Meeting		April 2013
  Intrachromosomal amplification of chromosome 21 (iAMP21) in childhood preB ALL	Seattle Childrens Hematopathology Conference		2015
  Anthracycline Related Cardiotoxicity: An Evaluation of Doxorubicin Pharmacokinetics and Cardiac Troponins	UT Southwestern Department of Pediatrics Research Conference		2011
  General Principals in Leukemia	UT Southwestern Resident Board Review Conference		2011
  Evaluation of microRNAs as novel markers of cardiotoxicity in children treated with anthracycline chemotherapy	UT Southwestern Pediatrics Department Fellows Core Curriculum Conference		2012
  Coagulation basics	Resident Supervisors Conference	Childrens Hospital Colorado	2008
  Treatment of childhood and adolescent T-cell Acute Lymphoblastic Leukemia	Seattle Childrens Clinical Standard Practice		2015
  Cardiotoxicity in Childhood Cancer Survivors	Childrens Medical Center Nursing Education Curriculum Lecture Series		2012
  Local Control for Ewings Sarcoma	Childrens Medical Center Tumor Board		2011

• Research Funding

  Grant Title	Grantor	Amount	Award Date
  Clinical Research Scholar Program		$90,000	2016 - 2018
  Hyundai Hope on Wheels Senior Research Award	Hyundai Hope on Wheels	$250,000	2015 - 2018
  Childrens Cancer Fund Dallas		$28,000	2012 - 2014
  T32HL007360-35 NIH Training in Cardiovascular Research Grant			2012 - 2014