John K McGuire, MD

Critical Care, Pediatric Intensive Care Unit (PICU), Bronchopulmonary Dysplasia Program

On staff since November 2004

Children's Title: Chief, Division of Pediatrics Critical Care Medicine

Academic Title: Associate Professor

Research Center: Center for Respiratory Biology and Therapeutics

"Every day, I am reminded of the special privilege and honor that it is to participate in the care of the children and families in the Pediatric ICU at Seattle Children's Hospital. This inspires me to do my very best to provide outstanding patient care and education in pediatric critical care."

• Biography

  John K. McGuire, MD, is the Chief of the Division of Pediatric Critical Care Medicine at Seattle Children's Hospital and Associate Professor of Pediatrics at the University of Washington School of Medicine. Dr. McGuire earned his MD from Northwestern University and trained in general pediatrics and pediatric critical care medicine at Childrens Memorial Hospital and Northwestern University in Chicago. Prior to joining the group in Seattle, he worked at Washington University in St. Louis.

  He is board certified in general pediatrics and pediatric critical care medicine and is a member of several academic societies including the American Thoracic Society, Society for Critical Care Medicine, and the American Society for Matrix Biology. Dr. McGuire is a member of the University of Washington Center for Lung Biology. His laboratory work is directed at understanding how epithelial responses to acute injury and infection regulate repair and resolution of inflammation. Related projects are focused on elucidating the role of matrix metalloproteinases in viral and bacterial lung infections. These studies receive funding from the National Institutes of Health and the Cystic Fibrosis Foundation. Dr. McGuire serves as a member of the Accreditation Council for Graduate Medical Education Board of Appeals Panel for Pediatrics and as a reviewer for the National Institutes of Health, the American Heart Association Research Program and several journals.

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• Awards and Honors

  Award Name	Award Description	Awarded By	Award Date
  SEATTLE TOP DOCTOR - 2022		Seattle Magazine	2022
  SEATTLE MAGAZINE TOP DOCTOR - 2016		Seattle Magazine	2016
  Seattles Top Doctor 2016		Seattle Met Magazine	2016
  SEATTLE MAGAZINE TOP DOCTOR - 2015		Seattle Magazine	2015
  Pediatric Critical Care Medicine Fellowship Outstanding Mentor Award		Seattle Children's Hospital	Jul 1, 2011
  Pediatric Critical Care Medicine Fellowship Outstanding Teacher Award		Seattle Children's Hospital	2009
  Elected to membership		Society for Pediatric Research	2008
  Outstanding Subspecialty Teacher		Saint Louis Childrens Hospital	2003
  Resident Teaching Award		Northwestern University Medical School	1995
  Outstanding PL-2 Resident Teacher		1995 Childrens Memorial Hospital	1995
  Outstanding PL-1 Resident Teacher		Childrens Memorial Hospital	1994
  United States Public Health Service Citation			1990

• Publications

  Manuscripts in Refereed Journals

  • 1. Schnaper HW, McGuire J, Runyan C, Hubchak SC.
    Sex steroids and the endothelium.
    Current Medicinal Chemistry, 2000 : 7(5):519-31.
  • Jaspan HB, Brothers AW, Campbell AJ, McGuire JK, Browd SR, Manley TJ, Pak D, Weissman SJ
    Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
    20010311 The Pediatric infectious disease journal, : 379-81

  Other Publications

  • Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P
    Syndecan-1 Attenuates Lung Injury During Influenza Infection By Potentiating c-Met Signaling to Suppress Epithelial Apoptosis.
    26959387 American journal of respiratory and critical care medicine, 2016 Mar 9
  • Lee V, McMahan RS, Hu X, Gao X, Faustman EM, Griffith WC, Kavanagh TJ, Eaton DL, McGuire JK, Parks WC
    Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages.
    24983898 Nanotoxicology, 2014 Jul 1 : 1-8
  • Rims CR, McGuire JK
    Matrilysin (MMP-7) catalytic activity regulates -catenin localization and signaling activation in lung epithelial cells.
    24624896 Experimental lung research, 2014 April : 40(3)126-36
  • Gill SE, Gharib SA, Bench EM, Sussman SW, Wang RT, Rims C, Birkland TP, Wang Y, Manicone AM, McGuire JK, Parks WC
    Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.
    23742180 American journal of respiratory cell and molecular biology, 2013 Nov. : 49(5)768-77 PMCID:PMC3931094
  • Tanino Y, Chang MY, Wang X, Gill SE, Skerrett S, McGuire JK, Sato S, Nikaido T, Kojima T, Munakata M, Mongovin S, Parks WC, Martin TR, Wight TN, Frevert CW
    Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide.
    22427536 American journal of respiratory cell and molecular biology, 2012 Aug. : 47(2)196-202 PMCID:PMC3423465
  • John K. McGuire, MD, Deeter K, McGuire JK
    Submersion Injury in Children
    Perinatal and Pediatric Respiratory Care. 3rd Edition. Saint Louis: Saunders-Elsevier, 2010
  • Manicone AM, Huizar I, McGuire JK
    Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin).
    19893044 The American journal of pathology, 2009 Dec. : 2319-31
  • Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC
    Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
    18334539 Journal of leukocyte biology, 2008 June : 1404-12
  • Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK
    Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.
    18385523 The American journal of pathology, 2008 May : 1256-70
  • Manicone AM, McGuire JK
    Matrix metalloproteinases as modulators of inflammation.
    17707664 Seminars in cell & developmental biology, 2008 Feb. : 34-41
  • Kassim SY, Gharib SA, Mecham BH, Birkland TP, Parks WC, McGuire JK
    Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
    17923522 Infection and immunity, 2007 Dec. : 5640-50
  • Thill PJ, McGuire JK, Baden HP, Green TP, Checchia PA
    Noninvasive positive-pressure ventilation in children with lower airway obstruction.
    15215002 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2004 July : 337-42
  • Surendran K, Simon TC, Liapis H, McGuire JK
    Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4.
    15149334 Kidney international, 2004 June : 2212-22
  • McGuire JK, Li Q, Parks WC
    Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.
    12759241 The American journal of pathology, 2003 June : 1831-43

• Presentations

  Presentation Title	Event	Location	Date
  Mechanisms of lung repairResolution biology as a pathway to new ARDS treatment	8th Annual Ron Lemire Northwest Pediatric Critical Care Symposium	Seattle, WA	2015
  Resolution of Acute Lung Injury: Regulating the regulators.	British Columbia Childrens Hospital	Vancouver, B.C.	2013
  Epithelial-leukocyte interactions in acute lung injury	2012 University of Texas-Southwestern	Dallas TX	2012
  Scientific Symposium: APCs in resolution of acute lung injury	American Thoracic Society International Conference	San Francisco, CA	2012
  ARDS in Children: Pathophysiology and Management	Gertrudes Childrens Hospital	Nairobi, Kenya	2012
  Dendritic cells promote resolution of lung injury.	University of Colorado	Denver, CO	2012
  ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient	2010 Ain-Shams Medical School International Pediatric Critical Care Conference	Cairo, Egypt	2010
  ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient	2010 Ain-Shams Medical School International Pediatric Critical Care Conference	Cairo, Egypt	2010
  Resolution of acute lung injury: Putting out the fire.	Seattle Childrens Hospital, Pediatrics Grand Rounds	Seattle, WA	2009
  Epithelial-leukocyte interactions in the resolution of acute lung injury	2008 University of Washington, Department of Anesthesia Grand Rounds	Seattle, WA	2008
  Resolving acute lung injury: Getting the horse back in the barn	2008 First Annual Ron Lemire Northwest Pediatric Critical Care Symposium	Seattle, WA	2008
  Shed E-cadherin controls influx of CD103+ dendritic cells	American Society of Matrix Biology	Nashville, TN	2006
  Matrix metalloproteinases in epithelial injury: A role for MMP-7 in inflammation and re-epithelialization	European Tissue Repair Society	Stuttgart, Germany	2005
  Proteinase function in epithelial repair and fibrosis	Second World Union of Wound Healing Societies	Paris, France	2004

• Research Funding

  Grant Title	Grantor	Amount	Award Date
  Cystic Fibrosis Research Center: Cell Culture Core	Cystic Fibrosis Foundation	$120,000	Oct. 2015 - Sept. 1919
  Regulatory T cell function in cystic fibrosis lung disease	Cystic Fibrosis Foundation	$180,000	April 2013 - March 2015
  E-cadherin shedding in chronic lung injury	NIH-NHLBI	$1,250,000	Jan. 2010 - Feb. 2015
  E-cadherin shedding in chronic lung injury	NIH-NHLBI	$1,250,000.00	Dec 1, 2009
  Epithelial-leukocyte interactions in regulation of pulmonary inflammation in cystic fibrosis	Cystic Fibrosis Foundation-Research Development Program	$36,000	Oct 1, 2009
  Mechanisms in the Remodeling of Lung Structure	NIH-NHLBI	$1,350,000	Sep 1, 2008
  Function in Pulmonary Fibrosis	American Heart Association	$120,000	Jul 1, 2008
  Cystic Fibrosis Research Center: Epithelial biology core	Cystic Fibrosis Foundation	$360,000	Oct. 2007 - Sept. 2015
  Arnold Lee Smith Endowed Professorship for Research Faculty Development	Arnold Lee Smith Endowement	$140,000.00	Sep 1, 2006