J Lawrence L Merritt II, MD
Non-Malignant Transplant Program, Biochemical Genetics, Genetics
On staff since July 2007
Children's Title: Medical Director, Biochemical Genetics; Program Director, Medical Biochemical Genetics Fellowship
Academic Title: Professor
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Lawrence Merritt, II, MD, is attending physician at Seattle Childrens Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. He joined Childrens after completing his pediatric residency, medical genetics residency and biochemical genetics fellowship at the Mayo Clinic in Rochester, MN.
He provides inpatient and outpatient clinical services in biochemical genetics at Children's hospital campus in Seattle and Bellevue clinics and at the Spokane newborn screening outreach clinic. His clinical interests include long-term follow up of infants with abnormal newborn screens, urea cycle disorders and fatty acid oxidation disorders. His clinical work has led efforts to further understand how we can better promote educational efforts and improve the quality of our follow-up of these infants. He is the site principle investigator for the Urea Cycle Disorders Consortium Longitudinal study and received a grant to study the effects of newborn screening in patients and families with urea cycle disorders. He is involved with development of novel pharmaceutical therapies for treatment of urea cycle disorders, fatty acid oxidation disorders, organic acidemias, glycogen storage diseases and lysosomal storage diseases. The expansion of newborn screening the the past two decades has driven much of his clinical work. He serves as the Program Director for the Medical Biochemical Genetics Fellowship program here at the University of Washington.
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Dr. Merritt has a gentle and kind demeanor(very understanding and empathetic), has always exhibited it since his days in early post secondary university in TX. I highly recommend him and have been keenly interested in his research for over a decade. One of the finest pediatric specialists in the US.
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Doctor Merritt is an amazing physician willing to go the extra mile searching for a diagnosis, treating the patient and working with parents in the process. We are forever grateful for his diligence in searching for the source of our son's issues. We were seen in a timely fashion for each appointment and never rushed through visits no matter how many questions we had. He is thoughtful and thorough and does not give up. He is a true asset to the field of Biochemical Genetics.
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Dr. Merritt LISTENS. He hears everything and responds and does not make us feel foolish for all of our questions that I'm sure he's heard a million times. I am so impressed that he is not threatened by patients researching and learning about their disorder, but encourages it. We are thankful to have been referred to him!
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Dr. Merritt has been our doctor for the past 2 1/2 years. Their is no one finer than him and his team. My son was sleepy and not doing normal day to day activities before meeting Dr. Merritt. After meeting him, Dr. Merritt and his team started him on the medicine that helped him have more energy and be able to play and have fun. My husband and I will be forever grateful to him. He is truly the best in his field. He is caring, compassionate, and truly loves what he does. I highly recommend him and his staff.
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Dr. Merritt is wonderful! He's super patient, has a great bedside manner and is fantastic with children. My daughter loves him....as do I! If you have a biochemical issue, I highly recommend seeing Dr. Merritt.
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Manuscripts in Refereed Journals
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Golden-Grant K, Merritt JL 2nd, Scott CREthical considerations of population screening for late-onset genetic disease.
25677830 Clinical genetics, 2015 Dec. : 88(6)589-92 -
Nagamani SC, Diaz GA, Rhead W, Berry SA, Le Mons C, Lichter-Konecki U, Bartley J, Feigenbaum A, Schulze A, Longo N, Berquist W, Gallagher R, Bartholomew D, Harding CO, Korson MS, McCandless SE, Smith W, Vockley J, Kronn D, Zori R, Cederbaum S, Merritt JL 2nd, Wong D, Coakley DF, Scharschmidt BF, Dickinson K, Marino M, Lee BH, Mokhtarani MSelf-reported treatment-associated symptoms among patients with urea cycle disorders participating in glycerol phenylbutyrate clinical trials.
26296711 Molecular genetics and metabolism, 2015 Sept. : 116(1-2)29-34 -
Lee B, Diaz GA, Rhead W, Lichter-Konecki U, Feigenbaum A, Berry SA, Le Mons C, Bartley JA, Longo N, Nagamani SC, Berquist W, Gallagher R, Bartholomew D, Harding CO, Korson MS, McCandless SE, Smith W, Cederbaum S, Wong D, Merritt JL 2nd, Schulze A, Vockley G, Kronn D, Zori R, Summar M, Milikien DA, Marino M, Coakley DF, Mokhtarani M, Scharschmidt BFBlood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder.
25503497 Genetics in medicine : official journal of the American College of Medical Genetics, 2014 Dec 11 -
Merritt JL 2nd, Berry S, Le Mons C, Teigen C, Matern D, Rinaldo P.Rationale For Newborn Screening For Proximal Urea Cycle Disorders.
2014 May -
Merritt JL 2nd, Vedal S, Abdenur JE, Au SM, Barshop BA, Feuchtbaum L, Harding CO, Hermerath C, Lorey F, Sesser DE, Thompson JD, Yu AInfants suspected to have very-long chain acyl-CoA dehydrogenase deficiency from newborn screening.
24503138 Molecular genetics and metabolism, 2014 April : 111(4)484-92 -
J Lawrence Merritt II, MD, Underhill HR, Hahn SH, Hale S, Merritt JL 2nd.Asymptomatic methylmalonic acidemia in a homozygous MUT mutation (p.P86L).
Pediatr Int., 2013 Dec. : 55(6)e156-8 -
Ruhoy IS, Merritt JL 2nd, Amlie-Lefond CCystathionine Beta-synthase Deficiency Heralded by Cerebral Sinus Venous Thrombosis and Stroke.
24138954 Pediatric neurology, 2013 Oct. -
Ah Mew N, Krivitzky L, McCarter R, Batshaw M, Tuchman M, Urea Cycle Disorders Consortium of the Rare Diseases Clinical Research NetworkClinical outcomes of neonatal onset proximal versus distal urea cycle disorders do not differ.
22901741 The Journal of pediatrics, 2013 Feb. : 162(2)324-9.e1 -
Merritt JL 2nd, Askenazi D, Hahn SHNewborn screening and renal disease: where we have been; where we are now; where we are going.
21947256 Pediatric nephrology (Berlin, Germany), 2011 Sep 27 -
Lichter-Konecki U, Diaz GA, Merritt JL 2nd, Feigenbaum A, Jomphe C, Marier JF, Beliveau M, Mauney J, Dickinson K, Martinez A, Mokhtarani M, Scharschmidt B, Rhead WAmmonia control in children with urea cycle disorders (UCDs); phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate.
21612962 Molecular genetics and metabolism, 2011 Aug. : 103(4)323-9 -
Seminara J, Tuchman M, Krivitzky L, Krischer J, Lee HS, Lemons C, Baumgartner M, Cederbaum S, Diaz GA, Feigenbaum A, Gallagher RC, Harding CO, Kerr DS, Lanpher B, Lee B, Lichter-Konecki U, McCandless SE, Merritt JL, Oster-Granite ML, Seashore MR, Stricker T, Summar M, Waisbren S, Yudkoff M, Batshaw MLEstablishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium.
20188616 Molecular genetics and metabolism, 2010 : S97-105 -
Bachmann-Gagescu R, Merritt JL 2nd, Hahn SHA cognitively normal PDH-deficient 18-year-old man carrying the R263G mutation in the PDHA1 gene.
19639391 Journal of inherited metabolic disease, 2009 Jul 29 -
Merritt JL 2nd, Nguyen T, Daniels J, Matern D, Schowalter DBBiochemical correction of very long-chain acyl-CoA dehydrogenase deficiency following adeno-associated virus gene therapy.
19156135 Molecular therapy : the journal of the American Society of Gene Therapy, 2009 March : 17(3)425-9 PMCID:PMC2835097 -
Merritt JL, Lindor NMFurther clinical description of duplication of Williams-Beuren region presenting with congenital glaucoma and brachycephaly.
18266245 American journal of medical genetics. Part A, 2008 Apr 15 : 146A(8)1055-8 -
Merritt JL 2nd, Zou Y, Jalal SM, Michels VVDelineation of the cryptic 1qter deletion phenotype.
17304549 American journal of medical genetics. Part A, 2007 Mar 15 : 599-603 -
Hu WT, Kantarci OH, Merritt JL 2nd, McGrann P, Dyck PJ, Lucchinetti CF, Tippmann-Peikert MOrnithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgery.
17210820 Archives of neurology, 2007 Jan. : 126-8 -
Merritt JL 2nd, Davis DM, Pittelkow MR, Babovic-Vuksanovic DExtensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with TSC2 mutations.
16835931 American journal of medical genetics. Part A, 2006 Aug 1 : 140(15)1669-72 -
Merritt JL 2nd, Matern D, Vockley J, Daniels J, Nguyen TV, Schowalter DBIn vitro characterization and in vivo expression of human very-long chain acyl-CoA dehydrogenase.
16621643 Molecular genetics and metabolism, 2006 Aug. : 88(4)351-8 -
Merritt JL 2nd, Jalal SM, Barbaresi WJ, Babovic-Vuksanovic D14q32.3 deletion syndrome with autism.
15657934 American journal of medical genetics. Part A, 2005 Feb 15 : 99-100 -
Arakawa T, Chong DK, Merritt JL, Langridge WHExpression of cholera toxin B subunit oligomers in transgenic potato plants.
9423288 Transgenic research, 1997 Nov. : 6(6)403-13
Book Chapters
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JL Merritt, IIPatau Syndrome
Brenner's Encyclopedia of Genetics, 2nd Edition, 2013 : Vol. 5375-376 -
J Lawrence Merritt II, MD, Sihoun Hahn, MD, PhDChapter 26 Inherited Metabolic Disorders
Oxford American Handbook of Pediatrics, 2009 : Oxford Uni
Published Abstracts
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Merritt JL 2nd.Ethical Rationale For Reconsidering Newborn Screening For Proximal Urea Cycle Disorders.
2014 March -
Merritt JL 2nd, Abdenur JE, Au SM, Barshop BA, Feuchtbaum L, Harding C, Hermerath C, Lorey FW, Sesser DE, Thompson JD, Vedal S, Yu A.Newborn Screening for Infants with Suspected Very Long-Chain Acyl-COA Dehydrogenase Deficiency in the Western United States.
2010 May 5 - 2013 May 10
Other Publications
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JL Merritt, IIBrachydactyly
Brenner's Encyclopedia of Genetics, 2nd Edition, 2013 : Vol. 1369-370 -
JL Merritt, IIMetabolic Disorders, Mutants
Brenner's Encyclopedia of Genetics, 2nd Edition, 2013 : Vol. 4375-376 -
JL Merritt, IIGaucher's Disease
Brenner's Encyclopedia of Genetics, 2013 : 3(2nd Ed.)162-163 -
Johannesen KM, Gardella E, Linnankivi T, Courage C, de Saint Martin A, Lehesjoki AE, Mignot C, Afenjar A, Lesca G, Abi-Warde MT, Chelly J, Piton A, Merritt JL 2nd, Rodan LH, Tan WH, Bird LM, Nespeca M, Gleeson JG, Yoo Y, Choi M, Chae JH, Czapansky-Beilman D, Reichert SC, Pendziwiat M, Verhoeven JS, Schelhaas HJ, Devinsky O, Christensen J, Specchio N, Trivisano M, Weber YG, Nava C, Keren B, Doummar D, Schaefer E, Hopkins S, Dubbs H, Shaw JE, Pisani L, Myers CT, Tang S, Tang S, Pal DK, Millichap JJ, Carvill GL, Helbig KL, Mecarelli O, Striano P, Helbig I, Rubboli G, Mefford HC, Møller RSDefining the phenotypic spectrum of SLC6A1 mutations.
29315614 Epilepsia, 59(2)389-402 PMCID:PMC5912688 -
Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB, SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS.Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants: Executive Summary.
27244836 Pediatrics, 137(5) -
Johannesen KM, Gardella E, Linnankivi T, Courage C, de Saint Martin A, Lehesjoki AE, Mignot C, Afenjar A, Lesca G, Abi-Warde MT, Chelly J, Piton A, Merritt JL 2nd, Rodan LH, Tan WH, Bird LM, Nespeca M, Gleeson JG, Yoo Y, Choi M, Chae JH, Czapansky-Beilman D, Reichert SC, Pendziwiat M, Verhoeven JS, Schelhaas HJ, Devinsky O, Christensen J, Specchio N, Trivisano M, Weber YG, Nava C, Keren B, Doummar D, Schaefer E, Hopkins S, Dubbs H, Shaw JE, Pisani L, Myers CT, Tang S, Tang S, Pal DK, Millichap JJ, Carvill GL, Helbig KL, Mecarelli O, Striano P, Helbig I, Rubboli G, Mefford HC, Møller RSDefining the phenotypic spectrum of SLC6A1 mutations.
29315614 Epilepsia, 59(2)389-402 PMCID:PMC5912688 -
Posset R, Garbade SF, Boy N, Burlina AB, Dionisi-Vici C, Dobbelaere D, Garcia-Cazorla A, de Lonlay P, Teles EL, Vara R, Ah Mew N, Batshaw ML, Baumgartner MR, McCandless S, Seminara J, Summar M, Hoffmann GF, Kölker S, Burgard P, Additional individual contributors of the UCDC and the E-IMD consortium.Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-a successful strategy for clinical research of rare diseases.
29974348 Journal of inherited metabolic disease -
Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB, SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS.Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants: Executive Summary.
27244836 Pediatrics, 137(5)
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Presentations Title Event Location Date Neurology Grand Rounds. University of Washington Medical Center Seattle, WA Apr 18, 2013 A Clinical Approach to Inborn Errors of Metabolism. Excellence in Pediatrics 2012. Madrid, Spain. Nov 29, 2012 The Diagnosis of Genetic Disease. 3) Northwest Medical Laboratory Symposium. American Society for Clinical Laboratory Science, Region IX. Seattle, WA Oct 23, 2009 Newborn Screening: An Update on the Expansion. Pediatric Grand Rounds, Seattle Children's Hospital Seattle, WA Jan 29, 2009 Metabolic Disorders for all ages. WWAMI Visiting Professor Grand Rounds, 2 lectures. St. Lukes Regional Medical Center, Boise, ID and Mercy Medical Center, Nampa, ID Sep 24, 2008 -
Grant Title Grantor Amount Award Date An Open Label Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate (GPB; RAVICTI®) in Pediatric Subjects under Two Years of Age with Urea Cycle Disorders (UCDs) (HPN-100-009) Horizon Therapeutics, Inc. Apr 22, 2015 - Jan 27, 2017 Development of a Long-term Outcome Study of Newborn Screening for Urea Cycle Disorders (NBS+UCD) Horizon Therapeutics, Inc. Investigator Initiated Study Feb 5, 2015 - Mar 31, 2015 Longitudinal Study of Urea Cycle Disorders, O’Malley Family Foundation O’Malley Family Foundation June 2008 - Dec. 2018
Overview
- Board Certification(s)
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Clinical Biochemical Genetics
Pediatrics
Clinical Genetics and Genomics (MD)
- Medical/Professional School
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Loma Linda University School Of Medicine, Loma Linda, CA
- Residency
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Mayo Clinic College of Medicine, Rochester, MN
- Fellowship
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Mayo Clinic College of Medicine, Rochester, MN
- Clinical Interests
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Treatment and management of individuals with inborn errors of metabolism, with an emphasis on fatty acid oxidation disorders and infants with abnormal newborn screening results.
- Research Description
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Areas of focus include newborn screening, urea cycle disorders, and fatty acid oxidation disorders
- Research Focus Area
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Translational Research, Biochemical Genetics, Mitochondrial disease