Hans D Ochs, MD

Hans D Ochs, MD

Immunology, Non-Malignant Transplant Program

On staff since February 1974

Academic Title: Professor, Pediatrics

Research Title: Principal Investigator

Foundation Title: Jeffrey Modell Endowed Chair in Pediatric Immunology Research

Research Center: Center for Immunity and Immunotherapies

"I decided to enter the medical profession because the Hippocratic Oath rendered it unique, apolitical and not money-driven; at the same time, medicine promised to be a field where research has a purpose, teaching has an impact and providing care for patients is considered a privilege and a vocation. I am content and happy I did."

  • Hans D. Ochs, MD, is attending physician at Seattle Children’s Hospital. He earned his MD summa cum laude from the University of Freiburg, Germany. He completed his residency in pediatrics at the University of Washington.

    The focus of his research is the molecular definition of primary immunodeficiency diseases (PIDD) and the investigation of new techniques to confirm the diagnosis. He and his collaborators contributed significantly to the identification of a number of genes associated with PIDD located on the X chromosome (CD40L, Wiskott-Aldrich syndrome protein [WASP], FOXP3, gp91phox) or on autosomes (uracil-DNA glycosulase; Rag1, Rag2 hypomorphic mutations as the cause of Omenn syndrome, STAT3 responsible for AD-HIES). Ochs started the Immunodeficiency Clinic at Seattle Children’s in 1985, providing evaluation and care for both pediatric and adult patients with immunodeficiency disorders. He has initiated clinical trials for new immunoglobulin preparations for intravenous and subcutaneous infusions and has collaborated with the bone marrow transplant team in the design of new protocols for stem cell transplant and gene therapy. He was principal investigator for U.S. Immune Deficiency Network (USIDnet) and is co-founder and member of the summer school faculty devoted to primary immune deficiencies. He is principal editor for the medical textbook Primary Immunodeficiency Diseases: A Molecular and Genetic Approach and co-editor for Immunological Disorders in Infants and Children.

    • Cindy Federal way Wa 01.24.17

      I still remember the call I received while in my infants hospital room from a man with a thick accent telling me he believed my son had been misdiagnosed and there was a treatment available he would like to discuss. I had just been told my son would not live another year. We are celebrating his 18th birthday in two weeks and my only complaint is that beard of his. He is beautiful and perfect. And we owe every good thing to the amazing Hans Ochs. If he is an option for you, seek him out at all costs. You will be grateful you did

    • Colleen Salt Lake City, UT 06.16.14

      Dr. Ochs treated my two immune-deficient sons years ago when we lived in Washington. He was very helpful and straightforward in giving my sons what they needed and introducing us to IVIG. He has been a trusted resource I could call over the years even when we lived in other states. He is an excellent researcher. I would highly recommend him.

  • Award Name Award Description Awarded By Award Date
     Clinical Immunology Society President’s Award Clinical Immunology Society Jan 1, 2009
  • Other Publications

    • Freire PP, Marques AH, Baiocchi GC, Schimke LF, Fonseca DL, Salgado RC, Filgueiras IS, Napoleao SM, Plaça DR, Akashi KT, Hirata TDC, El Khawanky N, Giil LM, Cabral-Miranda G, Carvalho RF, Ferreira LCS, Condino-Neto A, Nakaya HI, Jurisica I, Ochs HD, Camara NOS, Calich VLG, Cabral-Marques O
      The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age.
      34027897 JCI insight, 2021 May 24 : 6(10)
    • Renner ED, Krätz CE, Orange JS, Hagl B, Rylaarsdam S, Notheis G, Durandy A, Torgerson TR, Ochs HD
      Class Switch Recombination Defects: impact on B cell maturation and antibody responses.
      33276124 Clinical immunology (Orlando, Fla.), 2021 Jan. : 222108638
    • Darbeheshti F, Abolhassani H, Bashashati M, Ghavami S, Shahkarami S, Zoghi S, Gupta S, Orange JS, Ochs HD, Rezaei N
      Coronavirus: Pure Infectious Disease or Genetic Predisposition.
      33973174 Advances in experimental medicine and biology, 2021 : 131891-107
    • Kappes L, Amer RL, Sommerlatte S, Bashir G, Plattfaut C, Gieseler F, Gemoll T, Busch H, Altahrawi A, Al-Sbiei A, Haneefa SM, Arafat K, Schimke LF, Khawanky NE, Schulze-Forster K, Heidecke H, Kerstein-Staehle A, Marschner G, Pitann S, Ochs HD, Mueller A, Attoub S, Fernandez-Cabezudo MJ, Riemekasten G, Al-Ramadi BK, Cabral-Marques O
      Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis.
      32985601 Scientific reports, 2020 Sep 28 : 10(1)15931 PMCID:PMC7522204
    • Peter HH, Ochs HD, Cunningham-Rundles C, Vinh DC, Kiessling P, Greve B, Jolles S
      Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations.
      32896308 The Journal of allergy and clinical immunology, 2020 Sept. : 146(3)479-491.e5 PMCID:PMC7471860
    • Rzymski P, Nowicki M, Mullin GE, Abraham A, Rodríguez-Román E, Petzold MB, Bendau A, Sahu KK, Ather A, Naviaux AF, Janne P, Gourdin M, Delanghe JR, Ochs HD, Talmadge JE, Garg M, Hamblin MR, Rezaei N
      Quantity does not equal quality: Scientific principles cannot be sacrificed.
      32585609 International immunopharmacology, 2020 Sept. : 86106711 PMCID:PMC7307981
    • Momtazmanesh S, Ochs HD, Uddin LQ, Perc M, Routes JM, Vieira DN, Al-Herz W, Baris S, Prando C, Rosivall L, Abdul Latiff AH, Ulrichs T, Roudenok V, Aldave Becerra JC, Salunke DB, Goudouris E, Condino-Neto A, Stashchak A, Kryvenko O, Stashchak M, Bondarenko A, Rezaei N
      All together to Fight COVID-19.
      32323644 The American journal of tropical medicine and hygiene, 2020 June : 102(6)1181-1183 PMCID:PMC7253116
    • Moradian N, Ochs HD, Sedikies C, Hamblin MR, Camargo CA Jr, Martinez JA, Biamonte JD, Abdollahi M, Torres PJ, Nieto JJ, Ogino S, Seymour JF, Abraham A, Cauda V, Gupta S, Ramakrishna S, Sellke FW, Sorooshian A, Wallace Hayes A, Martinez-Urbistondo M, Gupta M, Azadbakht L, Esmaillzadeh A, Kelishadi R, Esteghamati A, Emam-Djomeh Z, Majdzadeh R, Palit P, Badali H, Rao I, Saboury AA, Jagan Mohan Rao L, Ahmadieh H, Montazeri A, Fadini GP, Pauly D, Thomas S, Moosavi-Movahed AA, Aghamohammadi A, Behmanesh M, Rahimi-Movaghar V, Ghavami S, Mehran R, Uddin LQ, Von Herrath M, Mobasher B, Rezaei N
      The urgent need for integrated science to fight COVID-19 pandemic and beyond.
      32430070 Journal of translational medicine, 2020 May 19 : 18(1)205 PMCID:PMC7236639
    • Leung D, Chua GT, Mondragon AV, Zhong Y, Nguyen-Ngoc-Quynh L, Imai K, Vignesh P, Suratannon N, Mao H, Lee WI, Kim YJ, Chan GCF, Liew WK, Huong LTM, Kanegane H, Muktiarti D, Zhao X, Santos-Ocampo FJ, Latiff AHA, Seger R, Ochs HD, Singh S, Lee PP, Lau YL
      Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific.
      32903579 Frontiers in immunology, 2020 : 111605 PMCID:PMC7438539
    • Collins CJ, Yi F, Dayuha R, Whiteaker JR, Ochs HD, Freeman A, Su HC, Paulovich AG, Segundo GRS, Torgerson T, Hahn SH
      Multiplexed Proteomic Analysis for Diagnosis and Screening of Five Primary Immunodeficiency Disorders From Dried Blood Spots.
      32296420 Frontiers in immunology, 2020 : 11464 PMCID:PMC7141245
    • Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, Notarangelo L, Ochs HD, Fleisher T, Kastner D, Chanock SJ, Jain A
      A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.
      20652909 Human mutation, 2010 Sept. : 1080-8
    • Moes N, Rieux-Laucat F, Begue B, Verdier J, Neven B, Patey N, Torgerson TT, Picard C, Stolzenberg MC, Ruemmele C, Rings EH, Casanova JL, Piloquet H, Biver A, Breton A, Ochs HD, Hermine O, Fischer A, Goulet O, Cerf-Bensussan N, Ruemmele FM
      Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy.
      20537998 Gastroenterology, 2010 Sept. : 770-8
    • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
      Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
      20643476 The Journal of allergy and clinical immunology, 2010 Jul 17
    • Quan PL, Wagner TA, Briese T, Torgerson TR, Hornig M, Tashmukhamedova A, Firth C, Palacios G, Baisre-De-Leon A, Paddock CD, Hutchison SK, Egholm M, Zaki SR, Goldman JE, Ochs HD, Lipkin WI
      Astrovirus encephalitis in boy with X-linked agammaglobulinemia.
      20507741 Emerging infectious diseases, 2010 June : 918-25
    • Albert MH, Bittner TC, Nonoyama S, Notarangelo LD, Burns S, Imai K, Espanol T, Fasth A, Pellier I, Strauss G, Morio T, Gathmann B, Noordzij JG, Fillat C, Hoenig M, Nathrath M, Meindl A, Pagel P, Wintergerst U, Fischer A, Thrasher AJ, Belohradsky BH, Ochs HD
      X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options.
      20173115 Blood, 2010 Apr 22 : 3231-8
    • Yamazaki K, Yamazaki T, Taki S, Miyake K, Hayashi T, Ochs HD, Agematsu K
      Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling.
      20133206 Clinical immunology (Orlando, Fla.), 2010 April : 125-36
    • Kumánovics A, Wittwer CT, Pryor RJ, Augustine NH, Leppert MF, Carey JC, Ochs HD, Wedgwood RJ, Faville RJ Jr, Quie PG, Hill HR
      Rapid molecular analysis of the STAT3 gene in Job syndrome of hyper-IgE and recurrent infectious diseases.
      20093388 The Journal of molecular diagnostics : JMD, 2010 March : 213-9
    • Skoda-Smith S, Torgerson TR, Ochs HD
      Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
      20169031 Therapeutics and clinical risk management, 2010 Feb 2 : 1-10
    • Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT
      Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
      20004776 The Journal of allergy and clinical immunology, 2009 Dec. : 1152-60.e12
    • Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, Conley ME, Cunningham-Rundles C, Etzioni A, Hammartröm L, Nonoyama S, Ochs HD, Puck J, Roifman C, Seger R, Wedgwood J
      Primary immunodeficiencies: 2009 update.
      20004777 The Journal of allergy and clinical immunology, 2009 Dec. : 1161-78
    • Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
      Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
      19770362 Blood, 2009 Nov 12 : 4373-82
    • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
      CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
      19713458 Blood, 2009 Nov 5 : 4034-44
    • Renner ED, Hartl D, Rylaarsdam S, Young ML, Monaco-Shawver L, Kleiner G, Markert ML, Stiehm ER, Belohradsky BH, Upton MP, Torgerson TR, Orange JS, Ochs HD
      Comèl-Netherton syndrome defined as primary immunodeficiency.
      19683336 The Journal of allergy and clinical immunology, 2009 Sept. : 536-43
    • Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Añover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ
      FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
      19564342 Journal of immunology (Baltimore, Md. : 1950), 2009 Jul 15 : 907-15
    • Astrakhan A, Ochs HD, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
      19494259 Journal of immunology (Baltimore, Md. : 1950), 2009 Jun 15 : 7370-80
    • Ochs HD, Oukka M, Torgerson TR
      TH17 cells and regulatory T cells in primary immunodeficiency diseases.
      19410687 The Journal of allergy and clinical immunology, 2009 May : 977-83; quiz 984-5
    • Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G
      Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines.
      19232702 The Journal of allergy and clinical immunology, 2009 April : 900-5
    • Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, Terayama Y, Yamaya K, Ohyama C, Nonoyama S, Ochs HD
      FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.
      19155218 The Journal of biological chemistry, 2009 Mar 27 : 8548-56
    • Salzer U, Bacchelli C, Buckridge S, Pan-Hammarström Q, Jennings S, Lougaris V, Bergbreiter A, Hagena T, Birmelin J, Plebani A, Webster AD, Peter HH, Suez D, Chapel H, McLean-Tooke A, Spickett GP, Anover-Sombke S, Ochs HD, Urschel S, Belohradsky BH, Ugrinovic S, Kumararatne DS, Lawrence TC, Holm AM, Franco JL, Schulze I, Schneider P, Gertz EM, Schäffer AA, Hammarström L, Thrasher AJ, Gaspar HB, Grimbacher B
      Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.
      18981294 Blood, 2009 Feb 26 : 1967-76
    • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
      Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
      18952502 Clinical immunology (Orlando, Fla.), 2009 Feb. : 162-74
    • Kobayashi S, Haruo N, Sugane K, Ochs HD, Agematsu K
      Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells.
      19026702 Human immunology, 2009 Jan. : 35-40
    • Ochs HD, Filipovich AH, Veys P, Cowan MJ, Kapoor N
      Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment.
      19147084 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009 Jan. : 84-90
    • Ochs HD
      Mutations of the Wiskott-Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes.
      19082760 Immunologic research, 2009 : 84-8
    • Westerberg LS, de la Fuente MA, Wermeling F, Ochs HD, Karlsson MC, Snapper SB, Notarangelo LD
      WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.
      18772454 Blood, 2008 Nov 15 : 4139-47
    • Krueger JG, Ochs HD, Patel P, Gilkerson E, Guttman-Yassky E, Dummer W
      Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: results of a randomized, single blind study.
      18496564 The Journal of investigative dermatology, 2008 Nov. : 2615-24
    • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
      Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
      18574023 Blood, 2008 Sep 1 : 1662-72
    • Oxelius VA, Ochs HD, Hammarström L
      Restricted immunoglobulin constant heavy G chain genes in primary immunodeficiencies.
      18502179 Clinical immunology (Orlando, Fla.), 2008 Aug. : 190-8
    • Schultz KA, Neglia JP, Smith AR, Ochs HD, Torgerson TR, Kumar A
      Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemia.
      18421721 Pediatric blood & cancer, 2008 Aug. : 293-5
    • Renner ED, Rylaarsdam S, Anover-Sombke S, Rack AL, Reichenbach J, Carey JC, Zhu Q, Jansson AF, Barboza J, Schimke LF, Leppert MF, Getz MM, Seger RA, Hill HR, Belohradsky BH, Torgerson TR, Ochs HD
      Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome.
      18602572 The Journal of allergy and clinical immunology, 2008 July : 181-7
    • Ochs HD
      Patients with abnormal IgM levels: assessment, clinical interpretation, and treatment.
      18517086 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008 May : 509-11
    • Notarangelo LD, Miao CH, Ochs HD
      Wiskott-Aldrich syndrome.
      18043243 Current opinion in hematology, 2008 Jan. : 30-6
    • Torgerson TR, Ochs HD
      Regulatory T cells in primary immunodeficiency diseases.
      17989528 Current opinion in allergy and clinical immunology, 2007 Dec. : 515-21
    • Fuchizawa T, Adachi Y, Ito Y, Higashiyama H, Kanegane H, Futatani T, Kobayashi I, Kamachi Y, Sakamoto T, Tsuge I, Tanaka H, Banham AH, Ochs HD, Miyawaki T
      Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations.
      17916446 Clinical immunology (Orlando, Fla.), 2007 Dec. : 237-46
    • Sedivá A, Smith CI, Asplund AC, Hadac J, Janda A, Zeman J, Hansíková H, Dvoráková L, Mrázová L, Velbri S, Koehler C, Roesch K, Sullivan KE, Futatani T, Ochs HD
      Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L, and DRP2 genes.
      17851739 Journal of clinical immunology, 2007 Nov. : 640-6
    • Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD
      STAT3 mutation in the original patient with Job's syndrome.
      17942886 The New England journal of medicine, 2007 Oct 18 : 1667-8
    • Shearer WT, Cunningham-Rundles C, Ballow M, Ochs HD, Geha RS
      Images in immunodeficiency.
      17931568 The Journal of allergy and clinical immunology, 2007 Oct. : 982-4
    • Geha RS, Notarangelo LD, Casanova JL, Chapel H, Conley ME, Fischer A, Hammarström L, Nonoyama S, Ochs HD, Puck JM, Roifman C, Seger R, Wedgwood J
      Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee.
      17952897 The Journal of allergy and clinical immunology, 2007 Oct. : 776-94
    • Torgerson TR, Linane A, Moes N, Anover S, Mateo V, Rieux-Laucat F, Hermine O, Vijay S, Gambineri E, Cerf-Bensussan N, Fischer A, Ochs HD, Goulet O, Ruemmele FM
      Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene.
      17484868 Gastroenterology, 2007 May : 1705-17
    • Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM
      A potential screening tool for IPEX syndrome.
      17378693 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 2007 March : 98-105
    • de la Fuente MA, Sasahara Y, Calamito M, Antón IM, Elkhal A, Gallego MD, Suresh K, Siminovitch K, Ochs HD, Anderson KC, Rosen FS, Geha RS, Ramesh N
      WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
      17213309 Proceedings of the National Academy of Sciences of the United States of America, 2007 Jan 16 : 926-31
    • Ochs HD, Gambineri E, Torgerson TR
      IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.
      17917016 Immunologic research, 2007 : 112-21
    • Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H
      Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.
      17088085 Immunity, 2006 Nov. : 745-55
    • Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD, Ziegler SF
      Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.
      16920951 Journal of immunology (Baltimore, Md. : 1950), 2006 Sep 1 : 3133-42
    • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
      Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
      16507778 Blood, 2006 Jul 1 : 19-27
    • Winkelstein JA, Marino MC, Lederman HM, Jones SM, Sullivan K, Burks AW, Conley ME, Cunningham-Rundles C, Ochs HD
      X-linked agammaglobulinemia: report on a United States registry of 201 patients.
      16862044 Medicine, 2006 July : 193-202
    • Ochs HD, Gupta S, Kiessling P, Nicolay U, Berger M
      Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases.
      16783465 Journal of clinical immunology, 2006 May : 265-73
    • Tsuboi S, Nonoyama S, Ochs HD
      Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.
      16582881 EMBO reports, 2006 May : 506-11
    • Ochs HD, Thrasher AJ
      The Wiskott-Aldrich syndrome.
      16630926 The Journal of allergy and clinical immunology, 2006 April : 725-38; quiz 739
    • Trakultivakorn M, Ochs HD
      X-linked agammaglobulinemia in northern Thailand.
      16913189 Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand, 2006 March : 57-63
    • Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman CM, Gardulf A, Eichmann F, Haag S, Massion C, Ochs HD
      Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home.
      16418804 Journal of clinical immunology, 2006 Jan. : 65-72
    • Notarangelo LD, Notarangelo LD, Ochs HD
      WASP and the phenotypic range associated with deficiency.
      16264326 Current opinion in allergy and clinical immunology, 2005 Dec. : 485-90
    • Bindl L, Torgerson T, Perroni L, Youssef N, Ochs HD, Goulet O, Ruemmele FM
      Successful use of the new immune-suppressor sirolimus in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome).
      16126062 The Journal of pediatrics, 2005 Aug. : 256-9
    • Ochs HD, Notarangelo LD
      Structure and function of the Wiskott-Aldrich syndrome protein.
      15928485 Current opinion in hematology, 2005 July : 284-91
    • Vogt G, Chapgier A, Yang K, Chuzhanova N, Feinberg J, Fieschi C, Boisson-Dupuis S, Alcais A, Filipe-Santos O, Bustamante J, de Beaucoudrey L, Al-Mohsen I, Al-Hajjar S, Al-Ghonaium A, Adimi P, Mirsaeidi M, Khalilzadeh S, Rosenzweig S, de la Calle Martin O, Bauer TR, Puck JM, Ochs HD, Furthner D, Engelhorn C, Belohradsky B, Mansouri D, Holland SM, Schreiber RD, Abel L, Cooper DN, Soudais C, Casanova JL
      Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations.
      15924140 Nature genetics, 2005 July : 692-700
    • Oda A, Miki H, Wada I, Yamaguchi H, Yamazaki D, Suetsugu S, Nakajima M, Nakayama A, Okawa K, Miyazaki H, Matsuno K, Ochs HD, Machesky LM, Fujita H, Takenawa T
      WAVE/Scars in platelets.
      15280206 Blood, 2005 Apr 15 : 3141-8
    • Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD
      Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome.
      15358621 Blood, 2005 Mar 1 : 1881-90
    • Huang W, Ochs HD, Dupont B, Vyas YM
      The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement.
      15728466 Journal of immunology (Baltimore, Md. : 1950), 2005 Mar 1 : 2602-11
    • Ochs HD, Ziegler SF, Torgerson TR
      FOXP3 acts as a rheostat of the immune response.
      15661028 Immunological reviews, 2005 Feb. : 156-64
    • Bearden CM, Agarwal A, Book BK, Vieira CA, Sidner RA, Ochs HD, Young M, Pescovitz MD
      Rituximab inhibits the in vivo primary and secondary antibody response to a neoantigen, bacteriophage phiX174.
      15636611 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005 Jan. : 50-7
    • Jin Y, Mazza C, Christie JR, Giliani S, Fiorini M, Mella P, Gandellini F, Stewart DM, Zhu Q, Nelson DL, Notarangelo LD, Ochs HD
      Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation.
      15284122 Blood, 2004 Dec 15 : 4010-9
    • Etzioni A, Ochs HD
      The hyper IgM syndrome--an evolving story.
      15319456 Pediatric research, 2004 Oct. : 519-25
    • Ochs HD, Notarangelo LD
      X-linked immunodeficiencies.
      15283872 Current allergy and asthma reports, 2004 Sept. : 339-48
    • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
      Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
      15233948 Molecular therapy : the journal of the American Society of Gene Therapy, 2004 July : 117-26
    • Ochs HD, Pinciaro PJ
      Octagam 5%, an intravenous IgG product, is efficacious and well tolerated in subjects with primary immunodeficiency diseases.
      15114062 Journal of clinical immunology, 2004 May : 309-14
    • Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA
      Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
      15096376 Archives of dermatology, 2004 April : 466-72
    • Shearer WT, Cunningham-Rundles C, Ochs HD
      Primary immunodeficiency: looking backwards, looking forwards.
      15100662 The Journal of allergy and clinical immunology, 2004 April : 607-9
    • Imai K, Morio T, Zhu Y, Jin Y, Itoh S, Kajiwara M, Yata J, Mizutani S, Ochs HD, Nonoyama S
      Clinical course of patients with WASP gene mutations.
      12969986 Blood, 2004 Jan 15 : 456-64
    • Imai K, Nonoyama S, Ochs HD
      WASP (Wiskott-Aldrich syndrome protein) gene mutations and phenotype.
      14612666 Current opinion in allergy and clinical immunology, 2003 Dec. : 427-36
    • Gottlieb AB, Casale TB, Frankel E, Goffe B, Lowe N, Ochs HD, Roberts JL, Washenik K, Vaishnaw AK, Gordon KB
      CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study.
      14576659 Journal of the American Academy of Dermatology, 2003 Nov. : 816-25
    • Lee WI, Zhu Q, Gambineri E, Jin Y, Welcher AA, Ochs HD
      Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis.
      14610488 The Journal of allergy and clinical immunology, 2003 Nov. : 958-64
    • Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, Yel L, Forveille M, Kavli B, Krokan HE, Ochs HD, Fischer A, Durandy A
      Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
      12958596 Nature immunology, 2003 Oct. : 1023-8
    • Notarangelo LD, Ochs HD
      Wiskott-Aldrich Syndrome: a model for defective actin reorganization, cell trafficking and synapse formation.
      14499269 Current opinion in immunology, 2003 Oct. : 585-91
    • Shi Y, Agematsu K, Ochs HD, Sugane K
      Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM.
      12921759 Clinical immunology (Orlando, Fla.), 2003 Aug. : 128-37
    • Kobayashi N, Agematsu K, Sugita K, Sako M, Nonoyama S, Yachie A, Kumaki S, Tsuchiya S, Ochs HD, Sugita K, Fukushima Y, Komiyama A
      Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families.
      12592555 Human genetics, 2003 April : 348-52
    • Rodríguez C, Carrión F, Marinovic MA, Chávez E, Preisler J, Pooley F, Futatani T, Ochs HD
      [X-linked hyper-IGM syndrome associated to sclerosing cholangitis and gallbladder neoplasm: clinical case]
      12790080 Revista medica de Chile, 2003 March : 303-8
    • Torgerson TR, Ochs HD
      Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation.
      14752330 Current opinion in allergy and clinical immunology, 2002 Dec. : 481-7
    • Brunner C, Kreth HW, Ochs HD, Schuster V
      Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia.
      12148599 Journal of clinical immunology, 2002 July : 244-51
    • Aiuti A, Vai S, Mortellaro A, Casorati G, Ficara F, Andolfi G, Ferrari G, Tabucchi A, Carlucci F, Ochs HD, Notarangelo LD, Roncarolo MG, Bordignon C
      Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement.
      11984564 Nature medicine, 2002 May : 423-5
    • Ochs HD
      The Wiskott-Aldrich syndrome.
      12040832 The Israel Medical Association journal : IMAJ, 2002 May : 379-84
    • Agematsu K, Futatani T, Hokibara S, Kobayashi N, Takamoto M, Tsukada S, Suzuki H, Koyasu S, Miyawaki T, Sugane K, Komiyama A, Ochs HD
      Absence of memory B cells in patients with common variable immunodeficiency.
      11987983 Clinical immunology (Orlando, Fla.), 2002 April : 34-42
    • Notarangelo LD, Mazza C, Giliani S, D'Aria C, Gandellini F, Ravelli C, Locatelli MG, Nelson DL, Ochs HD, Notarangelo LD
      Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia.
      11877312 Blood, 2002 Mar 15 : 2268-9
    • Sarpong S, Skolnick HS, Ochs HD, Futatani T, Winkelstein JA
      Survival of wild polio by a patient with XLA.
      11814279 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002 Jan. : 59-60
    • Ziegner UH, Kobayashi RH, Cunningham-Rundles C, Español T, Fasth A, Huttenlocher A, Krogstad P, Marthinsen L, Notarangelo LD, Pasic S, Rieger CH, Rudge P, Sankar R, Shigeoka AO, Stiehm ER, Sullivan KE, Webster AD, Ochs HD
      Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment.
      11781063 Clinical immunology (Orlando, Fla.), 2002 Jan. : 19-24


Board Certification(s)

Allergy & Immunology

Medical/Professional School

Albert-Ludwigs Universitat Freiburg, D-79110 Freiburg Im Breisgau


University of Washington School of Medicine, Seattle, WA


University of Washington School of Medicine, Seattle, WA

Research Description

Dr. Ochs' research focuses on the molecular basis of Primary Immune Deficiency Diseases with special interest in the genes that have been linked to the Wiskott Aldrich Syndrome, Hyper IgM syndromes, X-linked Agammaglobulinemia, IPEX syndrome, autosomal recessive Hyper IgE syndrome. To improve the long-term outcome of these disorders, he has actively participated in clinical trials to develop immunoglobulin replacement, hematopoietic stem cell transplantation, and gene therapy.

Dr. Ochs' clinical interests focus on the use of intravenous and subcutaneous immunoglobulin and the in vivo analysis of antibody production using Bacteriophage FX174. He and his collaborators contributed to the identification of several genes associated with PIDD located on the X chromosome, including CD40L, Wiskott-Aldrich Syndrome protein, BTK, and FOXP3.

Recently, he focused on the gene Uracil-DNA Glycosulase, causing a rare form of autosomal recessive hyper IgM syndrome and on STAT3, the gene causing autosomal dominant Hyper IgE Syndrome if mutated. In 1995, he moved the immunodeficiency clinic from the University to Children's Hospital, providing diagnostic evaluations and clinical care for both pediatric and adult patients with PIDD. He initiated and maintained a successful cooperation with the bone marrow transplant unit since the early 70s and participated in the design of protocols related to stem cell transplantation for patients with SCID, Wiskott-Aldrich Syndrome, GGD, and Hyper IgM Syndrome.

He is a PI for the NIH contract supporting the United States Immune Deficiency Network (USIDNet) and member of the U.S. Summer School Faculty devoted to teaching fellows interested in primary immunodeficiency diseases. As co-editor of the textbooks Primary Immunodeficiency Diseases, A Molecular and Genetic Approach, 2nd Edition and for Immunologic Disorders in Infants and Children, 3rd Edition.

The Ochs/Torgerson Lab focuses on:

1) The molecular basis of primary immunodeficiency disorders
2) Autoimmunity and Immune dysregulation
3) Regulatory T cells and mutations of FOXP3
4) Eventual consequences of heterozygous hypermorphic STAT3 mutations and their relationship to autosomal dominant Hyper IgE syndrome.

Research Focus Area