Eric Allenspach, MD, PhD

Eric Allenspach, MD, PhD

Immunology, Rheumatology, Non-Malignant Transplant Program

On staff since July 2016

Academic Title: Assistant Professor

Research Title: Principal Investigator

Research Center: Center for Immunity and Immunotherapies

"As a parent and physician, I am honored to receive the trust from patients and their families to participate in their care. I strive to develop strong relationships with my patients to find the best diagnosis and treatment for their disease. There can be a diagnostic journey and often a need for unique treatments for children with chronic immune disorders and I’m grateful for the opportunity to provide my expertise and try to help."

  • Biography

    Eric J. Allenspach, MD, PhD, is an attending physician and the medical director of Diagnostics for the Center for Immunity and Immunotherapies and the division of Immunology at Seattle Children's Hospital. He is also an attending physician in the division of Pediatric Rheumatology.

    He is an assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. He received his MD and Immunology PhD from University of Pennsylvania School of Medical School in the Medical Scientist Training Program.  He completed his pediatrics internship and residency as well as his pediatric rheumatology fellowship at Seattle Children's.

    • Related Pages

    • Dr. Allenspach's publications

      Dr. Allenspach's publications

    • Allenspach Lab

      Allenspach Lab

      The Allenspach Lab focuses on translational work to understand immune dysregulation disorders – those with overlapping immunodeficiency and autoimmune features.

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Distinguished Fellow Award American College of Rheumatology 2016
    Scientist Development Award Rheumatology Research Foundation (RRF) 2016 - 2018
    Fellow and Resident Research Day Presentation Award 2016
    Research Fellowship Award Mallinckrodt Pharmaceuticals 2015 - 2016

  • Publications

    Other Publications

    • Poskanzer SA, Schultz MJ, Turgeon CT, Vidal-Folch N, Liedtke K, Oglesbee D, Gavrilov DK, Tortorelli S, Matern D, Rinaldo P, Bennett JT, Thies JM, Chang IJ, Beck AE, Raymond K, Allenspach EJ, Lam C
      Immune dysfunction in MGAT2-CDG: A clinical report and review of the literature.
      33044030 American journal of medical genetics. Part A, 2021 Jan. : 185(1)213-218
    • Meitlis I, Allenspach EJ, Bauman BM, Phan IQ, Dabbah G, Schmitt EG, Camp ND, Torgerson TR, Nickerson DA, Bamshad MJ, Hagin D, Luthers CR, Stinson JR, Gray J, Lundgren I, Church JA, Butte MJ, Jordan MB, Aceves SS, Schwartz DM, Milner JD, Schuval S, Skoda-Smith S, Cooper MA, Starita LM, Rawlings DJ, Snow AL, James RG
      Multiplexed Functional Assessment of Genetic Variants in CARD11.
      33202260 American journal of human genetics, 2020 Dec 3 : 107(6)1029-1043 PMCID:PMC7820631
    • Perazzio SF, Allenspach EJ, Eklund KK, Varjosalo M, Shinohara MM, Torgerson TR, Seppänen MRJ
      Behçet disease (BD) and BD-like clinical phenotypes: NF-κB pathway in mucosal ulcerating diseases.
      32889730 Scandinavian journal of immunology, 2020 Nov. : 92(5)e12973
    • Chau AS, Cole BL, Debley JS, Nanda K, Rosen ABI, Bamshad MJ, Nickerson DA, Torgerson TR, Allenspach EJ
      Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares.
      33066778 Pediatric rheumatology online journal, 2020 Oct 16 : 18(1)80 PMCID:PMC7565350
    • de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R
      Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
      31874111 The Journal of clinical investigation, 2020 Apr 1 : 130(4)1669-1682 PMCID:PMC7108905
    • Chan AY, Leiding JW, Liu X, Logan BR, Burroughs LM, Allenspach EJ, Skoda-Smith S, Uzel G, Notarangelo LD, Slatter M, Gennery AR, Smith AR, Pai SY, Jordan MB, Marsh RA, Cowan MJ, Dvorak CC, Craddock JA, Prockop SE, Chandrakasan S, Kapoor N, Buckley RH, Parikh S, Chellapandian D, Oshrine BR, Bednarski JJ, Cooper MA, Shenoy S, Davila Saldana BJ, Forbes LR, Martinez C, Haddad E, Shyr DC, Chen K, Sullivan KE, Heimall J, Wright N, Bhatia M, Cuvelier GDE, Goldman FD, Meyts I, Miller HK, Seidel MG, Vander Lugt MT, Bacchetta R, Weinacht KG, Andolina JR, Caywood E, Chong H, de la Morena MT, Aquino VM, Shereck E, Walter JE, Dorsey MJ, Seroogy CM, Griffith LM, Kohn DB, Puck JM, Pulsipher MA, Torgerson TR
      Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.
      32153572 Frontiers in immunology, 2020 : 11239 PMCID:PMC7046837
    • Krevet S, Shen L, Bohnen T, Schoenenberger B, Meier R, Obkircher M, Bangert K, Koehling R, Allenspach E, Wohlgemuth R, Siebers B, Bräsen C
      Corrigendum: Enzymatic Synthesis of 2-Keto-3-Deoxy-6-Phosphogluconate by the 6-Phosphogluconate-Dehydratase From Caulobacter crescentus.
      32850694 Frontiers in bioengineering and biotechnology, 2020 : 8761 PMCID:PMC7399627
    • Krevet S, Shen L, Bohnen T, Schoenenberger B, Meier R, Obkircher M, Bangert K, Koehling R, Allenspach E, Wohlgemuth R, Siebers B, Bräsen C
      Enzymatic Synthesis of 2-Keto-3-Deoxy-6-Phosphogluconate by the 6-Phosphogluconate-Dehydratase From Caulobacter crescentus.
      32266226 Frontiers in bioengineering and biotechnology, 2020 : 8185 PMCID:PMC7099567
    • Tirosh I, Yamazaki Y, Frugoni F, Ververs FA, Allenspach EJ, Zhang Y, Burns S, Al-Herz W, Noroski L, Walter JE, Gennery AR, van der Burg M, Notarangelo LD, Lee YN
      Recombination activity of human recombination-activating gene 2 (RAG2) mutations and correlation with clinical phenotype.
      29772310 The Journal of allergy and clinical immunology, 2019 Feb. : 143(2)726-735 PMCID:PMC6295349
    • Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ
      The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.
      30740104 Frontiers in immunology, 2019 : 1044 PMCID:PMC6355696
    • Forbes LR, Vogel TP, Cooper MA, Castro-Wagner J, Schussler E, Weinacht KG, Plant AS, Su HC, Allenspach EJ, Slatter M, Abinun M, Lilic D, Cunningham-Rundles C, Eckstein O, Olbrich P, Guillerman RP, Patel NC, Demirdag YY, Zerbe C, Freeman AF, Holland SM, Szabolcs P, Gennery A, Torgerson TR, Milner JD, Leiding JW
      Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.
      30092289 The Journal of allergy and clinical immunology, 2018 Nov. : 142(5)1665-1669 PMCID:PMC6322659
    • Rosenberg JM, Maccari ME, Barzaghi F, Allenspach EJ, Pignata C, Weber G, Torgerson TR, Utz PJ, Bacchetta R
      Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked.
      29651287 Frontiers in immunology, 2018 : 9544 PMCID:PMC5885158
    • Gambineri E, Ciullini Mannurita S, Hagin D, Vignoli M, Anover-Sombke S, DeBoer S, Segundo GRS, Allenspach EJ, Favre C, Ochs HD, Torgerson TR
      Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome.
      30443250 Frontiers in immunology, 2018 : 92411 PMCID:PMC6223101
    • Allenspach EJ, Finn LS, Rendi MH, Eken A, Singh AK, Oukka M, Taylor SD, Altman MC, Fligner CL, Ochs HD, Rawlings DJ, Torgerson TR
      Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.
      28322850 The Journal of allergy and clinical immunology, 2017 Aug. : 140(2)616-619.e7
    • Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ
      The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
      28553952 Nature immunology, 2017 July : 18(7)744-752 PMCID:PMC5697900
    • Allenspach E, Torgerson TR
      Autoimmunity and Primary Immunodeficiency Disorders.
      27210535 Journal of clinical immunology, 2016 May : 36 Suppl 157-67
    • Kolhatkar NS, Brahmandam A, Thouvenel CD, Becker-Herman S, Jacobs HM, Schwartz MA, Allenspach EJ, Khim S, Panigrahi AK, Luning Prak ET, Thrasher AJ, Notarangelo LD, Candotti F, Torgerson TR, Sanz I, Rawlings DJ
      Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.
      26371186 The Journal of experimental medicine, 2015 Sep 21 : 212(10)1663-77 PMCID:PMC4577851
    • Archambault AS, Carrero JA, Barnett LG, McGee NG, Sim J, Wright JO, Raabe T, Chen P, Ding H, Allenspach EJ, Dragatsis I, Laufer TM, Wu GF
      Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.
      23772037 Journal of immunology (Baltimore, Md. : 1950), 2013 Jul 15 : 191(2)545-50 PMCID:PMC3711531
    • Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR
      Common variable immunodeficiency as the initial presentation of dyskeratosis congenita.
      23403051 The Journal of allergy and clinical immunology, 2013 July : 132(1)223-6 PMCID:PMC4560355
    • Wu GF, Shindler KS, Allenspach EJ, Stephen TL, Thomas HL, Mikesell RJ, Cross AH, Laufer TM
      Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity.
      21095100 Journal of autoimmunity, 2011 Feb. : 36(1)56-64 PMCID:PMC3053076
    • Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D
      MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
      19465906 Nature immunology, 2009 July : 10(7)697-705 PMCID:PMC2711559
    • Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA
      Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.
      19342644 Journal of immunology (Baltimore, Md. : 1950), 2009 Apr 15 : 182(8)4686-95 PMCID:PMC2922395
    • Allenspach EJ, Lemos MP, Porrett PM, Turka LA, Laufer TM
      Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells.
      18951047 Immunity, 2008 Nov 14 : 29(5)795-806 PMCID:PMC2746692
    • Kambayashi T, Baranski JD, Baker RG, Zou T, Allenspach EJ, Shoag JE, Jones PL, Koretzky GA
      Indirect involvement of allergen-captured mast cells in antigen presentation.
      18032707 Blood, 2008 Feb 1 : 111(3)1489-96 PMCID:PMC2214744
    • Tong J, Allenspach EJ, Takahashi SM, Mody PD, Park C, Burkhardt JK, Sperling AI
      CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism.
      15117976 The Journal of experimental medicine, 2004 May 3 : 199(9)1277-83 PMCID:PMC2211903
    • Allenspach EJ, Maillard I, Aster JC, Pear WS
      Notch signaling in cancer.
      12496471 Cancer biology & therapy, 2002 Sept. : 1(5)466-76
    • Allenspach E, Rawlings DJ, Scharenberg AM, Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A
      X-Linked Severe Combined Immunodeficiency
      20301584 1993

Overview

Board Certification(s)

Pediatrics
Pediatric Rheumatology

Medical/Professional School

University of Pennsylvania School of Medicine, Philadelphia, PA

Residency

University of Washington School of Medicine, Seattle, WA

Fellowship

Seattle Children's Hospital, Seattle, WA

Clinical Interests

Pediatric autoimmune diseases; Primary immune dysregulation and immunodeficiency disorders; Immunogenetics of autoimmunity and immunodeficiency; Diagnostic testing

Research Description

My primary research interests include understanding how children develop autoimmunity and why they are at higher risk of infections compared to other children. My laboratory uses expertise in genetic testing and immunophenotyping to help in diagnosis of patients in a direct translational effort to help children.  We also enroll families in our immune disorders biorepository study to test samples to further our understanding of these immune disorders. For a select group of genetic disorders, we have made animal models to mimic the human disorder with the ultimate goal of understanding the diseases at a mechanistic level and developing translational therapies to treat these disorders.