Douglas S Hawkins, MD

Douglas S Hawkins, MD

Cancer and Blood Disorders Center, Thyroid Program, Bone Tumors and Soft Tissue Tumors, Solid Tumors Oncology

On staff since February 1996

Children's Title: Chair, Children's Oncology Group

Academic Title: Professor, Hematology-Oncology

Research Center: Ben Towne Center for Childhood Cancer Research

"I feel exceptionally fortunate to work with some of the smartest people I know. Each day brings new opportunities to learn from my colleagues, patients and families. By the nature of our work in Hematology/Oncology, we see the importance of what we do every day. I am continually impressed by our ability to change the lives of children and young adults for the better, both with good clinical care and by clinical and translational research efforts. My hope is that the clinical research done by the Children's Oncology Group and at Seattle Children's Hospital today will lead to more effective treatments with fewer side effects for children and young adults in the future."

  • Biography

    Douglas S. Hawkins, MD, is the Group Chair of the Children's Oncology Group (COG).  COG is the world’s largest organization devoted exclusively to childhood and adolescent cancer research.  COG unites over 10,000 experts in childhood cancer at more than 200 leading children’s hospitals, universities, and cancer centers across North America, Australia, and New Zealand in the fight against childhood cancer.  Dr. Hawkins is a clinician at Seattle Children's Hospital and Professor of Pediatrics at the University of Washington School of Medicine.

    Dr. Hawkins is Group Chair of the Children's Oncology Group (COG).  Prior to becoming COG Group Chair in 2020, he was the Chair of the COG Soft Tissue Sarcoma Committee, overseeing the conduct of biology studies and clinical trials for rhabdomyosarcoma and other soft tissue sarcomas across North America.  Dr. Hawkins was a member of the COG Bone Tumor Steering Committee.  His academic career has focused on clinical research, particularly in the treatment of pediatric sarcomas. He was the chair of two COG clinical trials, one for Ewing sarcoma and another for rhabdomyosarcoma. He chairs the international EURO EWING Consortium External Advisory Board, and also chairs the international Frontline and Relapse in RhabdoMyoSarcoma Study (FaR-RMS) Data Monitoring Committee.

  • Patient Testimonials

    • Lynora Ketchikan,Alaska 01.31.24

      Dr. Hawkins is an amazing and personable doctor. On our first visit after diagnosis, he was so encouraging. Our son was 8, and had Hodgkins Lymphoma. He’s now 26 and a pilot for a major airlines. ♥️

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2012 to 2022 Seattle Magazine 2022
    Seattle's Top Doctor 2020 Seattle Met 2020
    Seattle's Top Doctor 2016 Seattle Met Magazine 2016
    Seattle's Top Doctor 2013 Seattle Met Magazine 2013
    U.S. News Top Doctor U.S. News and World Report 2012
    Newsweek Health: Top Cancer Doctors 2015 Newsweek 2015
  • Publications

    Other Publications

    • Eckstein OS, Allen CE, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey B, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga J, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
      Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the NCI-COG Pediatric MATCH Trial.
      35363510 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022 Apr 1 : JCO2102840
    • Haduong JH, Heske CM, Allen-Rhoades W, Xue W, Teot LA, Rodeberg DA, Donaldson SS, Weiss A, Hawkins DS, Venkatramani R
      An update on rhabdomyosarcoma risk stratification and the rationale for current and future Children's Oncology Group clinical trials.
      35129294 Pediatric blood & cancer, 2022 April : 69(4)e29511 PMCID:PMC8976559
    • Parsons DW, Janeway KA, Patton DR, Winter CL, Coffey B, Williams PM, Roy-Chowdhuri S, Tsongalis GJ, Routbort M, Ramirez NC, Saguilig L, Piao J, Alonzo TA, Berg SL, Fox E, Hawkins DS, Abrams JS, Mooney M, Takebe N, Tricoli JV, Seibel NL, NCI-COG Pediatric MATCH Team.
      Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients With Refractory Cancers in the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial.
      35353553 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022 Mar 30 : JCO2102838
    • Crane JN, Xue W, Qumseya A, Gao Z, Arndt CAS, Donaldson SS, Harrison DJ, Hawkins DS, Linardic CM, Mascarenhas L, Meyer WH, Rodeberg DA, Rudzinski ER, Shulkin BL, Walterhouse DO, Venkatramani R, Weiss AR
      Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group.
      35253352 Pediatric blood & cancer, 2022 Mar 6 : e29644
    • Fetzko S, Fonseca A, Frances Wedekind M, Gupta AA, Setty BA, Schraw J, Lupo PJ, Guillerman RP, Butala AA, Russell H, Nicholls L, Walterhouse D, Hawkins DS, Okcu MF
      Is Detection of Relapse by Surveillance Imaging Associated With Longer Survival in Patients With Rhabdomyosarcoma?
      35137727 Journal of pediatric hematology/oncology, 2022 Feb 9
    • Russell HV, Chi YY, Okcu MF, Bernhardt MB, Rodriguez-Galindo C, Gupta AA, Hawkins DS
      Rising drug cost impacts on cost-effectiveness of 2 chemotherapy regimens for intermediate-risk rhabdomyosarcoma: A report from the Children's Oncology Group.
      34623638 Cancer, 2022 Jan 15 : 128(2)317-325 PMCID:PMC8738099
    • Pearson AD, Rossig C, Mackall C, Shah NN, Baruchel A, Reaman G, Ricafort R, Heenen D, Bassan A, Berntgen M, Bird N, Bleickardt E, Bouchkouj N, Bross P, Brownstein C, Cohen SB, de Rojas T, Ehrlich L, Fox E, Gottschalk S, Hanssens L, Hawkins DS, Horak ID, Taylor DH, Johnson C, Karres D, Ligas F, Ludwinski D, Mamonkin M, Marshall L, Masouleh BK, Matloub Y, Maude S, McDonough J, Minard-Colin V, Norga K, Nysom K, Pappo A, Pearce L, Pieters R, Pule M, Quintás-Cardama A, Richardson N, Schüßler-Lenz M, Scobie N, Sersch MA, Smith MA, Sterba J, Tasian SK, Weigel B, Weiner SL, Zwaan CM, Lesa G, Vassal G
      Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
      34840026 European journal of cancer (Oxford, England : 1990), 2022 Jan. : 160112-133
    • Leavey PJ, Laack NN, Krailo MD, Buxton A, Randall RL, DuBois SG, Reed DR, Grier HE, Hawkins DS, Pawel B, Nadel H, Womer RB, Letson GD, Bernstein M, Brown K, Maciej A, Chuba P, Ahmed AA, Indelicato DJ, Wang D, Marina N, Gorlick R, Janeway KA, Mascarenhas L
      Phase III Trial Adding Vincristine-Topotecan-Cyclophosphamide to the Initial Treatment of Patients With Nonmetastatic Ewing Sarcoma: A Children's Oncology Group Report.
      34652968 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021 Dec 20 : 39(36)4029-4038 PMCID:PMC8677904
    • Collier AB 3rd, Krailo MD, Dang HM, DuBois SG, Hawkins DS, Bernstein ML, Bomgaars LR, Reed DR, Gorlick RG, Janeway KA
      Outcome of patients with relapsed or progressive Ewing sarcoma enrolled on cooperative group phase 2 clinical trials: A report from the Children's Oncology Group.
      34496122 Pediatric blood & cancer, 2021 Dec. : 68(12)e29333 PMCID:PMC8541905
    • Pinto N, Navarro SL, Rimorin C, Wurscher M, Hawkins DS, McCune JS
      Pharmacogenomic associations of cyclophosphamide pharmacokinetic candidate genes with event-free survival in intermediate-risk rhabdomyosarcoma: A report from the Children's Oncology Group.
      34245211 Pediatric blood & cancer, 2021 Nov. : 68(11)e29203 PMCID:PMC8719493
    • Brady C, Manning SC, Rudzinski E, Paulson V, Wang X, Liu YJ, Parikh SR, Bonilla-Velez J, Hawkins DS, Dahl J
      Clinical Outcomes of Diffuse Sclerosing Variant Papillary Thyroid Carcinoma in Pediatric Patients.
      34713899 The Laryngoscope, 2021 Oct 29
    • Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
      Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
      34166060 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021 Sep 10 : 39(26)2859-2871 PMCID:PMC8425837
    • Avutu V, Weiss AR, Reed DR, Ahmed SK, Allen-Rhoades WA, Chen YE, Davis LE, Eaton BR, Hawkins DS, Indelicato DJ, Patel SR, Randall RL, Reinke DK, Riedel RF, Scharschmidt TJ, Thornton KA, Wang D, Janeway KA, Kopp LM
      Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321.
      34515544 Journal of adolescent and young adult oncology, 2021 Sep 9
    • Million L, Hayes-Jordan A, Chi YY, Donaldson SS, Wolden S, Morris C, Terezakis S, Laurie F, Morano K, Fitzgerald TJ, Yock TI, Rodeberg DA, Anderson JR, Speights RA, Black JO, Coffin C, McCarville MB, Kao SC, Hawkins DS, Spunt SL, Randall RL
      Local Control For High-Grade Nonrhabdomyosarcoma Soft Tissue Sarcoma Assigned to Radiation Therapy on ARST0332: A Report From the Childrens Oncology Group.
      33548339 International journal of radiation oncology, biology, physics, 2021 Jul 1 : 110(3)821-830 PMCID:PMC8767764
    • Li H, Sisoudiya SD, Martin-Giacalone BA, Khayat MM, Dugan-Perez S, Marquez-Do DA, Scheurer ME, Muzny D, Boerwinkle E, Gibbs RA, Chi YY, Barkauskas DA, Lo T, Hall D, Stewart DR, Schiffman JD, Skapek SX, Hawkins DS, Plon SE, Sabo A, Lupo PJ
      Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.
      33372952 Journal of the National Cancer Institute, 2021 Jul 1 : 113(7)875-883 PMCID:PMC8246828
    • Kohli K, Yao L, Nowicki TS, Zhang S, Black RG, Schroeder BA, Farrar EA, Cao J, Sloan H, Stief D, Cranmer LD, Wagner MJ, Hawkins DS, Pillarisetty VG, Ribas A, Campbell J, Pierce RH, Kim EY, Jones RL, Riddell SR, Yee C, Pollack SM
      IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy.
      33963013 Journal for immunotherapy of cancer, 2021 May : 9(5) PMCID:PMC8108691
    • Chugh R, Ballman KV, Helman LJ, Patel S, Whelan JS, Widemann B, Lu Y, Hawkins DS, Mascarenhas L, Glod JW, Ji J, Zhang Y, Reinke D, Strauss SJ
      SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.
      33289920 Cancer, 2021 Apr 15 : 127(8)1301-1310 PMCID:PMC8246769
    • Pacenta HL, Allen-Rhoades W, Langenau D, Houghton PJ, Keller C, Heske CM, Deel MD, Linardic CM, Shern JF, Stewart E, Turpin B, Harrison DJ, Khan J, Mascarenhas L, Skapek SX, Meyer WH, Hawkins DS, Chen EY, Amatruda JF, Hingorani P, Laetsch TW
      Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children's Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force.
      33915882 Journal of clinical medicine, 2021 Apr 1 : 10(7) PMCID:PMC8037615
    • Rogers TN, Seitz G, Fuchs J, Martelli H, Dasgupta R, Routh JC, Hawkins DS, Koscielniak E, Bisogno G, Rodeberg DA
      Surgical management of paratesticular rhabdomyosarcoma: A consensus opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.
      33522706 Pediatric blood & cancer, 2021 April : 68(4)e28938
    • Heske CM, Chi YY, Venkatramani R, Li M, Arnold MA, Dasgupta R, Hiniker SM, Hawkins DS, Mascarenhas L
      Survival outcomes of patients with localized FOXO1 fusion-positive rhabdomyosarcoma treated on recent clinical trials: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      33216382 Cancer, 2021 Mar 15 : 127(6)946-956 PMCID:PMC8601034
    • Gallego S, Chi YY, De Salvo GL, Li M, Merks JHM, Rodeberg DA, van Scheltinga ST, Mascarenhas L, Orbach D, Jenney M, Million L, Minard-Colin V, Wolden S, Zanetti I, Parham DM, Mandeville H, Venkatramani R, Bisogno G, Hawkins DS, European paediatric Soft tissue sarcoma Study Group and Children's Oncology Group.
      Alveolar rhabdomyosarcoma with regional nodal involvement: Results of a combined analysis from two cooperative groups.
      33245207 Pediatric blood & cancer, 2021 March : 68(3)e28832 PMCID:PMC8414760
    • Moreira DC, Millen GC, Sands S, Kearns PR, Hawkins DS
      The Care of Children With Cancer During the COVID-19 Pandemic.
      33989020 American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2021 March : 411-10
    • Rudzinski ER, Kelsey A, Vokuhl C, Linardic CM, Shipley J, Hettmer S, Koscielniak E, Hawkins DS, Bisogno G
      Pathology of childhood rhabdomyosarcoma: A consensus opinion document from the Children's Oncology Group, European Paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.
      33306276 Pediatric blood & cancer, 2021 March : 68(3)e28798
    • Harrison DJ, Chi YY, Tian J, Hingorani P, Mascarenhas L, McCowage GB, Weigel BJ, Venkatramani R, Wolden SL, Yock TI, Rodeberg DA, Hayes-Jordan AA, Teot LA, Spunt SL, Meyer WH, Hawkins DS, Shulkin BL, Parisi MT
      Metabolic response as assessed by 18 F-fluorodeoxyglucose positron emission tomography-computed tomography does not predict outcome in patients with intermediate- or high-risk rhabdomyosarcoma: A report from the Children's Oncology Group Soft Tissue Sarcoma Committee.
      33340280 Cancer medicine, 2021 Feb. : 10(3)857-866 PMCID:PMC7897958
    • Lautz TB, Chi YY, Li M, Wolden SL, Casey DL, Routh JC, Granberg CF, Binite O, Rudzinski ER, Hawkins DS, Venkatramani R, Rodeberg DA
      Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group.
      33079399 Cancer, 2021 Jan 15 : 127(2)275-283 PMCID:PMC7790947
    • Kim J, Light N, Subasri V, Young EL, Wegman-Ostrosky T, Barkauskas DA, Hall D, Lupo PJ, Patidar R, Maese LD, Jones K, Wang M, Tavtigian SV, Wu D, Shlien A, Telfer F, Goldenberg A, Skapek SX, Wei JS, Wen X, Catchpoole D, Hawkins DS, Schiffman JD, Khan J, Malkin D, Stewart DR
      Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma.
      34095712 JCO precision oncology, 2021 : 5 PMCID:PMC8169077
    • Shenoy A, Alvarez E, Chi YY, Li M, Shern JF, Khan J, Hiniker SM, Granberg CF, Hawkins DS, Parham DM, Teot LA, Rudzinski ER
      The prognostic significance of anaplasia in childhood rhabdomyosarcoma: A report from the Children's Oncology Group.
      33302115 European journal of cancer (Oxford, England : 1990), 2021 Jan. : 143127-133 PMCID:PMC8842073
    • Bertagnolli MM, Blanke CD, Curran WJ, Hawkins DS, Mannel RS, O'Dwyer PJ, Schnall MD, Wolmark N
      What happened to the US cancer cooperative groups? A status update ten years after the Institute of Medicine report.
      32970346 Cancer, 2020 Dec 1 : 126(23)5022-5029 PMCID:PMC7667615
    • Hawkins DS, Bisogno G, Koscielniak E
      Introducing INSTRuCT: An international effort to promote cooperation and data sharing.
      32918788 Pediatric blood & cancer, 2020 Sep 12 : e28701
    • Orbach D, Sparber-Sauer M, Laetsch TW, Minard-Colin V, Bielack SS, Casanova M, Corradini N, Koscielniak E, Scheer M, Hettmer S, Bisogno G, Hawkins DS, Ferrari A
      Spotlight on the treatment of infantile fibrosarcoma in the era of neurotrophic tropomyosin receptor kinase inhibitors: International consensus and remaining controversies.
      32784118 European journal of cancer (Oxford, England : 1990), 2020 Aug 9 : 137183-192
    • Morris CD, Tunn PU, Rodeberg DA, Terwisscha van Scheltinga S, Binitie O, Godzinski J, Dall'Igna P, Million L, Hawkins DS, Koscielniak E, Bisogno G, Rogers TN
      Surgical management of extremity rhabdomyosarcoma: A consensus opinion from the Children's Oncology Group, the European Pediatric Soft-Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.
      32776456 Pediatric blood & cancer, 2020 Aug 9 : e28608
    • Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G, INSTRuCT group.
      Local treatment of rhabdomyosarcoma of the female genital tract: Expert consensus from the Children's Oncology Group, the European Soft-Tissue Sarcoma Group, and the Cooperative Weichteilsarkom Studiengruppe.
      32762004 Pediatric blood & cancer, 2020 Aug 6 : e28601
    • Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
      Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
      32702309 The Lancet. Oncology, 2020 Aug. : 21(8)1110-1122
    • Hingorani P, Dinu V, Zhang X, Lei H, Shern JF, Park J, Steel J, Rauf F, Parham D, Gastier-Foster J, Hall D, Hawkins DS, Skapek SX, Labaer J, McEachron TA
      Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children's Oncology Group.
      32703985 Scientific reports, 2020 Jul 23 : 10(1)12318 PMCID:PMC7378211
    • Schultz L, Link MP, Rheingold S, Hawkins DS, Dome JS, Wickiser J, Kung AL, Henderson TO, Aftandilian C
      Summary of COVID-19 clinical practice adjustments across select institutions.
      32779834 Pediatric blood & cancer, 2020 Jul 19 : e28411
    • Kazahaya K, Prickett KK, Paulson VA, Dahl JP, Manning SC, Rudzinski ER, Rastatter JC, Parikh SR, Hawkins DS, Brose MS, Bauer AJ
      Targeted Oncogene Therapy Before Surgery in Pediatric Patients With Advanced Invasive Thyroid Cancer at Initial Presentation: Is It Time for a Paradigm Shift?
      32614439 JAMA otolaryngology-- head & neck surgery, 2020 Jul 2
    • Sullivan M, Bouffet E, Rodriguez-Galindo C, Luna-Fineman S, Khan MS, Kearns P, Hawkins DS, Challinor J, Morrissey L, Fuchs J, Marcus K, Balduzzi A, Basset-Salom L, Caniza M, Baker JN, Kebudi R, Hessissen L, Sullivan R, Pritchard-Jones K
      The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global.
      32400924 Pediatric blood & cancer, 2020 July : 67(7)e28409 PMCID:PMC7235469
    • Routh JC, Dasgupta R, Chi YY, Shnorhavorian M, Tian J, Walterhouse DO, Breneman J, Wolden SL, Arndt CA, Hawkins DS, Rodeberg DA
      Impact of Local Control and Surgical Lymph Node Evaluation in Localized Paratesticular Rhabdomyosarcoma: A Report from the Children's Oncology Group Soft Tissue Sarcoma Committee.
      32525556 International journal of cancer, 2020 Jun 11
    • Prasad PK, Mahajan P, Hawkins DS, Mostoufi-Moab S, Venkatramani R
      Management of pediatric differentiated thyroid cancer: An overview for the pediatric oncologist.
      32275118 Pediatric blood & cancer, 2020 June : 67(6)e28141
    • Bisogno G, Hawkins DS
      An unresolved issue in rhabdomyosarcoma treatment: The duration of chemotherapy.
      31994316 Pediatric blood & cancer, 2020 May : 67(5)e28174
    • Aye JM, Chi YY, Tian J, Rudzinski ER, Binitie OT, Dasgupta R, Wolden SL, Hawkins DS, Gupta AA
      Do children and adolescents with completely resected alveolar rhabdomyosarcoma require adjuvant radiation? A report from the Children's Oncology Group.
      32124549 Pediatric blood & cancer, 2020 May : 67(5)e28243
    • Lautz TB, Chi YY, Tian J, Gupta AA, Wolden SL, Routh JC, Casey DL, Dasgupta R, Hawkins DS, Rodeberg DA
      Relationship between tumor response at therapy completion and prognosis in patients with Group III rhabdomyosarcoma: A report from the Children's Oncology Group.
      32012255 International journal of cancer, 2020 Feb 3
    • Spunt SL, Million L, Chi YY, Anderson J, Tian J, Hibbitts E, Coffin C, McCarville MB, Randall RL, Parham DM, Black JO, Kao SC, Hayes-Jordan A, Wolden S, Laurie F, Speights R, Kawashima E, Skapek SX, Meyer W, Pappo AS, Hawkins DS
      A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study.
      31786124 The Lancet. Oncology, 2020 Jan. : 21(1)145-161 PMCID:PMC6946838
    • Dirksen U, Brennan B, Le Deley MC, Cozic N, van den Berg H, Bhadri V, Brichard B, Claude L, Craft A, Amler S, Gaspar N, Gelderblom H, Goldsby R, Gorlick R, Grier HE, Guinbretiere JM, Hauser P, Hjorth L, Janeway K, Juergens H, Judson I, Krailo M, Kruseova J, Kuehne T, Ladenstein R, Lervat C, Lessnick SL, Lewis I, Linassier C, Marec-Berard P, Marina N, Morland B, Pacquement H, Paulussen M, Randall RL, Ranft A, Le Teuff G, Wheatley K, Whelan J, Womer R, Oberlin O, Hawkins DS, Euro-E.W.I.N.G. 99 and Ewing 2008 Investigators.
      High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008.
      31553693 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019 Dec 1 : 37(34)3192-3202 PMCID:PMC6881099
    • Mascarenhas L, Chi YY, Hingorani P, Anderson JR, Lyden ER, Rodeberg DA, Indelicato DJ, Kao SC, Dasgupta R, Spunt SL, Meyer WH, Hawkins DS
      Randomized Phase II Trial of Bevacizumab or Temsirolimus in Combination With Chemotherapy for First Relapse Rhabdomyosarcoma: A Report From the Children's Oncology Group.
      31513481 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019 Nov 1 : 37(31)2866-2874 PMCID:PMC6823886
    • Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, Chen E, Collins N, Ehrlich A, Galindo RL, Gryder BE, Hahn H, Hammond S, Hatley ME, Hawkins DS, Hayes MN, Hayes-Jordan A, Helman LJ, Hettmer S, Ignatius MS, Keller C, Khan J, Kirsch DG, Linardic CM, Lupo PJ, Rota R, Shern JF, Shipley J, Sindiri S, Tapscott SJ, Vakoc CR, Wexler LH, Langenau DM
      Insights into pediatric rhabdomyosarcoma research: Challenges and goals.
      31222885 Pediatric blood & cancer, 2019 Oct. : 66(10)e27869 PMCID:PMC6707829
    • Hibbitts E, Chi YY, Hawkins DS, Barr FG, Bradley JA, Dasgupta R, Meyer WH, Rodeberg DA, Rudzinski ER, Spunt SL, Skapek SX, Wolden SL, Arndt CAS
      Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group.
      31456361 Cancer medicine, 2019 Oct. : 8(14)6437-6448 PMCID:PMC6797586
    • Paulson VA, Rudzinski ER, Hawkins DS
      Thyroid Cancer in the Pediatric Population.
      31540418 Genes, 2019 Sep 18 : 10(9) PMCID:PMC6771006
    • Casey DL, Chi YY, Donaldson SS, Hawkins DS, Tian J, Arndt CA, Rodeberg DA, Routh JC, Lautz TB, Gupta AA, Yock TI, Wolden SL
      Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children's Oncology Group.
      31174239 Cancer, 2019 Sep 15 : 125(18)3242-3248 PMCID:PMC6717036
    • Mascarenhas L, Lyden ER, Breitfeld PP, Walterhouse DO, Donaldson SS, Rodeberg DA, Parham DM, Anderson JR, Meyer WH, Hawkins DS
      Risk-based treatment for patients with first relapse or progression of rhabdomyosarcoma: A report from the Children's Oncology Group.
      31067356 Cancer, 2019 Aug 1 : 125(15)2602-2609 PMCID:PMC7069123
    • Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Pal R, Davies AM, Ashok A, Bushby D, Mancini M, Noakes C, Goodwin NC, Ordentlich P, Keck J, Hawkins DS, Rudzinski ER, Mansoor A, Perkins TJ, Vakoc CR, Michalek JE, Keller C
      Preclinical rationale for entinostat in embryonal rhabdomyosarcoma.
      31113472 Skeletal muscle, 2019 May 21 : 9(1)12 PMCID:PMC6528217
    • Spunt SL, Francotte N, De Salvo GL, Chi YY, Zanetti I, Hayes-Jordan A, Kao SC, Orbach D, Brennan B, Weiss AR, van Noesel MM, Million L, Alaggio R, Parham DM, Kelsey A, Randall RL, McCarville MB, Bisogno G, Hawkins DS, Ferrari A
      Clinical features and outcomes of young patients with epithelioid sarcoma: an analysis from the Children's Oncology Group and the European paediatric soft tissue Sarcoma Study Group prospective clinical trials.
      30954717 European journal of cancer (Oxford, England : 1990), 2019 May : 11298-106 PMCID:PMC6944741
    • Lowery CD, Dowless M, Renschler M, Blosser W, VanWye AB, Stephens JR, Iversen PW, Lin AB, Beckmann RP, Krytska K, Cole KA, Maris JM, Hawkins DS, Rubin BP, Kurmasheva RT, Houghton PJ, Gorlick R, Kolb EA, Kang MH, Reynolds CP, Erickson SW, Teicher BA, Smith MA, Stancato LF
      Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.
      30563935 Clinical cancer research : an official journal of the American Association for Cancer Research, 2019 Apr 1 : 25(7)2278-2289 PMCID:PMC6445779
    • Davis JL, Lockwood CM, Stohr B, Boecking C, Al-Ibraheemi A, DuBois SG, Vargas SO, Black JO, Cox MC, Luquette M, Turpin B, Szabo S, Laetsch TW, Albert CM, Parham DM, Hawkins DS, Rudzinski ER
      Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors.
      30585824 The American journal of surgical pathology, 2019 April : 43(4)435-445
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      Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.
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      The addition of cixutumumab or temozolomide to intensive multiagent chemotherapy is feasible but does not improve outcome for patients with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group.
      30351457 Cancer, 2019 Jan 15 : 125(2)290-297 PMCID:PMC6329653
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      Rhabdomyosarcoma.
      30617281 Nature reviews. Disease primers, 2019 Jan 7 : 5(1)1
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      Larotrectinib for the treatment of TRK fusion solid tumors.
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      Genome-Informed Targeted Therapy for Osteosarcoma.
      30266815 Cancer discovery, 2019 Jan. : 9(1)46-63 PMCID:PMC7134333
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      Treatment Approach and Outcomes in Infants With Localized Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      30138647 International journal of radiation oncology, biology, physics, 2019 Jan 1 : 103(1)19-27 PMCID:PMC6301106
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      The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma.
      30459282 Science signaling, 2018 Nov 20 : 11(557) PMCID:PMC6432638
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      Demographic and Treatment Variables Influencing Outcome for Localized Paratesticular Rhabdomyosarcoma: Results From a Pooled Analysis of North American and European Cooperative Groups.
      30351998 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018 Oct 23 : JCO2018789388 PMCID:PMC6286163
    • Hawkins DS, Chi YY, Anderson JR, Tian J, Arndt CAS, Bomgaars L, Donaldson SS, Hayes-Jordan A, Mascarenhas L, McCarville MB, McCune JS, McCowage G, Million L, Morris CD, Parham DM, Rodeberg DA, Rudzinski ER, Shnorhavorian M, Spunt SL, Skapek SX, Teot LA, Wolden S, Yock TI, Meyer WH
      Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
      30091945 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018 Sep 20 : 36(27)2770-2777 PMCID:PMC6145831
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      Localized vaginal/uterine rhabdomyosarcoma-results of a pooled analysis from four international cooperative groups.
      29781567 Pediatric blood & cancer, 2018 Sept. : 65(9)e27096
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      Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes.
      29972784 Cell reports, 2018 Jul 3 : 24(1)238-251 PMCID:PMC7293769
    • Teot LA, Schneider M, Thorner AR, Tian J, Chi YY, Ducar M, Lin L, Wlodarski M, Grier HE, Fletcher CDM, van Hummelen P, Skapek SX, Hawkins DS, Wagers AJ, Rodriguez-Galindo C, Hettmer S
      Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group.
      29461635 Cancer, 2018 May 1 : 124(9)1973-1981 PMCID:PMC5910184
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      Undifferentiated sarcomas in children harbor clinically-relevant oncogenic fusions and gene copy-number alterations: A report from the Children's Oncology Group.
      29691299 Clinical cancer research : an official journal of the American Association for Cancer Research, 2018 Apr 24
    • Ronsley R, Rassekh SR, Shen Y, Lee AF, Jantzen C, Halparin J, Albert C, Hawkins DS, Amed S, Rothstein R, Mungall AJ, Dix D, Blair G, Nadel H, Jones SJM, Laskin J, Marra MA, J Deyell R
      Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma.
      29610391 Cold Spring Harbor molecular case studies, 2018 April : 4(2) PMCID:PMC5880264
    • Laetsch TW, DuBois SG, Mascarenhas L, Turpin B, Federman N, Albert CM, Nagasubramanian R, Davis JL, Rudzinski E, Feraco AM, Tuch BB, Ebata KT, Reynolds M, Smith S, Cruickshank S, Cox MC, Pappo AS, Hawkins DS
      Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.
      29606586 The Lancet. Oncology, 2018 Mar 29
    • Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM
      Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.
      29466156 The New England journal of medicine, 2018 Feb 22 : 378(8)731-739 PMCID:PMC5857389
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      Infantile NTRK-associated Mesenchymal Tumors.
      28683589 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 2018 Jan. : 21(1)68-78
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      Desmoid tumours in children: when wait-and-see becomes wait-and-treat.
      30169177 The Lancet. Child & adolescent health, 2017 Dec. : 1(4)253-254
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      Histology, fusion status, and outcome in metastatic rhabdomyosarcoma: A report from the Children's Oncology Group.
      28521080 Pediatric blood and cancer, 2017 Dec. : 64(12) PMCID:PMC5647228
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      Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.
      28976792 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017 Nov 10 : 35(32)3688-3696 PMCID:PMC5678343
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      Patterns of PD-1, PD-L1, and PD-L2 expression in pediatric solid tumors.
      28488345 Pediatric blood and cancer, 2017 Nov. : 64(11)
    • Ren T, Piperdi S, Koirala P, Park A, Zhang W, Ivenitsky D, Zhang Y, Villanueva-Siles E, Hawkins DS, Roth M, Gorlick R
      CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression.
      29152125 Oncotarget, 2017 Oct 20 : 8(50)87848-87859 PMCID:PMC5675677
    • Davis LE, Janeway KA, Weiss AR, Chen YE, Scharschmidt TJ, Krailo M, Glade Bender JL, Kopp LM, Patel SR, Schwartz GK, Horvath LE, Hawkins DS, Chuk MK, Reinke DK, Gorlick RG, Randall RL
      Clinical trial enrollment of adolescents and young adults with sarcoma.
      28493547 Cancer, 2017 Sep 15 : 123(18)3434-3440 PMCID:PMC5650232
    • Gupta AA, Chi YY, Anderson JR, Lyden E, Weigel B, Arndt C, Meyer WH, Rosenberg A, Hawkins DS
      Patterns of chemotherapy-induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group.
      28333415 Pediatric blood and cancer, 2017 Sept. : 64(9) PMCID:PMC5567865
    • Ermoian RP, Breneman J, Walterhouse DO, Chi YY, Meza J, Anderson J, Hawkins DS, Hayes-Jordan AA, Parham DM, Yock TI, Donaldson SS, Wolden SL
      45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to 12 weeks of ARST0331 chemotherapy: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      28548706 Pediatric blood and cancer, 2017 Sept. : 64(9) PMCID:PMC5568701
    • Walterhouse DO, Pappo AS, Meza JL, Breneman JC, Hayes-Jordan A, Parham DM, Cripe TP, Anderson JR, Meyer WH, Hawkins DS
      Reduction of cyclophosphamide dose for patients with subset 2 low-risk rhabdomyosarcoma is associated with an increased risk of recurrence: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      28211936 Cancer, 2017 Jun 15 : 123(12)2368-2375 PMCID:PMC5662934
    • Ferrari A, Chi YY, De Salvo GL, Orbach D, Brennan B, Randall RL, McCarville MB, Black JO, Alaggio R, Hawkins DS, Bisogno G, Spunt SL
      Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group.
      28391003 European journal of cancer (Oxford, England : 1990), 2017 June : 781-6 PMCID:PMC5567853
    • Cross NM, Stanescu AL, Rudzinski ER, Hawkins DS, Parisi MT
      Vaginal Ewing Sarcoma: An Uncommon Clinical Entity in Pediatric Patients.
      28589056 Journal of clinical imaging science, 2017 : 717 PMCID:PMC5433652
    • Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KLB, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS, Hardes J, Hawkins DS, Helmke K, Hogendoorn PCW, Isakoff MS, Janeway KA, Jürgens H, Kager L, Kühne T, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Meyers PA, Mottl H, Nathrath M, Papai Z, Randall RL, Reichardt P, Renard M, Safwat AA, Schwartz CL, Stevens MCG, Strauss SJ, Teot L, Werner M, Sydes MR, Whelan JS
      Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial.
      27569442 The Lancet. Oncology, 2016 Oct. : 17(10)1396-1408 PMCID:PMC5052459
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      Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children's Oncology Group.
      27642091 Scientific reports, 2016 Sep 19 : 633429 PMCID:PMC5027578
    • Lagmay JP, Krailo MD, Dang H, Kim A, Hawkins DS, Beaty O 3rd, Widemann BC, Zwerdling T, Bomgaars L, Langevin AM, Grier HE, Weigel B, Blaney SM, Gorlick R, Janeway KA
      Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward.
      27400942 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016 Sep 1 : 34(25)3031-8 PMCID:PMC5012712
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      Opportunities for Improvement in Pathology Reporting of Childhood Nonrhabdomyosarcoma Soft Tissue Sarcomas:  A Report From Children's Oncology Group (COG) Study ARST0332.
      27510717 American journal of clinical pathology, 2016 Sept. : 146(3)328-38
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      The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group.
      27198935 Pediatric blood and cancer, 2016 Sept. : 63(9)1557-62 PMCID:PMC4955701
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      Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index.
      27501955 Diagnostic pathology, 2016 Aug 8 : 11(1)71 PMCID:PMC4977669
    • Vo KT, Edwards JV, Epling CL, Sinclair E, Hawkins DS, Grier HE, Janeway KA, Barnette P, McIlvaine E, Krailo MD, Barkauskas DA, Matthay KK, Womer RB, Gorlick RG, Lessnick SL, Mackall CL, DuBois SG
      Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group.
      26861456 Clinical cancer research : an official journal of the American Association for Cancer Research, 2016 Jul 15 : 22(14)3643-50 PMCID:PMC4947459
    • Hingorani P, Janeway K, Crompton BD, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, Mody R, DuBois SG, Parsons DW, Khanna C, Lau C, Hawkins DS, Randall RL, Smith M, Sorensen PH, Plon SE, Skapek SX, Lessnick S, Gorlick R, Reed DR
      Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.
      27132463 Cancer genetics, 2016 May : 209(5)182-94 PMCID:PMC5497490
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      Histology, Fusion Status, and Outcome in Alveolar Rhabdomyosarcoma With Low-Risk Clinical Features: A Report From the Children's Oncology Group.
      26756883 Pediatric blood and cancer, 2016 April : 63(4)634-9 PMCID:PMC4755849
    • Richards MK, Dahl JP, Gow K, Goldin AB, Doski J, Goldfarb M, Nuchtern J, Langer M, Beierle EA, Vasudevan S, Hawkins DS, Parikh SR
      Factors Associated With Mortality in Pediatric vs Adult Nasopharyngeal Carcinoma.
      26769566 JAMA otolaryngology-- head and neck surgery, 2016 March : 142(3)217-22
    • Vo KT, Edwards JV, Epling CL, Sinclair E, Hawkins DS, Grier HE, Janeway KA, Barnette P, McIlvaine E, Krailo M, Barkauskas DA, Matthay KK, Womer RB, Gorlick R, Lessnick SL, Mackall CL, Dubois SG
      Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group.
      26861456 Clinical cancer research : an official journal of the American Association for Cancer Research, 2016 Feb 9
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      Second Malignant Neoplasms in Rhabdomyosarcoma: Victims of Our Own Success or an Underlying Genetic Predisposition Syndrome?
      26505490 Pediatric blood and cancer, 2016 Feb. : 63(2)189-90
    • Weigel BJ, Lyden E, Anderson JR, Meyer WH, Parham DM, Rodeberg DA, Michalski JM, Hawkins DS, Arndt CA
      Intensive Multiagent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide and Vincristine/Doxorubicin/Cyclophosphamide, Irinotecan, and Radiation, in Patients With High-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.
      26503200 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016 Jan 10 : 34(2)117-22 PMCID:PMC5070550
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      Local Control for Intermediate-Risk Rhabdomyosarcoma: Results From D9803 According to Histology, Group, Site, and Size: A Report From the Children's Oncology Group.
      26581144 International journal of radiation oncology, biology, physics, 2015 Dec 1 : 93(5)1071-6 PMCID:PMC5147527
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      Prognostic Factors for Outcome in Localized Extremity Rhabdomyosarcoma. Pooled Analysis from Four International Cooperative Groups.
      26257045 Pediatric blood and cancer, 2015 Dec. : 62(12)2125-31 PMCID:PMC5002346
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      Clinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group.
      26473193 Clinical cancer research : an official journal of the American Association for Cancer Research, 2015 Oct 15 : 21(20)4733-9 PMCID:PMC4610152
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      The World Health Organization Classification of Skeletal Muscle Tumors in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.
      25989287 Archives of pathology and laboratory medicine, 2015 Oct. : 139(10)1281-7 PMCID:PMC4651658
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      Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
      26304893 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015 Sep 20 : 33(27)3036-46
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      MRI and CT of Low-Grade Fibromyxoid Sarcoma in Children: A Report From Children's Oncology Group Study ARST0332.
      26204295 AJR. American journal of roentgenology, 2015 Aug. : 205(2)414-20 PMCID:PMC4570741
    • Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P, Gorlick R, Windhager R, Helmke K, Eriksson M, Hoogerbrugge PM, Schomberg P, Tunn PU, Kühne T, Jürgens H, van den Berg H, Böhling T, Picton S, Renard M, Reichardt P, Gerss J, Butterfass-Bahloul T, Morris C, Hogendoorn PC, Seddon B, Calaminus G, Michelagnoli M, Dhooge C, Sydes MR, Bernstein M, EURAMOS-1 investigators.
      Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.
      26033801 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015 Jul 10 : 33(20)2279-87 PMCID:PMC4486345
    • Rodeberg DA, Wharam MD, Lyden ER, Stoner JA, Brown K, Wolden SL, Paidas CN, Donaldson SS, Hawkins DS, Spunt SL, Arndt CA
      Delayed primary excision with subsequent modification of radiotherapy dose for intermediate-risk rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.
      25418440 International journal of cancer, 2015 Jul 1 : 137(1)204-11 PMCID:PMC4474372
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      Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database.
      25809884 Cancer medicine, 2015 May : 4(5)781-90 PMCID:PMC4430270
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      Clonality and evolutionary history of rhabdomyosarcoma.
      25768946 PLoS genetics, 2015 March : 11(3)e1005075 PMCID:PMC4358975
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      Assessing the scale of tumor heterogeneity by complete hierarchical segmentation of MRI.
      25575341 Physics in medicine and biology, 2015 Feb 7 : 60(3)977-93
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      Ganglioside GD2 expression is maintained upon recurrence in patients with osteosarcoma.
      25642322 Clinical sarcoma research, 2015 : 5(1)4 PMCID:PMC4311500
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      Shorter-duration therapy using vincristine, dactinomycin, and lower-dose cyclophosphamide with or without radiotherapy for patients with newly diagnosed low-risk rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      25267746 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014 Nov 1 : 32(31)3547-52 PMCID:PMC4209105
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      Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children's Oncology Group.
      24831857 Cancer causes and control : CCC, 2014 July : 25(7)905-13 PMCID:PMC4091713
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      Myogenin, AP2, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      24618610 The American journal of surgical pathology, 2014 Mar 10
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      Early response as assessed by anatomic imaging does not predict failure-free survival among patients with Group III rhabdomyosarcoma: a report from the Children's Oncology Group.
      24361229 European journal of cancer (Oxford, England : 1990), 2014 March : 50(4)816-23 PMCID:PMC3944684
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      What is new in the biology and treatment of pediatric rhabdomyosarcoma?
      24326270 Current opinion in pediatrics, 2014 Feb. : 26(1)50-6 PMCID:PMC4096484
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      Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
      24436047 Cancer discovery, 2014 Feb. : 4(2)216-31
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      Cost minimization analysis of two treatment regimens for low-risk rhabdomyosarcoma in children: A report from the Children's Oncology Group.
      24453105 Pediatric blood & cancer, 2014 Jan 22
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      Sarcoma mid-therapy [F-18]fluorodeoxyglucose positron emission tomography (FDG PET) and patient outcome.
      24430415 The Journal of bone and joint surgery. American volume, 2014 Jan 15 : 96(2)152-8 PMCID:PMC3903137
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      Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma: a report from the Children's Oncology Group.
      23824786 International journal of cancer. Journal international du cancer, 2014 Jan 15 : 134(2)431-6 PMCID:PMC3869863
    • Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA, St. Jude Childrens Research HospitalWashington University Pediatric Cancer Genome Project
      Targeting oxidative stress in embryonal rhabdomyosarcoma.
      24332040 Cancer cell, 2013 Dec 9 : 24(6)710-24 PMCID:PMC3904731
    • Spalding AC, Hawkins DS, Donaldson SS, Anderson JR, Lyden E, Laurie F, Wolden SL, Arndt CA, Michalski JM
      The effect of radiation timing on patients with high-risk features of parameningeal rhabdomyosarcoma: an analysis of IRS-IV and D9803.
      24074925 International journal of radiation oncology, biology, physics, 2013 Nov 1 : 87(3)512-6
    • Wilson RA, Teng L, Bachmeyer KM, Bissonnette ML, Husain AN, Parham DM, Triche TJ, Wing MR, Gastier-Foster JM, Barr FG, Hawkins DS, Anderson JR, Skapek SX, Volchenboum SL
      A novel algorithm for simplification of complex gene classifiers in cancer.
      23913937 Cancer research, 2013 Sep 15 : 73(18)5625-32
    • Weiss AR, Lyden ER, Anderson JR, Hawkins DS, Spunt SL, Walterhouse DO, Wolden SL, Parham DM, Rodeberg DA, Kao SC, Womer RB
      Histologic and clinical characteristics can guide staging evaluations for children and adolescents with rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.
      23940218 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013 Sep 10 : 31(26)3226-32 PMCID:PMC3757291
    • Skapek SX, Anderson J, Barr FG, Bridge JA, Gastier-Foster JM, Parham DM, Rudzinski ER, Triche T, Hawkins DS
      PAX-FOXO1 fusion status drives unfavorable outcome for children with rhabdomyosarcoma: a children's oncology group report.
      23526739 Pediatric blood & cancer, 2013 Sept. : 60(9)1411-7
    • Lupo PJ, Zhou R, Skapek SX, Hawkins DS, Spector LG, Scheurer ME, Fatih Okcu M, Melin B, Papworth K, Erhardt EB, Grufferman S
      Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma: A report from the children's oncology group.
      23824786 International journal of cancer. Journal international du cancer, 2013 Jul 3
    • Skapek SX, Anderson JR, Hill DA, Henry D, Spunt SL, Meyer W, Kao S, Hoffer FA, Grier HE, Hawkins DS, Raney RB
      Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: results of a Children's Oncology Group (COG) phase II study.
      23281268 Pediatric blood & cancer, 2013 July : 60(7)1108-12
    • Rudzinski ER, Teot LA, Anderson JR, Moore J, Bridge JA, Barr FG, Gastier-Foster JM, Skapek SX, Hawkins DS, Parham DM
      Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
      23765537 American journal of clinical pathology, 2013 July : 140(1)82-90
    • Skapek SX, Anderson JR, Hill DA, Henry D, Spunt SL, Meyer W, Kao S, Hoffer FA, Grier HE, Hawkins DS, Raney RB
      Safety and efficacy of high-dose tamoxifen and sulindac for desmoid tumor in children: results of a Children's Oncology Group (COG) phase II study.
      23281268 Pediatric blood & cancer, 2013 July : 60(7)1108-12
    • Newman EN, Jones RL, Hawkins DS
      An evaluation of [F-18]-fluorodeoxy-D-glucose positron emission tomography, bone scan, and bone marrow aspiration/biopsy as staging investigations in Ewing sarcoma.
      23192939 Pediatric blood & cancer, 2013 July : 60(7)1113-7
    • Hawkins DS, Spunt SL, Skapek SX, COG Soft Tissue Sarcoma Committee
      Children's Oncology Group's 2013 blueprint for research: Soft tissue sarcomas.
      23255356 Pediatric blood & cancer, 2013 June : 60(6)1001-8 PMCID:PMC3777409
    • Raney B, Huh W, Hawkins D, Hayes-Jordan A, Million L, Rodeberg D, Teot L, Anderson J, Soft Tissue Sarcoma Committee of the Children's Oncology Group, Arcadia, CA
      Outcome of patients with localized orbital sarcoma who relapsed following treatment on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-III and -IV, 1984-1997: a report from the Children's Oncology Group.
      22961750 Pediatric blood & cancer, 2013 March : 60(3)371-6
    • MacQuarrie KL, Yao Z, Fong AP, Diede SJ, Rudzinski ER, Hawkins DS, Tapscott SJ
      Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors.
      23230269 Molecular and cellular biology, 2013 Feb. : 33(4)773-84 PMCID:PMC3571334
    • Gardner RA, Thomson B, Hawkins DS
      Substitution with doxorubicin for daunorubicin during induction for high risk pediatric acute lymphoblastic leukemia results in increased toxicity.
      23015453 Pediatric blood & cancer, 2013 Feb. : 60(2)338-9
    • Soundararajan A, Abraham J, Nelon LD, Prajapati SI, Zarzabal LA, Michalek JE, McHardy SF, Hawkins DS, Malempati S, Keller C
      18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models.
      22238194 Pediatric blood & cancer, 2012 Sept. : 59(3)485-92
    • Malempati S, Hawkins DS
      Rhabdomyosarcoma: review of the Children's Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies.
      22378628 Pediatric blood & cancer, 2012 Jul 15 : 59(1)5-10
    • Rosenberg AR, Skapek SX, Hawkins DS
      The inconvenience of convenience cohorts: rhabdomyosarcoma and the PAX-FOXO1 biomarker.
      22564868 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012 July : 21(7)1012-8 PMCID:PMC3392538
    • Spunt SL, Vargas SO, Coffin CM, Skapek SX, Parham DM, Darling J, Hawkins DS, Keller C
      The clinical, research, and social value of autopsy after any cancer death: a perspective from the Children's Oncology Group Soft Tissue Sarcoma Committee.
      22006470 Cancer, 2012 Jun 15 : 118(12)3002-9 PMCID:PMC3274663
    • Breneman J, Meza J, Donaldson SS, Raney RB, Wolden S, Michalski J, Laurie F, Rodeberg DA, Meyer W, Walterhouse D, Hawkins DS
      Local control with reduced-dose radiotherapy for low-risk rhabdomyosarcoma: a report from the Children's Oncology Group D9602 study.
      22104356 International journal of radiation oncology, biology, physics, 2012 Jun 1 : 83(2)720-6 PMCID:PMC3305826
    • Gupta AA, Anderson JR, Pappo AS, Spunt SL, Dasgupta R, Indelicato DJ, Hawkins DS
      Patterns of chemotherapy-induced toxicities in younger children and adolescents with rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.
      21761400 Cancer, 2012 Feb 15 : 118(4)1130-7
    • Raccor BS, Claessens AJ, Dinh JC, Park JR, Hawkins DS, Thomas SS, Makar KW, McCune JS, Totah RA
      Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo.
      21976622 Drug metabolism and disposition: the biological fate of chemicals, 2012 Jan. : 40(1)54-63 PMCID:PMC3250049
    • Hingorani P, Seidel K, Krailo M, Mascarenhas L, Meyers P, Marina N, Conrad EU, Hawkins DS
      Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group.
      21480474 Pediatric blood & cancer, 2011 Dec 1 : 57(6)939-42 PMCID:PMC3135763
    • Hawkins DS
      Sarcomas gone bad: what to do about recurrent Ewing sarcoma.
      21681926 Pediatric blood & cancer, 2011 Oct. : 57(4)535-6
    • Stephenson J, Gow KW, Meehan J, Hawkins DS, Avansino J
      Ewing sarcoma/primitive neuroectodermal tumor arising from the adrenal gland in an adolescent.
      21681923 Pediatric blood & cancer, 2011 Oct. : 57(4)691-2
    • Malempati S, Rodeberg DA, Donaldson SS, Lyden ER, Anderson JR, Hawkins DS, Arndt CA
      Rhabdomyosarcoma in infants younger than 1 year: a report from the Children's Oncology Group.
      21264837 Cancer, 2011 Aug 1 : 117(15)3493-501 PMCID:PMC3140625
    • Foster JH, Hawkins DS, Loken MR, Wells DA, Thomson B
      Minimal residual disease detected prior to hematopoietic cell transplantation.
      21370437 Pediatric blood & cancer, 2011 Jul 15 : 57(1)163-5
    • Walterhouse DO, Meza JL, Breneman JC, Donaldson SS, Hayes-Jordan A, Pappo AS, Arndt C, Raney RB, Meyer WH, Hawkins DS
      Local control and outcome in children with localized vaginal rhabdomyosarcoma: a report from the Soft Tissue Sarcoma committee of the Children's Oncology Group.
      21298768 Pediatric blood & cancer, 2011 Jul 15 : 57(1)76-83 PMCID:PMC3459820
    • La TH, Wolden SL, Rodeberg DA, Hawkins DS, Brown KL, Anderson JR, Donaldson SS
      Regional nodal involvement and patterns of spread along in-transit pathways in children with rhabdomyosarcoma of the extremity: a report from the Children's Oncology Group.
      20542386 International journal of radiation oncology, biology, physics, 2011 Jul 15 : 80(4)1151-7 PMCID:PMC3116031
    • Million L, Anderson J, Breneman J, Hawkins DS, Laurie F, Michalski J, Rodeberg D, Wharam M, Wolden S, Donaldson SS, Soft Tissue Sarcoma Committee of the Children's Oncology Group
      Influence of noncompliance with radiation therapy protocol guidelines and operative bed recurrences for children with rhabdomyosarcoma and microscopic residual disease: a report from the Children's Oncology Group.
      20646841 International journal of radiation oncology, biology, physics, 2011 Jun 1 : 80(2)333-8
    • Rodeberg DA, Stoner JA, Garcia-Henriquez N, Randall RL, Spunt SL, Arndt CA, Kao S, Paidas CN, Million L, Hawkins DS
      Tumor volume and patient weight as predictors of outcome in children with intermediate risk rhabdomyosarcoma: a report from the Children's Oncology Group.
      24048802 Cancer, 2011 Jun 1 : 117(11)2541-50 PMCID:PMC3117103
    • La TH, Wolden SL, Su Z, Linardic C, Randall RL, Hawkins DS, Donaldson SS
      Local therapy for rhabdomyosarcoma of the hands and feet: is amputation necessary? A report from the Children's Oncology Group.
      20646853 International journal of radiation oncology, biology, physics, 2011 May 1 : 80(1)206-12 PMCID:PMC3075377
    • Rodeberg DA, Garcia-Henriquez N, Lyden ER, Davicioni E, Parham DM, Skapek SX, Hayes-Jordan AA, Donaldson SS, Brown KL, Triche TJ, Meyer WH, Hawkins DS
      Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group.
      21357792 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011 Apr 1 : 29(10)1304-11 PMCID:PMC3083998
    • Eary JF, Hawkins DS, Rodler ET, Conrad EU 3rd
      (18)F-FDG PET in sarcoma treatment response imaging.
      23133794 American journal of nuclear medicine and molecular imaging, 2011 : 1(1)47-53 PMCID:PMC3477719
    • Rodeberg DA, Stoner JA, Garcia-Henriquez N, Randall RL, Spunt SL, Arndt CA, Kao S, Paidas CN, Million L, Hawkins DS
      Tumor volume and patient weight as predictors of outcome in children with intermediate risk rhabdomyosarcoma: a report from the children's oncology group.
      21157950 Cancer, 2010 Dec 14
    • Mascarenhas L, Lyden ER, Breitfeld PP, Walterhouse DO, Donaldson SS, Paidas CN, Parham DM, Anderson JR, Meyer WH, Hawkins DS
      Randomized phase II window trial of two schedules of irinotecan with vincristine in patients with first relapse or progression of rhabdomyosarcoma: a report from the Children's Oncology Group.
      20837952 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010 Oct 20 : 28(30)4658-63 PMCID:PMC2974343
    • Anderson JR, Barr FG, Hawkins DS, Parham DM, Skapek SX, Triche TJ
      Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature.
      20697086 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010 Oct 10 : 28(29)e587-8; author reply e589-90
    • Minn AY, Lyden ER, Anderson JR, Million L, Arndt CA, Brown K, Hawkins DS, Donaldson SS
      Early treatment failure in intermediate-risk rhabdomyosarcoma: results from IRS-IV and D9803--a report from the Children's Oncology Group.
      20713850 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010 Sep 20 : 28(27)4228-32 PMCID:PMC2953975
    • Arndt CA, Koshkina NV, Inwards CY, Hawkins DS, Krailo MD, Villaluna D, Anderson PM, Goorin AM, Blakely ML, Bernstein M, Bell SA, Ray K, Grendahl DC, Marina N, Kleinerman ES
      Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: effects on disease-free survival and immunomodulation. a report from the Children's Oncology Group.
      20576718 Clinical cancer research : an official journal of the American Association for Cancer Research, 2010 Aug 1 : 16(15)4024-30 PMCID:PMC2989183
    • Koschmann C, Thomson B, Hawkins DS
      No evidence of a trial effect in newly diagnosed pediatric acute lymphoblastic leukemia.
      20194252 Archives of pediatrics & adolescent medicine, 2010 March : 214-7
    • Schmale GA, Hawkins DS, Rutledge J, Conrad EU
      Malignant progression in two children with multiple osteochondromas.
      20467466 Sarcoma, 2010 : 2010417105 PMCID:PMC2866243
    • Fox E, Widemann BC, Hawkins DS, Jayaprakash N, Dagher R, Aikin AA, Bernstein D, Long L, Mackall C, Helman L, Steinberg SM, Balis FM
      Randomized trial and pharmacokinetic study of pegfilgrastim versus filgrastim after dose-intensive chemotherapy in young adults and children with sarcomas.
      19920107 Clinical cancer research : an official journal of the American Association for Cancer Research, 2009 Dec 1 : 15(23)7361-7 PMCID:PMC2787766
    • Arndt CA, Stoner JA, Hawkins DS, Rodeberg DA, Hayes-Jordan AA, Paidas CN, Parham DM, Teot LA, Wharam MD, Breneman JC, Donaldson SS, Anderson JR, Meyer WH
      Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803.
      19770373 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Nov 1 : 27(31)5182-8 PMCID:PMC2773476
    • Borinstein SC, Pollard J, Winter L, Hawkins DS
      Pegfilgrastim for prevention of chemotherapy-associated neutropenia in pediatric patients with solid tumors.
      19484756 Pediatric blood & cancer, 2009 Sept. : 53(3)375-8
    • Rodeberg DA, Stoner JA, Hayes-Jordan A, Kao SC, Wolden SL, Qualman SJ, Meyer WH, Hawkins DS
      Prognostic significance of tumor response at the end of therapy in group III rhabdomyosarcoma: a report from the children's oncology group.
      19470937 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Aug 1 : 3705-11
    • Rodeberg DA, Stoner JA, Hayes-Jordan A, Kao SC, Wolden SL, Qualman SJ, Meyer WH, Hawkins DS
      Prognostic significance of tumor response at the end of therapy in group III rhabdomyosarcoma: a report from the children's oncology group.
      19470937 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009 Aug 1 : 27(22)3705-11 PMCID:PMC3020959
    • Hawkins DS, Conrad EU 3rd, Butrynski JE, Schuetze SM, Eary JF
      [F-18]-fluorodeoxy-D-glucose-positron emission tomography response is associated with outcome for extremity osteosarcoma in children and young adults.
      19517457 Cancer, 2009 Aug 1 : 115(15)3519-25 PMCID:PMC2716419
    • Imran H, Enders F, Krailo M, Sim F, Okuno S, Hawkins D, Neglia J, Randall RL, Womer R, Mascarenhas L, Arndt CA
      Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma.
      19255220 The Journal of bone and joint surgery. American volume, 2009 Mar 1 : 91(3)604-12 PMCID:PMC2701597
    • Cengiz P, Zemlan F, Ellenbogen R, Hawkins D, Zimmerman JJ
      Cerebrospinal fluid cleaved-tau protein and 9-hydroxyoctadecadienoic acid concentrations in pediatric patients with hydrocephalus.
      18679140 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2008 Sept. : 9(5)524-9
    • Rodriguez NI, Hoots WK, Koshkina NV, Morales-Arias JA, Arndt CA, Inwards CY, Hawkins DS, Munsell MF, Kleinerman ES
      COX-2 expression correlates with survival in patients with osteosarcoma lung metastases.
      18797196 Journal of pediatric hematology/oncology, 2008 July : 30(7)507-12 PMCID:PMC2771732
    • Wirojanan J, Kraff J, Hawkins DS, Laird C, Gane LW, Angkustsiri K, Tassone F, Hagerman RJ
      Two boys with fragile x syndrome and hepatic tumors.
      18376289 Journal of pediatric hematology/oncology, 2008 March : 30(3)239-41
    • Borinstein SC, Xu M, Hawkins DS
      Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia.
      17387701 Pediatric blood & cancer, 2008 Jan. : 50(1)189
    • Arndt CA, Hawkins DS, Meyer WH, Sencer SF, Neglia JP, Anderson JR
      Comparison of results of a pilot study of alternating vincristine/doxorubicin/cyclophosphamide and etoposide/ifosfamide with IRS-IV in intermediate risk rhabdomyosarcoma: a report from the Children's Oncology Group.
      17091486 Pediatric blood & cancer, 2008 Jan. : 50(1)33-6
    • Douglas JG, Arndt CA, Hawkins DS
      Delayed radiotherapy following dose intensive chemotherapy for parameningeal rhabdomyosarcoma (PM-RMS) of childhood.
      17368885 European journal of cancer (Oxford, England : 1990), 2007 April : 43(6)1045-50
    • Greene S, Hawkins DS, Rutledge JC, Tsuchiya KD, Douglas J, Ellenbogen RG, Avellino AM
      Pediatric intradural extramedullary synovial sarcoma: case report.
      17277671 Neurosurgery, 2006 Dec. : E1339; discussion E1339
    • Hawkins DS, Bradfield S, Whitlock JA, Krailo M, Franklin J, Blaney SM, Adamson PC, Reaman G
      Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study.
      16435380 Pediatric blood & cancer, 2006 Nov. : 47(6)790-4
    • Taylor JA, Winter L, Geyer LJ, Hawkins DS
      Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia.
      16909415 Cancer, 2006 Sep 15 : 107(6)1400-6
    • Morgan HD, Cizik AM, Leopold SS, Hawkins DS, Conrad EU 3rd
      Survival of tumor megaprostheses replacements about the knee.
      16906094 Clinical orthopaedics and related research, 2006 Sept. : 45039-45
    • Hawkins DS, Schuetze SM, Butrynski JE, Rajendran JG, Vernon CB, Conrad EU 3rd, Eary JF
      [18F]Fluorodeoxyglucose positron emission tomography predicts outcome for Ewing sarcoma family of tumors.
      16314643 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005 Dec 1 : 23(34)8828-34
    • Cole PD, Drachtman RA, Smith AK, Cate S, Larson RA, Hawkins DS, Holcenberg J, Kelly K, Kamen BA
      Phase II trial of oral aminopterin for adults and children with refractory acute leukemia.
      16299240 Clinical cancer research : an official journal of the American Association for Cancer Research, 2005 Nov 15 : 11(22)8089-96 PMCID:PMC2906753
    • Gordon N, Arndt CA, Hawkins DS, Doherty DK, Inwards CY, Munsell MF, Stewart J, Koshkina NV, Kleinerman ES
      Fas expression in lung metastasis from osteosarcoma patients.
      16282894 Journal of pediatric hematology/oncology, 2005 Nov. : 27(11)611-5
    • Spiller SE, Hawkins DS, Finn LS, Sze RW, Sybert V
      Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy.
      15800910 Pediatric blood & cancer, 2005 July : 45(1)60-3
    • Barker LM, Pendergrass TW, Sanders JE, Hawkins DS
      Survival after recurrence of Ewing's sarcoma family of tumors.
      15781881 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005 Jul 1 : 23(19)4354-62
    • Schuetze SM, Rubin BP, Vernon C, Hawkins DS, Bruckner JD, Conrad EU 3rd, Eary JF
      Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy.
      15578712 Cancer, 2005 Jan 15 : 103(2)339-48
    • Hawkins DS
      Transatlantic collaboration in pediatric oncology: now is the time.
      15591895 Journal of pediatric hematology/oncology, 2004 Dec. : 26(12)783-4
    • Thomson B, Park JR, Felgenhauer J, Meshinchi S, Holcenberg J, Geyer JR, Avramis V, Douglas JG, Loken MR, Hawkins DS
      Toxicity and efficacy of intensive chemotherapy for children with acute lymphoblastic leukemia (ALL) after first bone marrow or extramedullary relapse.
      15382275 Pediatric blood & cancer, 2004 Oct. : 571-9
    • Hawkins DS, Park JR, Thomson BG, Felgenhauer JL, Holcenberg JS, Panosyan EH, Avramis VI
      Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia.
      15328169 Clinical cancer research : an official journal of the American Association for Cancer Research, 2004 Aug 15 : 5335-41
    • McCune JS, Friedman DL, Schuetze S, Blough D, Magbulos M, Hawkins DS
      Influence of age upon Ifosfamide-induced nephrotoxicity.
      15049014 Pediatric blood & cancer, 2004 May : 42(5)427-32
    • Bradfield SM, Douglas JG, Hawkins DS, Sanders JE, Park JR
      Fractionated low-dose radiotherapy after myeloablative stem cell transplantation for local control in patients with high-risk neuroblastoma.
      15022296 Cancer, 2004 Mar 15 : 100(6)1268-75
    • Finn LS, Hawkins DS, Rutledge JC, Patterson K
      Evaluation of early marrow response in childhood aneuploid acute lymphoblastic leukemia: flow cytometric DNA analysis versus standard morphology.
      15255034 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 2004 Jan. : 7(1)39-47
    • Hawkins DS, Arndt CA
      Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy.
      14635080 Cancer, 2003 Dec 1 : 98(11)2447-56
    • Smith SC, Lindsley SK, Felgenhauer J, Hawkins DS, Douglas JG
      Intensive induction chemotherapy and delayed irradiation in the management of parameningeal rhabdomyosarcoma.
      14528099 Journal of pediatric hematology/oncology, 2003 Oct. : 25(10)774-9
    • Wright JA, Bradfield SM, Park JR, Hawkins DS
      Prolonged survival after invasive aspergillosis: a single-institution review of 11 cases.
      12679641 Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 2003 April : 286-91
    • Park JR, Coughlin J, Hawkins D, Friedman DL, Burns JL, Pendergrass T
      Ciprofloxacin and amoxicillin as continuation treatment of febrile neutropenia in pediatric cancer patients.
      12461792 Medical and pediatric oncology, 2003 Feb. : 40(2)93-8
    • Hawkins DS, Felgenhauer J, Park J, Kreissman S, Thomson B, Douglas J, Rowley SD, Gooley T, Sanders JE, Pendergrass TW
      Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas.
      12216105 Cancer, 2002 Sep 15 : 1354-65
    • Mansky PJ, Liewehr DJ, Steinberg SM, Chrousos GP, Avila NA, Long L, Bernstein D, Mackall CL, Hawkins DS, Helman LJ
      Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels.
      12218590 Journal of pediatric hematology/oncology, 2002 Aug. : 24(6)440-6
    • Hawkins DS, Rajendran JG, Conrad EU 3rd, Bruckner JD, Eary JF
      Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography.
      12115361 Cancer, 2002 Jun 15 : 94(12)3277-84
  • Presentations

    Presentation Title Event Location Date
    Successes and challenges in pediatric cancer: the Children’s Oncology Group (COG) perspective Biopathology Center at Nationwide Children’s Hospital, Columbus, OH 2022
    Successes and challenges in pediatric cancer: the Children’s Oncology Group (COG) perspective American Medical School Pediatric Department Chair Annual Meeting Virtual 2022
    Update on the medical management of osteosarcoma 2021 Pakistan Orthopedic Oncology Virtual Conference Virtual 2021
    Evolution of risk stratification of rhabdomyosarcoma and its role in management Pakistan Society of Pediatric Oncology Symposium Virtual 2021
    Pediatric early phase drug development: the world is wide enough for POETIC and COG Pediatric Oncology Experimental Therapeutics Investigator’s Consortium (POETIC) Fall 2021 Meeting Virtual 2021
    NCI Molecular Characterization Protocol and Project:EveryChild approach National Cancer Institute Childhood Cancer Data Initiative Annual Symposium Virtual 2021
    Current and future NCI-COG strategies for precision medicine in pediatric rhabdomyosarcoma Summer’s Way Rhabdomyosarcoma Workshop Virtual 2021
    Biology and treatment of rhabdomyosarcoma: lessons from the Children's Oncology Group Norton Children’s Hospital Pediatric Grand Rounds Virtual 2021
    Successes and challenges in pediatric cancer: the Children’s Oncology Group (COG) perspective Evan Dunbar Lectureship Louisville, KY 2021
    Successes and challenges in pediatric cancer: the Children’s Oncology Group (COG) perspective Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Annual Scientific Meeting Virtual 2021
    COG perspective on the impact of COVID-19 on pediatric oncology clinical trials and implications for the future American Society of Clinical Oncology Annual Meeting Virtual 2021
    Informing pediatric clinical research strategies and drug development through RWE Food and Drug Administration, Center for Drug Evaluation and Research, Pediatric Oncology Subcommittee of the Oncologic Drugs Advisory Committee Meeting Virtual 2021
    Incorporating Pediatric PRO-CTCAE in NCTN clinical trials Food and Drug Administration, Center for Drug Evaluation and Research, Pediatric Oncology Subcommittee of the Oncologic Drugs Advisory Committee Meeting Virtual 2021
    Successes and challenges in pediatric cancer: the Children’s Oncology Group (COG) perspective Science of Childhood Cancer, St. Jude Cancer Research Hospital Virtual 2021
    Successes and challenges in pediatric cancer: the Children’s Oncology Group (COG) perspective University of Iowa Stead Family Department of Pediatric Grand Rounds Virtual 2021
    Children’s Oncology Group strategies for treatment of rhabdomyosarcoma 5th Pediatric Hematology & Oncology Updates King Faisal Specialist Hospital & Research Center, Saudi Arabia,Saudi Arabia (virtual) 2020
    Perspectives from the new COG Group Chair Coalition Against Childhood Cancer 8th Annual Summit On-line 2020
    The past, present, and future of maintenance chemotherapy in rhabdomyosarcoma 2020 Pediatric Soft Tissue Sarcoma Conference Houston, TX 2020
    Children’s Oncology Group Soft Tissue Sarcoma Committee update to EpSSG European Paediatric Soft Tissue Sarcoma Meeting London, United Kingdom 2019
    Multidisciplinary management of parameningeal rhabdomyosarcoma: point of view of the pediatrician International Society of Paediatric Oncology Lyon, France 2019
    Lessons from the COG Soft Tissue Sarcoma Committee for international collaboration European Society for Paediatric Oncology Prague, Czech Republic 2019
    DICER1 Mutations in Sarcomas European Society for Paediatric Oncology Prague, Czech Republic 2019
    Children’s Oncology Group Strategies for Ewing sarcoma treatment Grupo de America Latina de Oncologia Pediatrica Buenos Aires, Argentina 2019
    2019 update from Children’s Oncology Group Soft Tissue Sarcoma Committee American Society of Pediatric Hematology/Oncology New Orleans, LA 2019
    Chemotherapy for rhabdomyosarcoma: the Children’s Oncology Group perspective West Coast Sarcoma Conference Vancouver, British Columbia 2019
    Clinical trials past, present, and future for rhabdomyosarcoma: the Children’s Oncology Group perspective Ruth Rappaport Annual Meeting in Pediatric Oncology, Northern Israel Haifa, Israel 2019
    Clinical trials past, present, and future for rhabdomyosarcoma: the Children’s Oncology Group perspective Japanese Society of Pediatric Hematology/Oncology Kyoto, Japan 2018
    Discussant, Plenary Session American Society of Clinical Oncology Chicago, IL 2018
    The Past and Present State of Treatment for Rhabdomyosarcoma: the COG perspective Summer’s Way Rhabdomyosarcoma Workshop Denver, CO 2018
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Lyon, France 2017
    Lessons Learned in the Search of New Treatment for Pediatric Sarcomas New Horizons in Young Adult Oncology Symposium Cincinnati, Ohio 2017
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Copenhagen, Denmark 2017
    Biology and Treatment of Rhabdomyosarcoma in the Genomics Age Hematology/Oncology Grand Rounds, Children’s National Medical Center Washington, DC 2017
    Risk Stratification for Rhabdomyosarcoma in the Modern Era Cooperative Weichteilsarkom Studiengruppe, European Paediatric Soft Tissue Sarcoma, and Children’s Oncology Group Soft Tissue Sarcoma Meeting Stuttgart, Germany 2016
    Treating Pediatric Soft Tissue Sarcomas in the Genomic and Targeted Therapy Age: the COG Approach Soft Tissue Sarcoma in the Young: Expectations, Achievements and Perspectives Stuttgart, Germany 2016
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Barcelona, Spain 2016
    Very high risk alveolar rhabdomyosarcoma: comparative analysis of Children’s Oncology Group European Paediatric Soft Tissue Sarcoma studies European Paediatric Soft Tissue Sarcoma Meeting Barcelona, Spain 2016
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Amsterdam, The Netherlands 2015
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Sutton, United Kingdom 2015
    Children’s Oncology Group: Future Plans and Ongoing Studies in Ewing Sarcoma Sarkomkonferenz Münster, Germany 2015
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Lyon, France 2014
    Children’s Oncology Group Approach to Treatment of Rhabdomyosarcoma Pablove Foundation International Think Tank Los Angeles, CA 2014
    Rhabdomyosarcoma: How many and how to treat? Joseph McBride Memorial Sarcoma Lecture, Inova Comprehensive Cancer & Research Institute Fairfax, VA 2014
    Children’s Oncology Group Update on Soft Tissue Sarcoma Clinical Trials European Paediatric Soft Tissue Sarcoma Meeting Milan, Italy 2014
    Rhabdomyosarcoma: How many and how to treat? Grand Rounds, St. Jude Children’s Research Hospital Memphis, TN 2014
    What Children with Rhabdomyosarcoma Have Taught Me Pediatric Grand Rounds, Alfred I. duPont Hospital for Children Wilmington, DE 2013 - 2013
    COG approach to identification and introduction of new/targeted therapies in RMS/STS European Paediatric Soft Tissue Sarcoma Meeting Paris, France, Mar 22, 2013
    Rhabdomyosarcoma: How many and how to treat Texas Childrens Cancer Center Houston, TX Feb 14, 2013
    What children have taught me about rhabdomyosarcoma Pediatric Grand Rounds, Childrens Hospital at Montefiore Bronx, NY Jan 30, 2013
    From Seattle to Sydney: lessons from selected pediatric sarcoma cases Pediatric Oncology Conference Sydney, Australia Oct 8, 2012
    Childrens Oncology Group update on soft tissue sarcoma clinical trials International Symposium on the Biology and Treatment of the Pediatric Soft Tissue Sarcomas Padova, Italy Dec 6, 2011
  • Research Funding

    Grant Title Grantor Amount Award Date
    COG NCTN Integrated Translational Science Center for Hematopoietic Malignancies in Children National Cancer Institute 2020 - 2025
    COG NCORP Research Base National Cancer Institute 2020 - 2025
    COG NCTN Network Group Operations Center Grant National Cancer Institute $119,586,932 2020 - 2025

Overview

Board Certification(s)

Pediatric Hematology-Oncology

Medical/Professional School

Harvard Medical School, Boston, MA

Residency

University of Washington School of Medicine, Seattle, WA

Clinical Interests

Sarcomas, clinical trials

Research Description

The goals of the Children's Oncology Group are to: 1) design and conduct collaborative clinical-translational studies for children with cancer that build on an increasing understanding of the molecular basis for pediatric malignancies, bridge gaps in knowledge, and have the highest potential to improve outcome for all childhood cancer patients; 2) conduct research that lessens the morbidity of cancer therapy and improves the quality of life for children throughout their care, spanning diagnosis, treatment and survivorship; 3) collect and highly annotate biospecimens from all children with cancer, leveraging COG’s nearly population based research enterprise, to provide the foundation for discovery of the molecular basis of all childhood cancers, no matter how rare, and accelerate the most promising translational research efforts conducted at laboratories around the world

Research Focus Area

Cancer, Novel Therapeutics, Refractory and recurrent cancer, Sarcomas, Thyroid Cancer