Daryl M Okamura, MD

Daryl M Okamura, MD

Nephrology, Autoimmune Kidney Disease, Dialysis, Apheresis, Kidney Transplant

On staff since October 2002

Academic Title: Associate Professor, Pediatrics

Research Center: Center for Developmental Biology and Regenerative Medicine

  • Daryl M. Okamura, MD, is an attending physician at Seattle Children’s and an Assistant Professor of Pediatrics at the University of Washington School of Medicine. He earned his MD and completed his pediatric residency training at the University of Hawaii, after which he completed his pediatric nephrology fellowship at Seattle Children’s.

    Dr. Okamura has an active, NIH-funded, basic science research program that is focused on halting and potentially reversing progressive kidney failure through further elucidation of the pathogenic mechanisms involved in renal fibrosis.  Currently, his lab is investigating the role of macrophages in mediating both inflammatory and oxidative pathways and their role in cellular crosstalk with interstitial fibroblasts during chronic kidney injury. His clinical interests include the diagnosis and management of infants, children and adolescents with renal disease, particularly renal vasculitis, hypertension and chronic kidney disease.

    • Noah Montana 07.08.22

      Dr. Okamura is amazing to work with, and helped my parents and I understand my medical issues very quickly. He’s very kind, knowledgeable, and approachable. He’s all around a pretty great guy and an amazing doctor.

    • Milisa Edgemont, SD 11.04.12

      Dr. Okamura was very up front and compassionate in our diagnosis with HSP and IgA Nephropothy. I wholeheartedly recommend Dr. Okamura and his team.

  • Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
  • Other Publications

    • Okamura DM, Himmelfarb J
      Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease.
      19421784 Pediatric nephrology (Berlin, Germany), 2009 Dec. : 2309-19
    • Okamura DM, Pennathur S, Pasichnyk K, López-Guisa JM, Collins S, Febbraio M, Heinecke J, Eddy AA
      CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.
      19211715 Journal of the American Society of Nephrology : JASN, 2009 March : 495-505
    • Okamura DM, López-Guisa JM, Koelsch K, Collins S, Eddy AA
      Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury.
      17537985 American journal of physiology. Renal physiology, 2007 Aug. : F575-85
    • Yamaguchi I, Lopez-Guisa JM, Cai X, Collins SJ, Okamura DM, Eddy AA
      Endogenous urokinase lacks antifibrotic activity during progressive renal injury.
      17356128 American journal of physiology. Renal physiology, 2007 July : F12-9
    • Collins SJ, Alexander SL, Lopez-Guisa JM, Cai X, Maruvada R, Chua SC, Zhang G, Okamura DM, Matsuo S, Eddy AA
      Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.
      16735799 Nephron. Experimental nephrology, 2006 : e23-34
    • Matsuo S, López-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA
      Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.
      15882265 Kidney international, 2005 June : 2221-38
  • Presentations Title Event Location Date
    Role of oxidized lipids in progression of chronic kidney disease 8. American Society of Pediatric Nephrology Annual Meeting Baltimore, Maryland May 3, 2009
  • Grant Title Grantor Amount Award Date
    Uncovering CD36-mediated oxidative and inflammatory pathways in progressive renal fibrosis unknown $50,000.00 Apr 1, 2009
    Cysteamine effects on extracellular matrix accumulation in chronic kidney disease Cystinosis Research Foundation Award $89,069.00 Jul 1, 2008
    Role of CD36 in oxidative and inflammatory pathways in renal fibrosis National Kidney Foundation $50,000.00 Jul 1, 2007
    Multifunctional role of CD36 in progressive renal fibrosis unknown $128,250.00 Jul 1, 2006
    Multifunctional role of CD36 in progressive renal fibrosis NIH $35,000.00 Jul 1, 2004


Board Certification(s)

Pediatric Nephrology

Medical/Professional School

University of Hawaii, Honolulu, HI


Seattle Children's Hospital, Seattle, WA

Clinical Interests

Diagnosis and management of infants, children and adolescents with renal disease, particularly renal vasculitis, glomerulonephritis, and chronic kidney disease.

Research Focus Area

Tissue Response to Injury