Danielle Crawford Kirkey, MD

Danielle Crawford Kirkey, MD

Cancer and Blood Disorders Center, Leukemia and Lymphoma Program, High-Risk Leukemia Program, Immunotherapy Program

On staff since July 2023

Children's Title: Attending Physician, Pediatric Hematology/Oncology and Bone Marrow Transplant

Academic Title: Acting Instructor

  • Patient Testimonials
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  • Awards and Honors
    Award Name Award Description Awarded By Award Date
    Alberta Corkery Travel Award Seattle Children's Hospital June 2023
    COG Translational Research Young Investigator Award Childen's Oncology Group Sept. 2022
    American Society of Hematology (ASH) Abstract Achievement Award ASH Dec. 2021
    Gold Humanism Honor Society 2016
    Alpha Omega Alpha Honor Society 2016
  • Publications

    Other Publications

    • Le Q, Tang T, Leonti A, Castro S, McKay CN, Perkins L, Pardo L, Kirkey D, Hylkema T, Call L, Manselle M, Abrahams C, Bedard K, Molina A, Brodersen LE, Loken MR, Tarlock K, Meshinchi S, Loeb KR
      Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia.
      36595452 Blood advances, 2023 May 9 : 7(9)1666-1670 PMCID:PMC10182275
    • Kirkey DC, Loeb AM, Castro S, McKay CN, Perkins L, Pardo L, Leonti AR, Tang TT, Loken MR, Brodersen LE, Loeb KR, Scheinberg DA, Le Q, Meshinchi S
      Therapeutic targeting of PRAME with mTCRCAR T cells in acute myeloid leukemia.
      35984639 Blood advances, 2023 Apr 11 : 7(7)1178-1189 PMCID:PMC10111362
    • Manselle MK, Ries RE, Hylkema T, Leonti A, Kirkey DC, Furlan SN, Meshinchi S
      Functional consequence and therapeutic targeting of cryptic ALK fusions in monosomy 7 acute myeloid leukemia.
      36720638 Pediatric blood & cancer, 2023 April : 70(4)e30180
    • Vitanza NA, Ronsley R, Choe M, Henson C, Breedt M, Barrios-Anderson A, Wein A, Brown C, Beebe A, Kong A, Kirkey D, Lee BM, Leary SES, Crotty EE, Hoeppner C, Holtzclaw S, Wilson AL, Gustafson JA, Foster JB, Iliff JJ, Goldstein HE, Browd SR, Lee A, Ojemann JG, Pinto N, Gust J, Gardner RA, Jensen MC, Hauptman JS, Park JR
      Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety.
      36599192 Neoplasia (New York, N.Y.), 2023 Feb. : 36100870 PMCID:PMC9823206
    • Tang T, Le Q, Castro S, Pardo L, McKay CN, Perkins L, Smith J, Kirkey D, Abrahams C, Bedard K, Molina A, Brodersen LE, Loken MR, Tarlock K, Meshinchi S, Loeb KR
      Targeting FOLR1 in high-risk CBF2AT3-GLIS2 pediatric AML with STRO-002 FOLR1-antibody-drug conjugate.
      36149945 Blood advances, 2022 Nov 22 : 6(22)5933-5937 PMCID:PMC9701621
    • Lyle ANJ, Spurr R, Kirkey D, Albert CM, Billimoria Z, Perez J, Puia-Dumitrescu M
      Case report of congenital methemoglobinemia: an uncommon cause of neonatal cyanosis.
      36114590 Maternal health, neonatology and perinatology, 2022 Sep 16 : 8(1)7 PMCID:PMC9479420
    • Selling SK, Kirkey D, Goyal T, Singh A, Gold CA, Hilgenberg SL, Weimer-Elder B, Kuo KW, Rassbach CE
      Impact of a relationship-centered care communication curriculum on pediatric residents' practice, perspectives, and opportunities to Develop expertise.
      34538683 Patient education and counseling, 2022 May : 105(5)1290-1297
    • Dasgupta MN, Kirkey DC, Weatherly JA, Kuo KW, Rassbach CE
      Using Self-Determination Theory to Drive an Evidence-Based Medicine Curriculum for Pediatric Residents: A Mixed Methods Study.
      34929387 Academic pediatrics, 2022 April : 22(3)486-494

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  • Presentations
    Presentations Title Event Location Date
    CLEC2A is a novel AML-restricted Immunotherapeutic Target enriched in High Risk Acute Myeloid Leukemia 65th ASH Annual Meeting San Diego, CA Dec. 2023
    Immunotherapeutic Targeting of AML-restricted Antigens in Pediatric Acute Myeloid Leukemia St. Jude Cell and Gene Therapy Seminar Memphis, TN Nov. 2023
    Therapeutic Targeting of PRAME with TCR mimic CAR T cells in AML Fred Hutchinson Cancer Center Immunotherapy Retreat Cle Elum, WA Oct. 2023
    Preclinical evaluation of targeting PRAME with TCR mimic CAR T cells in AML ASCO National Meeting Chicago, IL June 2023
    Clinical and Functional Implications of MYC Variants as a New Class of Pathogenic Variants in AML – A TARGET AML Discovery Children's Oncology Group (COG) Fall Meeting New Orleans, LA Sept. 2022
    KMT2A Partial Tandem Duplications (KMT2A-PTD) Is a Rare, but Recurrent Genomic Event in Childhood AML and Associated with High Rate of Co-Occurring FLT3 Mutations 63rd ASH Annual Meeting Atlanta, GA Dec. 2021
  • Research Funding
    Grant Title Grantor Amount Award Date
    K12 Career Development in Pediatric and Medical Oncology Award NIH March 2024 - Feb. 2026
    Conquer Cancer Young Investigator Award American Society of Clinical Oncology (ASCO) July 2023 - June 2024
    Fred Hutch Evergreen Pilot Award Fred Hutchinson Cancer Center Jan. 2023 - Dec. 2023
    COG HM-ITSC Grant Children's Oncology Group Jan. 2023 - Dec. 2023

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

Rush Medical College at Rush University, Chicago, IL

Residency

Lucile Salter Packard Children's Hospital-Stanford, Palo Alto, CA
Stanford University School of Medicine, Stanford, CA

Fellowship

University of Washington Hematology/Oncology GME, Seattle, WA

Research Focus Area

Cancer biology, Immunotherapy, CAR-T cells, Epigenetic modifying agents, cell-free DNA