Christina T Lam, MD

Christina T Lam, MD

Biochemical Genetics, Genetics, Non-Malignant Transplant Program

On staff since July 2016

Children's Title: Interim Medical Director, Biochemical Genetics Clinic; Director, CDG Center of Excellence (Congenital Disorders of Glycosylation)

Academic Title: Associate Professor

Research Center: Center for Integrative Brain Research

  • Christina Lam, MD is an attending physician at Seattle Childrens Hospital (SCH) and Assistant Professor in the Department of Pediatrics at the University of Washington School of Medicine (UW). She joined UW/SCH after completing her pediatric and medical genetics residency at UCLA, and her medical biochemical genetics fellowship at the National Institutes of Health.

    She provides inpatient and outpatient clinical services in biochemical genetics at Seattle Childrens Hospital, Seattle Childrens at Bellevue Clinic, and at the University of Washington Medical Center. Her research focuses on clinical aspects of inborn errors of metabolism, especially in congenital disorders of glycosylation and NGLY1-CDDG. She is a co-investigator of the Clinical and Basic Investigations into Known and Suspected Congenital Disorders of Glycosylation protocol at the National Human Genome Research Institute at the NIH. She is also a member of the medical advisory committee of patient advocacy groups.

    • Liz Edmonds, WA 09.19.18

      Dr. Lam has provided incredible care to our son since he was two weeks old. She helped me and my husband, as first-time parents, understand the complexity of his early symptoms and eventual diagnosis with genuine empathy and deep knowledge. Now two years into our journey with a medically complex child, we look forward to our visits with her and the entire Biochemical Genetics team. We always receive valuable information and wonderful encouragement.

  • Award Name Award Description Awarded By Award Date
    Society for Inherited Metabolic Disorders Travel Award SIMD 2015
    National Urea Cycle Disorders Foundation Travel Award NUCDF 2012
    Upper Class Merit Award Scholarship Caltech 2001 - 2003
  • Other Publications

    • Lam C, Ferreira C, Krasnewich D, Toro C, Latham L, Zein WM, Lehky T, Brewer C, Baker EH, Thurm A, Farmer CA, Rosenzweig SD, Lyons JJ, Schreiber JM, Gropman A, Lingala S, Ghany MG, Solomon B, Macnamara E, Davids M, Stratakis CA, Kimonis V, Gahl WA, Wolfe L
      Prospective phenotyping of NGLY1-CDDG, the first congenital disorder of deglycosylation.
      27388694 Genetics in medicine : official journal of the American College of Medical Genetics, 2016 July 7
    • Ng BG, Shiryaev SA, Rymen D, Eklund EA, Raymond K, Kircher M, Abdenur JE, Alehan F, Midro AT, Bamshad MJ, Barone R, Berry GT, Brumbaugh JE, Buckingham KJ, Clarkson K, Cole FS, O'Connor S, Cooper GM, Van Coster R, Demmer LA, Diogo L, Fay AJ, Ficicioglu C, Fiumara A, Gahl WA, Ganetzky R, Goel H, Harshman LA, He M, Jaeken J, James PM, Katz D, Keldermans L, Kibaek M, Kornberg AJ, Lachlan K, Lam C, Yaplito-Lee J, Nickerson DA, Peters HL, Race V, Régal L, Rush JS, Rutledge SL, Shendure J, Souche E, Sparks SE, Trapane P, Sanchez-Valle A, Vilain E, Vøllo A, Waechter CJ, Wang RY, Wolfe LA, Wong DA, Wood T, Yang AC, University of Washington Center for Mendelian Genomics, Matthijs G, Freeze HH
      ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients.
      26931382 Human mutation, 2016 July : 37(7)653-60 PMCID:PMC4907823
    • Lam C, Golas GA, Davids M, Huizing M, Kane MS, Krasnewich DM, Malicdan MC, Adams DR, Markello TC, Zein WM, Gropman AL, Lodish MB, Stratakis CA, Maric I, Rosenzweig SD, Baker EH, Ferreira CR, Danylchuk NR, Kahler S, Garnica AD, Bradley Schaefer G, Boerkoel CF, Gahl WA, Wolfe LA
      Expanding the clinical and molecular characteristics of PIGT-CDG, a disorder of glycosylphosphatidylinositol anchors.
      25943031 Molecular genetics and metabolism, 2015 June : 115(2-3)128-40
    • Lam C, Gallo LK, Dineen R, Ciccone C, Dorward H, Hoganson GE, Wolfe L, Gahl WA, Huizing M
      Two novel compound heterozygous mutations in OPA3 in two siblings with OPA3-related 3-methylglutaconic aciduria.
      24749080 Molecular genetics and metabolism reports, 2014 Jan. 1 : 1114-123 PMCID:PMC3987911

  • Presentations Title Event Location Date
    The Clinical Spectrum of the CDG Rainbow CDG Family Conference Del Mar, California, USA 2016
    A Sweet Branch of Metabolic Genetics Genetics Case Conference NIH, Bethesda, MD 2015
    Saliva and Tears: A Clinical Introduction to NGLY1 Deficiency Clinical Glycobiology Meeting NIH, Bethesda, MD, USA 2015
    Clarifying the phenotype of NGLY1 deficiency, the first congenital disorder of deglycosylation Society of Inherited Metabolic Disorders Salt Lake City, UT, USA 2015
    Congenital Disorders of Glycosylation: a Sweet Branch of Metabolism Freeze Group Meeting Sanford Burnham Medical Research Institute, La Jolla, CA 2015
    NGLY1 Deficiency: A New Neuro-Developmental Disorder and First Congenital Disorder of Deglycosylation Neurology Grand Rounds Universtiy of Utah, Salt Lake City, UT, USA 2015
    6 and 7 Year Old Siblings with Severe Developmental Delay, Intractable Seizures, and Craniofacial Dysmorphology NIDRC Clinicopathological Conference Bethesda, MD 2015


Board Certification(s)

Medical Genetics, Clinical Genetics (M.D.)
Medical Biochemical Genetics

Medical/Professional School

University of California Los Angeles, Los Angeles, CA


National Institutes of Health, NIH, Bethesda, MD


National Institutes of Health, NIH, Bethesda, MD

Clinical Interests

Inborn errors of metabolism

Research Description

Congenital disorders of glycosylation and deglycosylation

Research Focus Area

Translational Research