Betty Zheng, MD

Gastroenterology

On staff since October 2016

Academic Title: Acting Assistant Professor

  • Dr. Betty Zheng studies the field of mucosal immunology as it pertains to mucosal disease such as in inflammatory bowel disease (IBD) and Graft-versus-Host Disease (GVHD). She uses the application of basic science to clinical practice through clinical trials and human tissue/blood analysis. She graduated from Massachusetts Institute of Technology with a major in Biology and a minor in Biomedical Engineering. She then pursued her medical education at University of Maryland School of Medicine and continued on at the University of Maryland Pediatrics Residency. Following her residency, she sought out additional training in Pediatric Gastroenterology, Nutrition, and Hepatology fellowship at Seattle Children’s Hospital.

    During her Pediatric Gastroenterology fellowship at Seattle Children’s Hospital, Dr. Zheng and her team has launched the translational clinical trial PREDICT (Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy, and Transplantation) to deeply understanding the mechanisms of disease process and more importantly the rationale behind using the appropriate therapeutic agent in each case. Her lab is dedicated towards understanding the pathways of disease in blood and target organ invovlement through techniques such as flow cytometry and single cell RNA sequencings (scRNAseq).

  • Other Publications

    • Zheng HB, Yeung C, Summers C, Lee D, Wahbeh G, Braly K, Suskind D
      Dietary Therapy in Conjunction with Immunosuppression to Treat Gastrointestinal Graft-Versus-Host Disease (GVHD).
      30676523 Journal of pediatric gastroenterology and nutrition, 2019 Jan. 21
    • Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS
      Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
      30361514 Nature communications, 2018 Oct. 25 : 9(1)4438 PMCID:PMC6202377
    • Ambartsumyan L, Zheng HB, Iyer RS, Soares J, Henstorf G, Stevens AM
      Relationship between esophageal abnormalities on fluoroscopic esophagram and pulmonary function testing in juvenile systemic sclerosis.
      30295423 Arthritis care & research, 2018 Oct. 8
    • Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS
      CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.
      30102255 The Journal of clinical investigation, 2018 Aug. 31 : 128(9)3991-4007 PMCID:PMC6118599
    • Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell SR, Gardner R, Kean LS, Jensen MC
      Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.
      29563103 Cancer discovery, 2018 June : 8(6)750-763 PMCID:PMC6058704
    • Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS
      Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
      28931653 Science translational medicine, 2017 Sept. 20 : 9(408) PMCID:PMC5681253
    • Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS
      The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
      27500470 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017 March : 17(3)657-670 PMCID:PMC5338742

Overview

Board Certification(s)

Pediatrics
Pediatric Gastroenterology

Medical/Professional School

University of Maryland School of Medicine, Baltimore

Residency

Pediatrics, University of Maryland Medical Center, Baltimore

Fellowship

Pediatric Gastroenterology, University of Washington, Seattle

About My Work

https://www.seattlechildrens.org/research/centers-programs/immunity-and-immunotherapies/about/our-labs/zheng-lab/