Betty Zheng, MD

Betty  Zheng, MD

Gastroenterology and Hepatology, Inflammatory Bowel Disease Center

On staff since October 2016

Children's Title: Program Director, Advanced Inflammatory Bowel Disease Fellowship

Academic Title: Assistant Professor

  • Dr. Betty Zheng studies the field of mucosal immunology as it pertains to mucosal disease such as in inflammatory bowel disease (IBD) and Graft-versus-Host Disease (GVHD). She uses the application of basic science to clinical practice through clinical trials and human tissue/blood analysis. She graduated from Massachusetts Institute of Technology with a major in Biology and a minor in Biomedical Engineering. She then pursued her medical education at University of Maryland School of Medicine and continued on at the University of Maryland Pediatrics Residency. Following her residency, she sought out additional training in Pediatric Gastroenterology, Nutrition, and Hepatology fellowship at Seattle Children’s Hospital

    Dr Zheng and her team continues to work on the translational clinical trial PREDICT (Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy, and Transplantation) to deeply understanding the mechanisms of disease process and more importantly, the rationale behind using the appropriate therapeutic agent in each case. She is dedicated towards understanding the pathways of disease in blood and target organ invovlement through techniques such as flow cytometry and single cell RNA sequencings (scRNAseq).

    • Tiffany Anacortes, WA 08.25.21

      Dr. Zheng is wonderful! She is full of information on the microbiome and living a healthy gut lifestyle. Thank you for helping my daughter Andee recover.

  • Other Publications

    • Frolova Gregory P, Angus J, Brothers AW, Gray AN, Skeen K, Gooley T, Davis C, Kim HHR, Weissman SJ, Zheng HB, Mallhi K, Baker KS
      Risk Factors for Development of Pneumatosis Intestinalis after Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Case-Control Study.
      36038104 Transplantation and cellular therapy, 2022 Nov. : 28(11)785.e1-785.e7
    • Duong JT, Geddis A, Carlberg K, Rudzinski E, Len M, Zheng HB
      Sirolimus for management of GI bleeding in blue rubber bleb nevus syndrome: A case series.
      36094280 Pediatric blood & cancer, 2022 Nov. : 69(11)e29970
    • Levine AE, Zheng HB, Suskind DL
      Linking Genetic Diagnosis to Therapeutic Approach in Very Early Onset Inflammatory Bowel Disease: Pharmacologic Considerations.
      35467244 Paediatric drugs, 2022 May : 24(3)207-216
    • Zheng HB, Doran BA, Kimler K, Yu A, Tkachev V, Niederlova V, Cribbing K, Flemin R, Bratrude B, Betz K, Cagnin L, McGucking C, Keskula P, Albanese A, Sacta M, de Sousa Casal J, Taliaferro F, Ford M, Ambartsumyan L, Suskind DL, Lee D, Deutsch G, Deng X, Collen LV, Mitsiali V, Snapper SB, Wahbeh G, Shalek AK, Ordovase-Montantes J, Kean LS.
      A Treatment-Naïve Cellular Atlas of Pediatric Crohn’s Disease Predicts Disease Severity and Therapeutic Response
      2021
    • Zheng HB, Len M, Pattamanuch N.
      Effective use of topical sucralfate in the conservative management of expanded gastrostomy tract reduction.
      JPGN Reports , 2021
    • Zheng HB, Teresa de la Morena M, Suskind DL.
      The Growing Need to Understand Very Early Onset Inflammatory Bowel Disease (VEO-IBD).
      2021 : PMCID:34122435
    • Tkachev V, Kaminiski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan J, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS.
      Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.
      Sci Transl Med., 2021 : PMCID:33441422.
    • Tkachev V, Kaminski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan JT, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS
      Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8(+) T cells drive gastrointestinal acute graft-versus-host disease.
      33441422 Science translational medicine, 2021 Jan. 13 : 13(576) PMCID:PMC9469805
    • Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth II MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovi M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi JLF, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J, HCA Lung Biological Network.
      SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelia cells and is detected in specific cell subsets across tissue. Cell.
      2020 : PMCID:32413319.
    • Zheng HB, Yeung C, Summers C, Lee D, Wahbeh G, Braly K, Suskind D
      Dietary Therapy in Conjunction with Immunosuppression to Treat Gastrointestinal Graft-Versus-Host Disease (GVHD).
      30676523 Journal of pediatric gastroenterology and nutrition, 2019 Jan. 21
    • Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS
      Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
      30361514 Nature communications, 2018 Oct. 25 : 9(1)4438 PMCID:PMC6202377
    • Ambartsumyan L, Zheng HB, Iyer RS, Soares J, Henstorf G, Stevens AM
      Relationship between esophageal abnormalities on fluoroscopic esophagram and pulmonary function testing in juvenile systemic sclerosis.
      30295423 Arthritis care & research, 2018 Oct. 8
    • Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS
      CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.
      30102255 The Journal of clinical investigation, 2018 Aug. 31 : 128(9)3991-4007 PMCID:PMC6118599
    • Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell SR, Gardner R, Kean LS, Jensen MC
      Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.
      29563103 Cancer discovery, 2018 June : 8(6)750-763 PMCID:PMC6058704
    • Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS
      Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
      28931653 Science translational medicine, 2017 Sept. 20 : 9(408) PMCID:PMC5681253
    • Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS
      The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
      27500470 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017 March : 17(3)657-670 PMCID:PMC5338742

  • Presentations Title Event Location Date
    Single Cell-omics and Beyond North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Annual International Meeting Orlando, FL 2022
    A Treatment-Naïve Cellular Atlas of Pediatric Crohn’s Disease Predicts Disease Severity and Therapeutic Response North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Annual International Meeting Nashville, TN 2021
    Single-Cell Analysis of T cell pathogenesis in Pediatric Crohn’s Disease Digestive Disorders Week annual national meeting San Diego, CA 2019

Overview

Board Certification(s)

Pediatrics
Pediatric Gastroenterology

Medical/Professional School

University of Maryland School of Medicine, Baltimore, MD

Fellowship

University of Washington, Seattle, WA