Betty Zheng, MD

Betty Zheng, MD

Gastroenterology and Hepatology, Inflammatory Bowel Disease Center

On staff since October 2016

Children's Title: Program Director, Advanced Inflammatory Bowel Disease Fellowship

Academic Title: Assistant Professor

Research Center: Center for Immunity and Immunotherapies

  • Biography

    Dr. Betty Zheng studies the field of mucosal immunology as it pertains to mucosal disease such as in inflammatory bowel disease (IBD) and Graft-versus-Host Disease (GVHD). She uses the application of basic science to clinical practice through clinical trials and human tissue/blood analysis. She graduated from Massachusetts Institute of Technology with a major in Biology and a minor in Biomedical Engineering. She then pursued her medical education at University of Maryland School of Medicine and continued on at the University of Maryland Pediatrics Residency. Following her residency, she sought out additional training in Pediatric Gastroenterology, Nutrition, and Hepatology fellowship at Seattle Children’s Hospital

    Dr Zheng works on the translational clinical trials to understand the pathogenesis and therapy response in pediatric Inflammatory Bowel Disease. She believes in collaboration and team science in asking clinically relevent questions to provide novel immunological techniques (such as single-cell multi-omics and spatial transcriptomics) in patient tissue and blood. She has worked on PREDICT ( and the Healthy Endoscopy Study ( She is also interested in understanding genetic alterations in the Very Early Onset IBD (VEO-IBD) cohorts. 

  • Patient Testimonials

    • Tiffany Anacortes, WA 08.25.21

      Dr. Zheng is wonderful! She is full of information on the microbiome and living a healthy gut lifestyle. Thank you for helping my daughter Andee recover.

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    IBD Horizons Plenary Abstract Award IBD Horizons 2023
    NASPGHAN Grand Watkins Award NASPGHAN 2021
  • Publications

    Other Publications

    • Kaenkumchorn TK, Mark D, Niedner K, Paratore PD, Carlin K, Merkouris R, Musburger B, Suskind DL, Zheng HB
      Association between iron deficit repletion with ferric carboxymaltose relative to iron sucrose in children with inflammatory bowel disease: a retrospective cohort study.
      37199058 JPEN. Journal of parenteral and enteral nutrition, 2023 May 18
    • Levine AE, Mark D, Smith L, Zheng HB, Suskind DL
      Pharmacologic Management of Monogenic and Very Early Onset Inflammatory Bowel Diseases.
      36986830 Pharmaceutics, 2023 Mar 17 : 15(3) PMCID:PMC10059893
    • Frolova Gregory P, Angus J, Brothers AW, Gray AN, Skeen K, Gooley T, Davis C, Kim HHR, Weissman SJ, Zheng HB, Mallhi K, Baker KS
      Risk Factors for Development of Pneumatosis Intestinalis after Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Case-Control Study.
      36038104 Transplantation and cellular therapy, 2022 Nov. : 28(11)785.e1-785.e7
    • Duong JT, Geddis A, Carlberg K, Rudzinski E, Len M, Zheng HB
      Sirolimus for management of GI bleeding in blue rubber bleb nevus syndrome: A case series.
      36094280 Pediatric blood & cancer, 2022 Nov. : 69(11)e29970
    • Levine AE, Zheng HB, Suskind DL
      Linking Genetic Diagnosis to Therapeutic Approach in Very Early Onset Inflammatory Bowel Disease: Pharmacologic Considerations.
      35467244 Paediatric drugs, 2022 May : 24(3)207-216
    • Zheng HB, Doran BA, Kimler K, Yu A, Tkachev V, Niederlova V, Cribbing K, Flemin R, Bratrude B, Betz K, Cagnin L, McGucking C, Keskula P, Albanese A, Sacta M, de Sousa Casal J, Taliaferro F, Ford M, Ambartsumyan L, Suskind DL, Lee D, Deutsch G, Deng X, Collen LV, Mitsiali V, Snapper SB, Wahbeh G, Shalek AK, Ordovase-Montantes J, Kean LS.
      A Treatment-Naïve Cellular Atlas of Pediatric Crohn’s Disease Predicts Disease Severity and Therapeutic Response
    • Zheng HB, Len M, Pattamanuch N.
      Effective use of topical sucralfate in the conservative management of expanded gastrostomy tract reduction.
      JPGN Reports , 2021
    • Zheng HB, Teresa de la Morena M, Suskind DL.
      The Growing Need to Understand Very Early Onset Inflammatory Bowel Disease (VEO-IBD).
      2021 : PMCID:34122435
    • Tkachev V, Kaminiski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan J, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS.
      Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.
      Sci Transl Med., 2021 : PMCID:33441422.
    • Tkachev V, Kaminski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan JT, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS
      Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8(+) T cells drive gastrointestinal acute graft-versus-host disease.
      33441422 Science translational medicine, 2021 Jan 13 : 13(576) PMCID:PMC9469805
    • Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth II MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovi M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi JLF, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J, HCA Lung Biological Network.
      SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelia cells and is detected in specific cell subsets across tissue. Cell.
      2020 : PMCID:32413319.
    • Zheng HB, Yeung C, Summers C, Lee D, Wahbeh G, Braly K, Suskind D
      Dietary Therapy in Conjunction with Immunosuppression to Treat Gastrointestinal Graft-Versus-Host Disease (GVHD).
      30676523 Journal of pediatric gastroenterology and nutrition, 2019 Jan 21
    • Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS
      Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
      30361514 Nature communications, 2018 Oct 25 : 9(1)4438 PMCID:PMC6202377
    • Ambartsumyan L, Zheng HB, Iyer RS, Soares J, Henstorf G, Stevens AM
      Relationship between esophageal abnormalities on fluoroscopic esophagram and pulmonary function testing in juvenile systemic sclerosis.
      30295423 Arthritis care & research, 2018 Oct 8
    • Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS
      CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.
      30102255 The Journal of clinical investigation, 2018 Aug 31 : 128(9)3991-4007 PMCID:PMC6118599
    • Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell SR, Gardner R, Kean LS, Jensen MC
      Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.
      29563103 Cancer discovery, 2018 June : 8(6)750-763 PMCID:PMC6058704
    • Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS
      Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
      28931653 Science translational medicine, 2017 Sep 20 : 9(408) PMCID:PMC5681253
    • Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS
      The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
      27500470 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017 March : 17(3)657-670 PMCID:PMC5338742
  • Presentations

    Presentation Title Event Location Date
    Single-cell intestinal changes in pediatric Crohn’s disease before and after anti-TNF blockade. Digestive Disorders Week Chicago, IL 2023
    Single Cell-omics and Beyond North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Annual International Meeting Orlando, FL 2022
    A Treatment-Naïve Cellular Atlas of Pediatric Crohn’s Disease Predicts Disease Severity and Therapeutic Response North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Annual International Meeting Nashville, TN 2021
    Single-Cell Analysis of T cell pathogenesis in Pediatric Crohn’s Disease Digestive Disorders Week annual national meeting San Diego, CA 2019


Board Certification(s)

Pediatric Gastroenterology

Medical/Professional School

University of Maryland School of Medicine, Baltimore, MD


University of Maryland School of Medicine, Baltimore, MD


University of Washington, Seattle, WA