Amy Elizabeth Geddis, MD

Amy Elizabeth Geddis, MD

Cancer and Blood Disorders Center, Bone Marrow Failure Program, Non-Malignant Transplant Program, Vascular Anomalies, Apheresis

On staff since December 2015

"I love how we can use scientific advances in hematology to improve our diagnosis and management of children with blood disorders. "

  • Biography

    I graduated from medical school at Jefferson Medical College, where I also obtained a PhD in Biochemistry at Thomas Jefferson University.  I then completed my pediatric residency training at Children’s Hospital in Pittsburgh.  My training then took me to the west coast where I started my pediatric hematology oncology fellowship at Fred Hutchinson Cancer Research Center and Seattle Children’s Hospital (then known as Children’s Hospital and Regional Medical Center).  During my fellowship, I worked with Dr. Kenneth Kaushansky at the University of Washington studying megakaryocyte and platelet development.  I continued this work in Dr. Kaushansky’s laboratory at University of California San Diego, where I was on the pediatric faculty for approximately 13 years.  In 2015, I returned to Seattle Children’s Hospital where I assumed directorship of the bone marrow failure program.  I directed the pediatric hematology oncology fellowship program for 3 years until 2021, at which time I became director of clinical hematology.

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  • Publications

    Other Publications

    • Mallhi KK, Srikanthan MA, Baker KK, Frangoul HA, Torgerson TR, Petrovic A, Geddis AE, Carpenter PA, Baker KS, Sandmaier BM, Thakar MS, Skoda-Smith S, Kiem HP, Storb R, Woolfrey AE, Burroughs LM
      HLA-Haploidentical Hematopoietic Cell Transplantation for Treatment of Nonmalignant Diseases Using Nonmyeloablative Conditioning and Post-Transplant Cyclophosphamide.
      32234377 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2020 July : 26(7)1332-1341 PMCID:PMC7306430
    • Furutani E, Shah AS, Zhao Y, Andorsky D, Dedeoglu F, Geddis A, Zhou Y, Libermann TA, Myers KC, Shimamura A
      Inflammatory manifestations in patients with Shwachman-Diamond syndrome: A novel phenotype.
      32293785 American journal of medical genetics. Part A, 2020 July : 182(7)1754-1760
    • Verboon JM, Mahmut D, Kim AR, Nakamura M, Abdulhay NJ, Nandakumar SK, Gupta N, Akie TE, Geddis AE, Manes B, Kapp ME, Hofmann I, Gabriel SB, Klein DE, Williams DA, Frangoul HA, Parkhurst SM, Crane GM, Cantor AB, Sankaran VG
      Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
      32303876 Journal of clinical immunology, 2020 May : 40(4)554-566 PMCID:PMC7253386
    • Rogers ZR, Nakano TA, Olson TS, Bertuch AA, Wang W, Gillio A, Coates TD, Chawla A, Castillo P, Kurre P, Gamper C, Bennett CM, Joshi S, Geddis AE, Boklan J, Nalepa G, Rothman JA, Huang JN, Kupfer GM, Cada M, Glader B, Walkovich KJ, Thompson AA, Hanna R, Vlachos A, Malsch M, Weller EA, Williams DA, Shimamura A
      Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study.
      30948484 Haematologica, 2019 Oct. : 104(10)1974-1983 PMCID:PMC6886407
    • Grace RF, Shimano KA, Bhat R, Neunert C, Bussel JB, Klaassen RJ, Lambert MP, Rothman JA, Breakey VR, Hege K, Bennett CM, Rose MJ, Haley KM, Buchanan GR, Geddis A, Lorenzana A, Jeng M, Pastore YD, Crary SE, Neier M, Neufeld EJ, Neu N, Forbes PW, Despotovic JM
      Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes.
      30945320 American journal of hematology, 2019 July : 94(7)741-750 PMCID:PMC6527349
    • Chisholm KM, Denton C, Keel S, Geddis AE, Xu M, Appel BE, Cantor AB, Fleming MD, Shimamura A
      Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy.
      30600763 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 2019 July : 22(4)315-328
    • Grace RF, Despotovic JM, Bennett CM, Bussel JB, Neier M, Neunert C, Crary SE, Pastore YD, Klaassen RJ, Rothman JA, Hege K, Breakey VR, Rose MJ, Shimano KA, Buchanan GR, Geddis A, Haley KM, Lorenzana A, Thompson A, Jeng M, Neufeld EJ, Brown T, Forbes PW, Lambert MP
      Physician decision making in selection of second-line treatments in immune thrombocytopenia in children.
      29659042 American journal of hematology, 2018 July : 93(7)882-888 PMCID:PMC6037544
    • Padia R, Bly R, Bull C, Geddis AE, Perkins J
      Medical Management of Vascular Anomalies.
      30505648 Current treatment options in pediatrics, 2018 June : 4(2)221-236 PMCID:PMC6261360
    • Chisholm KM, Xu M, Davis B, Ogi A, Pacheco MC, Geddis AE, Tsuchiya KD, Rutledge JC
      Evaluation of the Utility of Bone Marrow Morphology and Ancillary Studies in Pediatric Patients Under Surveillance for Myelodysplastic Syndrome.
      29659673 American journal of clinical pathology, 2018 April 25 : 149(6)499-513
    • Noris P, Favier R, Alessi MC, Geddis AE, Kunishima S, Heller PG, Giordano P, Niederhoffer KY, Bussel JB, Podda GM, Vianelli N, Kersseboom R, Pecci A, Gnan C, Marconi C, Auvrignon A, Cohen W, Yu JC, Iguchi A, Miller Imahiyerobo A, Boehlen F, Ghalloussi D, De Rocco D, Magini P, Civaschi E, Biino G, Seri M, Savoia A, Balduini CL
      ANKRD26-related thrombocytopenia and myeloid malignancies.
      24030261 Blood, 2013 Sept. 12 : 122(11)1987-9
    • Amy E. Geddis
      Megakaryocytes
      Wintrobe's Clinical Hematology, 13th edition, 2013 : 371-388
    • Geddis AE
      A POTEntial new gene for thrombocytopenia.
      21680804 Blood, 2011 June 16 : 117(24)6406-8
    • Geddis AE
      Shedding light on endomitosis.
      20884810 Blood, 2010 Sept. 30 : 116(13)2202-3
    • Diz-Kucukkaya R, Chen J, Geddis AE, and Lopez J
      Thrombocytopenia
      Williams Hematology, 8th edition, 2010
    • Geddis AE
      Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii.
      19327586 Hematology/oncology clinics of North America, 2009 April : 23(2)321-31 PMCID:PMC2757092
    • Geddis AE, Fox NE, Tkachenko E, Kaushansky K
      Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression.
      17312391 Cell cycle (Georgetown, Tex.), 2007 Feb. 15 : 6(4)455-60
    • Geddis AE, Kaushansky K
      Megakaryocytes express functional Aurora-B kinase in endomitosis.
      15130946 Blood, 2004 Aug. 15 : 104(4)1017-24

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Overview

Board Certification(s)

Pediatric Hematology-Oncology

Medical/Professional School

Jefferson Medical College of Thomas Jefferson University, Philadelphia
Thomas Jefferson University, Philadelphia

Residency

Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh

Fellowship

Pediatric Hematology Oncology, Seattle Children's Hospital, Seattle

Clinical Interests

Bone marrow failure, general hematology, vascular malformations