Alan Aderem, PhD

  • Biography

    Alan Aderem, PhD, is a biologist, specializing in immunology and cell biology, with emphasis on the innate immune system, generally regarded as the body’s first line of defense to any pathogen. Aderem co-founded the Institute for Systems Biology (ISB) with Leroy Hood and Ruedi Aebersold in 2000 and served as its director until 2011.

    A native of South Africa, Aderem obtained his PhD at the University of Cape Town and completed a postdoctoral fellowship at the Rockefeller University in New York in the laboratory of Dr. Zanvil Cohn. He rose through the ranks at the Rockefeller University, becoming head of the Laboratory of Signal Transduction in 1991. In 1996, he accepted a professorship of immunology and medicine at the University of Washington in Seattle. 

  • Patient Testimonials

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Doctor of Science, honoris causa University of KwaZulu-Natal, South Africa 2015
    Elected Fellow American Association for the Advancement of Science 2014
    Scholar Award - Molecular Parasitology Burroughs Wellcome 2000 - 2004
    Richard Blandau Teaching Award University of Washington 1998
    MERIT Award National Institute of Allergy and Infectious Diseases 1995 - 2005
    Paul Ehrlich Chair The Rockefeller University 1991 - 1996
    Established Investigator American Heart Association 1990 - 1995
    Bristol-Myers Squibb Fellow The Rockefeller University 1983 - 1985
  • Publications

    Manuscripts in Refereed Journals

    • Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST.
      Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
      31534238 Nature immunology, 2019 Oct. : 20(10)1299-1310.
    • Rothchild AC, Olson GS, Nemeth J, Amon LM, Mai D, Gold ES, Diercks AH, Aderem A.
      Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo.
      31350281 Science immunology, 2019 Jul 26 : 4(37)
    • Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A.
      CD8+ T cells induce cachexia during chronic viral infection.
      31110314 Nature immunology, 2019 June : 20(6)701-710. PMCID:PMC6531346
    • Kain HS, Glennon EKK, Vijayan K, Arang N, Douglass AN, Fortin CL, Zuck M, Lewis AJ, Whiteside SL, Dudgeon DR, Johnson JS, Aderem A, Stevens KR, Kaushansky A
      Liver stage malaria infection is controlled by host regulators of lipid peroxidation.
      31065106 Cell death and differentiation, 2019 May 7
    • Peterson EJ, Bailo R, Rothchild AC, Arrieta-Ortiz ML, Kaur A, Pan M, Mai D, Abidi AA, Cooper C, Aderem A, Bhatt A, Baliga NS
      Path-seq identifies an essential mycolate remodeling program for mycobacterial host adaptation.
      30833303 Molecular systems biology, 2019 Mar 4 : 15(3)e8584. PMCID:PMC6398593
    • Suliman S, Thompson E, Sutherland J, Weiner Rd J, Ota MOC, Shankar S, Penn-Nicholson A, Thiel B, Erasmus M, Maertzdorf J, Duffy FJ, Hill PC, Hughes EJ, Stanley K, Downing K, Fisher ML, Valvo J, Parida SK, van der Spuy G, Tromp G, Adetifa IMO, Donkor S, Howe R, Mayanja-Kizza H, Boom WH, Dockrell H, Ottenhoff THM, Hatherill M, Aderem A, Hanekom WA, Scriba TJ, Kaufmann SH, Zak DE, Walzl G, GC6-74 and ACS cohort study groups.
      Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis.
      29624071 American journal of respiratory and critical care medicine, 2018 Apr 6 : PMCID:PMC6019933
    • Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner JA, Aderem A, Flynn JL, Lin PL, Zak DE
      Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures.
      29325117 The Journal of infectious diseases, 2018 Mar 28 : 217(8)1318-1322. PMCID:PMC6018950
    • Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A.
      Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.
      29544097 Cell host & microbe, 2018 Mar 14 : 23(3)366-381.e9 PMCID:PMC6176724
    • Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Valvo J, Braun JM, Shankar S, Lu L, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Axthelm MK, Früh K, Edlefsen PT, Picker LJ.
      Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.
      29334373 Nature medicine, 2018 Feb. : 24(2)130-143. PMCID:PMC5909823
    • Thompson EG, Du Y, Malherbe ST, Shankar S, Braun J, Valvo J, Ronacher K, Tromp G, Tabb DL, Alland D, Shenai S, Via LE, Warwick J, Aderem A, Scriba TJ, Winter J, Walzl G, Zak DE, Catalysis TB-Biomarker Consortium.
      Host blood RNA signatures predict the outcome of tuberculosis treatment.
      29050771 Tuberculosis (Edinburgh, Scotland), 2017 Dec. : 10748-58. PMCID:PMC5658513
    • Francica JR, Zak DE, Linde C, Siena E, Johnson C, Juraska M, Yates NL, Gunn B, De Gregorio E, Flynn BJ, Valiante NM, Malyala P, Barnett SW, Sarkar P, Singh M, Jain S, Ackerman M, Alam M, Ferrari G, Salazar A, Tomaras GD, O'Hagan DT, Aderem A, Alter G, Seder RA.
      Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs.
      Blood Adv., 2017 Nov 17 : 1(25)2329-2342. PMCID:PMC5729628
    • Scriba TJ, Penn-Nicholson A, Shankar S, Hraha T, Thompson EG, Sterling D, Nemes E, Darboe F, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Johnson JL, Boom WH, Hatherill M, Valvo J, De Groote MA, Ochsner UA, Aderem A, Hanekom WA, Zak DE, other members of the ACS cohort study team.
      Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.
      29145483 PLoS pathogens, 2017 Nov. : 13(11)e1006687. PMCID:PMC5689825
    • Heit A, Schmitz F, Gerdts S, Flach B, Moore MS, Perkins JA, Robins HS, Aderem A, Spearman P, Tomaras GD, De Rosa SC, McElrath MJ
      Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.
      28637884 The Journal of experimental medicine, 2017 Jul 3 : 214(7)2139-2152. PMCID:PMC5502430
    • Rosenberger CM, Podyminogin RL, Diercks AH, Treuting PM, Peschon JJ, Rodriguez D, Gundapuneni M, Weiss MJ, Aderem A.
      miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.
      28380049 PLoS pathogens, 2017 April : 13(4)e1006305. PMCID:PMC5393898
    • Kazmin D, Nakaya HI, Lee EK, Johnson MJ, van der Most R, van den Berg RA, Ballou WR, Jongert E, Wille-Reece U, Ockenhouse C, Aderem A, Zak DE, Sadoff J, Hendriks J, Wrammert J, Ahmed R, Pulendran B
      Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.
      28193898 Proceedings of the National Academy of Sciences of the United States of America, 2017 Feb 28 : 114(9)2425-2430. PMCID:PMC5338562
    • Askovich PS, Ramsey SA, Diercks AH, Kennedy KA, Knijnenburg TA, Aderem A.
      Identifying novel transcription factors involved in the inflammatory response by using binding site motif scanning in genomic regions defined by histone acetylation.
      28922390 PloS one, 2017 : 12(9)e0184850. PMCID:PMC5602638
    • Rothchild AC, Sissons JR, Shafiani S, Plaisier C, Min D, Mai D, Gilchrist M, Peschon J, Larson RP, Bergthaler A, Baliga NS, Urdahl KB, Aderem A.
      MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis.
      27681624 Proceedings of the National Academy of Sciences of the United States of America, 2016 Oct 11 : 113(41)E6172-E6181. PMCID:PMC5068277
    • Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff THM, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SHE, Walzl G, Aderem A, Hanekom WA, ACS and GC6-74 cohort study groups.
      A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
      27017310 Lancet (London, England), 2016 Jun 4 : 387(10035)2312-2322. PMCID:PMC5392204
    • Hoft DF, Blazevic A, Selimovic A, Turan A, Tennant J, Abate G, Fulkerson J, Zak DE, Walker R, McClain B, Sadoff J, Scott J, Shepherd B, Ishmukhamedov J, Hokey DA, Dheenadhayalan V, Shankar S, Amon L, Navarro G, Podyminogin R, Aderem A, Barker L, Brennan M, Wallis RS, Gershon AA, Gershon MD, Steinberg S.
      Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial.
      27322481 EBioMedicine, 2016 May : 7278-86. PMCID:PMC4909487
    • Nakaya HI, Clutterbuck E, Kazmin D, Wang L, Cortese M, Bosinger SE, Patel NB, Zak DE, Aderem A, Dong T, Del Giudice G, Rappuoli R, Cerundolo V, Pollard AJ, Pulendran B, Siegrist CA.
      Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
      26755593 Proceedings of the National Academy of Sciences of the United States of America, 2016 Feb 16 : 113(7)1853-8. PMCID:PMC4763735
    • Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A.
      Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
      26588782 Immunity, 2015 Nov 17 : 43(5)974-86. PMCID:PMC4658338
    • Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA.
      Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
      26320999 Cell host & microbe, 2015 Sep 9 : 18(3)320-32. PMCID:PMC4567510
    • Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.
      Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
      26153856 Nature, 2015 Sep 3 : 525(7567)144.
    • Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM.
      Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
      26282876 The Journal of experimental medicine, 2015 Aug 24 : 212(9)1449-63. PMCID:PMC4548054
    • Gillespie MA, Gold ES, Ramsey SA, Podolsky I, Aderem A, Ranish JA.
      An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.
      25755249 The EMBO journal, 2015 May 5 : 34(9)1244-58. PMCID:PMC4426483
    • Cronk JC, Derecki NC, Ji E, Xu Y, Lampano AE, Smirnov I, Baker W, Norris GT, Marin I, Coddington N, Wolf Y, Turner SD, Aderem A, Klibanov AL, Harris TH, Jung S, Litvak V, Kipnis J.
      Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.
      25902482 Immunity, 2015 Apr 21 : 42(4)679-91. PMCID:PMC4407145
    • Quinn KM, Zak DE, Costa A, Yamamoto A, Kastenmuller K, Hill BJ, Lynn GM, Darrah PA, Lindsay RW, Wang L, Cheng C, Nicosia A, Folgori A, Colloca S, Cortese R, Gostick E, Price DA, Gall JG, Roederer M, Aderem A, Seder RA.
      Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling.
      25642773 The Journal of clinical investigation, 2015 Mar 2 : 125(3)1129-46. PMCID:PMC4362254
    • Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminanthan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A.
      The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
      25419628 Nature immunology, 2015 Jan. : 16(1)67-74. PMCID:PMC4320687
    • Ramsey SA, Vengrenyuk Y, Menon P, Podolsky I, Feig JE, Aderem A, Fisher EA, Gold ES.
      Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.
      25474352 PLoS genetics, 2014 Dec. : 10(12)e1004828. PMCID:PMC4256277
    • Gold ES, Diercks AH, Podolsky I, Podyminogin RL, Askovich PS, Treuting PM, Aderem A.
      25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
      24994901 Proceedings of the National Academy of Sciences of the United States of America, 2014 Jul 22 : 111(29)10666-71. PMCID:PMC4115544
    • Knijnenburg TA, Ramsey SA, Berman BP, Kennedy KA, Smit AF, Wessels LF, Laird PW, Aderem A, Shmulevich I.
      Multiscale representation of genomic signals.
      24727652 Nature methods, 2014 June : 11(6)689-94. PMCID:PMC4040162
    • Yang Y, Kulka K, Montelaro RC, Reinhart TA, Sissons J, Aderem A, Ojha AK.
      A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis.
      24528862 Cell host & microbe, 2014 Feb 12 : 15(2)153-63. PMCID:PMC3974621
    • Rosenberger CM, Podyminogin RL, Askovich PS, Navarro G, Kaiser SM, Sanders CJ, McClaren JL, Tam VC, Dash P, Noonan JG, Jones BG, Surman SL, Peschon JJ, Diercks AH, Hurwitz JL, Doherty PC, Thomas PG, Aderem A.
      Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model.
      24243730 The Journal of general virology, 2014 Feb. : 95(Pt 2)350-62. PMCID:PMC3917066
    • Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.
      Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
      24284630 Nature, 2014 Jan 30 : 505(7485)691-5. PMCID:PMC4077721
    • Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A 3rd, Bolles M, Carter V, Chang J, Clauss TR, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josset L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, Tilton SC, Totura A, Wang J, Webb-Robertson BJ, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, Kawaoka Y, Baric R, Aderem A, Katze MG, Scheuermann RH.
      A comprehensive collection of systems biology data characterizing the host response to viral infection.
      25977790 Scientific data, 2014 : 1140033. PMCID:PMC4410982
    • Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A.
      Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation.
      23827684 Cell, 2013 Jul 3 : 154(1)213-27. PMCID:PMC3753192
    • Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA.
      Caspase-11 protects against bacteria that escape the vacuole.
      23348507 Science (New York, N.Y.), 2013 Feb 22 : 339(6122)975-8. PMCID:PMC3697099
    • Askovich PS, Sanders CJ, Rosenberger CM, Diercks AH, Dash P, Navarro G, Vogel P, Doherty PC, Thomas PG, Aderem A.
      Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses.
      24073225 PloS one, 2013 : 8(9)e74863. PMCID:PMC3779241
    • Rosenberger CM, Podyminogin RL, Navarro G, Zhao GW, Askovich PS, Weiss MJ, Aderem A.
      miR-451 regulates dendritic cell cytokine responses to influenza infection.
      23169590 Journal of immunology (Baltimore, Md. : 1950), 2012 Dec 15 : 189(12)5965-75. PMCID:PMC3528339
    • Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
      Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.
      23152562 Journal of immunology (Baltimore, Md. : 1950), 2012 Dec 15 : 189(12)5903-11.
    • Zak DE, Andersen-Nissen E, Peterson ER, Sato A, Hamilton MK, Borgerding J, Krishnamurty AT, Chang JT, Adams DJ, Hensley TR, Salter AI, Morgan CA, Duerr AC, De Rosa SC, Aderem A, McElrath MJ.
      Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity.
      23151505 Proceedings of the National Academy of Sciences of the United States of America, 2012 Dec 11 : 109(50)E3503-12. PMCID:PMC3528489
    • Litvak V, Ratushny AV, Lampano AE, Schmitz F, Huang AC, Raman A, Rust AG, Bergthaler A, Aitchison JD, Aderem A.
      A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.
      22982991 Nature, 2012 Oct 18 : 490(7420)421-5. PMCID:PMC3556990
    • Sissons JR, Peschon JJ, Schmitz F, Suen R, Gilchrist M, Aderem A.
      Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells.
      22661094 Journal of immunology (Baltimore, Md. : 1950), 2012 Jul 1 : 189(1)23-7. PMCID:PMC3381877
    • Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T.
      Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.
      22610141 Nature immunology, 2012 May 20 : 13(7)659-66.
    • Gold ES, Ramsey SA, Sartain MJ, Selinummi J, Podolsky I, Rodriguez DJ, Moritz RL, Aderem A.
      ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation.
      22473958 The Journal of experimental medicine, 2012 Apr 9 : 209(4)807-17. PMCID:PMC3328364
    • Zak DE, Schmitz F, Gold ES, Diercks AH, Peschon JJ, Valvo JS, Niemistö A, Podolsky I, Fallen SG, Suen R, Stolyar T, Johnson CD, Kennedy KA, Hamilton MK, Siggs OM, Beutler B, Aderem A.
      Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.
      21709223 Proceedings of the National Academy of Sciences of the United States of America, 2011 Jul 12 : 108(28)11536-41. PMCID:PMC3136315
    • Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B.
      Systems biology of vaccination for seasonal influenza in humans.
      21743478 Nature immunology, 2011 Jul 10 : 12(8)786-95. PMCID:PMC3140559
    • Warren SE, Duong H, Mao DP, Armstrong A, Rajan J, Miao EA, Aderem A.
      Generation of a Listeria vaccine strain by enhanced caspase-1 activation.
      21538346 European journal of immunology, 2011 July : 41(7)1934-40. PMCID:PMC3375905
    • Cortez M, Huynh C, Fernandes MC, Kennedy KA, Aderem A, Andrews NW.
      Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200.
      21669395 Cell host & microbe, 2011 Jun 16 : 9(6)463-71. PMCID:PMC3118640
    • Rappuoli R, Aderem A.
      A 2020 vision for vaccines against HIV, tuberculosis and malaria.
      21614073 Nature, 2011 May 26 : 473(7348)463-9.
    • Rajan JV, Rodriguez D, Miao EA, Aderem A.
      The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.
      21289120 Journal of virology, 2011 May : 85(9)4167-72. PMCID:PMC3126243
    • Aderem A, Adkins JN, Ansong C, Galagan J, Kaiser S, Korth MJ, Law GL, McDermott JG, Proll SC, Rosenberger C, Schoolnik G, Katze MG.
      A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm.
      21285433 mBio, 2011 Mar 1 : 2(1)e00325-10. PMCID:PMC3034460
    • Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A.
      Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
      21057511 Nature immunology, 2010 Dec. : 11(12)1136-42. PMCID:PMC3058225
    • Rajan JV, Warren SE, Miao EA, Aderem A.
      Activation of the NLRP3 inflammasome by intracellular poly I:C.
      20971108 FEBS letters, 2010 Nov 19 : 584(22)4627-32. PMCID:PMC3005299
    • Yin X, Wolford CC, Chang YS, McConoughey SJ, Ramsey SA, Aderem A, Hai T.
      ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells.
      20930144 Journal of cell science, 2010 Oct 15 : 123(Pt 20)3558-65. PMCID:PMC2951469
    • Mirzaei H, Rogers RS, Grimes B, Eng J, Aderem A, Aebersold R.
      Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry.
      20694217 Molecular bioSystems, 2010 Oct. : 6(10)2004-14. PMCID:PMC3057100
    • Ramsey SA, Knijnenburg TA, Kennedy KA, Zak DE, Gilchrist M, Gold ES, Johnson CD, Lampano AE, Litvak V, Navarro G, Stolyar T, Aderem A, Shmulevich I.
      Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites.
      20663846 Bioinformatics (Oxford, England), 2010 Sep 1 : 26(17)2071-5. PMCID:PMC2922897
    • Warren SE, Armstrong A, Hamilton MK, Mao DP, Leaf IA, Miao EA, Aderem A.
      Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.
      20562263 Journal of immunology (Baltimore, Md. : 1950), 2010 Jul 15 : 185(2)818-21. PMCID:PMC2993756
    • Gilchrist M, Henderson WR Jr, Morotti A, Johnson CD, Nachman A, Schmitz F, Smith KD, Aderem A.
      A key role for ATF3 in regulating mast cell survival and mediator release.
      20203264 Blood, 2010 Jun 10 : 115(23)4734-41. PMCID:PMC2890168
    • Miao EA, Mao DP, Yudkovsky N, Bonneau R, Lorang CG, Warren SE, Leaf IA, Aderem A.
      Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.
      20133635 Proceedings of the National Academy of Sciences of the United States of America, 2010 Feb 16 : 107(7)3076-80. PMCID:PMC2840275
    • Shimada T, Park BG, Wolf AJ, Brikos C, Goodridge HS, Becker CA, Reyes CN, Miao EA, Aderem A, Götz F, Liu GY, Underhill DM.
      Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.
      20114027 Cell host & microbe, 2010 Jan 21 : 7(1)38-49. PMCID:PMC2818986
    • Hertz AL, Bender AT, Smith KC, Gilchrist M, Amieux PS, Aderem A, Beavo JA.
      Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.
      19959669 Proceedings of the National Academy of Sciences of the United States of America, 2009 Dec 22 : 106(51)21978-83. PMCID:PMC2799834
    • Hawn TR, Scholes D, Wang H, Li SS, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM.
      Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
      20016852 PloS one, 2009 Dec 15 : 4(12)e8300. PMCID:PMC2788705
    • Zak DE, Aderem A.
      A systems view of host defense.
      19898453 Nature biotechnology, 2009 Nov. : 27(11)999-1001. PMCID:PMC3076594
    • Selinummi J, Ruusuvuori P, Podolsky I, Ozinsky A, Gold E, Yli-Harja O, Aderem A, Shmulevich I.
      Bright field microscopy as an alternative to whole cell fluorescence in automated analysis of macrophage images.
      19847301 PloS one, 2009 Oct 22 : 4(10)e7497. PMCID:PMC2760782
    • Bochud PY, Sinsimer D, Aderem A, Siddiqui MR, Saunderson P, Britton S, Abraham I, Tadesse Argaw A, Janer M, Hawn TR, Kaplan G.
      Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy.
      Eur J Clin Microbiol Infect Dis., 2009 Sept. : 28(9)1055-65. PMCID:PMC3016895
    • Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM.
      Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
      19576795 Immunity, 2009 Jul 17 : 31(1)110-21. PMCID:PMC2759279
    • Hawn TR, Scholes D, Li SS, Wang H, Yang Y, Roberts PL, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM.
      Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
      19543401 PloS one, 2009 Jun 22 : 4(6)e5990. PMCID:PMC2696082
    • Litvak V, Ramsey SA, Rust AG, Zak DE, Kennedy KA, Lampano AE, Nykter M, Shmulevich I, Aderem A.
      Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals.
      19270711 Nature immunology, 2009 April : 10(4)437-43. PMCID:PMC2780024
    • Diercks AH, Ozinsky A, Hansen CL, Spotts JM, Rodriguez DJ, Aderem A.
      A microfluidic device for multiplexed protein detection in nano-liter volumes.
      19133224 Analytical biochemistry, 2009 Mar 1 : 386(1)30-5. PMCID:PMC2678059
    • Hemmi H, Idoyaga J, Suda K, Suda N, Kennedy K, Noda M, Aderem A, Steinman RM.
      A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.
      19155473 Journal of immunology (Baltimore, Md. : 1950), 2009 Feb 1 : 182(3)1278-86. PMCID:PMC2843158
    • Querec TD, Akondy RS, Lee EK, Cao W, Nakaya HI, Teuwen D, Pirani A, Gernert K, Deng J, Marzolf B, Kennedy K, Wu H, Bennouna S, Oluoch H, Miller J, Vencio RZ, Mulligan M, Aderem A, Ahmed R, Pulendran B.
      Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
      19029902 Nature immunology, 2009 Jan. : 10(1)116-125. PMCID:PMC4049462
    • Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, Gersuk VH, Aderem A, Hawn TR, Nepom GT.
      The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.
      19357791 PloS one, 2009 : 4(4)e5063. PMCID:PMC2666970
    • Wu Z, Jia X, de la Cruz L, Su XC, Marzolf B, Troisch P, Zak D, Hamilton A, Whittle B, Yu D, Sheahan D, Bertram E, Aderem A, Otting G, Goodnow CC, Hoyne GF.
      Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.
      19100700 Immunity, 2008 Dec 19 : 29(6)863-75. PMCID:PMC3057111
    • Lee WW, Cui D, Czesnikiewicz-Guzik M, Vencio RZ, Shmulevich I, Aderem A, Weyand CM, Goronzy JJ.
      Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling.
      19072254 Rejuvenation research, 2008 Dec. : 11(6)1001-11. PMCID:PMC2848531
    • Thuong NT, Dunstan SJ, Chau TT, Thorsson V, Simmons CP, Quyen NT, Thwaites GE, Thi Ngoc Lan N, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR.
      Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.
      19057661 PLoS pathogens, 2008 Dec. : 4(12)e1000229. PMCID:PMC2585058
    • Bochud PY, Chien JW, Marr KA, Leisenring WM, Upton A, Janer M, Rodrigues SD, Li S, Hansen JA, Zhao LP, Aderem A, Boeckh M.
      Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation.
      18946062 The New England journal of medicine, 2008 Oct 23 : 359(17)1766-77. PMCID:PMC2656610
    • Leng X, Lin H, Ding T, Wang Y, Wu Y, Klumpp S, Sun T, Zhou Y, Monaco P, Belmont J, Aderem A, Akira S, Strong R, Arlinghaus R.
      Lipocalin 2 is required for BCR-ABL-induced tumorigenesis.
      Oncogene., 2008 Oct 16 : 27(47)6110-9. PMCID:PMC2756829
    • Aderem A, Shmulevich I.
      Taming data.
      18854235 Cell host & microbe, 2008 Oct 16 : 4(4)312-3 PMCID:PMC3074406
    • Wilson J, Huynh C, Kennedy KA, Ward DM, Kaplan J, Aderem A, Andrews NW.
      Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis.
      18927622 PLoS pathogens, 2008 Oct. : 4(10)e1000179. PMCID:PMC2562527
    • Gilchrist M, Henderson WR Jr, Clark AE, Simmons RM, Ye X, Smith KD, Aderem A.
      Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation.
      18794337 The Journal of experimental medicine, 2008 Sep 29 : 205(10)2349-57. PMCID:PMC2556774
    • Warren SE, Mao DP, Rodriguez AE, Miao EA, Aderem A.
      Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.
      18490757 Journal of immunology (Baltimore, Md. : 1950), 2008 Jun 1 : 180(11)7558-64. PMCID:PMC2991040
    • Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD.
      The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
      18391000 Infection and immunity, 2008 June : 76(6)2439-47. PMCID:PMC2423085
    • Shattock RJ, Haynes BF, Pulendran B, Flores J, Esparza J, Working Group convened by the Global HIV Vaccine Enterprise.
      Improving defences at the portal of HIV entry: mucosal and innate immunity.
      18384232 PLoS medicine, 2008 Apr 1 : 5(4)e81. PMCID:PMC2276525
    • Ramsey SA, Klemm SL, Zak DE, Kennedy KA, Thorsson V, Li B, Gilchrist M, Gold ES, Johnson CD, Litvak V, Navarro G, Roach JC, Rosenberger CM, Rust AG, Yudkovsky N, Aderem A, Shmulevich I.
      Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.
      18369420 PLoS computational biology, 2008 Mar 21 : 4(3)e1000021. PMCID:PMC2265556
    • Rosenberger CM, Clark AE, Treuting PM, Johnson CD, Aderem A.
      ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells.
      18268321 Proceedings of the National Academy of Sciences of the United States of America, 2008 Feb 19 : 105(7)2544-9. PMCID:PMC2268173
    • Miao EA, Ernst RK, Dors M, Mao DP, Aderem A.
      Pseudomonas aeruginosa activates caspase 1 through Ipaf.
      18256184 Proceedings of the National Academy of Sciences of the United States of America, 2008 Feb 19 : 105(7)2562-7. PMCID:PMC2268176
    • Bochud PY, Hawn TR, Siddiqui MR, Saunderson P, Britton S, Abraham I, Argaw AT, Janer M, Zhao LP, Kaplan G, Aderem A.
      Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.
      18177245 The Journal of infectious diseases, 2008 Jan 15 : 197(2)253-61. PMCID:PMC3077295
    • Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ.
      Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
      17982089 Journal of immunology (Baltimore, Md. : 1950), 2007 Nov 15 : 179(10)6981-7.
    • Roach JC, Smith KD, Strobe KL, Nissen SM, Haudenschild CD, Zhou D, Vasicek TJ, Held GA, Stolovitzky GA, Hood LE, Aderem A.
      Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells.
      17913878 Proceedings of the National Academy of Sciences of the United States of America, 2007 Oct 9 : 104(41)16245-50. PMCID:PMC2042192
    • Miao EA, Andersen-Nissen E, Warren SE, Aderem A.
      TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
      17690885 Seminars in immunopathology, 2007 Sept. : 29(3)275-88.
    • Bochud PY, Magaret AS, Koelle DM, Aderem A, Wald A.
      Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection.
      17624834 The Journal of infectious diseases, 2007 Aug 15 : 196(4)505-9.
    • Hawn TR, Misch EA, Dunstan SJ, Thwaites GE, Lan NT, Quy HT, Chau TT, Rodrigues S, Nachman A, Janer M, Hien TT, Farrar JJ, Aderem A.
      A common human TLR1 polymorphism regulates the innate immune response to lipopeptides.
      17595679 European journal of immunology, 2007 Aug. : 37(8)2280-9.
    • Thuong NT, Hawn TR, Thwaites GE, Chau TT, Lan NT, Quy HT, Hieu NT, Aderem A, Hien TT, Farrar JJ, Dunstan SJ.
      A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis.
      Genes Immun., 2007 July : 8(5)422-8.
    • Andersen-Nissen E, Hawn TR, Smith KD, Nachman A, Lampano AE, Uematsu S, Akira S, Aderem A.
      Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
      17404249 Journal of immunology (Baltimore, Md. : 1950), 2007 Apr 15 : 178(8)4717-20.
    • Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, Takai T, Aderem A.
      Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production.
      17371981 Journal of immunology (Baltimore, Md. : 1950), 2007 Apr 1 : 178(7)4250-9.
    • Andersen-Nissen E, Smith KD, Bonneau R, Strong RK, Aderem A.
      A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.
      17283206 The Journal of experimental medicine, 2007 Feb 19 : 204(2)393-403. PMCID:PMC2118731
    • Bochud PY, Hersberger M, Taffé P, Bochud M, Stein CM, Rodrigues SD, Calandra T, Francioli P, Telenti A, Speck RF, Aderem A; Swiss HIV Cohort Study.
      Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.
      17301562 AIDS (London, England), 2007 Feb 19 : 21(4)441-6.
    • Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD.
      The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.
      17060628 Proceedings of the National Academy of Sciences of the United States of America, 2006 Oct 31 : 103(44)16502-7. PMCID:PMC1637611
    • Hawn TR, Dunstan SJ, Thwaites GE, Simmons CP, Thuong NT, Lan NTN, Quy HT, Chau TTH, Hieu NT, Rodrigues S, Janer M, Zhao LP, Hien TT, Farrar JJ, Aderem A.
      A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis.
      16991088 The Journal of infectious diseases, 2006 Oct 15 : 194(8)1127-1134. PMCID:PMC4333200
    • Hawn TR, Smith KD, Aderem A, Skerrett SJ.
      Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila.
      16703513 The Journal of infectious diseases, 2006 Jun 15 : 193(12)1693-702.
    • Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A.
      Cytoplasmic flagellin activates Caspase 1 and IL-1β secretion through Ipaf.
      16648853 Nature immunology, 2006 June : 7(6)569-75.
    • Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Roach JC, Kennedy K, Hai T, Bolouri H, Aderem A.
      Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
      16688168 Nature, 2006 May 11 : 441(7090)173-8.
    • Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV.
      TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.
      16492804 The Journal of experimental medicine, 2006 Mar 20 : 203(3)553-61. PMCID:PMC2118244
    • Hawn TR, Wu H, Grossman JM, Hahn BH, Tsao BP, Aderem A.
      A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus.
      16027372 Proceedings of the National Academy of Sciences of the United States of America, 2005 Jul 26 : 102(30)10593-7. PMCID:PMC1180760
    • Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood LE, Aderem A.
      The evolution of vertebrate Toll-like receptors.
      15976025 Proceedings of the National Academy of Sciences of the United States of America, 2005 Jul 5 : 102(27)9577-82. PMCID:PMC1172252
    • Hawn TR, Ozinsky A, Williams LM, Rodrigues S, Clark A, Pham U, Hill HR, Ochs H, Aderem A, Liles WC.
      Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes.
      16112032 Human immunology, 2005 July : 66(7)842-7.
    • Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A.
      Evasion of Toll-like receptor 5 by flagellated bacteria.
      15956202 Proceedings of the National Academy of Sciences of the United States of America, 2005 Jun 28 : 102(26)9247-52. PMCID:PMC1166605
    • Dunstan SJ, Hawn TR, Hue NT, Parry CP, Ho VA, Vinh H, Diep TS, House D, Wain J, Aderem A, Hien TT, Farrar JJ.
      Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam.
      15747241 The Journal of infectious diseases, 2005 Apr 1 : 191(7)1068-71
    • Bergman MA, Cummings LA, Barrett SL, Smith KD, Lara JC, Aderem A, Cookson BT.
      CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles.
      15731032 Infection and immunity, 2005 March : 73(3)1350-6. PMCID:PMC1064935
    • Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, Aderem A.
      Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.
      15699327 Proceedings of the National Academy of Sciences of the United States of America, 2005 Feb 15 : 102(7)2487-9. PMCID:PMC549026
    • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R.
      Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
      15642101 Genome biology, 2005 : 6(1)R9. PMCID:PMC549070
    • Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A.
      Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
      15531878 Nature, 2004 Dec 16 : 432(7019)917-21.
    • Gold ES, Simmons RM, Petersen TW, Campbell LA, Kuo CC, Aderem A.
      Amphiphysin IIm is required for survival of Chlamydia pneumoniae in macrophages.
      15337791 The Journal of experimental medicine, 2004 Sep 6 : 200(5)581-6. PMCID:PMC2212749
    • Matsumoto M, Einhaus D, Gold ES, Aderem A.
      Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors.
      15187114 Journal of immunology (Baltimore, Md. : 1950), 2004 Jun 15 : 172(12)7377-84.
    • Ogushi K, Wada A, Niidome T, Okuda T, Llanes R, Nakayama M, Nishi Y, Kurazono H, Smith KD, Aderem A, Moss J, Hirayama T.
      Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells.
      14707135 The Journal of biological chemistry, 2004 Mar 26 : 279(13)12213-9.
    • Lefkir Y, Malbouyres M, Gotthardt D, Ozinsky A, Cornillon S, Bruckert F, Aderem AA, Soldati T, Cosson P, Letourneur F.
      Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis.
      14617812 Molecular biology of the cell, 2004 Feb. : 15(2)861-9. PMCID:PMC329399
    • Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A.
      Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility.
      14625549 Nature immunology, 2003 Dec. : 4(12)1247-53.
    • Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A.
      A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
      14623910 The Journal of experimental medicine, 2003 Nov 17 : 198(10)1563-72. PMCID:PMC2194120
    • Marr KA, Balajee SA, Hawn TR, Ozinsky A, Pham U, Akira S, Aderem A, Liles WC.
      Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.
      12933875 Infection and immunity, 2003 Sept. : 71(9)5280-6. PMCID:PMC187297
    • Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
      The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
      12734364 Journal of immunology (Baltimore, Md. : 1950), 2003 May 15 : 170(10)5165-75.
    • Bochud PY, Hawn TR, Aderem A.
      Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.
      12646604 Journal of immunology (Baltimore, Md. : 1950), 2003 Apr 1 : 170(7)3451-4.
    • Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah S, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, Casanova JL.
      Pyogenic bacterial infections in humans with IRAK-4 deficiency.
      12637671 Science (New York, N.Y.), 2003 Mar 28 : 299(5615)2076-9.
    • Hawn TR, Ozinsky A, Underhill DM, Buckner FS, Akira S, Aderem A.
      Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.
      12270723 Microbes and infection, 2002 July : 4(8)763-71.
    • Hamerman JA, Hayashi F, Schroeder LA, Gygi SP, Haas AL, Hampson L, Coughlin P, Aebersold R, Aderem A.
      Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.
      11859133 Journal of immunology (Baltimore, Md. : 1950), 2002 Mar 1 : 168(5)2415-23.
    • Ravasi T, Wells C, Forest A, Underhill DM, Wainwright BJ, Aderem A, Grimmond S, Hume DA.
      Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes.
      11751944 Journal of immunology (Baltimore, Md. : 1950), 2002 Jan 1 : 168(1)44-50.

    Other Publications

    • Zak DE, Aderem A.
      Systems integration of innate and adaptive immunity.
      26102534 Vaccine, 2015 Sep 29 : 33(40)5241-8. Review.
    • Tam VC, Aderem A.
      Macrophage activation as an effector mechanism for cell-mediated immunity.
      25240016 Journal of immunology (Baltimore, Md. : 1950), 2014 Oct 1 : 193(7)3183-4. Review.
    • Zak DE, Tam VC, Aderem A.
      Systems-level analysis of innate immunity.
      24655298 Annual review of immunology, 2014 : 32547-77. Review. PMCID:PMC4084718
    • Aderem A.
      Editorial overview. System immunology.
      24238223 Seminars in immunology, 2013 Oct 31 : 25(3)191-2.
    • Diercks A, Aderem A.
      Systems approaches to dissecting immunity.
      22886541 Current topics in microbiology and immunology, 2013 : 3631-19. Review.
    • Aderem A, Czerkinsky C.
      Vaccines. Editorial overview.
      22698983 Current opinion in immunology, 2012 June : 24(3)308-9.
    • Zak DE, Aderem A.
      Overcoming limitations in the systems vaccinology approach: a pathway for accelerated HIV vaccine development.
      22156843 Current opinion in HIV and AIDS, 2012 Jan. : 7(1)58-63. Review.
    • Miao EA, Rajan JV, Aderem A.
      Caspase-1-induced pyroptotic cell death.
      21884178 Immunological reviews, 2011 Sept. : 243(1)206-14. Review. PMCID:PMC3609431
    • Aderem A.
      Alan Aderem. Interview with Asher Mullard.
      21720398 Nature reviews. Drug discovery, 2011 Jul 1 : 10(7)486.
    • Aderem A.
      Fast track to vaccines.
      21595406 Scientific American, 2011 May : 304(5)66-71.
    • Ramsey SA, Gold ES, Aderem A.
      A systems biology approach to understanding atherosclerosis.
      20201031 EMBO molecular medicine, 2010 March : 2(3)79-89. Review. PMCID:PMC2992755
    • Zak DE, Aderem A.
      Systems biology of innate immunity.
      19120490 Immunological reviews, 2009 Jan. : 227(1)264-82. Review. PMCID:PMC2697920
    • Korb M, Rust AG, Thorsson V, Battail C, Li B, Hwang D, Kennedy KA, Roach JC, Rosenberger CM, Gilchrist M, Zak D, Johnson C, Marzolf B, Aderem A, Shmulevich I, Bolouri H.
      The Innate Immune Database (IIDB).
      18321385 BMC immunology, 2008 Mar 5 : 97. PMCID:PMC2268913
    • Aderem A.
      Alan Aderem: from molecules to megabytes. Interviewed by Nicole LeBrasseur.
      18227276 The Journal of cell biology, 2008 Jan 28 : 180(2)252-3. PMCID:PMC2213585
    • Ravetch J, Aderem A.
      Phagocytic cells.
      17850477 Immunological reviews, 2007 Oct. : 2195-7. Review.
    • Aderem A.
      Systems biology: its practice and challenges.
      15907465 Cell, 2005 May 20 : 121(4)511-513. Review.
    • Aderem A, Smith KD.
      A systems approach to dissecting immunity and inflammation.
      14751764 Seminars in immunology, 2004 Feb. : 16(1)55-67. Review.
    • Aderem A.
      Phagocytosis and the inflammatory response.
      12792849 The Journal of infectious diseases, 2003 Jun 15 : 187 SupplS340-5.
    • Aderem A.
      How to eat something bigger than your head.
      12150991 Cell, 2002 Jul 12 : 110(1)5-8.
  • Research Funding

    Grant Title Grantor Amount Award Date
    Immune Mechanisms of Protection Against Mycobacterium tuberculosis Center (IMPAc-TB) - 75N93019C00070 (Urdahl) NIH/NIAID $5,590,281 Total Award (Aderem only) Sept. 2019 - Sept. 2026
    Omics for TB: Response to Infection and Treatment. - U19 AI135976 (Aderem-Sherman) NIH/NIAID $17,250,000 Total Award Feb. 2018 - Jan. 2023
    Systems Approach to Immunity and Inflammation. - U19 AI100927 (Ulevitch) NIH/NIAID $3,118,318 Total Award (Aderem only) Sept. 2017 - Aug. 2022
    LPS Signaling in Macrophage: The Role of Toll. - R01 AI32972 (Aderem) NIH/NIAID $4,950,640 Total Award July 2016 - June 2021


Research Description

Scientists in the Aderem Lab are studying innate responses to HIV, tuberculosis, influenza and other pathogens that significantly impact global health. Our goal is to define the mechanisms that result in a successful immune response to infection or vaccination and identify targets for therapeutic intervention to correct inadequate or dysregulated responses. By integrating systems biology-based “omics” approaches (genomics, transcriptomics, proteomics, metabolomics, etc.), we aim to develop predictive models of the complex interactions that maintain the fine balance between host defense and inflammatory disease. Read more about the Aderem Lab.

Research Focus Area

Big Data, Computational Biology, Data Analysis, Genomics, Global Health, HIV/AIDS, Host-Pathogen Interaction, Immunology, Infectious Disease, Influenza (Flu), OMICS, Predictive Analytics, Proteomics, Systems Biology, Tuberculosis