Adam Joseph Lamble, MD

Cancer and Blood Disorders Center, High-Risk Leukemia Program, Leukemia and Lymphoma Program

On staff since August 2017

Children's Title: Attending Physician, Cancer and Blood Disorders Center

Academic Title: Assistant Professor, Pediatrics

Research Center: Ben Towne Center for Childhood Cancer Research

"It’s an honor to work at Seattle Children’s hospital because of the people who work here and the revolutionary clinical and translational research that is being conducted. But most of all, it’s a privilege to partner with families and provide individualized care for children and young adults with cancer. I have a particular interest in high-risk leukemia and utilizing immune based therapies to improve outcomes and reduce toxicity in children with cancer."

• Biography

  Adam Lamble, MD, is an attending physician at Seattle Children’s Hospital, Assistant Professor of Pediatrics at the University of Washington School of Medicine.

  Dr. Lamble’s clinical and research interests focus on high-risk hematologic malignancies and immune based therapies. He is a member of the Children’s Oncology Group (COG) myeloid diseases committee and is currently leading a Phase I clinical trial for pediatric patients with multiply relapsed acute myeloid leukemia (AML). Dr. Lamble provides consultations through both the High-Risk Leukemia Clinic and the Immunotherapy Team.

• Patient Testimonials

  • Jana Anchorage, Alaska 01.19.21

    Dr. Lamble has a brilliant mind and we are so thankful to him for saving our son’s life. He always made sure we were well-informed and comfortable with any treatment decision and took the time to answer our many questions. He also brought just the right touch of humor that we appreciated during an extremely stressful time. Thank you, Dr. Lamble!

  Recommend Adam Joseph Lamble, MD

• Awards and Honors

  Award Name	Award Description	Awarded By	Award Date
  Pediatric Fellowship Research Award		Oregon Health and Science University	2017
  Young Investigator Award		American Society of Pediatric Hematology/Oncology	2015
  Alpha Omega Alpha Medical Honor Society		University of Kansas Medical Center	2011
  Gold Humanism Honor Society		University of Kansas Medical Center	2011

• Publications

  Other Publications

  • Lamble AJ, Eidenschink Brodersen L, Alonzo TA, Wang J, Pardo L, Sung L, Cooper TM, Kolb EA, Aplenc R, Tasian SK, Loken MR, Meshinchi S
    CD123 Expression Is Associated With High-Risk Disease Characteristics in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group.
    34855461 Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022 Jan. 20 : 40(3)252-261 PMCID:PMC8769096
  • Tarlock K, Lamble AJ, Wang YC, Gerbing RB, Ries RE, Loken MR, Brodersen LE, Pardo L, Leonti A, Smith JL, Hylkema TA, Woods WG, Cooper TM, Kolb EA, Gamis AS, Aplenc R, Alonzo TA, Meshinchi S
    CEBPA-bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children's Oncology Group.
    33951732 Blood, 2021 Sept. 30 : 138(13)1137-1147
  • Field MT, Lamble AJ, Holtzclaw SL, Tucker SA, Ketterl TG
    Chemotherapy roadmaps in pediatric oncology: A digital electronic medical record integrated solution.
    34558367 Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021 Sept. 24 : 10781552211040450
  • Leonard JT, Kosaka Y, Malla P, LaTocha D, Lamble A, Hayes-Lattin B, Byrd K, Druker BJ, Tyner JW, Chang BH, Lind E
    Concomitant use of a dual Src/ABL kinase inhibitor eliminates the in vitro efficacy of blinatumomab against Ph+ ALL.
    32898857 Blood, 2021 Feb. 18 : 137(7)939-944 PMCID:PMC7918187
  • Lamble AJ, Gardner R
    CAR T cells for other pediatric non-B-cell hematologic malignancies.
    33275678 Hematology. American Society of Hematology. Education Program, 2020 Dec. 4 : 2020(1)494-500 PMCID:PMC7727568
  • Lamble AJ, Kosaka Y, Laderas T, Maffit A, Kaempf A, Brady LK, Wang W, Long N, Saultz JN, Mori M, Soong D, LeFave CV, Huang F, Adams H 3rd, Loriaux MM, Tognon CE, Lo P, Tyner JW, Fan G, McWeeney SK, Druker BJ, Lind EF
    Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia.
    32513686 Proceedings of the National Academy of Sciences of the United States of America, 2020 June 23 : 117(25)14331-14341 PMCID:PMC7321988
  • Lamble AJ, Tasian SK
    Opportunities for immunotherapy in childhood acute myeloid leukemia.
    31808843 Hematology. American Society of Hematology. Education Program, 2019 Dec. 6 : 2019(1)218-225 PMCID:PMC6913480
  • Lamble AJ, Dietz M, Laderas T, McWeeney S, Lind EF
    Integrated functional and mass spectrometry-based flow cytometric phenotyping to describe the immune microenvironment in acute myeloid leukemia.
    29175391 Journal of immunological methods, 2018 Feb. : 45344-52
  • Lamble AJ, Lind EF
    Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity.
    29951373 Frontiers in oncology, 2018 : 8213 PMCID:PMC6008423
  • Lamble A, Phelan R, Burke M
    When Less Is Good, Is None Better? The Prognostic and Therapeutic Significance of Peri-Transplant Minimal Residual Disease Assessment in Pediatric Acute Lymphoblastic Leukemia.
    28686179 Journal of clinical medicine, 2017 July 7 : 6(7) PMCID:PMC5532574
  • Lamble A, Nguyen T, Lindemulder S, Spiro D, Malempati S, Nolt D, Stork L
    A Clinical Pathway to Reduce Time to Antibiotic Administration in Pediatric Cancer Patients With Fever and Potential Neutropenia
    Journal of Clinical Pathways, 2015 Nov. 3 : 1(2)33-42

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• Presentations

  Presentations Title	Event	Location	Date
  KMT2A Rearrangements Are Associated with Lineage Switch Following CD19 Targeting CAR T-Cell Therapy	American Society for Hematology Annual Conference	Atlanta, GA	2021
  Correlation of CD123 Expression Level with Disease Characteristics and Outcomes in Pediatric Acute Myeloid Leukemia: A Report from the Children’s Oncology Group	American Society for Hematology Annual Conference	San Diego, CA	2019