ADAPT: Assessing the Determinants of young Adult Pain Trajectories
Funding agency: Seattle Children’s Research Institute, Center for Child Health, Behavior & Development, Mentored Scholars Award
Funding period: 08/2021 – 08/2023
PI: Caitlin Murray
Although adolescents and young adults (AYAs; ages 18-25) experience disabling chronic pain at rates similar to older adults, there is limited research to inform interventions for this age group. This project will be the first to 1) rigorously characterize pain and disability and their longitudinal impact in AYAs with chronic pain and to 2) identify underlying risk and protective factors that drive pain and adverse developmental and health outcomes. Knowledge gained from this project will advance intervention efforts to disrupt lifelong trajectories of chronic pain and disability and lessen the economic and social impact in adulthood.
An Update and Revision of the PedIMMPACT Statement on Chronic Pain Outcome Measures
Funding Agency: Mayday Fund
Funding period: 01/1/2019 - 12/31/2021
MPI: Gary Walco, Tonya Palermo
The proposed project aims to develop a new core outcome set for clinical trials focused on pediatric chronic pain management.
Funding agency: Scan|Design Foundation
Funding period: 06/2020-06/2022
PI: Cornelius Groenewald
The goal of this research study is to advance the evidence base necessary to guide opioid prescribing following surgery by improving our understanding of opioid use patterns and risk & protective factors associated with opioid use following surgery. We will also gain knowledge on which adolescents are at risk for transitioning to problematic opioid use behaviors, including misuse and persistent use.
iCanCope with Sickle Cell Disease
Funding agency: NIH/NICHD (R01HD086978)
Funding period: 09/01/2016 – 08/31/2022 (NCE)
MPI: Tonya Palermo, Carlton Dampier, Jennifer Stinson
The objectives of this study are to improve pain self-management and functioning in youth with sickle cell disease by developing and testing a tailored web and smartphone-based application (iCanCope with SCD).
An Innovative Tailored Intervention as Assessed by the Triple Aim Approach for Improving Children’s Postoperative Recovery
Funding agency: NIH/NICHD (R01HD091286)
Funding period: 12/01/2018 – 11/30-2022
PI: Zeev Kain, Co-investigator: Tonya Palermo
This project aims to develop and evaluate the efficacy of a novel web-based intervention (WebTIPS) for young children undergoing outpatient surgery.
K23 award; SaSSy
Funding agency: National Heart, Lung, and Blood Institute (NHLBI)
Funding period: 04/2018-04/2023
PI: Cornelius Groenewald
Children surviving critical illness have profound long term health and quality of life impairments. The goal of this research program is to characterize the role of persistent sleep deficiency on long term health outcomes following critical illness in children. This information will be used to develop intervention strategies to improve outcomes following critical illness.
A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic Pancreatitis
Funding agency: NIH/NIDDK (R01 DK118752)
Funding period: 09/15/2018- 06/30/2023
MPI: Tonya Palermo, Aliye Uc
The project is designed to apply our expertise in delivering Internet-based pain management programs to the largest cohort (INSPPIRE: INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) of well-phenotyped children with CP to reduce pain, disability, and improve HRQOL.
Mechanisms of Transition from Acute to Chronic Pain in Youth Undergoing Musculoskeletal Surgery
Funding Agency: NIAMS (R01AR073780)
Funding Period: 07/12/2018-06/30/2023
PI: Jennifer A. Rabbitts
The aims of this study are to develop acute recovery indices associated with higher rates of CPSP, and identify the psychophysical and psychosocial mechanisms that underlie the transition from acute to chronic pain after major pediatric surgery. This study is expected to identify modifiable factors underlying the transition from acute to chronic postsurgical pain (CPSP), to reduce exposure to opioids and decrease the overall incidence of CPSP, a disabling condition affecting 20% youth undergoing major surgery.
TEMPO: Identifying Risk for Transition From Acute to Chronic Musculoskeletal Pain in Youth
Funding agency: NIH/NIAMS (R01AR073186)
Funding period: 09/01/2018 – 6/30/2023
PI: Amy Holley, Co-Investigator: Tonya Palermo
The objective of this study is to identify how pain modulation, psychosocial factors and behavioral vulnerabilities confer risk for the transition from acute to chronic MSK pain in youth.
Sleep Deficiency and Autonomic Function in Pediatric Chronic Abdominal Pain
Funding Agency: NIDDK (K23DK118111)
Funding Period: 07/2019 – 06/2024
PI: See Wan Tham
The aims of this study are to compare the longitudinal trajectories of sleep deficiency, pain processing, autonomic and psychological function in adolescents with chronic abdominal pain compared to healthy adolescents.
Anesthesiology & Perioperative Medicine Research Training
Funding Agency: NIGMS (2T32GM086270-13)
Funding period: 07/01/2009 – 06/30/2024
PI: Tonya Palermo
The objective of this training program is to provide in-depth research training in cutting edge (and emerging) areas of biomedical science related to anesthesiology and perioperative medicine, including critical care.
Effectiveness of an mHealth psychosocial intervention to prevent transition from acute to chronic postsurgical pain in adolescents
Funding Agency: NICHD and HEAL Initiative, NIH (UH3HD102038)
MPIs: Jennifer Rabbitts, Tonya Palermo
Project Period: 9/30/2019 – 8/31/2024
This HEAL Comparative Effectiveness Trial will address the gap in non-pharmacological treatments in perioperative care of adolescents undergoing major musculoskeletal surgery. We will test our psychosocial intervention targeting psychosocial risk factors and teaching pain self-management strategies in 500 adolescents at 15 pediatric spine centers across the nation. If effective, this scalable, low-cost intervention will allow broad implementation to reduce opioid exposure and potential for addiction, and prevent chronic postsurgical pain in youth undergoing major musculoskeletal surgery.
Enhancing Efficacy of Migraine Self-Management in Children with Comorbid Insomnia
Funding Agency: NICHD (R01HD101471)
Funding Period: 4/1/2020-3/31/2025
PI: Emily F. Law, Co-Investigator: Tonya Palermo
The aims of this project are: 1) to evaluate the efficacy of an internet-delivered cognitive behavioral therapy insomnia intervention, and 2) to determine the combined effect of internet-delivered cognitive behavioral insomnia and pain intervention in a sample of children and adolescents with migraine and comorbid insomnia.