Press Releases

Northwest study to assess COVID vaccine effectiveness

Researchers are seeking to recruit 3,500 children and adults in the Pacific Northwest to assess how well vaccines protect against COVID-19 infection.


Pacific Northwest researchers will soon begin enrolling 3,500 children and adults to participate in a study to assess how well COVID-19 vaccines protect against infection in the community.

The project, called the CASCADIA study, is being jointly led by the University of Washington School of Medicine in Seattle and the Kaiser Permanente Center for Health Research (CHR) in Portland, Oregon. The study is funded by the U.S. Centers for Disease Control and Prevention.

While individuals aged 6 months to 49 years will be included in the study, the primary goal of the study is to assess how well COVID-19 vaccines protect children aged 5 to 18 years. Researchers will also be looking at infections among all participants, young and old, vaccinated and unvaccinated, to better understand the role variants of the virus have in infection and the effect of risk factors, such as age, health status and socio-demographic characteristics. Testing will also be done for flu and other viruses.

"This information will be vital for understanding how well vaccines work in the community over time, how long immunity lasts, and when boosters will be needed," said Dr. Helen Y. Chu, Associate Professor of Medicine at the University of Washington School of Medicine who will co-lead the study with Allison Naleway, PhD, associate director of CHR’s Science Programs.

In the study, vaccinated and unvaccinated participants will be followed for up to four years for SARS-CoV-2 infection, COVID-19-like illnesses and other respiratory infections such as influenza and respiratory syncytial virus (RSV).

During this time, they will be tested weekly for SARS-CoV-2 infection with at-home nasal swab kits. The children will be swabbed by their parents, and adults will self-administer the tests. In addition, participants will complete weekly symptom surveys either online or over the phone. Vaccinations will not be given through the study.

"There is no vaccine yet for kids under 5," said Dr. Janet Englund, an infectious disease specialist at Seattle Children’s and professor of pediatrics at the University of Washington School of Medicine. "Families who enroll in this study will get free testing with immediate results on a weekly basis," added Englund, who is a co-investigator for the study and leading the research at Seattle Children’s.

Blood samples to test for SARS-CoV-2 antibodies will be collected at the beginning of the study, annually, and after vaccination and infection. These samples will not only confirm whether an illness is due to SARS-CoV-2 but also help researchers understand how the immune system responds to vaccination, infection and reinfection.

Researchers will sequence the genome of viruses they isolate to see whether there are genetic differences between the variants that cause infections in unvaccinated participants, “breakthrough” infections in the vaccinated, and reinfections in the previously infected.

"The COVID-19 vaccines that have been approved in the U.S. have already shown high levels of safety and effectiveness in both children and adults," said CHR’s Naleway. "However, we know that we need to continue studying vaccine effectiveness on an on-going basis."

Individuals interested in participating in the study may do so by visiting

Media Contact: Casey Egan, Seattle Children's,

About Seattle Children’s

Seattle Children’s mission is to provide hope, care and cures to help every child live the healthiest and most fulfilling life possible. Together, Seattle Children’s Hospital, Research Institute and Foundation deliver superior patient care, identify new discoveries and treatments through pediatric research, and raise funds to create better futures for patients.

Ranked as one of the top children’s hospitals in the country by U.S. News & World Report, Seattle Children’s serves as the pediatric and adolescent academic medical center for Washington, Alaska, Montana and Idaho – the largest region of any children’s hospital in the country. As one of the nation’s top five pediatric research centers, Seattle Children’s Research Institute is internationally recognized for its work in neurosciences, immunology, cancer, infectious disease, injury prevention and much more. Seattle Children’s Foundation, along with Seattle Children’s Guild Association – the largest all volunteer fundraising network for any hospital in the country – works with our generous community to raise funds for lifesaving care and research.

For more information, visit or follow us on X, Facebook, LinkedIn, Instagram or on our On the Pulse blog.