Seth Friedman, PhD

  • Seth Friedman Ph.D. is presently the Manager of Innovation Imaging and Simulation Modeling and a member of the Center for Clinical and Translational Research where he has worked since 2008. For ten years prior, he was a faculty member at the University of Washington in Radiology. His group works on a broad range of imaging/biomarker projects. Examples relate to 3D/4D imaging quantification/flow modeling/3D-printing of airways, VR for cardiac applications, and software development for epilepsy surgical planning and interpretation. Other projects are related to understanding the overlap between MRI and molecular features (e.g. RNA) in muscular dystrophy and exploring how novel 3d printed constructs can expand the value of simulation.

  • Other Publications

    • Wisnowski JL, Bluml S, Panigrahy A, Mathur AM, Berman J, Chen PK, Dix J, Flynn T, Fricke S, Friedman SD, Head HW, Ho CY, Kline-Fath B, Oveson M, Patterson R, Pruthi S, Rollins N, Ramos YM, Rampton J, Rusin J, Shaw DW, Smith M, Tkach J, Vasanawala S, Vossough A, Whitehead MT, Xu D, Yeom K, Comstock B, Heagerty PJ, Juul SE, Wu YW, McKinstry RC, HEAL Study Group.
      Integrating neuroimaging biomarkers into the multicentre, high-dose erythropoietin for asphyxia and encephalopathy (HEAL) trial: rationale, protocol and harmonisation.
      33888528 BMJ open, 2021 April 22 : 11(4)e043852
    • Wang LH, Shaw DWW, Faino A, Budech CB, Lewis LM, Statland J, Eichinger K, Tapscott SJ, Tawil RN, Friedman SD
      Longitudinal study of MRI and functional outcome measures in facioscapulohumeral muscular dystrophy.
      33691664 BMC musculoskeletal disorders, 2021 March 10 : 22(1)262 PMCID:PMC7948347
    • Lam AS, Bindschadler MD, Evans KN, Friedman SD, Otjen JP, Zdanski CJ, Perez FA, Dahl JP
      4D Computed Tomography for Dynamic Upper Airway Evaluation in Robin Sequence.
      33689485 Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2021 March 9 : 1945998211002156
    • Wang LH, Johnstone LM, Bindschadler M, Tapscott SJ, Friedman SD
      Adapting MRI as a clinical outcome measure for a facioscapulohumeral muscular dystrophy trial of prednisone and tacrolimus: case report.
      33422031 BMC musculoskeletal disorders, 2021 Jan. 9 : 22(1)56 PMCID:PMC7797109
    • O'Reilly M, Hoff M, Friedman SD, Jones JFX, Cross NM
      Simulating Tissues with 3D-Printed and Castable Materials.
      32556912 Journal of digital imaging, 2020 Oct. : 33(5)1280-1291 PMCID:PMC7573067
    • Wong CJ, Wang LH, Friedman SD, Shaw D, Campbell AE, Budech CB, Lewis LM, Lemmers RJFL, Statland JM, van der Maarel SM, Tawil RN, Tapscott SJ
      Longitudinal measures of RNA expression and disease activity in FSHD muscle biopsies.
      32083293 Human molecular genetics, 2020 April 15 : 29(6)1030-1043 PMCID:PMC7158378
    • Bass DI, Shurtleff H, Warner M, Knott D, Poliakov A, Friedman S, Collins MJ, Lopez J, Lockrow JP, Novotny EJ, Ojemann JG, Hauptman JS
      Awake Mapping of the Auditory Cortex during Tumor Resection in an Aspiring Musical Performer: A Case Report.
      33260181 Pediatric neurosurgery, 2020 : 55(6)351-358
    • Saxena RC, Friedman S, Bly RA, Otjen J, Alessio AM, Li Y, Hannaford B, Whipple M, Moe KS
      Comparison of Micro-Computed Tomography and Clinical Computed Tomography Protocols for Visualization of Nasal Cartilage Before Surgical Planning for Rhinoplasty.
      30730533 JAMA facial plastic surgery, 2019 May 1 : 21(3)237-243 PMCID:PMC6537836
    • Slowik V, Monroe EJ, Friedman SD, Hsu EK, Horslen S
      Pressure gradients, laboratory changes, and outcomes with transjugular intrahepatic portosystemic shunts in pediatric portal hypertension.
      30932316 Pediatric transplantation, 2019 May : 23(3)e13387
    • Padia R, Miller C, Patak L, Friedman SD, Stone K, Otjen J, Johnson K
      Simulation-Guided Tracheotomy in a Patient With Fibrodysplasia Ossificans Progressiva.
      30582158 The Laryngoscope, 2019 April : 129(4)812-817
    • Wang LH, Friedman SD, Shaw D, Snider L, Wong CJ, Budech CB, Poliachik SL, Gove NE, Lewis LM, Campbell AE, Lemmers RJFL, Maarel SM, Tapscott SJ, Tawil RN
      MRI-informed muscle biopsies correlate MRI with pathology and DUX4 target gene expression in FSHD.
      30312408 Human molecular genetics, 2019 Feb. 1 : 28(3)476-486 PMCID:PMC6337697
    • Grassia F, Poliakov AV, Poliachik SL, Casimo K, Friedman SD, Shurtleff H, Giussani C, Novotny EJ, Ojemann JG, Hauptman JS
      Changes in resting-state connectivity in pediatric temporal lobe epilepsy.
      29932365 Journal of neurosurgery. Pediatrics, 2018 Sept. : 22(3)270-275
    • Oesch G, Maga AM, Friedman SD, Poliachik SL, Budech CB, Wright JN, Bok LA, Gospe SM Jr
      Geometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy.
      29875223 Neurology, 2018 July 3 : 91(1)e78-e86
    • Ferguson MR, Poliachik SL, Budech CB, Gove NE, Carter GT, Wang LH, Miller DG, Shaw DWW, Friedman SD
      MRI change metrics of facioscapulohumeral muscular dystrophy: Stir and T1.
      29236297 Muscle & nerve, 2018 June : 57(6)905-912
    • Friedman SD, Poliakov AV, Budech C, Shaw DWW, Breiger D, Jinguji T, Krabak B, Coppel D, Lewis TM, Browd S, Ojemann JG
      GABA alterations in pediatric sport concussion.
      29030453 Neurology, 2017 Nov. 21 : 89(21)2151-2156 PMCID:PMC5696637
    • Ferguson MR, Yu CK, Poliakov AV, Friedman SD, McClellan JM
      Capgras syndrome: neuroanatomical assessment of brain MRI findings in an adolescent patient.
      28582476 Brain : a journal of neurology, 2017 July 1 : 140(7)e43
    • Craft S, Claxton A, Baker LD, Hanson AJ, Cholerton B, Trittschuh EH, Dahl D, Caulder E, Neth B, Montine TJ, Jung Y, Maldjian J, Whitlow C, Friedman S
      Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial.
      28372335 Journal of Alzheimer's disease : JAD, 2017 : 57(4)1325-1334 PMCID:PMC5409050
    • Chrisman SP, Mac Donald CL, Friedman S, Andre J, Rowhani-Rahbar A, Drescher S, Stein E, Holm M, Evans N, Poliakov AV, Ching RP, Schwien CC, Vavilala MS, Rivara FP
      Head Impact Exposure During a Weekend Youth Soccer Tournament.
      26951540 Journal of child neurology, 2016 July : 31(8)971-8
    • Petek LM, Rickard AM, Budech C, Poliachik SL, Shaw D, Ferguson MR, Tawil R, Friedman SD, Miller DG
      A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD).
      27185459 Neuromuscular disorders : NMD, 2016 July : 26(7)405-13 PMCID:PMC4912392
    • Poliachik SL, Friedman SD, Poliakov AV, Budech CB, Ishak GE, Shaw DW, Gospe SM Jr
      Corpus Callosum Diffusion and Connectivity Features in High Functioning Subjects With Pyridoxine-Dependent Epilepsy.
      26547255 Pediatric neurology, 2016 Jan. : 5443-8
    • McEvoy SD, Lee A, Poliakov A, Friedman S, Shaw D, Browd SR, Ellenbogen RG, Ojemann JG, Mac Donald CL
      Longitudinal cerebellar diffusion tensor imaging changes in posterior fossa syndrome.
      27689022 NeuroImage. Clinical, 2016 : 12582-590 PMCID:PMC5031477
    • Hawkins CM, Shaw DW, Healey PJ, Horslen SP, Dick AA, Friedman S, Shivaram GM
      Pediatric liver transplant portal vein anastomotic stenosis: correlation between ultrasound and transhepatic portal venography.
      25648978 Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2015 April : 21(4)547-53
    • Otto RK, Friedman SD, Martin LD
      Pediatric sedation and magnetic resonance imaging: the potential for motion correction.
      24628931 Paediatric anaesthesia, 2014 April : 24(4)459-61
    • Friedman SD, Poliachik SL, Otto RK, Carter GT, Budech CB, Bird TD, Miller DG, Shaw DW
      Longitudinal features of STIR bright signal in FSHD.
      23720194 Muscle & nerve, 2014 Feb. : 49(2)257-60
    • Ferguson MR, Otto RK, Bender MA, Kolokythas O, Friedman SD
      Liver and heart MR relaxometry in iron loading: reproducibility of three methods.
      23172590 Journal of magnetic resonance imaging : JMRI, 2013 Oct. : 38(4)987-90
    • Corrigan NM, Shaw DW, Estes AM, Richards TL, Munson J, Friedman SD, Dawson G, Artru AA, Dager SR
      Atypical developmental patterns of brain chemistry in children with autism spectrum disorder.
      23903694 JAMA psychiatry, 2013 Sept. : 70(9)964-74
    • Friedman SD, Baker LD, Borson S, Jensen JE, Barsness SM, Craft S, Merriam GR, Otto RK, Novotny EJ, Vitiello MV
      Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging.
      23689947 JAMA neurology, 2013 July : 70(7)883-90 PMCID:PMC3764915
    • Baker LD, Barsness SM, Borson S, Merriam GR, Friedman SD, Craft S, Vitiello MV
      Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.
      22869065 Archives of neurology, 2012 Nov. : 69(11)1420-9 PMCID:PMC3764914
    • Lee MJ, Hatton BA, Villavicencio EH, Khanna PC, Friedman SD, Ditzler S, Pullar B, Robison K, White KF, Tunkey C, LeBlanc M, Randolph-Habecker J, Knoblaugh SE, Hansen S, Richards A, Wainwright BJ, McGovern K, Olson JM
      Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model.
      22550175 Proceedings of the National Academy of Sciences of the United States of America, 2012 May 15 : 109(20)7859-64 PMCID:PMC3356655
    • Khanna PC, Poliakov AV, Ishak GE, Poliachik SL, Friedman SD, Saneto RP, Novotny EJ Jr, Ojemann JG, Shaw DW
      Preserved interhemispheric functional connectivity in a case of corpus callosum agenesis.
      21553342 Neuroradiology, 2012 Feb. : 54(2)177-9
    • Otto R, Ferguson MR, Marro K, Grinstead JW, Friedman SD
      Limitations of using logarithmic transformation and linear fitting to estimate relaxation rates in iron-loaded liver.
      21607600 Pediatric radiology, 2011 Oct. : 41(10)1259-65
    • Marro K, Otto R, Kolokythas O, Shimamura A, Sanders JE, McDonald GB, Friedman SD
      A simulation-based comparison of two methods for determining relaxation rates from relaxometry images.
      21333480 Magnetic resonance imaging, 2011 May : 29(4)497-506 PMCID:PMC3078944
    • Marro KI, Lee D, Shankland EG, Mathis CM, Hayes CE, Friedman SD, Kushmerick MJ
      Quantitative in vivo magnetic resonance spectroscopy using synthetic signal injection.
      21203385 PloS one, 2010 Dec. 28 : 5(12)e15166 PMCID:PMC3010995
    • Friedman SD, Shaw DW, Ishak G, Gropman AL, Saneto RP
      The use of neuroimaging in the diagnosis of mitochondrial disease.
      20818727 Developmental disabilities research reviews, 2010 : 16(2)129-35
    • Jensen JE, Licata SC, Ongür D, Friedman SD, Prescot AP, Henry ME, Renshaw PF
      Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla.
      19388001 NMR in biomedicine, 2009 Aug. : 22(7)762-9
    • Friedman SD
      Taking responsibility for scientific discourse.
      18719265 Science (New York, N.Y.), 2008 Aug. 22 : 321(5892)1039-40 PMCID:PMC2649802
    • Friedman SD
      Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain".
      18669845 Science (New York, N.Y.), 2008 Aug. 1 : 321(5889)640 PMCID:PMC2643334
    • Borson S, Scanlan J, Friedman S, Zuhr E, Fields J, Aylward E, Mahurin R, Richards T, Anzai Y, Yukawa M, Yeh S
      Modeling the impact of COPD on the brain.
      18990971 International journal of chronic obstructive pulmonary disease, 2008 : 3(3)429-34 PMCID:PMC2629981