Sandra E. Juul, MD, PhD

Sandra E. Juul, MD, PhD

Neonatology

On staff since July 2000

Children's Title: Chief, Division of Neonatology; W. Alan Hodson Endowed Chair in Pediatrics

Academic Title: Professor of Pediatrics

"As a neonatologist, I am honored to participate in the care of precious, fragile individuals ranging from extremely preterm infants to term neonates with complex medical or surgical problems. These small patients and their families humble me with their endurance in the face of great adversity. I believe that my role as an academic neonatologist is to work to advance care and improve outcomes for our patient population. My research focuses on neonatal neuroprotection: how to optimize neurodevelopment, protect the newborn brain from injury, and how to repair the injured brain."

  • Dr. Sandra "Sunny" Juul, MD, PhD is Division Chief of Neonatology at Seattle Childrens Hospital and the University of Washington. After completing her medical degree, residency, fellowship and two years as an acting Assistant Professor at the University of Washington, Dr. Juul left Seattle in 1991 for the University of Chicago where she began a Ph.D. in Developmental Biology. She then joined the faculty at the University of Florida in 1993, where her Ph.D. work was completed. In 2000, Dr. Juul was successfully recruited back to Seattle. She is board certified in Pediatrics and Neonatology.

    Dr. Juul leads a translational neonatal neuroscience research program. The focus is to identify new therapeutic approaches to neonatal brain injury, determine whether they are safe and effective, and if so, bring these new treatments from the laboratory to the bedside. Dr. Juul identified Epo and its receptor in the developing human brain, demonstrated that it is neuroprotective and safe using multiple animal models of neonatal brain injury. Bringing this work from the bench to the bedside, Dr. Juul is currently Principal Investigator of a multicenter randomized controlled trial to determine whether Epo is a safe and effective neuroprotectant for extremely preterm infants. The study, Preterm Epo Neuroprotection (PENUT) is funded by NINDS, and has enrolled 940 babies born between 24-0/7 and 26-6/7 weeks of gestation. These children are currently being followed to two years of age for detailed neurodevelopmental assessments. Dr. Juul is also multi-PI with Dr. Yvonne Wu (UCSF) on the High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial, a randomized controlled trial of Epo neuroprotection for 500 term infants with hypoxic-ischemic encephalopathy (HIE). This multicenter trial will determine whether Epo in addition to therapeutic cooling will improve the outcome for infants with HIE.

  • Award Name Award Description Awarded By Award Date
    SEATTLE'S TOP DOCTOR 2018 Seattle Met Magazine 2018
    Seattles Top Doctor 2016 Seattle Met Magazine 2016
    SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
    Seattle's Top Doctor 2018 Seattle Met Magazine
  • Other Publications

    • Shah AR, Wilfond BS, Silvia A, Hancuch K, Woodrum D, Heagerty P, Ohls RK, Courtney SE, Frantz ID, Gogcu S, Bishop CE, Ahmad KA, Kathen C, Juul S, PENUT Neonatal Informed Consent Working Group.
      Informed consent for a neonatal clinical trial: parental experiences and perspectives.
      29795451 Journal of perinatology : official journal of the California Perinatal Association, 2018 July : 38(7)865-872
    • Eichenwald EC, COMMITTEE ON FETUS AND NEWBORN.
      Diagnosis and Management of Gastroesophageal Reflux in Preterm Infants.
      29915158 Pediatrics, 2018 July : 142(1)
    • Eichenwald EC, COMMITTEE ON FETUS AND NEWBORN.
      Diagnosis and Management of Gastroesophageal Reflux in Preterm Infants.
      29915158 Pediatrics, 2018 July : 142(1)
    • Shah AR, Wilfond BS, Silvia A, Hancuch K, Woodrum D, Heagerty P, Ohls RK, Courtney SE, Frantz ID, Gogcu S, Bishop CE, Ahmad KA, Kathen C, Juul S, PENUT Neonatal Informed Consent Working Group.
      Informed consent for a neonatal clinical trial: parental experiences and perspectives.
      29795451 Journal of perinatology : official journal of the California Perinatal Association, 2018 July : 38(7)865-872
    • Snyder JM, Wood TR, Corry K, Moralejo DH, Parikh P, Juul SE
      Ontogeny of white matter, toll-like receptor expression, and motor skills in the neonatal ferret.
      29791868 International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018 May 20
    • Snyder JM, Wood TR, Corry K, Moralejo DH, Parikh P, Juul SE
      Ontogeny of white matter, toll-like receptor expression, and motor skills in the neonatal ferret.
      29791868 International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018 May 20
    • Dhillon SK, Lear CA, Galinsky R, Wassink G, Davidson JO, Juul S, Robertson NJ, Gunn AJ, Bennet L
      The fetus at the tipping point: modifying the outcome of fetal asphyxia.
      29774532 The Journal of physiology, 2018 May 17
    • Dhillon SK, Lear CA, Galinsky R, Wassink G, Davidson JO, Juul S, Robertson NJ, Gunn AJ, Bennet L
      The fetus at the tipping point: modifying the outcome of fetal asphyxia.
      29774532 The Journal of physiology, 2018 May 17
    • Wassink G, Davidson JO, Lear CA, Juul SE, Northington F, Bennet L, Gunn AJ
      A working model for hypothermic neuroprotection.
      29660115 The Journal of physiology, 2018 April 16
    • Wassink G, Davidson JO, Lear CA, Juul SE, Northington F, Bennet L, Gunn AJ
      A working model for hypothermic neuroprotection.
      29660115 The Journal of physiology, 2018 April 16
    • Peeples ES, Ezeokeke CK, Juul SE, Mourad PD
      Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy.
      28960438 Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2018 April : 37(4)913-920 PMCID:PMC5867225
    • Peeples ES, Ezeokeke CK, Juul SE, Mourad PD
      Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy.
      28960438 Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2018 April : 37(4)913-920 PMCID:PMC5867225
    • German K, Vu PT, Grelli KN, Denton C, Lee G, Juul SE
      Zinc Protoporphyrin-to-Heme Ratio and Ferritin as Measures of Iron Sufficiency in the Neonatal Intensive Care Unit.
      29212619 The Journal of pediatrics, 2018 March : 19447-53
    • Massaro AN, Wu YW, Bammler TK, Comstock B, Mathur A, McKinstry RC, Chang T, Mayock DE, Mulkey SB, Van Meurs K, Juul S
      Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
      29478510 The Journal of pediatrics, 2018 March : 19467-75.e1
    • Massaro AN, Wu YW, Bammler TK, Comstock B, Mathur A, McKinstry RC, Chang T, Mayock DE, Mulkey SB, Van Meurs K, Juul S
      Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
      29478510 The Journal of pediatrics, 2018 March : 19467-75.e1
    • German K, Vu PT, Grelli KN, Denton C, Lee G, Juul SE
      Zinc Protoporphyrin-to-Heme Ratio and Ferritin as Measures of Iron Sufficiency in the Neonatal Intensive Care Unit.
      29212619 The Journal of pediatrics, 2018 March : 19447-53
    • Starr MC, Askenazi DJ, Goldstein SL, MacDonald JW, Bammler TK, Afsharinejad Z, D Brophy P, Juul SE, Mayock DE, Hingorani SR
      Impact of processing methods on urinary biomarkers analysis in neonates.
      28821985 Pediatric nephrology (Berlin, Germany), 2018 Jan. : 33(1)181-186 PMCID:PMC5700848
    • Parikh P, Juul SE
      Neuroprotective Strategies in Neonatal Brain Injury.
      29031859 The Journal of pediatrics, 2018 Jan. : 19222-32
    • Juul SE, Comstock BA, Heagerty PJ, Mayock DE, Goodman AM, Hauge S, Gonzalez F, Wu YW
      High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial - Background, Aims, and Study Protocol.
      29514165 Neonatology, 2018 : 113(4)331-338 PMCID:PMC5980685
    • Juul SE, Comstock BA, Heagerty PJ, Mayock DE, Goodman AM, Hauge S, Gonzalez F, Wu YW
      High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial - Background, Aims, and Study Protocol.
      29514165 Neonatology, 2018 : 113(4)331-338 PMCID:PMC5980685
    • Parikh P, Juul SE
      Neuroprotective Strategies in Neonatal Brain Injury.
      29031859 The Journal of pediatrics, 2018 Jan. : 19222-32
    • Starr MC, Askenazi DJ, Goldstein SL, MacDonald JW, Bammler TK, Afsharinejad Z, D Brophy P, Juul SE, Mayock DE, Hingorani SR
      Impact of processing methods on urinary biomarkers analysis in neonates.
      28821985 Pediatric nephrology (Berlin, Germany), 2018 Jan. : 33(1)181-186 PMCID:PMC5700848
    • Mulkey SB, Ramakrishnaiah RH, McKinstry RC, Chang T, Mathur AM, Mayock DE, Van Meurs KP, Schaefer GB, Luo C, Bai S, Juul SE, Wu YW
      Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome.
      28456387 The Journal of pediatrics, 2017 July : 186196-199
    • Mulkey SB, Ramakrishnaiah RH, McKinstry RC, Chang T, Mathur AM, Mayock DE, Van Meurs KP, Schaefer GB, Luo C, Bai S, Juul SE, Wu YW
      Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome.
      28456387 The Journal of pediatrics, 2017 July : 186196-199
    • Frymoyer A, Juul SE, Massaro AN, Bammler TK, Wu YW
      High-dose erythropoietin population pharmacokinetics in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.
      28099423 Pediatric research, 2017 June : 81(6)865-872 PMCID:PMC5476365
    • Frymoyer A, Juul SE, Massaro AN, Bammler TK, Wu YW
      High-dose erythropoietin population pharmacokinetics in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.
      28099423 Pediatric research, 2017 June : 81(6)865-872 PMCID:PMC5476365
    • McAdams RM, McPherson RJ, Kapur RP, Juul SE
      Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates.
      28343228 Developmental neuroscience, 2017 : 39(1-4)107-123 PMCID:PMC5519439
    • McAdams RM, Fleiss B, Traudt C, Schwendimann L, Snyder JM, Haynes RL, Natarajan N, Gressens P, Juul SE
      Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy.
      28486224 Developmental neuroscience, 2017 : 39(1-4)124-140 PMCID:PMC5519434
    • McAdams RM, Fleiss B, Traudt C, Schwendimann L, Snyder JM, Haynes RL, Natarajan N, Gressens P, Juul SE
      Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy.
      28486224 Developmental neuroscience, 2017 : 39(1-4)124-140 PMCID:PMC5519434
    • McAdams RM, McPherson RJ, Kapur RP, Juul SE
      Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates.
      28343228 Developmental neuroscience, 2017 : 39(1-4)107-123 PMCID:PMC5519439
    • Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby JC, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M Jr, Rajagopal L
      Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
      27618651 Nature medicine, 2016 Nov. : 22(11)1256-1259 PMCID:PMC5365281
    • Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby JC, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M Jr, Rajagopal L
      Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
      27618651 Nature medicine, 2016 Nov. : 22(11)1256-1259 PMCID:PMC5365281
    • McAdams RM, Juul SE
      Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
      27524449 Clinics in perinatology, 2016 Sept. : 43(3)485-500 PMCID:PMC4987711
    • McAdams RM, Juul SE
      Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
      27524449 Clinics in perinatology, 2016 Sept. : 43(3)485-500 PMCID:PMC4987711
    • Peeples ES, Strandjord TP, Juul SE
      Evaluating an Association between Ampicillin and Intraventricular Hemorrhage in Preterm Infants.
      27111026 Neuropediatrics, 2016 Aug. : 47(4)221-5
    • Peeples ES, Strandjord TP, Juul SE
      Evaluating an Association between Ampicillin and Intraventricular Hemorrhage in Preterm Infants.
      27111026 Neuropediatrics, 2016 Aug. : 47(4)221-5
    • Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA
      High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial.
      27244862 Pediatrics, 2016 June : 137(6)
    • Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA
      High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial.
      27244862 Pediatrics, 2016 June : 137(6)
    • Peeples ES, Mehic E, Mourad PD, Juul SE
      Fast Doppler as a novel bedside measure of cerebral perfusion in preterm infants.
      26539662 Pediatric research, 2016 Feb. : 79(2)333-8
    • Peeples ES, Mehic E, Mourad PD, Juul SE
      Fast Doppler as a novel bedside measure of cerebral perfusion in preterm infants.
      26539662 Pediatric research, 2016 Feb. : 79(2)333-8
    • Traudt CM, McPherson RJ, Studholme C, Millen KJ, Juul SE
      Systemic glycerol decreases neonatal rabbit brain and cerebellar growth independent of intraventricular hemorrhage.
      24346111 Pediatric research, 2014 March : 75(3)389-94 PMCID:PMC3943708
    • Traudt CM, McPherson RJ, Studholme C, Millen KJ, Juul SE
      Systemic glycerol decreases neonatal rabbit brain and cerebellar growth independent of intraventricular hemorrhage.
      24346111 Pediatric research, 2013 Dec. 17
    • Burbacher TM, Grant KS, Worlein J, Ha J, Curnow E, Juul S, Sackett GP
      Four decades of leading-edge research in the reproductive and developmental sciences: the Infant Primate Research Laboratory at the University of Washington National Primate Research Center.
      23873400 American journal of primatology, 2013 Nov. : 75(11)1063-83
    • Schober ME, Requena D, Block BP, Davis LJ, Rodesch C, Casper TC, Juul SE, Kesner RP, Lane RH
      Erythropoietin Improved Cognitive Function and Decreased Hippocampal Caspase Activity in Rat Pups after Traumatic Brain Injury.
      23972011 Journal of neurotrauma, 2013 Aug. 25
    • Hays SL, Valieva OA, McPherson RJ, Juul SE, Gleason CA
      Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment.
      23026365 International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2013 Feb. : 31(1)25-9 PMCID:PMC3525715
    • Traudt CM, Juul SE
      Erythropoietin as a neuroprotectant for neonatal brain injury: animal models.
      23456865 Methods in molecular biology (Clifton, N.J.), 2013 : 982113-26
    • Traudt CM, Juul SE
      Erythropoietin as a neuroprotectant for neonatal brain injury: animal models.
      23456865 Methods in molecular biology (Clifton, N.J.), 2013 : 982113-26
    • Traudt CM, McPherson RJ, Bauer LA, Richards TL, Burbacher TM, McAdams RM, Juul SE
      Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia.
      24192275 Developmental neuroscience, 2013 : 35(6)491-503 PMCID:PMC3873854
    • Juul SE
      Hypothermia plus erythropoietin for neonatal neuroprotection? Commentary on Fan et al. and Fang et al.
      23295358 Pediatric research, 2013 Jan. : 73(1)10-1 PMCID:PMC3604882
    • Traudt CM, McPherson RJ, Bauer LA, Richards TL, Burbacher TM, McAdams RM, Juul SE
      Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia.
      24192275 Developmental neuroscience, 2013 : 35491-503 PMCID:PMC3873854
    • Traudt CM, Juul SE
      Erythropoietin as a neuroprotectant for neonatal brain injury: animal models.
      23456865 Methods in molecular biology (Clifton, N.J.), 2013 : 982113-26
    • Wu YW, Bauer LA, Ballard RA, Ferriero DM, Glidden DV, Mayock DE, Chang T, Durand DJ, Song D, Bonifacio SL, Gonzalez FF, Glass HC, Juul SE
      Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics.
      23008465 Pediatrics, 2012 Oct. : 130(4)683-91 PMCID:PMC3457622
    • Juul S
      Neuroprotective role of erythropoietin in neonates.
      22958035 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012 Oct. : 25 Suppl 4105-7
    • Juul S
      Erythropoiesis and the approach to anemia in premature infants.
      23025780 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012 Oct. : 25(Suppl 5)97-9
    • Robertson NJ, Tan S, Groenendaal F, van Bel F, Juul SE, Bennet L, Derrick M, Back SA, Valdez RC, Northington F, Gunn AJ, Mallard C
      Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?
      22325255 The Journal of pediatrics, 2012 April : 160(4)544-552.e4

  • Presentations Title Event Location Date
    Urine hepcidin and iron regulation in preterm infants PAS 2018 Toronto, ON May 2018
    Examining pulmonary monocyte/macrophage populations in BPD pathogenesis PAS 2018 Toronto, ON May 2018
    Ontogeny Of Toll-Like 3 And 4 Receptor Expression And White Matter Development In The Ferret Brain PAS 2018 Toronto, ON May 2018
    Reticulocyte Hemoglobin Values in Preterm Infants PAS 2018 Toronto, ON May 2018
    Lysosomal Enzyme Activities Does Not Predict Development of Necrotizing Enterocolitis PAS 2018 Toronto, ON May 2018
    Use of sedation for neonatal MRI: change in practice variation within a multi-center trial PAS 2018 Toronto, ON May 2018
    Timing and Progression of Cranial Ultrasound (CUS) Abnormalities in Extremely Low Gestation Neonates (ELGANs). PAS 2018 Toronto, ON May 2018
    Prevalence of acute kidney injury (AKI) in extremely-low gestational age neonates (ELGANs) stratified by gestational age (GA) groups PAS Platform 2018 Toronto, ON May 2018
    Epigenetic Mechanisms of Erythropoietin (Epo) Induced Neuroprotection in Extremely Low Gestational Age Neonates (ELGAN) PAS 2018 Toronto, ON May 2018
    Variability in Hydrocortisone Dosing for Extremely Preterm Infants: A Multi-Center Analysis PAS 2018 Toronto, ON May 2018
    Dried blood spots (DBS) are not a reliable biospecimen for blood-based biomarkers of brain injury in neonatal PAS 2018 Toronto, ON May 2018
    Neuroprotective Strategies for High Risk Newborns Grand Rounds at Washington University St. Louis, MO Feb. 22, 2018
    Neonatal Neuroprotection A Day with the Newborn; an investment in our future St. Christophers Hospital for Children, Philadelphia, PA Jan. 26, 2018
    Curcumin-loaded brain-penetrating nanoparticles for the treatment of neonatal HIE Hershey 2018 2018
    Validating MRS lipids as biomarkers of brain injury in a non-human primate model of neonatal hypoxic-ischemic encephalopathy Hershey 2018 2018
    Neuroprotective strategies for premature (and other high risk) neonates Grand Rounds at the University of Chicago Chicago, IL May 24, 2017
    Prematurity and CP Prematurity Summit San Francisco, CA May 4, 2017
    Parental Attitudes Toward Neonatal Clinical Trial Enrollment PAS 2017 2017
    Curcumin is anti-inflammatory and reduces microglial cell death during oxygen-glucose deprivation PAS 2017 2017
    High-Dose Erythropoietin Population Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia PAS 2017 2017
    Epigenetic biomarkers of cerebral palsy in extremely low gestational age neonates (ELGANs) - A pilot study PAS 2017 2017
    A Novel Ferret Model of Encephalopathy of Prematurity: In Development PAS 2017 2017
    Characterization of Motor and Reflex Development in a Novel Ferret Model of Encephalopathy of Prematurity PAS 2017 2017
    Decreases the Volume of Brain Injury in Newborns with Hypoxic-Ischemic Encephalopathy CNS meeting Vancouver, BC Oct. 26, 2016 - Oct. 29, 2016
    Parental attitudes toward neonatal clinical trial enrollment AAP Poster presentation Oct. 21, 2016
    Epo and neonatal neuroprotection in very preterm neonates" and "Epo for Term neonates with hypoxic-ischemic encephalopathy 7th Dutch Neonatal Fellow Congress Leiden, Netherlands April 7, 2016
    Plasma biomarkers of brain injury in neonatal HIE Pediatric Academic Societies 2016
    A hybrid premature neonatal segmentation pipeline for clinical brain imaging acquired without dedicated neonatal coils ISMRM 2016 2016
    Metabolomic Differences After Umbilical Cord Occlusion (UCO) in a Non-Human Primate Model of Hypoxic-Ischemic Encephalopathy (HIE) Pediatric Academic Societies 2016
    Urine and Plasma Inflammatory Mediators Are Detectable Using the Meso Scale Discovery (MSD) Multiplex Platform in a Nonhuman Primate Model of Neonatal Hypoxic Ischemic Encephalopathy (HIE) Pediatric Academic Societies 2016
    Erythropoietin and hypothermia for neonatal neuroprotection: a phase II randomized controlled trial Pediatric Academic Societies 2016
    Brain injury volume in newborns with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia Pediatric Academic Societies 2016
    Pneumocystis jirovecii Infection Not Detected in NICU Infants Pediatric Academic Societies 2016
    Development of a Ferret Model: Combination of Systemic Inflammation, Hypoxia, and Hyperoxia Results in White Matter Injury Pediatric Academic Societies 2016
    Iron Sufficiency in the NICU, Platform Pediatric Academic Societies 2016
  • Grant Title Grantor Amount Award Date
    Epigenetic biomarkers of cerebral palsy in the ELGAN CP Alliance $179,925 2018 - 2020
    Uridine neuroprotection in neonatal hypoxic-ischemic brain injury Bill and Melinda Gates Foundation $489,128 2017 - 2019
    High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCC $10,100,000 2016 - 2022
    Biomarkers of neonatal encephalopathy in a nonhuman primate model $3,233,245 2013 - 2018
    Preterm Erythropoietin Neuroprotection Trial (PENUT Trial) CCC $10,145,741 2013 - 2018

Overview

Board Certification(s)

Pediatrics
Neonatal-Perinatal Medicine

Medical/Professional School

University of Washington School of Medicine, Seattle
University of Chicago, Chicago

Residency

Pediatrics, University of Washington School of Medicine, Seattle

Fellowship

Neonatal-Perinatal Medicine, Seattle Children's Hospital, Seattle

Clinical Interests

Non-hematopoietic effects of erythropoietin (Epo), particularly its neuroprotective effects. Hematopoiesis and iron balance in preterm infants are additional areas of interest and research.

Research Description

Recombinant erythropoietin (rEpo) has been used since 1989 as an erythropoietic agent in adults and children. More recently, Epo effects have been recognized in tissues other than bone marrow. Functional receptors for Epo are present in the developing brain, liver, heart, blood vessels, and intestine.

During development, endogenous Epo acts as a general trophic and anti-apoptotic factor. Mechanisms of Epo action are being investigated. Two promising areas of research include the use of rEpo to prevent or ameliorate necrotizing enterocolitis, and the use of rEpo to decrease brain damage following injury such as perinatal hypoxia-ischemia.

Using a variety of molecular biology, cell and tissue culture techniques, and in vivo models, Dr. Juul's research is focused on determining the effects of Epo on neurodevelopment, neuroprotection, intestinal development, and intestinal injury. Additional areas of interest include neonatal hematology, and iron deficiency in the developing neonate.

Research Focus Area
Neuroscience / Neurodevelopment