Liz Nguyen, MD, PhD

Liz Nguyen, MD, PhD

Nephrology

Children's Title: Attending Physician

Academic Title: Acting Assistant Professor

Research Center: Center for Developmental Biology and Regenerative Medicine

  • Dr. Nguyen is an acting assistant professor of nephrology with the University of Washington School of Medicine's Department of Pediatrics. She is also a principal investigator at Seattle Children's Research Institute's Center for Developmental Biology and Regenerative Medicine. Dr. Nguyen completed both her medical and graduate degrees at Vanderbilt University. Her graduate work focused on structural prediction of G-protein coupled receptors and drug design. She completed her pediatric residency and pediatric nephrology fellowship at Seattle Children's Hospital. As a physician-scientist, Dr. Nguyen also attends on the pediatric nephrology service at Seattle Children's Hospital, balancing responsibilities in patient care, research and teaching of medical trainees. Her clinical interests focus on genetic causes for renal disease.

    • Related Pages

    • Nguyen Lab

      In the Nguyen Lab, we investigate the genetic and epigenetic changes occurring after kidney injury.

  • Other Publications

    • Okamura DM, Brewer CM, Wakenight P, Bahrami N, Bernardi K, Tran A, Olson J, Shi X, Yeh SY, Piliponsky A, Collins SJ, Nguyen ED, Timms AE, MacDonald JW, Bammler TK, Nelson BR, Millen KJ, Beier DR, Majesky MW
      Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis.
      34849462 iScience, 2021 Nov. 19 : 24(11)103269 PMCID:PMC8609232
    • Okamura DM, Brewer CM, Wakenight P, Bahrami N, Bernardi K, Tran A, Olson J, Shi X, Yeh SY, Piliponsky A, Collins SJ, Nguyen ED, Timms AE, MacDonald JW, Bammler TK, Nelson BR, Millen KJ, Beier DR, Majesky MW
      Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis.
      34849462 iScience, 2021 Nov. 19 : 24(11)103269 PMCID:PMC8609232
    • Nguyen ED, Menon S
      For Whom the Bell Tolls: Acute Kidney Injury and Electronic Alerts for the Pediatric Nephrologist.
      33912520 Frontiers in pediatrics, 2021 : 9628096 PMCID:PMC8072003
    • Nguyen ED, Menon S
      For Whom the Bell Tolls: Acute Kidney Injury and Electronic Alerts for the Pediatric Nephrologist.
      33912520 Frontiers in pediatrics, 2021 : 9628096 PMCID:PMC8072003
    • Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T
      Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.
      29234062 Scientific reports, 2017 Dec. 12 : 7(1)17390 PMCID:PMC5727211
    • Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T
      Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.
      29234062 Scientific reports, 2017 Dec. 12 : 7(1)17390 PMCID:PMC5727211
    • Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J
      Improving prediction of helix-helix packing in membrane proteins using predicted contact numbers as restraints.
      28263405 Proteins, 2017 July : 85(7)1212-1221 PMCID:PMC5476507
    • Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J
      Improving prediction of helix-helix packing in membrane proteins using predicted contact numbers as restraints.
      28263405 Proteins, 2017 July : 85(7)1212-1221 PMCID:PMC5476507
    • Nguyen E, Claar D, McGuinn E, Mast K, Hartley K, McDonagh K
      Persistence Pays Off: Adult Langerhans Cell Histiocytosis.
      26968470 The American journal of medicine, 2016 July : 129(7)e55-9
    • Nguyen E, Claar D, McGuinn E, Mast K, Hartley K, McDonagh K
      Persistence Pays Off: Adult Langerhans Cell Histiocytosis.
      26968470 The American journal of medicine, 2016 July : 129(7)e55-9
    • Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J
      Accurate Prediction of Contact Numbers for Multi-Spanning Helical Membrane Proteins.
      26804342 Journal of chemical information and modeling, 2016 Feb. 22 : 56(2)423-34 PMCID:PMC5537626
    • Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J
      Accurate Prediction of Contact Numbers for Multi-Spanning Helical Membrane Proteins.
      26804342 Journal of chemical information and modeling, 2016 Feb. 22 : 56(2)423-34 PMCID:PMC5537626
    • Gregory KJ, Nguyen ED, Malosh C, Mendenhall JL, Zic JZ, Bates BS, Noetzel MJ, Squire EF, Turner EM, Rook JM, Emmitte KA, Stauffer SR, Lindsley CW, Meiler J, Conn PJ
      Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
      24528109 ACS chemical neuroscience, 2014 April 16 : 5(4)282-95 PMCID:PMC3990945
    • Gregory KJ, Nguyen ED, Malosh C, Mendenhall JL, Zic JZ, Bates BS, Noetzel MJ, Squire EF, Turner EM, Rook JM, Emmitte KA, Stauffer SR, Lindsley CW, Meiler J, Conn PJ
      Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
      24528109 ACS chemical neuroscience, 2014 April 16 : 5(4)282-95 PMCID:PMC3990945
    • Turlington M, Noetzel MJ, Chun A, Zhou Y, Gogliotti RD, Nguyen ED, Gregory KJ, Vinson PN, Rook JM, Gogi KK, Xiang Z, Bridges TM, Daniels JS, Jones C, Niswender CM, Meiler J, Conn PJ, Lindsley CW, Stauffer SR
      Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
      24050755 Journal of medicinal chemistry, 2013 Oct. 24 : 56(20)7976-96 PMCID:PMC3908770
    • Turlington M, Noetzel MJ, Chun A, Zhou Y, Gogliotti RD, Nguyen ED, Gregory KJ, Vinson PN, Rook JM, Gogi KK, Xiang Z, Bridges TM, Daniels JS, Jones C, Niswender CM, Meiler J, Conn PJ, Lindsley CW, Stauffer SR
      Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
      24050755 Journal of medicinal chemistry, 2013 Oct. 24 : 56(20)7976-96 PMCID:PMC3908770
    • Gregory KJ, Nguyen ED, Reiff SD, Squire EF, Stauffer SR, Lindsley CW, Meiler J, Conn PJ
      Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.
      23444015 Molecular pharmacology, 2013 May : 83(5)991-1006 PMCID:PMC3629835
    • Combs SA, Deluca SL, Deluca SH, Lemmon GH, Nannemann DP, Nguyen ED, Willis JR, Sheehan JH, Meiler J
      Small-molecule ligand docking into comparative models with Rosetta.
      23744289 Nature protocols, 2013 : 8(7)1277-98 PMCID:PMC5750396
    • Combs SA, Deluca SL, Deluca SH, Lemmon GH, Nannemann DP, Nguyen ED, Willis JR, Sheehan JH, Meiler J
      Small-molecule ligand docking into comparative models with Rosetta.
      23744289 Nature protocols, 2013 : 8(7)1277-98 PMCID:PMC5750396
    • Nguyen ED, Norn C, Frimurer TM, Meiler J
      Assessment and challenges of ligand docking into comparative models of G-protein coupled receptors.
      23844000 PloS one, 2013 : 8(7)e67302 PMCID:PMC3699586
    • Nguyen ED, Norn C, Frimurer TM, Meiler J
      Assessment and challenges of ligand docking into comparative models of G-protein coupled receptors.
      23844000 PloS one, 2013 : 8(7)e67302 PMCID:PMC3699586
    • Hui H, Khoury N, Zhao X, Balkir L, D'Amico E, Bullotta A, Nguyen ED, Gambotto A, Perfetti R
      Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.
      15677500 Diabetes, 2005 Feb. : 54(2)424-33

Overview

Research Description

The kidney undergoes injury as a common complication of infection, surgical procedures, medications, and systemic disease. Once injured, the kidney’s ability to return to its prior state of function is unfortunately compromised. The result is progressive and irreversible chronic kidney disease which at minimum require lifelong monitoring for systemic effects and at worse, results in end-stage kidney disease requiring dialysis or kidney transplant. Supportive measures only slow the progression of chronic kidney disease and currently, there is no treatment resulting in the functional repair of injured kidney tissue.

In collaboration with Dr. Mark Majesky & Dr. David Beier, our current projects focus on the role of histone modifications in the regulation of gene expression for models of kidney injury. Epigenetic regulation of transcription through the posttranslational modification of histones plays an important role in any situation where cells undergo transitional states. We investigate the proteomic, genetic and epigenetic changes that in the setting of kidney injury and repair with the goal of identifying mechanisms by which the response to kidney injury can be redirected from fibrosis to functional organ tissue.